STOCK TITAN

Axsome COO sells 10,000 shares after option exercise

Axsome Therapeutics’ chief operating officer exercised long-held options and sold 10,000 shares under a pre-approved Rule 10b5-1 trading plan.

(Neutral)
(Neutral)
Form Type
4

Rhea-AI Filing Summary

Axsome Therapeutics, Inc. (AXSM) reported that Chief Operating Officer Mark L. Jacobson exercised stock options for 10,000 shares of common stock on September 3, 2026 at an exercise price of $12.95 per share, then sold 10,000 shares of common stock the same day at a weighted average price of $208.65 per share. The options exercised had been held for about seven years and were exercised before their March 19, 2029 expiration. Jacobson continues to hold 104,954 stock options after the transaction, and the transactions were carried out under a pre-approved Rule 10b5-1 trading plan, with sale prices ranging between $206.41 and $210.34.

Positive

  • None.

Negative

  • None.
Insider Jacobson Mark L.
Role Chief Operating Officer
Sold 10,000 shs ($2.09M)
Approx. gross sale proceeds $2.09M
Approx. exercise cost $130K
Approx. pre-tax spread $1.96M
Type Security Shares Price Value
Exercise Stock Option (Right to Buy) F1, F2 10,000 $0.00 $0.00
Exercise Common Stock F1, F2 10,000 $12.95 $130K
Sale Common Stock F2, F3, F4 10,000 $208.65 $2.09M
Holdings After Transaction: Stock Option (Right to Buy) — 104,954 contracts (Direct); Common Stock — 0 shares (Direct)
Footnotes (4)
  1. F1. Represents an exercise of stock options which were held for 7 years and exercised prior to the 10 year expiration date of such options.
  2. F2. Such transaction was pursuant to a pre-approved 10b5-1 plan.
  3. F3. Represents the subsequent sale of the underlying shares of the aforementioned exercise of stock options.
  4. F4. Represents the weighted average sale price of a series of open market transactions with sale prices ranging between $206.41 and $210.34.
Options exercised 10,000 shares Stock options for Axsome Therapeutics common stock exercised on September 3, 2026
Exercise price $12.95 per share Exercise price of stock options exercised on September 3, 2026
Shares sold 10,000 shares Common shares sold on September 3, 2026 following option exercise
Weighted average sale price $208.65 per share Weighted average price of open market sales on September 3, 2026
Sale price range $206.41–$210.34 per share Range of prices for the series of open market sales on September 3, 2026
Options held after transaction 104,954 options Stock options for Axsome Therapeutics common stock held after the reported exercise
Option expiration date March 19, 2029 Expiration date of the stock options that were exercised for 10,000 shares
Rule 10b5-1 plan regulatory
"Such transaction was pursuant to a pre-approved 10b5-1 plan."
A Rule 10b5-1 plan is a prearranged, written schedule that lets corporate insiders buy or sell company stock at set times or amounts, even if they later learn material nonpublic information. Think of it like setting an automatic thermostat for trades: it creates a clear record that trades were planned in advance, reducing the risk of insider-trading accusations and helping investors trust that insider transactions are routine rather than based on secret information.
stock options financial
"Represents an exercise of stock options which were held for 7 years"
Stock options are agreements that give a person the right to buy or sell a company's stock at a specific price within a certain time frame. They are often used as a reward or incentive, similar to a coupon that can be used later if the stock price rises, allowing the holder to make a profit.
weighted average sale price financial
"Represents the weighted average sale price of a series of open market transactions"

FAQ

What insider transactions did AXSM’s chief operating officer report on September 3, 2026?

Mark L. Jacobson reported exercising 10,000 stock options at $12.95 per share and selling 10,000 shares of Axsome Therapeutics common stock the same day at a weighted average price of $208.65 per share, in open market transactions.

Were the September 3, 2026 AXSM insider transactions under a Rule 10b5-1 plan?

Yes. The filing states that the transactions were carried out pursuant to a pre-approved Rule 10b5-1 plan, indicating they followed a pre-established trading schedule rather than being initiated at the time of the trades.

What stock options did the AXSM COO exercise in this Form 4 filing?

Mark L. Jacobson exercised 10,000 stock options for Axsome Therapeutics common stock at an exercise price of $12.95 per share. The options had been held for about seven years and were exercised before their March 19, 2029 expiration date.

At what prices were the AXSM shares sold by the COO on September 3, 2026?

The 10,000 shares of Axsome Therapeutics common stock were sold at a weighted average price of $208.65 per share. The filing notes that individual sale prices in the series of open market transactions ranged from $206.41 to $210.34 per share.

How many Axsome Therapeutics options does the COO hold after these transactions?

After exercising and selling shares related to this grant, Mark L. Jacobson continues to hold 104,954 stock options of Axsome Therapeutics, according to the reported post-transaction derivative holdings in the filing.

Did the AXSM COO acquire or sell any other securities in this Form 4?

The Form 4 reports a single options exercise for 10,000 shares of common stock and a related sale of 10,000 shares of common stock. No additional acquisitions or dispositions are disclosed in this filing.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Jacobson Mark L.

(Last)(First)(Middle)
C/O AXSOME THERAPEUTICS, INC.
ONE WORLD TRADE CENTER, 29TH FLOOR

(Street)
NEW YORK NEW YORK 10007

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Axsome Therapeutics, Inc. [ AXSM ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director10% Owner
XOfficer (give title below)Other (specify below)
Chief Operating Officer
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
09/03/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock09/03/2026M(1)(2)10,000A$12.9510,000D
Common Stock09/03/2026S(2)(3)10,000D$208.65(4)0D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option (Right to Buy)$12.9509/03/2026M(1)(2)10,00003/19/202003/19/2029Common Stock10,000$0.00104,954D
Explanation of Responses:
1. Represents an exercise of stock options which were held for 7 years and exercised prior to the 10 year expiration date of such options.
2. Such transaction was pursuant to a pre-approved 10b5-1 plan.
3. Represents the subsequent sale of the underlying shares of the aforementioned exercise of stock options.
4. Represents the weighted average sale price of a series of open market transactions with sale prices ranging between $206.41 and $210.34.
/s/ Mark Jacobson09/03/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

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