[SCHEDULE 13G] Arrowhead Research Corporation SEC Filing

Rhea-AI Filing Summary

State Street Corporation filed a Schedule 13G reporting beneficial ownership of 6,371,056 shares of Arrowhead Pharmaceuticals Inc. common stock, representing 4.6% of the class as of the event date 06/30/2025. The filing is signed on behalf of State Street by Elizabeth Schaefer, Senior Vice President and Chief Accounting Officer, on 08/08/2025.

The statement shows no sole voting or dispositive power (0 shares) and records shared voting power of 5,952,902 shares and shared dispositive power of 6,371,056 shares. Item 7 identifies State Street advisory and funds entities as affiliated managers (for example, SSGA Funds Management, Inc.; State Street Global Advisors Europe Limited). The filing does not indicate a group filing or identify any other person with >5% ownership.

Insights

Securities Analyst

TL;DR: Passive institutional disclosure showing a meaningful but non-controlling stake; below 5% threshold for mandatory activist reporting.

State Street reports beneficial ownership of 6,371,056 shares, equal to 4.6% of Arrowhead Pharmaceuticals. The position is held with shared voting power of 5,952,902 and shared dispositive power of 6,371,056, while sole powers are zero. Because the stake is under 5%, it is typically treated as passive institutional ownership rather than an activist or control-seeking position. The identification of multiple State Street advisory affiliates in Item 7 is consistent with custody and advisory structures for institutional asset managers.

Corporate Governance Expert

TL;DR: Disclosure clarifies stewardship roles across State Street affiliates but shows no direct control or sole decision-making authority.

The filing discloses shared authority across State Street entities, listing specific affiliates in Item 7 (e.g., SSGA Funds Management, Inc.; State Street Global Advisors Europe Limited). Shared voting and dispositive powers indicate coordinated handling of assets by advisory arms rather than unilateral control. The result is transparency about who votes and disposes of shares, but the reported percentages and power breakdown do not signal governance change or takeover intent.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

ARROWHEAD PHARMACEUTICALS INC

(Name of Issuer)

COMMON STOCK

(Title of Class of Securities)

04280A100

(CUSIP Number)

06/30/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No. 04280A100

1

Names of Reporting Persons

STATE STREET CORPORATION

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

MASSACHUSETTS

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 5,952,902.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 6,371,056.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

6,371,056.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

4.6 %

12

Type of Reporting Person (See Instructions)

HC

SCHEDULE 13G

Item 1.
(a)	Name of issuer: ARROWHEAD PHARMACEUTICALS INC
(b)	Address of issuer's principal executive offices: 177 EAST COLORADO BLVD SUITE 700 , PASADENA, CALIFORNIA, 91105
Item 2.
(a)	Name of person filing: STATE STREET CORPORATION;
(b)	Address or principal business office or, if none, residence: ONE CONGRESS STREET, SUITE 1, BOSTON MA 02114, UNITED STATES
(c)	Citizenship: MA
(d)	Title of class of securities: COMMON STOCK
(e)	CUSIP No.: 04280A100
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 6371056.00
(b)	Percent of class: 4.6 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 0
	(ii) Shared power to vote or to direct the vote: 5,952,902
	(iii) Sole power to dispose or to direct the disposition of: 0
	(iv) Shared power to dispose or to direct the disposition of: 6,371,056
Item 5.	Ownership of 5 Percent or Less of a Class.
	Ownership of 5 percent or less of a class
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. NOT APPLICABLE
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. SSGA FUNDS MANAGEMENT, INC. (IA);STATE STREET GLOBAL ADVISORS EUROPE LIMITED (IA);STATE STREET GLOBAL ADVISORS LIMITED (IA);STATE STREET GLOBAL ADVISORS TRUST COMPANY (IA);STATE STREET GLOBAL ADVISORS, AUSTRALIA, LIMITED (IA);STATE STREET GLOBAL ADVISORS, LTD. (IA);
Item 8.	Identification and Classification of Members of the Group.
	If a group has filed this schedule pursuant to §240.13d-1(b)(1)(ii)(K), so indicate under Item 3(k) and attach an exhibit stating the identity and Item 3 classification of each member of the group. If a group has filed this schedule pursuant to §240.13d-1(c) or §240.13d-1(d), attach an exhibit stating the identity of each member of the group. NOT APPLICABLE
Item 9.	Notice of Dissolution of Group.
	Notice of dissolution of a group may be furnished as an exhibit stating the date of the dissolution and that all further filings with respect to transactions in the security reported on will be filed, if required, by members of the group, in their individual capacity. See Item 5. NOT APPLICABLE

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

STATE STREET CORPORATION

Signature:	ELIZABETH SCHAEFER
Name/Title:	SENIOR VICE PRESIDENT, CHIEF ACCOUNTING OFFICER
Date:	08/08/2025

FAQ

How many Arrowhead Pharmaceuticals (ARWR) shares does State Street own?

State Street reports beneficial ownership of 6,371,056 shares of Arrowhead Pharmaceuticals common stock.

What percentage of ARWR does State Street's holding represent?

The filing states the position represents 4.6% of the outstanding class.

What voting and dispositive powers are reported by State Street in this 13G?

The filing lists 0 shares with sole voting power, 5,952,902 with shared voting power, 0 with sole dispositive power, and 6,371,056 with shared dispositive power.

When is the event date that triggered this Schedule 13G filing?

The date of the event requiring this filing is listed as 06/30/2025.

Who signed the Schedule 13G for State Street and when?

The filing is signed by Elizabeth Schaefer, Senior Vice President and Chief Accounting Officer, on 08/08/2025.

Does the filing list any State Street subsidiaries or affiliates involved?

Item 7 names affiliated managers including SSGA Funds Management, Inc., State Street Global Advisors Europe Limited, State Street Global Advisors Limited, and others as identified in the filing.