Phillip Frost details 13.9% Cocrystal Pharma (COCP) stake in update

Rhea-AI Filing Summary

Phillip Frost, M.D. and Frost Gamma Investments Trust report updated ownership of Cocrystal Pharma, Inc. common stock. Dr. Frost is deemed to beneficially own 2,784,719 shares, representing 13.9% of the common stock, including direct holdings, shares held by the trust, vested options and warrants exercisable within 60 days.

Frost Gamma Investments Trust is reported as beneficially owning 2,712,977 shares, or 13.5% of the common stock, including common shares and warrants. On August 3 and 5, 2026, the reporting persons acquired 75,000 shares at $0.9412 and 10,000 shares at $0.9816, respectively, in open‑market purchases for investment purposes. Ownership percentages are based on 19,263,200 shares outstanding as of August 3, 2026, plus option and warrant shares issuable within 60 days.

Key Figures

Beneficial ownership – Phillip Frost: 2,784,719 shares Beneficial ownership – Frost Gamma Investments Trust: 2,712,977 shares Shares outstanding: 19,263,200 shares +4 more

7 metrics

Beneficial ownership – Phillip Frost 2,784,719 shares Represents 13.9% of Cocrystal Pharma common stock including shares, options and warrants

Beneficial ownership – Frost Gamma Investments Trust 2,712,977 shares Represents 13.5% of common stock including common shares and warrants

Shares outstanding 19,263,200 shares Common stock outstanding as of August 3, 2026 used for ownership calculations

Options exercisable within 60 days 51,417 shares Shares of common stock issuable to Dr. Frost upon exercise of vested options

Warrants exercisable within 60 days 719,426 shares Shares of common stock issuable upon exercise of warrants controlled by Dr. Frost

Open‑market purchase on August 3, 2026 75,000 shares at $0.9412 per share Cocrystal Pharma common stock purchased by the reporting persons

Open‑market purchase on August 5, 2026 10,000 shares at $0.9816 per share Additional Cocrystal Pharma common stock purchased by the reporting persons

Key Terms

beneficial owner, dispositive power, pecuniary interest, Securities Exchange Act of 1934, +1 more

5 terms

beneficial owner regulatory

"Dr. Frost may be deemed the beneficial owner of the shares of common stock held by Frost Gamma Investments Trust."

A beneficial owner is the person who ultimately owns or controls a financial asset or property, even if their name isn't directly on official documents. Think of it like someone who secretly holds the keys to a safe deposit box—others may appear to have access, but the true owner is the one who benefits from what's inside. Identifying beneficial owners helps ensure transparency and prevent illegal activities like money laundering or fraud.

dispositive power regulatory

"Dr. Frost has sole dispositive power with respect to 51,417 shares of common stock issuable upon exercise of vested options."

Dispositive power is the authority to decide the final outcome of an asset, legal claim, contract, or corporate action — in effect the power to dispose of or resolve something. For investors it matters because whoever holds that authority can determine who gets paid, who controls an asset or vote, and how risks and returns are allocated; think of it like holding the key that lets you lock in the winner or loser in a deal.

pecuniary interest regulatory

"Dr. Frost disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein."

Securities Exchange Act of 1934 regulatory

"for purposes of Section 16 of the Securities Exchange Act of 1934 or for any other purpose."

Schedule 13D regulatory

"amends and supplements Amendment No. 7 to the Schedule 13D and all previous filings."

A Schedule 13D is a legal document that investors file with regulators when they buy a large enough stake in a company to potentially influence its management or decisions. It provides details about the investor’s intention, ownership stake, and plans, helping other investors understand who is gaining control and what their motives might be.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 08/07/2026 - 05:12 PM Accepted by SEC EDGAR 08/07/2026 - 05:11 PM Learn about SEC filing dates

FAQ

What percentage of Cocrystal Pharma (COCP) does Phillip Frost beneficially own?

Phillip Frost beneficially owns 2,784,719 shares of Cocrystal Pharma common stock, representing 13.9% of the company. This total includes his directly held shares, shares held through Frost Gamma Investments Trust, and shares issuable upon exercise of vested options and warrants within 60 days.

How many Cocrystal Pharma (COCP) shares does Frost Gamma Investments Trust beneficially own?

Frost Gamma Investments Trust beneficially owns 2,712,977 shares of Cocrystal Pharma common stock, or 13.5% of the company. This amount includes 1,993,551 common shares and 719,426 shares issuable upon exercise of warrants within 60 days, all controlled by Dr. Frost as sole trustee.

What recent Cocrystal Pharma (COCP) share purchases did Phillip Frost report?

The reporting persons bought 75,000 shares at $0.9412 per share on August 3, 2026. They then purchased an additional 10,000 shares at $0.9816 per share on August 5, 2026. Both transactions were open‑market purchases of Cocrystal Pharma common stock for investment purposes.

How many Cocrystal Pharma (COCP) shares are used to calculate Phillip Frost’s ownership percentage?

Ownership percentages are based on 19,263,200 shares of Cocrystal Pharma common stock outstanding as of August 3, 2026. The calculation also includes 51,417 shares issuable upon option exercises and 719,426 shares issuable upon warrant exercises, all exercisable within 60 days.

How is Phillip Frost’s interest in Frost Gamma Investments Trust described for Cocrystal Pharma (COCP)?

Dr. Frost is the sole trustee of Frost Gamma Investments Trust and may be deemed the beneficial owner of its holdings. He disclaims beneficial ownership of the trust’s Cocrystal Pharma securities except to the extent of any pecuniary interest he has in those securities.

What is the stated purpose of Phillip Frost’s investment in Cocrystal Pharma (COCP)?

The shares of Cocrystal Pharma common stock were acquired for investment purposes. The securities are held by Frost Gamma Investments Trust, with a multi‑entity structure in which Dr. Frost serves as trustee and has indirect interests through Frost Gamma Limited Partnership and related entities.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13D

Under the Securities Exchange Act of 1934

(Amendment No. 8)

Cocrystal Pharma, Inc.

(Name of Issuer)

Common Stock, par value $0.001 per share

(Title of Class of Securities)

19188J409

(CUSIP Number)

Phillip Frost, M.D.
Frost Gamma Investments Trust, 4400 Biscayne Boulevard
Miami, FL, 33137
(305) 575-6015

(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)

08/03/2026

(Date of Event Which Requires Filing of This Statement)

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box.

The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

schemaVersion:

SCHEDULE 13D

CUSIP Number(s): 19188J409

1

Name of reporting person

Phillip Frost, M.D.

2

Check the appropriate box if a member of a Group (See Instructions)

(a)
(b)

3

SEC use only

4

Source of funds (See Instructions)

PF

5

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

6

Citizenship or place of organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

7	Sole Voting Power 2,013,876.00
8	Shared Voting Power 0.00
9	Sole Dispositive Power 2,013,876.00
10	Shared Dispositive Power 0.00

11

Aggregate amount beneficially owned by each reporting person

2,784,719.00

12

Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

13

Percent of class represented by amount in Row (11)

13.9 %

14

Type of Reporting Person (See Instructions)

IN

Comment for Type of Reporting Person:

(1) The amounts provided in Item 7 and 9 include (i) 20,325 shares of the Issuer's common stock and (ii) 1,993,551 shares of the Issuer's common stock held by Frost Gamma Investments Trust, which is controlled by Dr. Frost as sole trustee. Does not include options to acquire 51,417 shares of common stock and warrants to acquire 719,426 shares of common stock, both of which are exercisable within 60 days. (2) The amount provided in Item 11 includes (i) 20,325 shares of common stock owned, (ii) 1,993,551 shares of the Issuer's common stock held by Frost Gamma Investments Trust, which is controlled by Dr. Frost as sole trustee; (iii) options to acquire 51,417 shares of common stock, which are exercisable within 60 days and (iv) 719,426 warrants to acquire shares of common stock, which is controlled by Dr. Frost as sole trustee and are exercisable within 60 days. (3) The percentage provided in Item 13 is calculated based on (i) 19,263,200 shares of common stock outstanding as of August 3, 2026 and (ii) 51,417 shares of common stock issuable upon exercise of options and 719,426 shares of common stock issuable upon exercise of warrants within 60 days. The percentage reflected in the table above is rounded to the nearest tenth (one place after the decimal point) in accordance with the instructions to Schedule 13D.

SCHEDULE 13D

CUSIP Number(s): 19188J409

1

Name of reporting person

Frost Gamma Investments Trust

2

Check the appropriate box if a member of a Group (See Instructions)

(a)
(b)

3

SEC use only

4

Source of funds (See Instructions)

PF

5

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

6

Citizenship or place of organization

FLORIDA

Number of Shares Beneficially Owned by Each Reporting Person With:

7	Sole Voting Power 1,993,551.00
8	Shared Voting Power 0.00
9	Sole Dispositive Power 1,993,551.00
10	Shared Dispositive Power 0.00

11

Aggregate amount beneficially owned by each reporting person

2,712,977.00

12

Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

13

Percent of class represented by amount in Row (11)

13.5 %

14

Type of Reporting Person (See Instructions)

OO

Comment for Type of Reporting Person:

(1) The amounts provided in Item 7 and 9 include 1,993,551 shares of the Issuer's common stock, which is controlled by Dr. Frost as sole trustee. Does not include warrants to acquire 719,426 shares of common stock, which are exercisable within 60 days. (2) The amount provided in Item 11 includes (i) 1,993,551 shares of the Issuer's common stock and (ii) 719,426 warrants to acquire shares of the Issuer's common stock, which are exercisable within 60 days. The securities are controlled by Dr. Frost as sole trustee. (3) The percentage provided in Item 13 is calculated based upon 19,263,200 shares of common stock outstanding as of August 3, 2026 and 719,426 shares of common stock issuable upon exercise of warrants within 60 days. The percentage reflected in the table above is rounded to the nearest tenth (one place after the decimal point) in accordance with the instructions to Schedule 13D.

SCHEDULE 13D

Item 1.	Security and Issuer
(a)	Title of Class of Securities: Common Stock, par value $0.001 per share
(b)	Name of Issuer: Cocrystal Pharma, Inc.
(c)	Address of Issuer's Principal Executive Offices: 19805 North Creek Parkway,, Bothell, WASHINGTON , 98011.
Item 1 Comment: This Amendment No. 8 on Schedule 13D/A (this "Amendment") is being filed with the Securities and Exchange Commission (the "SEC") on behalf of the Reporting Persons (as defined below) and relates to the common stock, par value $0.001 per share, of Cocrystal Pharma, Inc. (the "Issuer"). This Amendment is being filed as a result of a change in the Reporting Person's beneficial ownership of the common stock, and in the total number of shares of the Issuer's issued and outstanding common stock and, where so stated, amends and supplements Amendment No. 7 to the Schedule 13D and all previous filings on Schedule 13D.
Item 2.	Identity and Background
(a)	This Amendment is filed on behalf of Phillip Frost, M.D. and Frost Gamma Investments Trust (together, the "Reporting Persons").
(b)	The principal business address of the Reporting Persons is 4400 Biscayne Boulevard, Miami, Florida 33137.
(d)	During the last five years, none of the Reporting Persons have been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors).
(e)	During the last five years, none of the Reporting Persons (or their directors, officers, or controllers, if applicable) have been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding were or are subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violations with respect to such laws.
(f)	Dr. Frost is a citizen of the United States of America. Frost Gamma Investments Trust was organized in the State of Florida.
Item 3.	Source and Amount of Funds or Other Consideration
	On August 3, 2026, the Reporting Persons purchased 75,000 shares of the Issuer's common stock in the open market at $0.9412 per share. On August 5, 2026, the Reporting Persons purchased an additional 10,000 shares of the Issuer's common stock in the open market at $0.9816 per share.
Item 4.	Purpose of Transaction
	The Reporting Persons acquired the shares of common stock for investment purposes. These securities are held by Frost Gamma Investments Trust, of which Phillip Frost, MD is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is the sole shareholder of Frost-Nevada Corporation. Dr. Frost disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that Dr. Frost is the beneficial owner of these securities for purposes of Section 16 of the Securities Exchange Act of 1934 or for any other purpose.
Item 5.	Interest in Securities of the Issuer
(a)	The beneficial ownership percentages disclosed below are based on 19,263,200 shares of common stock outstanding as of August 3, 2026, 51,417 shares of common stock issuable upon exercise of options and 719,426 shares of common stock issuable upon exercise of warrants, both within 60 days. Dr. Frost is the beneficial owner of 2,784,719 shares of common stock representing 13.9% of the shares outstanding of the Issuer, including (i) 1,993,551 shares of common stock held by Frost Gamma Investments Trust, (ii) 20,325 shares of the Issuer's common stock held by the Reporting Person, (iii) 51,417 shares of common stock issuable upon exercise of vested options and (iv) 719,426 shares of common stock issuable upon exercise of warrants. Dr. Frost is the trustee of Frost Gamma Investments Trust. Frost Gamma Limited Partnership is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma Limited Partnership. Dr. Frost is the sole shareholder of Frost-Nevada Corporation, which is the sole shareholder of Frost Gamma, Inc., the general partner of Frost Gamma Limited Partnership. As a result of the foregoing, Dr. Frost may be deemed the beneficial owner of the shares of common stock held by Frost Gamma Investments Trust. Dr. Frost disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein. Dr. Frost has sole dispositive power with respect to 51,417 shares of common stock issuable upon exercise of vested options.
(b)	The Reporting Persons have voting and dispositive power over the Issuer's securities as described above in Item 5(a).
(c)	Except as described in this Schedule 13D under Item 3 above, the Reporting Persons did not engage in any transactions in shares of the Company's common stock during the past 60 days.
(d)	Not Applicable.
(e)	Not Applicable.
Item 6.	Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer
	Not Applicable.
Item 7.	Material to be Filed as Exhibits.
	None.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Phillip Frost, M.D.

Signature:	/s/ Phillip Frost, M.D.
Name/Title:	Phillip Frost, M.D.
Date:	08/07/2026

Frost Gamma Investments Trust

Signature:	/s/ Phillip Frost, M.D.
Name/Title:	Phillip Frost, M.D., Trustee
Date:	08/07/2026