Caris Life Sciences (CAI) director reports stock gifts and ownership

Rhea-AI Filing Summary

Caris Life Sciences, Inc. reported that one of its directors and executive officers, who serves as Vice Chairman and Executive Vice President, made two stock gifts of the company’s common stock. On 12/10/2025 and 12/11/2025, the insider transferred 650 shares on each date as gifts at a reported price of $0 per share, reflecting that these were non-cash transfers.

After these transactions, the insider beneficially owns 161,128 shares of Caris common stock directly. In addition, 500,000 shares are reported as indirectly owned through trusts, with the insider stating that beneficial ownership of those shares is disclaimed except to the extent of any pecuniary interest. No derivative securities were reported.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Brille Brian J

(Last) (First) (Middle)

C/O CARIS LIFE SCIENCES, INC.

750 W. JOHN CARPENTER FREEWAY, SUITE 800

(Street)

IRVING TX 75039

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Caris Life Sciences, Inc. [ CAI ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	See Remarks

3. Date of Earliest Transaction (Month/Day/Year)
12/10/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	12/10/2025		G		650	D	$0	161,778	D
Common Stock	12/11/2025		G		650	D	$0	161,128	D
Common Stock								500,000	I	By Trusts(1)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. The Reporting Person disclaims beneficial ownership except to the extent of his pecuniary interest therein.

Remarks:

Vice Chairman and Executive Vice President

	/s/ J. Russel Denton, Attorney-in-Fact	12/12/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What insider transaction did Caris Life Sciences (CAI) report in this filing?

The filing shows that a Caris Life Sciences director and executive officer made two gifts of 650 shares of common stock each, on 12/10/2025 and 12/11/2025, at a reported price of $0 per share.

How many Caris Life Sciences (CAI) shares does the insider own after these transactions?

Following the reported gifts, the insider beneficially owns 161,128 shares of Caris Life Sciences common stock directly.

What indirect ownership in Caris Life Sciences (CAI) does the insider report?

The insider reports indirect beneficial ownership of 500,000 shares of Caris Life Sciences common stock held by trusts, while disclaiming beneficial ownership except to the extent of any pecuniary interest.

What is the relationship of the reporting person to Caris Life Sciences (CAI)?

The reporting person is both a director and an officer of Caris Life Sciences, serving as Vice Chairman and Executive Vice President.

Were any derivative securities reported by the Caris Life Sciences (CAI) insider?

No derivative securities, such as options or warrants, were reported; the filing’s activity relates only to non-derivative common stock.

Was this Caris Life Sciences (CAI) insider filing made by more than one reporting person?

No. The filing indicates it was a Form filed by one reporting person, not a joint or group filing.