STOCK TITAN

Cocrystal Pharma, Inc. (COCP) insider-linked trust purchases 75,000 shares

(Neutral)
(Positive)
Form Type
4

Rhea-AI Filing Summary

An entity associated with Cocrystal Pharma director and 10% owner Phillip Frost, M.D., Frost Gamma Investments Trust, purchased 75,000 shares of common stock on 2026-08-03 in an open-market or private transaction at a weighted average price of $0.9412 per share, with individual trade prices between $0.87 and $0.9499. Following this purchase, the trust holds 1,983,551 shares of Cocrystal Pharma common stock indirectly. Frost also has 27,100 shares held directly, which include shares issuable upon vesting of restricted stock units. Frost disclaims beneficial ownership of shares held by Frost Gamma Investments Trust and by OPKO Health, Inc., except to the extent of any pecuniary interest, and the transaction is not reported as made under a Rule 10b5-1 trading plan.

Positive

  • None.

Negative

  • None.
Insider FROST PHILLIP MD ET AL
Role Director, 10% Owner
Bought 75,000 shs ($71K)
Type Security Shares Price Value
Purchase Common Stock F1, F2 75,000 $0.9412 $71K
holding Common Stock F3 -- -- --
Holdings After Transaction: Common Stock — 1,983,551 shares (Indirect, By Frost Gamma Investments Trust); Common Stock — 27,100 shares (Direct)
Footnotes (3)
  1. F1. The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions ranging from $0.87 to $0.9499, inclusive. The reporting person undertakes to provide to Cocrystal Pharma, Inc., any security holder of Cocrystal Pharma, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the shares purchased at each separate price within the ranges set forth in the preceding sentence.
  2. F2. These shares are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole stockholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is the sole stockholder of Frost-Nevada Corporation. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.
  3. F3. Includes shares of common stock issuable upon vesting of restricted stock units.
Common stock purchased 75,000 shares Shares of Cocrystal Pharma common stock purchased on 2026-08-03 by Frost Gamma Investments Trust
Weighted average purchase price $0.9412 per share Weighted average price for the 75,000-share purchase; trades ranged from $0.87 to $0.9499
Trade price range $0.87–$0.9499 per share Price range of individual transactions comprising the reported weighted average purchase price
Indirect holdings after purchase 1,983,551 shares Cocrystal Pharma common shares held indirectly via Frost Gamma Investments Trust after the transaction
Direct holdings after transaction 27,100 shares Common shares held directly by Phillip Frost, including shares issuable upon vesting of RSUs
weighted average price financial
"The price reported in Column 4 is a weighted average price."
Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.
restricted stock units financial
"Includes shares of common stock issuable upon vesting of restricted stock units."
Restricted stock units are a type of company reward where employees are promised shares of stock, but they only fully own these shares after meeting certain conditions, like staying with the company for a set time. They matter because they can become valuable assets and are often used to motivate employees to help the company succeed.
pecuniary interest financial
"except to the extent of any pecuniary interest therein"
beneficial ownership financial
"disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust"
Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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FAQ

What insider purchase in Cocrystal Pharma (COCP) stock did Phillip Frost report?

Phillip Frost reported that Frost Gamma Investments Trust purchased 75,000 COCP common shares on 2026-08-03 at a weighted average price of $0.9412 per share, with individual trades executed between $0.87 and $0.9499 in open-market or private transactions.

How many COCP shares does Frost Gamma Investments Trust hold after this transaction?

After the reported purchase, Frost Gamma Investments Trust holds 1,983,551 shares of Cocrystal Pharma (COCP) common stock indirectly. This figure reflects the position following the 75,000-share acquisition disclosed in the Form 4 filing associated with Phillip Frost, M.D.

What was the price range for the recent Phillip Frost–related COCP share purchases?

The disclosed Cocrystal Pharma (COCP) purchases were made at prices ranging from $0.87 to $0.9499 per share. The Form 4 reports a weighted average purchase price of $0.9412 per share, based on multiple individual transactions within that stated range.

Does Phillip Frost have direct holdings in Cocrystal Pharma (COCP)?

Yes. In addition to indirect holdings through Frost Gamma Investments Trust, Phillip Frost directly holds 27,100 COCP shares. This direct position includes shares issuable upon vesting of restricted stock units, as noted in the footnotes to the Form 4 filing.

Was the reported COCP insider purchase made under a Rule 10b5-1 trading plan?

No. The Form 4’s Rule 10b5-1 checkbox is not marked as applicable, indicating the 75,000-share purchase of Cocrystal Pharma (COCP) common stock by Frost Gamma Investments Trust was not reported as executed under a Rule 10b5-1 trading plan.

How does Phillip Frost describe his beneficial ownership of COCP shares?

Phillip Frost disclaims beneficial ownership of Cocrystal Pharma (COCP) shares held by Frost Gamma Investments Trust and OPKO Health, Inc., except to the extent of any pecuniary interest. The filing states it should not be deemed an admission of beneficial ownership for Section 16 or other purposes.
SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
FROST PHILLIP MD ET AL

(Last)(First)(Middle)
4400 BISCAYNE BLVD

(Street)
MIAMI FLORIDA 33137-3227

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Cocrystal Pharma, Inc. [ COCP ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
XDirectorX10% Owner
Officer (give title below)Other (specify below)
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
08/03/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock08/03/2026P75,000A$0.9412(1)1,983,551IBy Frost Gamma Investments Trust(2)
Common Stock27,100(3)D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Explanation of Responses:
1. The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions ranging from $0.87 to $0.9499, inclusive. The reporting person undertakes to provide to Cocrystal Pharma, Inc., any security holder of Cocrystal Pharma, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the shares purchased at each separate price within the ranges set forth in the preceding sentence.
2. These shares are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole stockholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is the sole stockholder of Frost-Nevada Corporation. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.
3. Includes shares of common stock issuable upon vesting of restricted stock units.
Remarks:
This Form 4 does not include any of the securities owned directly by OPKO Health, Inc., a company of which Dr. Frost is the Chairman of the Board and Chief Executive Officer, concerning the securities of which Dr. Frost does not hold voting and investment control. Dr. Frost disclaims beneficial ownership of the securities held by OPKO Health, Inc. except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that Dr. Frost is the beneficial owner of the securities for purposes of Section 16 or for any other purpose.
/s/ Phillip Frost, MD ET AL08/05/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)