FMR LLC filed Amendment No. 1 to a Schedule 13G reporting beneficial ownership of 30,631,585 shares of Common Stock of Caris Life Sciences Inc. representing 10.8% of the class. The amendment lists sole voting power of 30,592,295 shares and sole dispositive power of 30,631,585, and cites related power-of-attorney exhibits.
Positive
None.
Negative
None.
Insights
FMR LLC reports a sizeable 10.8% passive stake in CAI.
FMR LLC's amendment documents a substantial beneficial position of 30,631,585 shares with sole dispositive authority. The filing follows Schedule 13G disclosure practice for large passive investors and lists voting and dispositive figures separately.
Watch future amendments or Schedule 13D filings for any change in intent; timing and any beneficiary identities are limited to the statements here.
Filing conforms to Schedule 13G/A formalities and cites exhibits for powers of attorney.
The amendment includes exhibit references (Exhibit 24 and Exhibit 99) and identifies filing and signature authority. It states that other persons may have dividend/proceeds rights but none exceed 5% individually, consistent with 13G reporting rules.
Subsequent filings may disclose any changes in ownership percentages or classifications.
Key Figures
Beneficial ownership:30,631,585 sharesPercent of class:10.8%Sole voting power:30,592,295 shares+3 more
6 metrics
Beneficial ownership30,631,585 sharesAmount beneficially owned as reported in Item 4
Percent of class10.8%Percent of the common stock class reported in Item 4
Sole voting power30,592,295 sharesSole voting power reported on the cover page
Sole dispositive power30,631,585 sharesSole power to dispose reported on the cover page
Filing date (cover reference)03/31/2026Date appearing on the cover header
Issuer address750 W John Carpenter Freeway, Suite 800, Irving, TXIssuer principal executive offices listed in Item 1
Key Terms
Schedule 13G/A, beneficial ownership, sole dispositive power, Exhibit 99
4 terms
Schedule 13G/Aregulatory
"Amendment No. 1 to Schedule 13G reporting beneficial ownership"
A Schedule 13G/A is an amended public filing with the U.S. securities regulator that updates a previous Schedule 13G, disclosing when an individual or group holds a substantial (typically over 5%) stake in a company and is claiming a passive, non‑controlling intent. Investors monitor these updates because rising or falling holdings can signal changing confidence, potential future moves, or shifts in voting power — like watching a public ledger where large shareholders quietly adjust their positions.
beneficial ownershipfinancial
"Amount beneficially owned: 30631585.00 (b) Percent of class: 10.8 %"
Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.
sole dispositive powerregulatory
"Sole Dispositive Power 30,631,585.00 on the cover page"
Sole dispositive power is the exclusive legal authority to decide what happens to a security — for example, whether to sell, transfer, or retain shares — without needing anyone else’s permission. Investors care because it signals who truly controls the economic outcome of an investment: like holding the only key to a safe, the holder can realize gains or losses and may trigger regulatory reporting, insider rules, or influence over corporate ownership.
Exhibit 99regulatory
"Please see Exhibit 99 for 13d-1(k)(1) agreement."
FMR LLC reports beneficial ownership of 30,631,585 shares of CAI, representing 10.8% of the common stock. The filing lists sole dispositive power over these shares and sole voting power of 30,592,295 shares.
Is FMR LLC the sole holder of voting and dispositive power?
The amendment reports sole voting power of 30,592,295 shares and sole dispositive power of 30,631,585 shares. It also states no single other person holds more than 5% of the class.
What form was filed to disclose FMR's position in CAI?
FMR LLC filed an Amendment No. 1 to Schedule 13G to disclose its beneficial ownership position and related voting/dispositive powers, including references to Exhibits 24 and 99 for powers of attorney and subsidiary identification.
Does the filing identify beneficiaries or other persons with rights to proceeds?
The filing states that one or more other persons may have rights to dividends or sale proceeds but no other individual holds over 5% of CAI's common stock; a full shareholder listing for certain pooled investors is not required.
Who signed the 13G/A amendment for FMR LLC?
The amendment is signed by Stephanie J. Brown as a duly authorized representative under powers of attorney, dated in the filing, on behalf of FMR LLC and Abigail P. Johnson.
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
UNDER THE SECURITIES EXCHANGE ACT OF 1934
(Amendment No. 1)
CARIS LIFE SCIENCES INC
(Name of Issuer)
COMMON STOCK
(Title of Class of Securities)
142152107
(CUSIP Number)
03/31/2026
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Rule 13d-1(b)
Rule 13d-1(c)
Rule 13d-1(d)
schemaVersion:
SCHEDULE 13G
CUSIP Number(s):
142152107
1
Names of Reporting Persons
FMR LLC
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
DELAWARE
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
30,592,295.00
6
Shared Voting Power
0.00
7
Sole Dispositive Power
30,631,585.00
8
Shared Dispositive Power
0.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
30,631,585.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
10.8 %
12
Type of Reporting Person (See Instructions)
HC
SCHEDULE 13G
CUSIP Number(s):
142152107
1
Names of Reporting Persons
Abigail P. Johnson
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
UNITED STATES
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
0.00
7
Sole Dispositive Power
30,631,585.00
8
Shared Dispositive Power
0.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
30,631,585.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
10.8 %
12
Type of Reporting Person (See Instructions)
IN
SCHEDULE 13G
Item 1.
(a)
Name of issuer:
CARIS LIFE SCIENCES INC
(b)
Address of issuer's principal executive offices:
750 W JOHN CARPENTER FREEWAY,SUITE 800,IRVING,TX,USA,75039
Item 2.
(a)
Name of person filing:
FMR LLC
(b)
Address or principal business office or, if none, residence:
245 Summer Street, Boston, Massachusetts 02210
(c)
Citizenship:
Not applicable
(d)
Title of class of securities:
COMMON STOCK
(e)
CUSIP No.:
Item 3.
If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)
Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)
Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)
Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)
Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)
An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)
An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)
A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)
A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)
A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)
A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
please specify the type of institution:
(k)
Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.
Ownership
(a)
Amount beneficially owned:
30631585.00
(b)
Percent of class:
10.8 %
(c)
Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote:
Please see the responses to Items 5 and 6 on the cover page.
(ii) Shared power to vote or to direct the vote:
0.00
(iii) Sole power to dispose or to direct the disposition of:
30631585.00
(iv) Shared power to dispose or to direct the disposition of:
0.00
Item 5.
Ownership of 5 Percent or Less of a Class.
Not Applicable
Item 6.
Ownership of more than 5 Percent on Behalf of Another Person.
If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required.
One or more other persons are known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the COMMON STOCK of CARIS LIFE SCIENCES INC. No one other person's interest in the COMMON STOCK of CARIS LIFE SCIENCES INC is more than five percent of the total outstanding COMMON STOCK.
Item 7.
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary.
See attached Exhibit 99.
Item 8.
Identification and Classification of Members of the Group.
Not Applicable
Item 9.
Notice of Dissolution of Group.
Not Applicable
Item 10.
Certifications:
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
FMR LLC
Signature:
Stephanie J. Brown
Name/Title:
Duly authorized under Power of Attorney effective as of January 3, 2023, by and on behalf of FMR LLC and its direct and indirect subsidiaries*
Date:
04/06/2026
Abigail P. Johnson
Signature:
Stephanie J. Brown
Name/Title:
Duly authorized under Power of Attorney effective as of January 26, 2023, by and on behalf of Abigail P. Johnson**
Date:
04/06/2026
Comments accompanying signature: * This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on January 10, 2023, accession number: 0000315066-23-000003. ** This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on January 31, 2023, accession number: 0000315066-23-000038.
