STOCK TITAN

Record Q4 for Biofrontera (NASDAQ: BFRI) with 36% revenue growth

Filing Impact
(Very High)
Filing Sentiment
(Neutral)
Form Type
8-K

Rhea-AI Filing Summary

Biofrontera Inc. reported record fourth quarter 2025 results, highlighted by strong growth and a swing to profitability. Q4 revenues rose 36% to $17.1 million from $12.6 million, with gross margin expanding to 82.4% from 58.0%. Operating income reached $4.6 million and net income was $5.6 million, both reversing prior-year losses.

For full year 2025, revenue increased 12% to $41.7 million, while the net loss narrowed to $10.5 million from $17.7 million. Adjusted EBITDA improved to $4.9 million in Q4 versus a $(1.4) million loss a year earlier, though it remained negative at $(10.6) million for the year. Cash and cash equivalents were $6.4 million as of December 31, 2025.

The company completed the purchase of all U.S. Ameluz and RhodoLED assets, reducing the earnout rate on U.S. net sales from 25%–35% to 12%–15%, and advanced its PDT pipeline with positive Phase 2b and Phase 3 data and an FDA-accepted sBCC sNDA with a PDUFA date in September 2026.

Positive

  • Record Q4 growth and profitability: Q4 2025 revenue rose 36% year over year to $17.1 million, gross margin expanded to 82.4%, and net income reached $5.6 million, marking a sharp improvement from prior-year losses.
  • Structurally better economics: Acquisition of U.S. Ameluz and RhodoLED assets cut the earnout rate on U.S. net sales from 25%–35% to 12%–15%, supporting materially higher gross margins.
  • Pipeline and regulatory momentum: Positive Phase 2b acne results, positive Phase 3 AK data, and FDA acceptance of an sNDA for sBCC with a September 2026 PDUFA date strengthen future growth prospects.

Negative

  • Business still loss-making for 2025: Despite a profitable Q4, full-year 2025 net loss was $10.5 million and Adjusted EBITDA was $(10.6) million, indicating the company has not yet reached sustained profitability.
  • Limited cash cushion relative to losses: Cash and cash equivalents of $6.4 million as of December 31, 2025 compare against operating cash outflows of $13.4 million in 2025, implying continued dependence on improved cash generation or additional financing.

Insights

Record Q4 profitability driven by higher margins, but the business is not yet profitable for the full year.

Biofrontera delivered a strong operational turnaround in Q4 2025. Revenue grew 36% year over year to $17.1 million, while gross margin jumped to 82.4% from 58.0%. This margin expansion stems from shifting away from the prior transfer-pricing model to a lower earnout structure following the 2025 asset purchase.

Full-year 2025 shows improvement but not completion of the turnaround. Revenue increased to $41.7 million from $37.3 million and the net loss narrowed to $10.5 million from $17.7 million. Adjusted EBITDA improved to $(10.6) million, reflecting better unit economics but ongoing scale and cost challenges.

Strategically, acquiring all U.S. Ameluz and RhodoLED assets and cutting earnouts to 12%–15% of U.S. net sales should structurally support margins. Pipeline progress, including an accepted sNDA for sBCC with a September 2026 PDUFA date and positive acne and AK data, ties future growth to regulatory outcomes and commercialization execution.

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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

 

FORM 8-K

 

CURRENT REPORT

PURSUANT TO SECTION 13 OR 15(D)

OF THE SECURITIES EXCHANGE ACT OF 1934

 

Date of Report (Date of earliest event reported): March 19, 2026

 

Biofrontera Inc.

(Exact name of registrant as specified in its charter)

 

Delaware   001-40943   47-3765675

(State or other jurisdiction

of incorporation)

 

(Commission

File Number)

 

(IRS Employer

Identification No.)

 

660 Main Street, First Floor

Woburn, Massachusetts

  01801
(Address of principal executive offices)   (Zip Code)

 

Registrant’s telephone number, including area code: (781) 245-1325

 

Not Applicable

(Former name or former address, if changed since last report)

 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

 

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
   
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
   
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
   
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

 

Securities registered pursuant to Section 12(b) of the Exchange Act:

 

Title of each class   Trading Symbol(s)   Name of each exchange on which registered
Common stock, par value $0.001 per share   BFRI   The Nasdaq Stock Market LLC
Warrants to purchase common stock   BFRIW   The Nasdaq Stock Market LLC

 

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (the “Exchange Act”) (§240.12b-2 of this chapter).

 

Emerging growth company

 

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.

 

 

 

 

 

 

Item 2.02 Results of Operations and Financial Condition.

 

On March 19, 2026, Biofrontera Inc. (the “Company”) issued a press release announcing its financial and operational results for the fourth quarter and fiscal year ended December 31, 2025. A copy of the press release is being furnished as Exhibit 99.1 attached hereto to this Current Report on Form 8-K.

 

The Company’s press release contains non-GAAP financial measures. Generally, a non-GAAP financial measure is a numerical measure of a company’s performance, financial position, or cash flows that either excludes or includes amounts that are not normally excluded or included in the most directly comparable measure calculated and presented in accordance with United States generally accepted accounting principles, or GAAP. Pursuant to the requirements of Regulation G, the Company has provided within the press release quantitative reconciliations of the non-GAAP financial measures to the most directly comparable GAAP financial measures.

 

The information contained in this Item 2.02 in the Current Report on Form 8-K (including Exhibit 99.1 attached hereto) is being furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, nor shall such information be deemed to be incorporated by reference in any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such filing.

 

Item 9.01 Financial Statements and Exhibits.

 

99.1 Press release dated March 19, 2026
104 Cover Page Interactive Data File (the cover page XBRL tags are embedded within the inline XBRL document)

 

 

 

 

SIGNATURE

 

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

 

March 19, 2026 Biofrontera Inc.
(Date) (Registrant)
   
  /s/ E. Fred Leffler III
  E. Fred Leffler, III
  Chief Financial Officer

 

 

 

 

Exhibit 99.1

 

 

Biofrontera Inc. Reports Record Fourth Quarter and Full Year 2025 Financial Results and Provides a Business Update

 

Conference call will be held today, Thursday, March 19 at 10:00 am ET

 

Woburn, MA (March 19, 2026) (GLOBE NEWSWIRE) — Biofrontera Inc. (NASDAQ:BFRI) (the “Company”), a biopharmaceutical company specializing in the development and commercialization of photodynamic therapy (PDT) in dermatology, today reported financial results for the three and twelve months ended December 31, 2025 and provided a business update.

 

Fourth Quarter Financial Highlights

 

Revenues for 4Q25 were a record $17.1 million, a 36% increase compared to $12.6 million for the same period in 2024.
Gross margins were 82.4%, a roughly 2,400 basis point year over year increase compared to 58.0% in 4Q24, reflecting the transition away from the transfer pricing model under the prior license and supply agreement.
Operating income was $4.6 million in 4Q25 compared to a loss of $1.7 million in 4Q24.
Cash balance was $6.4 million as of December 31, 2025.

 

Recent Operational Highlights

 

Announced positive results of its Phase 2b clinical trial evaluating Ameluz® topical gel, 10% used in combination with the RhodoLED® red-light lamp series for the treatment of moderate to severe acne vulgaris (AV).
Announced FDA’s completion of its filing review and filing acceptance of the Company’s supplemental New Drug Application (sNDA) for Ameluz® Photodynamic Therapy (PDT) for the treatment of superficial basal cell carcinoma (sBCC).
Announced positive and statistically significant top-line results from its Phase 3 clinical trial evaluating Ameluz® PDT with the red-light LED (RhodoLED®) platform for the treatment of mild to moderate actinic keratoses (AKs) on the extremities, neck, and trunk.
 Announced database lock of Phase 1 pharmacokinetics study required for FDA filing on treatment field on extremities, neck and trunk of up to 240 cm2.
Closed the purchase of all Ameluz and RhodoLED US Assets from Biofrontera AG. New earnout structure reduces payment rate from 25%–35% to 12%–15% of U.S. net sales.
Received the final $2.5 million of $11 million financing led by existing investors in October.
In November, announced the divestiture of its Xepi antibiotic cream to Pelthos Pharmaceuticals for $3 million at closing, $1 million upon commercial availability, and up to $6 million in milestone payments tied to revenue thresholds of $10 million and $15 million.

 

 

 

 

Hermann Luebbert, Chief Executive Officer and Chairman of Biofrontera Inc., stated: “2025 was a transformational year for Biofrontera. We delivered record annual and fourth quarter revenues, clear evidence that our refined commercial strategy is gaining traction and that the Ameluz PDT platform continues to resonate with dermatologists and their patients.

 

The completion of our strategic transaction with Biofrontera AG marks a fundamental inflection point for the Company. With full ownership and control of our U.S. assets—including intellectual property, regulatory approvals, and manufacturing rights—combined with a more favorable earnout structure, we have materially strengthened our cost profile. We saw this already in Q4 and expect the full annualized benefits of this transformation to be realized in 2026.

 

At the same time, our clinical pipeline is advancing with strong momentum, highlighted by a PDUFA date for sBCC in September 2026, positive Phase 3 results in AK on the extremities, and encouraging Phase 2b data in acne. With additional planned studies and patent protection extending through 2043, we believe we are uniquely positioned as the only company in the U.S. actively advancing FDA-controlled PDT clinical programs in dermatology.

 

Importantly, the combination of accelerating revenue growth, structurally lower cost of goods, and disciplined expense management drove profitability in the fourth quarter—the first full quarter reflecting our new cost structure. We believe this marks the beginning of a meaningful shift in our financial trajectory as we move toward sustained profitability and cash flow breakeven in 2026.”

 

Fourth Quarter Financial Results

 

Total revenues for the fourth quarter of 2025 were a record $17.1 million compared with $12.6 million for the fourth quarter of 2024. The 36% year-over-year growth was primarily driven by strong Ameluz sales execution and the pricing adjustment introduced in December 2025.

 

Gross profit margin in the fourth quarter of 2025 was 82.4% compared to 58.0% in 4Q24. Cost of goods sold related party decreased 45% year over year, driven by the transition from the pricing model under the prior license and supply agreement to the significantly lower earnout structure under the strategic transaction that took place in 2025.

 

Total operating expenses were $12.5 million for the fourth quarter of 2025 compared with $14.3 million for the fourth quarter of 2024.

 

Selling, general and administrative expenses were $8.7 million for the fourth quarter of 2025 compared with $8.2 million for the fourth quarter of 2024. The increase was mainly driven by legal costs.

 

Net income for the fourth quarter of 2025 was $5.6 million, compared with a net loss of $1.4 million for the prior-year quarter. This improvement was driven by higher revenues and materially lower cost of revenues resulting from the strategic transaction with Biofrontera AG, partially offset by higher legal and R&D expenses.

 

 

 

 

Adjusted EBITDA for the fourth quarter of 2025 was $4.9 million compared with $(1.4) million for the fourth quarter of 2024. We look at Adjusted EBITDA, a non-GAAP financial measure, as a indication of ongoing operations and this measurement is defined as net income or loss excluding interest income and expense, income taxes, depreciation and amortization, and certain other non-recurring or non-cash items.

 

Please refer to the table below which presents a GAAP to non-GAAP reconciliation of Adjusted EBITDA for the fourth quarters of 2025 and 2024.

 

Full Year 2025 Financial Results

 

Total revenues for full year 2025 increased 12% to $41.7 million compared with $37.3 million for the full year 2024.

 

Gross profit margin for the full year 2025 was 73.7% compared to 50.1% for the prior year. Cost of goods sold related party decreased 43% year over year, driven by the transition from the pricing model under the prior license and supply agreement to the significantly lower earnout structure under the strategic transaction that took place in 2025.

 

Total operating expenses were $53.1 million for the full year 2025 compared with $54.5 million for the same period in 2024. Increased legal expense was offset by reduced operational cost.

 

Net loss for the full year 2025 was $10.5 million compared to a loss of $17.7 million in the prior year.

 

Adjusted EBITDA was $(10.6) million for the full year 2025 compared with $(15.3) million for 2024.

 

Please refer to the table below which presents a GAAP to non-GAAP reconciliation of Adjusted EBITDA for the fiscal years of 2025 and 2024.

 

Conference Call Details

 

Conference call: Thursday, March 19, 2026 at 10:00 AM ET

Toll Free: 1-888-222-5806 (U.S. toll-free) International: 1-412-902-6516

Webcast: https://event.choruscall.com/mediaframe/webcast.html?webcastid=XTq1cPRZ

 

About Biofrontera Inc.

 

Biofrontera Inc. is a U.S.-based biopharmaceutical company commercializing a portfolio of pharmaceutical products for the treatment of dermatological conditions with photodynamic therapy (PDT). The Company’s products are used for the treatment of actinic keratoses, which are pre-cancerous skin lesions, and in development for additional indications. For more information, visit www.biofrontera-us.com and follow Biofrontera on LinkedIn and Twitter.

 

Contacts Investor Relations

 

Ben Shamsian

Lytham Partners

646-829-9701

shamsian@lythampartners.com


 

 

 

 

Forward-Looking Statements

 

Certain statements in this press release may constitute “forward-looking statements” within the meaning of the United States Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical facts, in this press release, including statements regarding our strategy, future operations, regulatory process, future financial position, future revenue, projected costs, prospects, plans, objectives of management and expected market growth, are forward-looking statements. The words “believe”, “anticipate”, “intend”, “expect”, “target”, “goal”, “estimate”, “plan”, “assume”, “may”, “will”, “predict”, “project”, “would”, “could” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. You should read this press release and any documents referenced herein completely and with the understanding that our actual future results may be materially different from what we expect. While we have based these forward-looking statements on our current expectations and projections about future events, we may not actually achieve the plans, intentions or expectations disclosed in or implied by our forward-looking statements, and you should not place undue reliance on our forward-looking statements.

 

These forward-looking statements are subject to risks, uncertainties and assumptions about us and accordingly, actual results or events could differ materially from the plans, intentions and expectations disclosed in or implied by the forward-looking statements we make. These risks and uncertainties, many of which are beyond our control, include, but are not limited to: our ability to achieve and sustain profitability; our ability to compete effectively in selling our products; our ability to expand, manage and maintain our direct sales and marketing efforts, including our ability to obtain the financing to develop our marketing strategy, if needed; changes in our relationship with our manufacturing partners and the possible impact of tariffs; our ability to manufacture our products; our ability to adequately protect our intellectual property and operate the business without infringing upon the intellectual property rights of others; our actual financial results may vary significantly from forecasts and from period to period; our estimates regarding anticipated operating losses, future revenues, capital requirements and our needs for additional financing; market risks regarding consolidation and group purchasing organizations (“GPOs”) in the healthcare industry; the willingness of healthcare providers to purchase our products if coverage, reimbursement and pricing from third-party payors for our products, or procedures using our products significantly declines; our ability to market, commercialize, achieve market acceptance for and sell our products; the fact that product quality issues or product defects may harm our business; any claims brough against the Company, including but not limited to product liability claims, claims of patent infringement, or claims challenging the validity of our intellectual property; our ability to maintain compliance with The Nasdaq Stock Market, LLC (“Nasdaq”) continued listing standards; our ability to comply with the requirements of being a public company; the progress, timing and completion of research, development and preclinical studies and clinical trials for our products; our ability to obtain and maintain the regulatory approvals necessary for the marketing of our products in the United States, and; and other factors that may be disclosed in the Company’s filings with the Securities and Exchange Commission (“SEC”), which can be obtained on the SEC website at www.sec.gov. Our forward-looking statements do not reflect the potential impact of any future acquisitions, mergers, dispositions, joint ventures or investments that we may make. We do not assume any obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law. Any forward-looking statements speak only as of the date on which they are made, and we undertake no obligation to publicly update or revise any forward-looking statements to reflect events or circumstances that may arise after the date of this press release, except as required by applicable law. Investors should evaluate any statements made by us in light of these important factors.

 

(Tables follow)

 

 

 

 

BIOFRONTERA INC.

CONDENSED CONSOLIDATED BALANCE SHEETS

(In thousands, except par value and share amounts)

 

   December 31, 
   2025   2024 
ASSETS          
Current assets:          
Cash and cash equivalents  $6,392   $5,905 
Investment, related party   9    7 
Accounts receivable, net   7,291    5,315 
Inventories   1,426    6,646 
Prepaid expenses and other current assets   2,279    527 
Asset held for sale   -    2,300 
Other assets, related party   686    - 
           
Total current assets   18,083    20,700 
           
Inventories, long term   3,729    - 
Property and equipment, net   2,158    80 
Operating lease right-of-use assets   1,584    903 
Intangible assets, net   2,650    35 
Other assets   360    383 
           
Total assets  $28,564   $22,101 
           
LIABILITIES AND STOCKHOLDERS’ EQUITY          
Current liabilities:          
Accounts payable   1,855    1,856 
Accounts payable, related parties, net   4,811    5,344 
Operating lease liabilities   332    548 
Accrued expenses and other current liabilities   4,897    4,273 
           
Total current liabilities   11,895    12,021 
           
Long-term liabilities:          
Convertible notes payable   4,589    4,098 
Warrant liabilities   351    1,250 
Operating lease liabilities, non-current   1,240    276 
Other liabilities   9    23 
           
Total liabilities   18,084    17,668 
           
Commitments and contingencies          
           
Stockholders’ equity:          
Convertible Preferred Stock, $0.001 par value, 20,000,000 shares authorized, no Series B-1; 2,050 and 3,366 Series B-2; 6,593 and 6,763 Series B-3; 10,719 and 0 Series C and 3,019 and 0 Series D shares issued and outstanding as of December 31, 2025 and 2024, respectively   -    - 
           
Common Stock, $0.001 par value, 70,000,000 shares authorized; 11,648,323 and 8,873,932 shares issued and outstanding as of December 31, 2025 and 2024, respectively   12    9 
Additional paid-in capital   138,413    121,833 
Accumulated deficit   (127,945)   (117,409)
           
Total stockholders’ equity   10,480    4,433 
           
Total liabilities and stockholders’ equity  $28,564   $22,101 

 

 

 

 

BIOFRONTERA INC.

CONSOLIDATED STATEMENTS OF OPERATIONS

(In thousands, except per share amounts and number of shares)

 

  

Three Months Ended

December 31,

  

Year Ended

December 31,

 
   2025   2024   2025   2024 
                 
Product revenues, net  $17,100   $12,560   $41,705   $37,303 
Revenues, related party   -    -    -    18 
                     
Total revenues, net   17,100    12,560    41,705    37,321 
                     
Operating expenses                    
Cost of revenues, related party   2,734    5,016    10,111    17,855 
Cost of revenues, other   275    256    853    752 
Selling, general and administrative   8,523    8,192    37,751    33,793 
Selling, general and administrative, related party   223    12    619    42 
Research and development   787    796    3,719    2,089 
                     
Total operating expenses   12,542    14,272    53,053    54,531 
                     
Income (Loss) from operations   4,558    (1,712)   (11,348)   (17,210)
                     
Other income (expense)                    
Change in fair value of warrant liabilities   482    351    899    1,680 
Change in fair value of investment, related party   (1)   (1)   2    (14)
Loss on debt extinguishment   -    -    -    (316)
Interest expense, net   (120)   (40)   (452)   (2,035)
Other income (expense), net   721    4    388    158 
                     
Total other income (expense)   1,082    314    837    (527)
                     
Income (loss) before income taxes   5,640    (1,398)   (10,511)   (17,737)
Income tax expense   -    (2)   25    22 
                     
Net income (loss)  $5,640   $(1,396)  $(10,536)  $(17,759)

 

 

 

 

BIOFRONTERA INC.

CONSOLIDATED STATEMENTS OF CASH FLOWS

(In Thousands)

 

   Years ended December 31, 
   2025   2024 
Cash flows from operating activities:          
           
Net loss  $(10,536)  $(17,759)
           
Adjustments to reconcile net loss to cash flows used in operations          
           
Depreciation and amortization   138    421 
Reduction in the carrying amount of right-of-use assets   730    728 
Stock-based compensation   951    1,019 
Non-cash interest expense   491    297 
Allowance for credit losses   (69)   162 
Change in fair value of warrant liabilities   (899)   (1,680)
Gain on sale of asset held for sale   (700)   - 
Loss from termination of operating leases   19    - 
Realized/unrealized loss in investment, related party   (2)   14 
Loss on debt extinguishment   -    316 
           
Changes in operating assets and liabilities:          
Accounts receivable   (1,907)   (315)
Other receivables, related party   -    2 
Prepaid expenses and other assets   (1,728)   (141)
Other assets, related party   (686)   5,159 
Inventories   1,445    4,233 
Accounts payable   (2)   (1,452)
Accounts payable, related parties, net   (533)   (355)
Operating lease liabilities   (683)   (689)
Accrued expenses and other liabilities   610    (230)
           
Cash flows used in operating activities   (13,361)   (10,270)
           
Cash flows from investing activities          
Proceeds from sale of asset held for sale   3,000    - 
Sales of investment, related party   -    57 
Purchase of intangible assets   -    (50)
Purchases of property and equipment   (2)   (10)
           
Cash flows provided by (used in) investing activities   2,998    (3)
           
Cash flows from financing activities          
Proceeds from issuance of Series C preferred stock, net of offering costs   10,850    - 
Proceeds from issuance of Series B-1 preferred stock and warrants to purchase series B-3 preferred stock, net of issuance costs   -    7,662 
Proceeds from issuance of Series B-3 preferred stock from exercise of warrants   -    7,438 
Proceeds from issuance of convertible notes, net of issuance costs        4,050 
Payment of principal short-term debt   -    (4,315)
           
Cash flows provided by financing activities   10,850    14,835 
           
Net increase in cash and cash equivalents   487    4,562 
Cash, cash equivalents and restricted cash, at the beginning of the year   6,105    1,543 
           
Cash, cash equivalents and restricted cash, at the end of the year  $6,592   $6,105 
           
Supplemental disclosure of cash flow information          
Interest paid  $6   $1,728 
Income tax paid, net  $25   $24 
           
Supplemental non-cash investing and financing activities          
Preferred stock issued as consideration in asset purchase acquisition (See Note 3. Asset Acquisition)  $4,782   $- 
Property, plant and equipment acquired   2,126    - 
Intangible asset acquired   2,656    - 
Addition of right-of-use assets in exchange for operating lease liabilities  $1,371   $55 

 

 

 

 

BIOFRONTERA INC.

GAAP TO NON-GAAP ADJUSTED EBITDA RECONCILIATION

(In thousands, except per share amounts and number of shares)

 

  

Three Months Ended

December 31,

  

Year Ended

December 31,

 
   2025   2024   2025   2024 
Net income (loss)  $5,640   $(1,396)  $(10,536)  $(17,759)
Interest expense, net   121    40    452    2,035 
Income tax expense   -    (3)   25    22 
Depreciation and amortization   62    34    138    421 
EBITDA   5,823    (1,325)   (9,921)   (15,281)
                     
Gain on sale of asset held for sale   (700)   -    (700)   - 
Change in fair value of warrant liabilities   (482)   (351)   (899)   (1,680)
Change in fair value of investment, related party   1    2    (2)   14 
Loss on debt extinguishment   -    -    -    316 
Stock based compensation   289    299    951    1,019 
Expensed issuance costs   -    -    -    354 
Adjusted EBITDA  $4,931   $(1,375)  $(10,571)  $(15,258)
Adjusted EBITDA margin   28.8%   -10.9%   -25.4%   -40.9%

 

 

 

FAQ

How did Biofrontera (BFRI) perform in Q4 2025?

Biofrontera posted record Q4 2025 revenue of $17.1 million, up 36% from $12.6 million a year earlier. Gross margin improved to 82.4%, and the company generated $4.6 million in operating income and $5.6 million in net income, reversing prior losses.

What were Biofrontera (BFRI)’s full-year 2025 financial results?

For full-year 2025, Biofrontera generated $41.7 million in revenue, up from $37.3 million in 2024. Gross margin rose to 73.7% from 50.1%, while the net loss narrowed to $10.5 million compared with a $17.7 million loss in the prior year.

How did Biofrontera’s Adjusted EBITDA change in 2025?

Biofrontera’s Adjusted EBITDA improved significantly in Q4 2025 to $4.9 million, versus a $(1.4) million loss in Q4 2024. For the full year, Adjusted EBITDA was $(10.6) million, better than $(15.3) million in 2024, reflecting higher margins and cost control.

What strategic transactions did Biofrontera (BFRI) complete in 2025?

Biofrontera closed the purchase of all U.S. Ameluz and RhodoLED assets from Biofrontera AG, lowering its earnout rate on U.S. net sales from 25%–35% to 12%–15%. It also divested its Xepi antibiotic cream for upfront and potential milestone payments.

What is the status of Biofrontera’s dermatology pipeline and FDA reviews?

Biofrontera reported positive Phase 2b acne results and positive Phase 3 data in actinic keratoses on extremities, neck, and trunk. The FDA has accepted its sNDA for Ameluz PDT in superficial basal cell carcinoma, with a PDUFA date in September 2026.

What is Biofrontera (BFRI)’s cash position at year-end 2025?

As of December 31, 2025, Biofrontera held $6.4 million in cash and cash equivalents. During 2025 it also received the final $2.5 million of an $11 million financing and generated $3 million from the sale of its Xepi asset.

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