Avalo Therapeutics ownership disclosure: FMR LLC (and Abigail P. Johnson in a related capacity) reports beneficial ownership of 2,879,481 shares of common stock, representing 12.6% of the class in an Amendment No. 1 to a Schedule 13G/A.
The filing lists sole dispositive power and, where applicable, sole voting power tied to the reported shares. Signatures are dated 05/05/2026.
Positive
None.
Negative
None.
Insights
FMR LLC holds a significant passive stake in Avalo Therapeutics.
FMR LLC is reported as beneficial owner of 2,879,481 shares, or 12.6%; the filing is an amendment to a Schedule 13G/A, indicating a passive reporting posture under the applicable rules.
Investor implications depend on whether the stake remains passive; subsequent filings could disclose any change in voting or control intentions.
Filing documents ownership and appoints power of attorney signatory.
The schedule shows sole voting/dispositive power entries and references a Power of Attorney effective 04/13/2026, with signatures dated 05/05/2026.
As a Schedule 13G/A amendment, it updates beneficial-ownership disclosure; follow-up filings would be required if ownership intent or control status changes.
Key Figures
Beneficial ownership:2,879,481 sharesPercent of class:12.6%CUSIP:05338F306+2 more
5 metrics
Beneficial ownership2,879,481 sharesAmount beneficially owned reported on Schedule 13G/A
Percent of class12.6%Percent of common stock represented by reported shares
CUSIP05338F306Identifier for Avalo Therapeutics common stock
Reporting reference date03/31/2026Date shown in the filing header
Signature date05/05/2026Date signatures were executed on the amendment
Key Terms
Schedule 13G/A, beneficially owned, Sole Dispositive Power
3 terms
Schedule 13G/Aregulatory
"Amendment No. 1 to a Schedule 13G/A reporting beneficial ownership"
A Schedule 13G/A is an amended public filing with the U.S. securities regulator that updates a previous Schedule 13G, disclosing when an individual or group holds a substantial (typically over 5%) stake in a company and is claiming a passive, non‑controlling intent. Investors monitor these updates because rising or falling holdings can signal changing confidence, potential future moves, or shifts in voting power — like watching a public ledger where large shareholders quietly adjust their positions.
beneficially ownedfinancial
"Amount beneficially owned: 2879481.00 (b) Percent of class: 12.6 %"
Beneficially owned describes securities or assets where a person has the economic rights and control—such as the right to receive dividends and to direct voting—even if legal title is held in another name. Think of it like having the keys and using a car that’s registered to someone else: you get the benefits and make decisions. Investors care because beneficial ownership reveals who truly controls value and voting power, affecting corporate decisions and takeover dynamics.
Sole Dispositive Powerregulatory
"Sole Dispositive Power 2,879,481.00 listed on the cover page"
Sole dispositive power is the exclusive legal authority to decide what happens to a security — for example, whether to sell, transfer, or retain shares — without needing anyone else’s permission. Investors care because it signals who truly controls the economic outcome of an investment: like holding the only key to a safe, the holder can realize gains or losses and may trigger regulatory reporting, insider rules, or influence over corporate ownership.
What stake does FMR LLC report in Avalo Therapeutics (AVTX)?
FMR LLC reports beneficial ownership of 2,879,481 shares representing 12.6% of Avalo Therapeutics' common stock. The amount and percentage are listed on the Schedule 13G/A amendment included in the filing.
Is the filing an initial disclosure or an amendment for AVTX?
The filing is identified as Amendment No. 1 to a Schedule 13G/A. It updates previously reported holdings rather than serving as the original Schedule 13G filing.
Who signed the Schedule 13G/A amendment for AVTX?
The Schedule 13G/A amendment was signed by Richard Bourgelas as authorized under a Power of Attorney, on behalf of FMR LLC and Abigail P. Johnson, dated 05/05/2026.
Does the filing state whether FMR LLC actively controls Avalo Therapeutics?
The filing reports beneficial ownership and voting/dispositive powers but is a Schedule 13G/A amendment, which indicates a passive investor disclosure rather than an active control statement.
What date is used as the reporting reference in the AVTX filing?
The header shows a reference date of 03/31/2026 and the signature dates are 05/05/2026; the report reflects ownership information tied to those dates.
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
UNDER THE SECURITIES EXCHANGE ACT OF 1934
(Amendment No. 1)
AVALO THERAPEUTICS INC
(Name of Issuer)
COMMON STOCK
(Title of Class of Securities)
05338F306
(CUSIP Number)
03/31/2026
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Rule 13d-1(b)
Rule 13d-1(c)
Rule 13d-1(d)
schemaVersion:
SCHEDULE 13G
CUSIP Number(s):
05338F306
1
Names of Reporting Persons
FMR LLC
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
DELAWARE
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
2,879,481.00
6
Shared Voting Power
0.00
7
Sole Dispositive Power
2,879,481.00
8
Shared Dispositive Power
0.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
2,879,481.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
12.6 %
12
Type of Reporting Person (See Instructions)
HC
SCHEDULE 13G
CUSIP Number(s):
05338F306
1
Names of Reporting Persons
Abigail P. Johnson
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
UNITED STATES
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
0.00
7
Sole Dispositive Power
2,879,481.00
8
Shared Dispositive Power
0.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
2,879,481.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
12.6 %
12
Type of Reporting Person (See Instructions)
IN
SCHEDULE 13G
Item 1.
(a)
Name of issuer:
AVALO THERAPEUTICS INC
(b)
Address of issuer's principal executive offices:
1500 LIBERTY RIDGE DRIVE,SUITE 321,WAYNE,PA,USA,19087
Item 2.
(a)
Name of person filing:
FMR LLC
(b)
Address or principal business office or, if none, residence:
245 Summer Street, Boston, Massachusetts 02210
(c)
Citizenship:
Not applicable
(d)
Title of class of securities:
COMMON STOCK
(e)
CUSIP No.:
05338F306
Item 3.
If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)
Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)
Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)
Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)
Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)
An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)
An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)
A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)
A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)
A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)
A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
please specify the type of institution:
(k)
Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.
Ownership
(a)
Amount beneficially owned:
2879481.00
(b)
Percent of class:
12.6 %
(c)
Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote:
Please see the responses to Items 5 and 6 on the cover page.
(ii) Shared power to vote or to direct the vote:
0.00
(iii) Sole power to dispose or to direct the disposition of:
2879481.00
(iv) Shared power to dispose or to direct the disposition of:
0.00
Item 5.
Ownership of 5 Percent or Less of a Class.
Not Applicable
Item 6.
Ownership of more than 5 Percent on Behalf of Another Person.
If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required.
One or more other persons are known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the COMMON STOCK of AVALO THERAPEUTICS INC. No one other person's interest in the COMMON STOCK of AVALO THERAPEUTICS INC is more than five percent of the total outstanding COMMON STOCK.
Item 7.
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary.
See attached Exhibit 99.
Item 8.
Identification and Classification of Members of the Group.
Not Applicable
Item 9.
Notice of Dissolution of Group.
Not Applicable
Item 10.
Certifications:
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
FMR LLC
Signature:
Richard Bourgelas
Name/Title:
Duly authorized under Power of Attorney effective as of April 13, 2026, by and on behalf of FMR LLC and its direct and indirect subsidiaries*
Date:
05/05/2026
Abigail P. Johnson
Signature:
Richard Bourgelas
Name/Title:
Duly authorized under Power of Attorney effective as of April 13, 2026, by and on behalf of Abigail P. Johnson*
Date:
05/05/2026
Comments accompanying signature: *This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on April 29,2026, accession number: 0000315066-26-000738.
