Welcome to our dedicated page for Caribou Biosciences SEC filings (Ticker: CRBU), a comprehensive resource for investors and traders seeking official regulatory documents including 10-K annual reports, 10-Q quarterly earnings, 8-K material events, and insider trading forms.
Caribou Biosciences filings document a clinical-stage CRISPR genome-editing biopharmaceutical company focused on allogeneic CAR-T therapies. Recent 8-K reports furnish quarterly and annual financial results, cash and operating-plan disclosures, business updates, and Regulation FD disclosures covering vispa-cel and CB-011 clinical and FDA-related developments.
Proxy materials describe annual meeting matters, board elections, auditor ratification, and proposed charter governance changes for the Delaware corporation. Other event filings record public-company status matters, including Nasdaq bid-price compliance notices and product-candidate regulatory designations.
Caribou Biosciences (CRBU) reported preliminary cash, cash equivalents, and marketable securities of $159.2 million as of September 30, 2025. The company also released new clinical data for its allogeneic CAR-T programs and outlined a pivotal plan for vispacabtagene regedleucel (vispa-cel).
In the ANTLER phase 1 trial’s 2L LBCL confirmatory cohort (N=22) with partial HLA matching and dosing at 80x10^6 cells, vispa-cel showed an 82% overall response rate (18/22), 64% complete response (14/22), and 51% 12‑month PFS at a 6.0‑month median follow-up. An optimized cohort (N=35) reported 86% ORR (30/35), 63% CR (22/35), and 53% 12‑month PFS at 11.8 months’ median follow‑up. Safety showed common TEAEs typical of CAR‑T; there were no GvHD cases, no grade ≥3 ICANS, fewer than 5% grade ≥3 CRS, and one vispa‑cel–related grade 5 IEC‑HS.
The company plans a randomized, controlled pivotal phase 3 in approximately 250 2L LBCL CD19‑naïve patients ineligible for transplant and autologous CAR‑T, with PFS as the primary endpoint. In multiple myeloma, CB‑011 dose escalation identified a recommended dose (450x10^6); in a 12‑patient BCMA‑naïve cohort at this dose, responses included 92% ORR (11/12), 75% CR/sCR (9/12), and 91% (10/11) MRD‑negativity at 8.3 months’ median follow‑up, with a manageable safety profile.
Caribou Biosciences reported a quarterly net loss of $54.1 million and a six-month net loss of $94.1 million, with licensing and collaboration revenue of $2.7 million for the quarter and $5.0 million for the six months ended June 30, 2025. Management reported cash, cash equivalents and marketable securities of $183.9 million as of June 30, 2025, which it expects will fund operations for at least the next 12 months.
The company announced a strategic pipeline prioritization that discontinues preclinical research and two programs (GALLOP and AMpLify) and reduced the workforce by 47 employees (~32%). It recorded $12.15 million of impairment charges and a $9.16 million impairment of its equity investment in Edge, remeasured the MSKCC success payments liability to zero following termination notice, and ended the quarter with total assets of $220.9 million and an accumulated deficit of $542.5 million.
Caribou Biosciences, Inc. furnished a press release announcing its financial results for the quarter ended June 30, 2025 and provided a business update. The press release is attached as Exhibit 99.1 to this Current Report and is incorporated by reference into the disclosure.
The filing specifies that the Item 2.02 information (including Exhibit 99.1) is being furnished and therefore is not deemed "filed" under the Exchange Act, meaning it is provided for investor information without extending Section 18 liabilities. The 8-K itself does not include separate financial tables or statements beyond the furnished press release.