FMR LLC holds 6.6% in Ascendis Pharma (NASDAQ: ASND) via 3.85M shares

Rhea-AI Filing Summary

Ascendis Pharma A/S files Amendment No. 12 to a Schedule 13G/A reporting beneficial ownership of 3,852,100.98 shares, representing 6.6% of common stock held by FMR LLC. The filing lists Abigail P. Johnson as having dispositive power over the same 3,852,100.98 shares.

The schedule notes the filing entity is FMR LLC (245 Summer Street, Boston) and references an attached Exhibit 99 and a Power of Attorney effective April 13, 2026.

Insights

Institutional Ownership Analyst

FMR LLC reports a 6.6% stake (3,852,100.98 shares) in Ascendis Pharma A/S.

FMR LLC is disclosed as beneficial owner with sole dispositive power for 3,852,100.98 shares, per the Schedule 13G/A amendment. The filing includes Abigail P. Johnson as having dispositive authority over the same share count.

Ownership is material for shareholder register tracking; subsequent filings or exhibits (Exhibit 99) may clarify subsidiary attributions. Timing and cash-flow treatment are not provided in the excerpt.

Key Figures

Shares beneficially owned: 3,852,100.98 shares Percent of class: 6.6% Sole voting power: 3,851,946 shares +1 more

4 metrics

Shares beneficially owned 3,852,100.98 shares Amount beneficially owned reported on Schedule 13G/A

Percent of class 6.6% Percent of common stock reported in Item 4

Sole voting power 3,851,946 shares Sole voting power shown on the cover-page entry

Power of Attorney date April 13, 2026 Power of Attorney effective date referenced for signatures

Key Terms

Schedule 13G/A, Beneficially owned, Sole dispositive power, Exhibit 99

4 terms

Schedule 13G/A regulatory

"Item 1 (a) Name of issuer: ASCENDIS PHARMA and form header"

A Schedule 13G/A is an amended public filing with the U.S. securities regulator that updates a previous Schedule 13G, disclosing when an individual or group holds a substantial (typically over 5%) stake in a company and is claiming a passive, non‑controlling intent. Investors monitor these updates because rising or falling holdings can signal changing confidence, potential future moves, or shifts in voting power — like watching a public ledger where large shareholders quietly adjust their positions.

Beneficially owned financial

"Item 4 (a) Amount beneficially owned: 3852100.98"

Beneficially owned describes securities or assets where a person has the economic rights and control—such as the right to receive dividends and to direct voting—even if legal title is held in another name. Think of it like having the keys and using a car that’s registered to someone else: you get the benefits and make decisions. Investors care because beneficial ownership reveals who truly controls value and voting power, affecting corporate decisions and takeover dynamics.

Sole dispositive power regulatory

"Item 4 (c)(iii) Sole power to dispose: 3852100.98"

Sole dispositive power is the exclusive legal authority to decide what happens to a security — for example, whether to sell, transfer, or retain shares — without needing anyone else’s permission. Investors care because it signals who truly controls the economic outcome of an investment: like holding the only key to a safe, the holder can realize gains or losses and may trigger regulatory reporting, insider rules, or influence over corporate ownership.

Exhibit 99 regulatory

"Exhibit Information Please see Exhibit 99 for 13d-1(k)(1) agreement."

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 12)

ASCENDIS PHARMA AS

(Name of Issuer)

COMMON STOCK

(Title of Class of Securities)

K08588103

(CUSIP Number)

03/31/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): K08588103

1

Names of Reporting Persons

FMR LLC

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 3,851,946.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 3,852,100.98
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

3,852,100.98

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

6.6 %

12

Type of Reporting Person (See Instructions)

HC

SCHEDULE 13G

CUSIP Number(s): K08588103

1

Names of Reporting Persons

Abigail P. Johnson

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 3,852,100.98
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

3,852,100.98

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

6.6 %

12

Type of Reporting Person (See Instructions)

IN

SCHEDULE 13G

Item 1.
(a)	Name of issuer: ASCENDIS PHARMA AS
(b)	Address of issuer's principal executive offices: TUBORG BOULEVARD 12,HELLERUP,G7,DK-2900
Item 2.
(a)	Name of person filing: FMR LLC
(b)	Address or principal business office or, if none, residence: 245 Summer Street, Boston, Massachusetts 02210
(c)	Citizenship: Not applicable
(d)	Title of class of securities: COMMON STOCK
(e)	CUSIP No.: K08588103
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 3852100.98
(b)	Percent of class: 6.6 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: Please see the responses to Items 5 and 6 on the cover page.
	(ii) Shared power to vote or to direct the vote: 0.00
	(iii) Sole power to dispose or to direct the disposition of: 3852100.98
	(iv) Shared power to dispose or to direct the disposition of: 0.00
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. One or more other persons are known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the COMMON STOCK of ASCENDIS PHARMA AS. No one other person's interest in the COMMON STOCK of ASCENDIS PHARMA AS is more than five percent of the total outstanding COMMON STOCK.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. See attached Exhibit 99.
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

FMR LLC

Signature:	Richard Bourgelas
Name/Title:	Duly authorized under Power of Attorney effective as of April 13, 2026, by and on behalf of FMR LLC and its direct and indirect subsidiaries*
Date:	05/05/2026

Abigail P. Johnson

Signature:	Richard Bourgelas
Name/Title:	Duly authorized under Power of Attorney effective as of April 13, 2026, by and on behalf of Abigail P. Johnson*
Date:	05/05/2026

Comments accompanying signature: *This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on April 29,2026, accession number: 0000315066-26-000738.

Exhibit Information

Please see Exhibit 99 for 13d-1(k) (1) agreement.

FAQ

What stake does FMR LLC report in Ascendis Pharma (ASND)?

FMR LLC reports beneficial ownership of 3,852,100.98 shares, equal to 6.6% of common stock. The Schedule 13G/A amendment lists sole dispositive power for that share count and cites Exhibit 99 for subsidiary details.

Who is listed as having dispositive power over the ASND shares?

Abigail P. Johnson is listed with sole dispositive power for 3,852,100.98 shares. The filing shows signatures executed under a Power of Attorney dated April 13, 2026.

What filing is this and what does Amendment No. 12 indicate?

This is a Schedule 13G/A amendment (No. 12) reporting beneficial ownership in Ascendis Pharma. It updates or restates institutional holdings and references Exhibit 99 and a Power of Attorney.

Does the filing state whether FMR LLC controls voting power?

The filing shows sole voting power: 3,851,946 (cover page) and sole dispositive power: 3,852,100.98. Shared voting and dispositive power are reported as 0.00.

Where can investors find supporting documents referenced in the filing?

The filing references Exhibit 99 for a 13d-1(k)(1) agreement and an Exhibit 24 Power of Attorney incorporated by reference. Those exhibits provide subsidiary and authority details.