Clene CEO buys 15K shares at $3.28 in offering

Clene Inc. (CLNN) reported that President & CEO and director Robert Dee Etherington acquired common stock.

Rhea-AI Filing Summary

Clene Inc. (CLNN) reported that President & CEO and director Robert Dee Etherington acquired common stock. On September 16, 2026, he purchased 15,244 shares of common stock at $3.28 per share in a registered direct offering approved by the board under Rule 16(b)-3, bringing his directly held position to 55,393 shares. He also reports indirect holdings through an LLC and a revocable trust.

Insider Trade Summary

Grant/Award: 15,244 shares

Grant/Award 3 txns

Insider Etherington Robert Dee

Role President & CEO

Type	Security	Shares	Price	Value
Grant/Award	common stock F1	15,244	$3.28	$50K
holding	common stock F2	--	--	--
holding	common stock F3	--	--	--

Holdings After Transaction: common stock — 55,393 shares (Direct); common stock — 636 shares (Indirect, By LLC); common stock — 1,250 shares (Indirect, By trust)

Footnotes (3)

1. F1. Mr. Etherington purchased 15,244 shares of common stock of Clene Inc. for a purchase price of $3.28 per share in a registered direct offering directly from the Issuer. The issuance of such securities was approved by the Issuer's board of directors in accordance with Rule 16 (b)-3 of the Securities Exchange Act of 1934, as amended.
2. F2. The securities are owned by RDE RX Ventures LLC. Mr. Etherington is the manager of RDE RX Ventures LLC. The shares owned by RDE RX Ventures LLC may be deemed to be beneficially owned by Mr. Etherington.
3. F3. The securities are owned by the Etherington Revocable Trust. Mr. Etherington is the co-trustee of the Etherington Revocable Trust. The shares owned by the Etherington Revocable Trust may be deemed to be owned by Mr. Etherington.

Key Figures

Shares purchased: 15,244 shares Purchase price per share: $3.28 per share Direct holdings after transaction: 55,393 shares +2 more

5 metrics

Shares purchased 15,244 shares Common stock acquired on September 16, 2026

Purchase price per share $3.28 per share Price paid in registered direct offering

Direct holdings after transaction 55,393 shares Common stock held directly by CEO after acquisition

Indirect LLC holdings 636 shares Common stock owned by RDE RX Ventures LLC

Indirect trust holdings 1,250 shares Common stock owned by Etherington Revocable Trust

Key Terms

registered direct offering, Rule 16 (b)-3, beneficially owned, Revocable Trust, +1 more

5 terms

registered direct offering financial

"purchased 15,244 shares of common stock ... in a registered direct offering"

A registered direct offering is a way for a company to sell new shares of its stock directly to select investors with regulatory approval. This method allows the company to raise funds quickly and efficiently without needing a public auction, similar to offering exclusive access to a limited number of buyers. For investors, it often provides an opportunity to purchase shares at a favorable price, while giving the company immediate access to capital.

Rule 16 (b)-3 regulatory

"approved by the Issuer's board of directors in accordance with Rule 16 (b)-3"

beneficially owned financial

"may be deemed to be beneficially owned by Mr. Etherington"

Beneficially owned describes securities or assets where a person has the economic rights and control—such as the right to receive dividends and to direct voting—even if legal title is held in another name. Think of it like having the keys and using a car that’s registered to someone else: you get the benefits and make decisions. Investors care because beneficial ownership reveals who truly controls value and voting power, affecting corporate decisions and takeover dynamics.

Revocable Trust financial

"The securities are owned by the Etherington Revocable Trust"

A revocable trust is a legal arrangement where the person who creates it keeps control and can change or cancel the trust at any time, while naming who will manage and receive the assets later. Think of it like a flexible folder for your investments and property that can be relabeled or reworked as circumstances change; it matters to investors because it determines how ownership is recorded, how easily assets transfer on incapacity or death, and whether holdings bypass public probate proceedings.

Rule 10b5-1 regulatory

"no Rule 10b5-1 trading plan is reported for this transaction"

Rule 10b5-1 is a regulation that allows company insiders to buy or sell their shares at predetermined times, even if they have access to non-public information. It acts like setting a schedule in advance for transactions, helping prevent accusations of unfair trading. This rule provides a way for insiders to plan trades transparently, giving investors confidence that these transactions are not based on hidden information.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What insider transaction did Clene Inc. (CLNN) report for Robert Dee Etherington?

Clene reported that President & CEO Robert Dee Etherington acquired 15,244 shares of its common stock on September 16, 2026, increasing his directly held position to 55,393 shares.

At what price did the Clene Inc. (CLNN) CEO acquire shares?

Robert Dee Etherington purchased the 15,244 shares of Clene common stock at a price of $3.28 per share in a registered direct offering.

How many Clene Inc. (CLNN) shares does the CEO now hold directly and indirectly?

After the reported transaction, Robert Dee Etherington holds 55,393 shares of Clene common stock directly, plus indirect holdings of 636 shares through an LLC and 1,250 shares through a revocable trust.

What type of transaction was used for the CEO’s Clene Inc. (CLNN) share purchase?

The CEO bought the shares in a registered direct offering directly from Clene Inc., with the issuance approved by the board of directors under Rule 16(b)-3 of the Exchange Act.

Was the Clene Inc. (CLNN) CEO’s share purchase made under a Rule 10b5-1 plan?

No. The filing indicates no Rule 10b5-1 trading plan is reported for this transaction.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 09/18/2026 - 01:42 PM Accepted by SEC EDGAR 09/18/2026 - 01:41 PM Learn about SEC filing dates

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Etherington Robert Dee

(Last) (First) (Middle)

6550 SOUTH MILLROCK DRIVE

SUITE G50

(Street)

SALT LAKE CITY UTAH 84121

(City) (State) (Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
Clene Inc. [ CLNN ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	President & CEO

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
09/16/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
common stock	09/16/2026		A		15,244	A	$3.28	55,393	D(1)
common stock								636	I	By LLC(2)
common stock								1,250	I	By trust(3)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. Mr. Etherington purchased 15,244 shares of common stock of Clene Inc. for a purchase price of $3.28 per share in a registered direct offering directly from the Issuer. The issuance of such securities was approved by the Issuer's board of directors in accordance with Rule 16 (b)-3 of the Securities Exchange Act of 1934, as amended.

2. The securities are owned by RDE RX Ventures LLC. Mr. Etherington is the manager of RDE RX Ventures LLC. The shares owned by RDE RX Ventures LLC may be deemed to be beneficially owned by Mr. Etherington.

3. The securities are owned by the Etherington Revocable Trust. Mr. Etherington is the co-trustee of the Etherington Revocable Trust. The shares owned by the Etherington Revocable Trust may be deemed to be owned by Mr. Etherington.

	/s/ Jerome T. Miraglia POA	09/18/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)