STOCK TITAN

Hemab Therapeutics (COAG) widens Q2 2026 loss but lifts cash to $237M

(Moderate)
(Neutral)
Form Type
8-K

Rhea-AI Filing Summary

Hemab Therapeutics Holdings, Inc. reported second quarter 2026 results, highlighting increased investment in its pipeline and a larger loss. For the quarter ended June 30, 2026, operating expenses were $26,079 thousand, up from $16,057 thousand a year earlier, leading to a net loss of $24,150 thousand versus $12,209 thousand in 2025.

The company strengthened its balance sheet in the first half of 2026, with cash and cash equivalents of $237,366 thousand and marketable securities of $220,094 thousand as of June 30, 2026, and total stockholders’ equity of $454,271 thousand. Net cash provided by financing activities was $317,119 thousand in the first six months.

Pipeline progress included FDA endorsement of the sutacimig data package as sufficient to proceed to a Phase 3 pivotal trial in Glanzmann thrombasthenia, with Phase 3 initiation planned in the second half of 2026. New HMB-002 data showed a ≥2.4-fold increase in Von Willebrand Factor and Factor VIII, and Hemab unveiled HMB-003, a novel peptide-based plasmin inhibitor initially targeting heavy menstrual bleeding.

Positive

  • Balance sheet strengthened with total stockholders’ equity improving to $454,271 thousand at June 30, 2026, from a deficit of $(176,635) thousand at December 31, 2025.
  • Net cash provided by financing activities was $317,119 thousand in the first half of 2026, supporting cash and cash equivalents of $237,366 thousand and marketable securities of $220,094 thousand at June 30, 2026.
  • FDA endorsed the sutacimig clinical data package as sufficient to proceed to a Phase 3 pivotal trial in Glanzmann thrombasthenia, with Phase 3 initiation planned in the second half of 2026.
  • New HMB-002 clinical data demonstrated a ≥ 2.4-fold increase in Von Willebrand Factor and Factor VIII, providing stronger than anticipated proof of mechanism in Von Willebrand Disease.

Negative

  • Quarterly net loss widened to $24,150 thousand in Q2 2026 from $12,209 thousand in Q2 2025, reflecting higher operating expenses.
  • Net cash used in operating activities increased to $44,221 thousand for the first half of 2026 compared with $28,366 thousand in the prior-year period.
Item 2.02 Results of Operations and Financial Condition Financial
Disclosure of earnings results, typically an earnings press release or preliminary financials.
Item 9.01 Financial Statements and Exhibits Exhibits
Financial statements, pro forma financial information, and exhibit attachments filed with this report.
Net loss Q2 2026 $24,150 thousand Three months ended June 30, 2026; compared with $12,209 thousand in 2025
Operating expenses Q2 2026 $26,079 thousand Three months ended June 30, 2026; includes research and development and general and administrative
Cash and cash equivalents $237,366 thousand Balance at June 30, 2026
Marketable securities $220,094 thousand Balance at June 30, 2026
Total assets $467,781 thousand Balance at June 30, 2026
Total stockholders’ equity $454,271 thousand Balance at June 30, 2026; improved from $(176,635) thousand at December 31, 2025
Net cash from financing H1 2026 $317,119 thousand Six months ended June 30, 2026
Net cash used in operating activities $44,221 thousand Six months ended June 30, 2026
Glanzmann thrombasthenia medical
"Long-term extension data for sutacimig showed sustained favorable results in Glanzmann thrombasthenia (GT)"
A rare inherited bleeding disorder in which platelets—the blood cells that act like tiny band‑aids—cannot stick together effectively, causing prolonged or spontaneous bleeding. For investors, it matters because the small patient population and clear biological cause make the condition a target for specialist drugs, diagnostics, or gene therapies, so clinical trial results, regulatory decisions, or product approvals can significantly affect the valuation of companies developing treatments.
Von Willebrand Disease medical
"encouraging preliminary clinical observations in Von Willebrand Disease (VWD)"
A genetic bleeding disorder caused by a shortage or malfunction of a protein that helps blood clot, so people bruise easily, bleed longer from cuts, or have heavy menstrual bleeding. It matters to investors because the condition drives demand for diagnostics, replacement therapies, and new treatments; changes in prevalence, clinical trial results, regulatory approvals, or reimbursement can directly affect companies working in blood disorders and related healthcare markets.
antifibrinolytic medical
"HMB-003 is a novel fatty-acid-conjugated peptide antifibrinolytic, designed to stabilize clots"
A drug that slows or stops the body from breaking down blood clots, helping bleeding to stop and wounds to stay sealed. Think of it as glue that holds a scab in place during surgery, trauma care, or certain bleeding disorders; for investors, antifibrinolytics matter because their use, safety profile, and approvals can drive hospital demand, treatment costs, and revenue potential for companies that develop or sell them.
bispecific antibody medical
"Sutacimig is a subcutaneously administered bispecific antibody that is designed to bind and stabilize"
A bispecific antibody is a specially designed protein that can attach to two different targets at the same time. Think of it as a custom-made connector that brings two things together—such as a disease cell and an immune system component—helping the body fight illnesses more effectively. For investors, understanding bispecific antibodies is important because they represent innovative therapies that could lead to new treatments and potentially lucrative market opportunities.
Fast Track Designation regulatory
"Sutacimig has received Fast Track, Orphan Drug, and Breakthrough Therapy Designations"
Fast track designation is a status the U.S. Food and Drug Administration grants to drugs intended to treat serious conditions and address an unmet medical need. It gives the developer more frequent communication with the FDA and can allow parts of the application to be reviewed on a rolling basis, and it may pave the way to priority review or accelerated approval. It can shorten development timelines, though it does not guarantee approval.
Priority Medicines (PRIME) regulatory
"the European Medicines Agency (EMA) has granted sutacimig access to the Priority Medicines (PRIME) scheme"
A regulatory program that gives promising new medicines extra support and a faster review path when they address serious unmet medical needs. Think of it as a fast lane and coaching service from regulators that can help a drug maker design better studies and reach patients sooner; for investors this can shorten time to sales, lower some development risks, and increase the chance of quicker returns, though approval is not guaranteed.
Net loss Q2 2026 $24,150 thousand vs $12,209 thousand in Q2 2025
Operating expenses Q2 2026 $26,079 thousand vs $16,057 thousand in Q2 2025
Net cash used in operating activities H1 2026 $44,221 thousand vs $28,366 thousand in H1 2025
Cash and cash equivalents $237,366 thousand at June 30, 2026; vs $87,974 thousand at December 31, 2025

FAQ

How did Hemab Therapeutics (COAG) perform financially in Q2 2026?

Hemab reported a Q2 2026 net loss of $24,150 thousand, compared with $12,209 thousand in Q2 2025. Operating expenses rose to $26,079 thousand, reflecting increased research and development and general and administrative spending.

What is Hemab Therapeutics’ (COAG) cash position as of June 30, 2026?

As of June 30, 2026, Hemab held $237,366 thousand in cash and cash equivalents and $220,094 thousand in marketable securities. Total assets were $467,781 thousand, supported by substantial first-half 2026 financing inflows.

How much cash did Hemab Therapeutics (COAG) raise in the first half of 2026?

Net cash provided by financing activities was $317,119 thousand in the six months ended June 30, 2026. This significantly increased the company’s liquidity and contributed to higher cash, marketable securities, and stockholders’ equity.

What progress did Hemab Therapeutics (COAG) report for sutacimig?

Hemab stated that the FDA endorsed the sutacimig clinical data package as sufficient to proceed to a Phase 3 pivotal trial in Glanzmann thrombasthenia. The company plans to initiate this Phase 3 trial in the second half of 2026.

What new clinical data did Hemab Therapeutics (COAG) share on HMB-002?

New HMB-002 data showed a ≥ 2.4-fold increase in Von Willebrand Factor and Factor VIII, described as stronger than anticipated proof of mechanism with encouraging preliminary clinical observations in Von Willebrand Disease.

What is HMB-003 in Hemab Therapeutics’ (COAG) pipeline?

HMB-003 is a peptide-based plasmin inhibitor designed as a novel antifibrinolytic to reduce bleeding. It will initially target heavy menstrual bleeding and is intended for multiple high-unmet-need conditions requiring sustained bleed protection.

AI-generated analysis. How Rhea-AI works. Not financial advice.

See more from StockTitan in Google Search and AI answers. Adds StockTitan as a preferred source · opens Google
Add on Google
Learn about SEC filing dates
false 0002114044 0002114044 2026-08-11 2026-08-11
 
 

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

 

 

FORM 8-K

 

 

CURRENT REPORT

Pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): August 11, 2026

 

 

Hemab Therapeutics Holdings, Inc.

(Exact Name of Registrant as Specified in Charter)

 

 

 

Delaware   001-43250   41-4241952

(State or Other Jurisdiction

of Incorporation)

 

(Commission

File Number)

 

(IRS Employer

Identification No.)

101 Main Street, Suite 1220

Cambridge, Massachusetts

  02142
(Address of Principal Executive Offices)   (Zip Code)

Registrant’s telephone number, including area code: (617) 553-3952

Not applicable

(Former Name or Former Address, if Changed Since Last Report)

 

 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

 

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

 

Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

 

Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

 

Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

 

Title of each class

 

Trading
symbol(s)

 

Name of each exchange
on which registered

Common stock, $0.0001 par value per share   COAG   Nasdaq Global Select Market

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company 

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. 

 

 
 


Item 2.02.

Results of Operations and Financial Condition.

On August 11, 2026, Hemab Therapeutics Holdings, Inc. (the “Company”) issued a press release announcing the Company’s financial results for the quarter ended June 30, 2026. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated herein by reference.

The information in this Form 8-K, including Exhibit 99.1 attached hereto, is being furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference into any filing by the Company under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such filling.

 

Item 9.01.

Financial Statements and Exhibits.

(d) Exhibits

 

Exhibit

No.

  

Description

99.1    Press Release issued by Hemab Therapeutics Holdings, Inc. on August 11, 2026
104    Cover Page Interactive Data File (embedded within the Inline XBRL document)


SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

 

    HEMAB THERAPEUTICS HOLDINGS, INC.
Date: August 11, 2026     By:  

/s/ Benny Sørensen, M.D., Ph.D.

      Name: Benny Sørensen, M.D., Ph.D.
      Title: President and Chief Executive Officer

Exhibit 99.1

 

LOGO

Hemab Therapeutics Reports Second Quarter 2026 Financial Results and Provides Corporate Update

Multiple scientific data presentations, including five oral presentations across three programs, at the International Society on Thrombosis and Haemostasis (ISTH) 2026 Congress in Paris, France

New clinical data on HMB-002 demonstrated 2.4-fold increase in Von Willebrand Factor (VWF) and Factor VIII (FVIII), stronger than anticipated proof of mechanism, and encouraging preliminary clinical observations in Von Willebrand Disease (VWD)

Unveiled HMB-003, a novel non-hormonal, peptide-based plasmin inhibitor designed to reduce bleeding across multiple settings, beginning with heavy menstrual bleeding indication

Long-term extension (LTE) data for sutacimig showed sustained favorable results in Glanzmann thrombasthenia (GT), and FDA endorsed the sutacimig clinical data package as sufficient to proceed to a Phase 3 pivotal trial in GT; Phase 3 initiation planned 2H 2026

CAMBRIDGE, MA, USA & COPENHAGEN, Denmark — August 11, 2026 — Hemab Therapeutics (Nasdaq: COAG), a clinical-stage biotechnology company developing therapies that reimagine the treatment of blood coagulation disorders to sustain life and human resilience, today announced financial results for the second quarter ended June 30, 2026, and recent business highlights.

“This was a very productive quarter for Hemab with continued execution across our pipeline,” said Benny Sørensen, MD, PhD, CEO of Hemab. “We had a significant presence at ISTH 2026, presenting data from all our programs. The strong interest we saw in that data underscores both the significant unmet need in bleeding disorders and the potential for our clinical and preclinical pipeline to redefine the standard of care in this space. We are particularly pleased to announce a new program, HMB-003, where we are addressing heavy menstrual bleeding, an indication that affects millions of women globally. HMB-003 is another example of how Hemab is developing treatments that could redefine care across high-unmet-need bleeding disorders. We look forward to providing additional updates on our programs later this year.”

Corporate Highlights

In July, the Company presented at the ISTH 2026 Congress in Paris, France, delivering nine presentations across three clinical and preclinical programs. All ISTH presentations are available on the Company’s corporate website (here).

Recent Business Highlights and Anticipated Milestones

Sutacimig: Sutacimig is a bispecific antibody in clinical development for two indications: GT and Factor VII deficiency (FVIID). Sutacimig has received Fast Track, Orphan Drug, and Breakthrough Therapy Designations from the U.S. Food and Drug Administration (FDA) for the treatment of GT. In Europe, the European Medicines Agency (EMA) has granted sutacimig Orphan Medicinal Product designation for the treatment of GT and access to the Priority Medicines (PRIME) scheme. Sutacimig has also received the Innovative Licensing and Access Pathway (ILAP) designation from the UK Medicines and Healthcare products Regulatory Agency (MHRA).


LOGO

 

Glanzmann Thrombasthenia: GT is a congenital, severe, lifelong bleeding disorder caused by defects in platelet aggregation, with substantial geographic variation in prevalence, from approximately 1 in 100,000 individuals in high-prevalence regions such as the Gulf Cooperation Council (GCC) countries to between 1 in 350,000 and 1 in 600,000 in the United States. There are currently no approved prophylactic treatment options for GT; management is limited to platelet transfusions, antifibrinolytics, recombinant Factor VIIa, and bone marrow transplantation.

 

   

In July, the Company presented Phase 2 LTE data for sutacimig at ISTH 2026. The data demonstrated clinically meaningful and sustained bleed reduction in 34 participants at a median timepoint of 6.9 months and up to 15.9 months of exposure. Ninety-two percent (92%) of participants who had bled during the run-in experienced reductions in treated bleed rates on sutacimig, and the mean high-intensity annualized treated bleed event rate (ATBR) was reduced by 62% over the treatment and extension period; in the low-dose weekly regimen cohort, mean ATBR was reduced by approximately 84%.

 

   

Adverse events were predominantly mild to moderate, with no Grade 3 or higher related adverse events. Three participants experienced Grade 2 thromboembolic events; these occurred in participants assigned to dose cohorts associated with higher exposure and/or with multiple concurrent risk factors, and all were managed with routine anticoagulation and were resolved or resolving at the data cut. The Phase 3 dose and regimen were selected to optimize bleed rate reduction while avoiding the high peak exposures associated with thromboembolic events observed in the Phase 1/2 trial.

 

   

The FDA has endorsed the Company’s clinical data package as sufficient to proceed to a Phase 3 pivotal trial in GT with a dose of 0.2 mg/kg once weekly. The Company plans to initiate the Phase 3 trial in the second half of 2026.

Factor VII Deficiency: FVIID is a congenital severe bleeding disorder, with prevalence of moderate and severe forms estimated at approximately 1 in 500,000 globally and characterized by impaired blood clotting and increased bleeding risk.

 

   

The Company is conducting an ongoing Phase 2 clinical trial of sutacimig for FVIID. New preclinical data for sutacimig presented at ISTH 2026 demonstrated restoration of thrombin generation under disease-mimicking conditions, with confirmed binding across 22 of 25 tested severe-to-moderate FVIID variants (88%), supporting broad patient applicability for the ongoing Phase 2 trial.

 

   

The Company expects to report data from the ongoing Phase 2 trial in late 2026 or early 2027.

HMB-002—Von Willebrand Disease: HMB-002 is a novel monovalent antibody designed for subcutaneous prophylactic treatment of VWD, the most common inherited bleeding disorder, with approximately 140,000 patients diagnosed across all severity levels in the United States, of whom more than an estimated 50,000 require treatment for bleeding events.


LOGO

 

   

In July, the Company presented new first-in-human data at ISTH 2026 supporting HMB-002 as a non-replacement approach to treating VWD. Data from the ongoing VELORA Pioneer Phase 1/2 trial demonstrated proof of mechanism, a ≥2.4-fold peak increase in VWF and FVIII, normalization of peak thrombin generation and APTT, and a durability profile supporting potential monthly subcutaneous dosing. The single ascending dose portion of the study was not designed to measure efficacy, and the following preliminary clinical observations are descriptive in nature. Across the single ascending dose cohorts, 8 of 9 evaluable patients had zero treated bleeds in the 28 days following HMB-002 dosing, with a mean ATBR of 1.6, compared with a baseline mean ATBR of 20.1 prior to treatment.

 

   

The Company expects to report additional data from the trial in late 2026 or early 2027.

HMB-003—Novel Antifibrinolytic Program: HMB-003 is a novel fatty-acid-conjugated peptide antifibrinolytic, designed to stabilize clots and reduce bleeding across multiple settings, beginning in heavy menstrual bleeding, an indication affecting one in three reproductive-age women, over 23 million women, in the U.S.

 

   

In July, the Company unveiled HMB-003, a long-acting subcutaneous plasmin inhibitor with the potential for cycle-matched dosing, initially being developed in heavy menstrual bleeding. HMB-003 is also being developed to address bleeding in additional high-unmet-need conditions, including hereditary hemorrhagic telangiectasia and peri-operative bleeding management.

 

   

Preclinical data presented at ISTH 2026 demonstrated potent and selective plasmin inhibition, with HMB-003 directly inhibiting plasmin at its active site and blocking fibrinolysis across both tPA- and uPA-driven pathways, while showing no effect on thrombin generation, platelet function, or coagulation. In a preclinical model, HMB-003 achieved rapid peak plasma levels within hours and sustained antifibrinolytic activity for approximately one week, supporting the potential for cycle-matched dosing in people experiencing heavy menstrual bleeding.

 

   

The Company plans to initiate first-in-human studies in the second half of 2026 with initial clinical data mid-2027.

Second Quarter 2026 Financial Results

 

   

Cash Position and Cash Runway: Cash, cash equivalents, and marketable securities totaled $457.5 million as of June 30, 2026, compared to $163.5 million as of March 31, 2026. The increase primarily reflects net proceeds of $317.2 million from the Company’s initial public offering completed in May 2026, partially offset by cash used in operating activities. The Company believes its current cash, cash equivalents, and marketable securities will enable it to fund its operating expenses and capital expenditure requirements into 2029.

 

   

Research and Development Expenses: Research and development expenses were $20.3 million for the three months ended June 30, 2026, compared to $12.9 million for the three months ended June 30, 2025. The increase was due to costs related to the advancement of clinical programs in addition to increases in equity-based compensation and personnel-related expenses related to company growth to support the advancement of our programs.

 

   

General and Administrative Expenses: General and administrative expenses were $5.7 million for the three months ended June 30, 2026, compared to $3.2 million for the three months ended June 30, 2025, due to equity-based compensation and other costs associated with operating as a public company.


LOGO

 

   

Net Loss: Net loss was $24.2 million, or $0.80 per share, for the three months ended June 30, 2026, compared to a net loss of $12.2 million, or $12.91 per share, for the three months ended June 30, 2025. The decrease in net loss per share primarily reflects the increase in weighted-average shares outstanding during the three months ended June 30, 2026 following the Company’s initial public offering and the subsequent conversion of preferred stock into common stock in May 2026.

Conference Call Information: Beginning with its third quarter 2026 financial results, Hemab Therapeutics plans to host quarterly conference calls to discuss its financial results and provide business updates. Details regarding the date, time and webcast registration for the third quarter 2026 call will be announced in a subsequent press release.

About Glanzmann Thrombasthenia

Glanzmann thrombasthenia (GT) is a severe bleeding disorder marked by debilitating, sometimes life-threatening bleeding episodes. Results from an international natural history study (Glanzmann’s 360) revealed the substantial burden of this disease: 88% of the 117 participants reported at least one bleed in the previous week with 65% requiring a bleed-related hospital visit in the prior six months. These bleeding episodes significantly impacted patients’ mental health and quality of life, with over 80% having missed work or school, over 50% facing limitations in attending social events, and over 50% experiencing restrictions in travel. To date, there are no approved prophylactic treatment options for GT. About Factor VII Deficiency Factor VII deficiency (FVIID) is a congenital severe bleeding disorder characterized by reduced levels of Factor VII, a naturally circulating blood coagulation protein. Patients with clinically severe FVIID suffer from recurrent, unpredictable, life-threatening or potentially disabling bleeding at critical sites, such as in the central nervous system, gastrointestinal tract and intra-articular locations, as well as recurrent mucocutaneous bleeds of the nose and gums with additional risks for female patients, consisting of heavy menstrual bleeding and potentially life-threatening post-partum hemorrhage.

About Sutacimig (formerly HMB-001)

Sutacimig is a subcutaneously administered bispecific antibody that is designed to bind and stabilize endogenous Factor VIIa with one antibody arm and bind to TLT-1 on activated platelets with the other arm. This mechanism is designed to allow for the accumulation of endogenous Factor VIIa in the body and recruitment of Factor VIIa directly to the surface of the activated platelets, where it amplifies thrombin generation at the platelet surface. Sutacimig is designed to be a first-in-class prophylactic treatment for Glanzmann thrombasthenia (GT) with the potential to treat other debilitating bleeding disorders. The U.S. Food and Drug Administration has granted Fast Track Designation, Orphan Drug Designation, and Breakthrough Therapy Designation to sutacimig for the treatment of GT, and the UK Medicines and Healthcare products Regulatory Agency has awarded sutacimig designation under the Innovative Licensing and Access Pathway (ILAP); it has been designated as an orphan medicinal product in the European Union for the treatment of GT, and the European Medicines Agency (EMA) has granted sutacimig access to the Priority Medicines (PRIME) scheme. For more information, please visit clinicaltrials.gov (NCT06211634).


LOGO

 

About Von Willebrand Disease

Von Willebrand Disease (VWD) is the most common inherited bleeding disorder, characterized by quantitative or qualitative defects in Von Willebrand Factor (VWF), often resulting in frequent mucocutaneous bleeding events and heavy menstrual bleeding in women. The severity of bleeding ranges from low-volume events to potentially life-threatening hemorrhages. Chronic blood loss frequently leads to iron deficiency anemia, exacerbating the disease burden and reducing quality of life, particularly for those with clinically understated subtypes. Despite its prevalence, current treatment options for VWD primarily focus on managing symptoms rather than addressing the underlying biology of the disease.

About HMB-002

HMB-002 is a monovalent human antibody being developed as the first-in-class subcutaneous prophylactic treatment for Von Willebrand Disease targeting the underlying cause of the disease, a condition driven by a deficiency or defect in Von Willebrand Factor (VWF), a key regulator of hemostasis. By specifically targeting the C-terminal CK domain of VWF, which is distinct from regions critical to its essential interactions, HMB-002 shields the protein from degradation, boosting endogenous levels without compromising its function. Clinical and nonclinical data suggest strong potential for meaningful therapeutic benefit. For more information, please visit clinicaltrials.gov (NCT06610201 and NCT06754852). About HMB-003 HMB-003 is a subcutaneously administered peptide-based plasmin inhibitor with a durable half-life — a proven therapeutic target in coagulation medicine — being developed as a novel antifibrinolytic designed to reduce bleeding across multiple settings. Engineered to directly inhibit plasmin at its active site, HMB-003 blocks fibrinolysis independently of the plasminogen activation pathway. HMB-003 is optimized to provide sustained bleed protection across multiple high-unmet-need conditions, ranging from heavy menstrual bleeding and hereditary hemorrhagic telangiectasia to peri-operative bleeding management.

About Hemab Therapeutics

Hemab Therapeutics Holdings, Inc. is a clinical-stage biotechnology company developing therapies that reimagine the treatment of blood coagulation disorders to sustain life and human resilience. Hemab’s mission is to discover, develop, and commercialize innovative therapies for the millions of patients worldwide suffering from serious bleeding and thrombotic diseases. Hemab is building a franchise of innovative therapeutics designed to address critical gaps in the treatment of coagulation disorders, including sutacimig (HMB-001), a bispecific antibody in clinical development for the prophylactic treatment of Glanzmann thrombasthenia and Factor VII deficiency, HMB-002, a monovalent antibody in clinical development for the prophylactic treatment of Von Willebrand Disease, and HMB-003, an antifibrinolytic targeting plasmin inhibition in preclinical development for multiple high-unmet-need conditions, ranging from heavy menstrual bleeding and hereditary hemorrhagic telangiectasia to peri-operative bleeding management.

Learn more at hemab.com. Follow us on LinkedIn, Facebook, Instagram, and X.

Forward-Looking Statements

This press release contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this press release, including statements regarding Hemab’s strategy, future operations, prospects and plans, objectives of management, the anticipated timelines for reporting data from Hemab’s clinical trials, the anticipated timelines for initiating a Phase 3 clinical trial of sutacimig and further development of HMB-002 and HMB-003, the clinical potential of sutacimig, HMB-002 and HMB-003, Hemab’s plans to expand its


LOGO

 

pipeline, and the sufficiency of Hemab’s cash resources for the period anticipated, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. The words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “objective,” “ongoing,” “plan,” “predict,” “project,” “potential,” “should,” or “would,” or the negative of these terms, or other comparable terminology are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Hemab may not actually achieve the plans, intentions or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various important factors, including: uncertainties inherent in the identification and development of product candidates, including the initiation and completion of preclinical studies and clinical trials; uncertainties as to the availability and timing of results from preclinical studies and clinical trials; the timing of and Hemab’s ability to initiate and enroll patients in clinical trials; whether results from preclinical studies and earlier clinical trials will be predictive of the results of later clinical trials; whether Hemab’s cash resources will be sufficient to fund Hemab’s foreseeable and unforeseeable operating expenses and capital expenditure requirements; as well as the risks and uncertainties identified in Hemab’s filings with the Securities and Exchange Commission (SEC), including Hemab’s most recent Form 10-Q and in subsequent filings Hemab may make with the SEC. In addition, the forward-looking statements included in this press release represent Hemab’s views as of the date of this press release. Hemab anticipates that subsequent events and developments will cause its views to change. However, while Hemab may elect to update these forward-looking statements at some point in the future, it specifically disclaims any obligation to do so. These forward-looking statements should not be relied upon as representing Hemab’s views as of any date subsequent to the date of this press release.

Media:

Deerfield Group

Peg Rusconi

peg.rusconi@deerfieldgroup.com

Investors:

Hemab Therapeutics

Mads Behrndt

investors@hemab.com


LOGO

 

Hemab Therapeutics Holdings, Inc.

Condensed Consolidated Statements of Operations and Comprehensive Loss

(In thousands, except share and per share data)

(Unaudited)

 

     Three Months Ended
June 30,
    Six Months Ended
June 30,
 
     2026     2025     2026     2025  

Operating expenses

        

Research and development

   $ 20,336     $ 12,874     $ 39,797     $ 26,975  

General and administrative

     5,743       3,183       9,894       5,642  
  

 

 

   

 

 

   

 

 

   

 

 

 

Total operating expenses

     26,079       16,057       49,691       32,617  
  

 

 

   

 

 

   

 

 

   

 

 

 

Loss from operations

     (26,079     (16,057     (49,691     (32,617

Other income (expense), net

        

Interest income

     2,858       335       4,077       808  

Other (expense) income, net

     (832     3,517       (1,114     4,108  
  

 

 

   

 

 

   

 

 

   

 

 

 

Total other income, net

     2,026       3,852       2,963       4,916  
  

 

 

   

 

 

   

 

 

   

 

 

 

Loss before income tax expense

     (24,053     (12,205     (46,728     (27,701

Income tax (expense) benefit

     (97     (4     (109     186  
  

 

 

   

 

 

   

 

 

   

 

 

 

Net loss

   $ (24,150   $ (12,209   $ (46,837   $ (27,515
  

 

 

   

 

 

   

 

 

   

 

 

 

Net loss per share, basic and diluted

   $ (0.80   $ (12.91   $ (3.00   $ (29.09

Weighted average shares outstanding, basic and diluted

     30,111,338       946,000       15,609,236       946,000  

Other comprehensive loss

        

Net loss

   $ (24,150   $ (12,209   $ (46,837   $ (27,515

Net unrealized (loss) gain on available-for-sale debt securities

     (2,309     (609     (2,923     365  
  

 

 

   

 

 

   

 

 

   

 

 

 

Total comprehensive loss

   $ (26,459   $ (12,818   $ (49,760   $ (27,150
  

 

 

   

 

 

   

 

 

   

 

 

 

Hemab Therapeutics Holdings, Inc.

Selected Consolidated Balance Sheets Data

(In thousands)

(Unaudited)

 

     June 30,
2026
     December 31,
2025
 

Assets

     

Cash and cash equivalents

   $ 237,366      $ 87,974  

Marketable securities

     220,094        97,511  

Prepaid expenses and other current assets

     6,538        7,066  

Property and equipment, net

     596        609  

Operating right-of-use assets

     901        1,092  

Other non-current assets

     2,286        531  
  

 

 

    

 

 

 

Total assets

     467,781        194,783  

Liabilities and stockholders’ equity (deficit)

     

Accounts payable

     6,232        5,734  

Operating lease liabilities

     460        647  

Operating lease liabilities, net of current portion

     566        573  
  

 

 

    

 

 

 

Accrued expenses and other current liabilities

     6,252        4,296  
  

 

 

    

 

 

 

Total liabilities

     13,510        11,250  

Total convertible preferred stock and convertible preference shares

     —         360,168  

Total stockholders’ equity (deficit)

   $ 454,271      $ (176,635


LOGO

 

Hemab Therapeutics Holdings, Inc.

Selected Consolidated Statements of Cash Flows Data

(In thousands)

(Unaudited)

 

     Six Months Ended June 30,  
     2026     2025     Change  

Net cash used in operating activities

     (44,221     (28,366     (15,855

Net cash (used in) provided by investing activities

     (123,284     15,508       (138,792

Net cash provided by (used in) financing activities

     317,119       (59     317,178  

Effect of foreign exchange rate changes on cash and cash equivalents

     (222     —        (222
  

 

 

   

 

 

   

 

 

 

Net increase (decrease) in cash and cash equivalents

   $ 149,392     $ (12,917   $ 162,309  
  

 

 

   

 

 

   

 

 

 

Filing Exhibits & Attachments

4 documents