Erasca updates Phase 1 ERAS-0015 safety data

Erasca, Inc. reported updated preliminary Phase 1 data from the ongoing AURORAS-1 trial of ERAS-0015, described as a potentially best-in-class, pan-RAS molecular glue in patients with RAS-mutant solid tumors.

Rhea-AI Filing Summary

Erasca, Inc. reported updated preliminary Phase 1 data from the ongoing AURORAS-1 trial of ERAS-0015, described as a potentially best-in-class, pan-RAS molecular glue in patients with RAS-mutant solid tumors. The update adds patients and longer follow-up to earlier April 2026 results.

Among 72 patients with RAS-mutant NSCLC and pancreatic ductal adenocarcinoma treated at the protocol-amended dose, treatment-related adverse events were mainly low grade. Rash occurred in 52 patients (72%), diarrhea in 23 (32%), stomatitis in 14 (19%), and nausea in 10 (14%). Events led to dose interruptions in 9 patients (13%) and dose reductions in 6 (8%), with no treatment-related adverse events causing discontinuation.

The company highlights encouraging monotherapy responses in second-line or later KRAS G12X pancreatic ductal adenocarcinoma, promising combination potential with panitumumab in metastatic colorectal cancer, and plans to accelerate potentially registration-enabling studies. Extensive risk disclosures emphasize that these are interim, forward-looking assessments subject to delay, changing data, regulatory feedback, safety and efficacy outcomes, intellectual property disputes, and funding constraints.

Filing Explained

ERAS-0015 remains preliminary and ongoing, advancing development disclosure without reporting a completed registration-enabling outcome.

The July 13, 2026 Form 8-K, which reports specified material events, discloses updated preliminary Phase 1 data for ERAS-0015 from the ongoing AURORAS-1 trial.

For Erasca, the filing updates the program’s development status and describes plans to accelerate potentially registration-enabling development, but it does not establish a completed registration-enabling outcome.

In 72 treated patients, all-grade treatment-related rash occurred in 72%, diarrhea in 32%, stomatitis in 19%, and nausea in 14%; treatment-related events led to dose interruptions in 13%, dose reductions in 8%, and no discontinuations.

The company characterizes the responses as encouraging and the combination potential as promising, while cautioning that these preliminary results may change as enrollment and follow-up continue.

The key watch item is whether follow-up confirms the reported responses and whether FDA feedback or requirements alter the planned potentially registration-enabling trials.

8-K Event Classification

Item 8.01 — Other Events

1 item

Item 8.01 Other Events Other

Voluntary disclosure of events the company deems important to shareholders but not covered by other items.

Key Figures

Patients at protocol-amended dose: 72 patients Rash (all grades): 52 patients (72%) Diarrhea (all grades): 23 patients (32%) +5 more

8 metrics

Patients at protocol-amended dose 72 patients RAS-mutant NSCLC and PDAC treated with ERAS-0015 at 16–32 mg in AURORAS-1

Rash (all grades) 52 patients (72%) Treatment-related adverse events occurring in ≥10% of AURORAS-1 patients

Diarrhea (all grades) 23 patients (32%) Treatment-related adverse events in patients at protocol-amended dose

Stomatitis (all grades) 14 patients (19%) Treatment-related adverse events in AURORAS-1 as of May 25, 2026 DCO

Nausea (all grades) 10 patients (14%) Treatment-related adverse events occurring in ≥10% of patients

Dose interruptions due to TRAEs 9 patients (13%) Treatment-related adverse events leading to dose interruptions in AURORAS-1

Dose reductions due to TRAEs 6 patients (8%) Treatment-related adverse events leading to dose reductions

Discontinuations due to TRAEs 0 patients Treatment-related adverse events leading to dose discontinuations in AURORAS-1

Key Terms

pan-RAS molecular glue, treatment-related adverse events, pancreatic ductal adenocarcinoma, registrational-enabling, +2 more

6 terms

pan-RAS molecular glue medical

"updated preliminary Phase 1 data for its potentially best-in-class, pan-RAS molecular glue ERAS-0015"

A pan‑RAS molecular glue is a small drug-like molecule designed to stick to RAS proteins and recruit another cellular partner to change or destroy them, and it works across the main RAS family members rather than just one subtype. For investors, this matters because RAS-driven cancers are common and hard to treat, so a broadly active molecular glue could address many tumor types, potentially creating a large market opportunity while carrying the usual high scientific and regulatory risk of new drug approaches.

treatment-related adverse events medical

"summarizes all treatment-related adverse events occurring in 10% or more of patients"

Treatment-related adverse events are harmful or unwanted health effects that doctors or regulators determine were caused by a drug, vaccine, device, or other medical therapy. Investors care because how often and how severe these side effects are can shape regulatory approval, labeling, sales potential and legal risk — similar to how product defects can stop or damage a company's ability to sell an item.

pancreatic ductal adenocarcinoma medical

"Encouraging Monotherapy Responses Observed in Second Line or Greater KRAS G12X Pancreatic Ductal Adenocarcinoma"

A fast-growing cancer that starts in the cells lining the pancreas’ small ducts; it is the most common and aggressive form of pancreatic cancer. It matters to investors because its severity and limited treatment options drive high unmet medical need, large potential markets for effective drugs or diagnostics, and strong sensitivity of company valuations to clinical trial results, regulatory approvals, or changes in treatment guidelines—similar to how fixing a main leak can prevent major damage in a building.

registrational-enabling regulatory

"Accelerating Potentially Registration-Enabling Development Plans in Highest Value Indications"

data cut-off date medical

"as of the May 25, 2026 DCO date Summary of TRAEs"

forward-looking statements regulatory

"cautions you that statements contained in this report regarding matters that are not historical facts are forward-looking statements"

Forward-looking statements are predictions or plans that companies share about what they expect to happen in the future, like estimating sales or profits. They matter because they help investors understand a company's outlook, but since they are based on guesses and assumptions, they can sometimes be wrong.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What did Erasca (ERAS) announce regarding the AURORAS-1 Phase 1 trial?

Erasca announced updated preliminary Phase 1 data from its AURORAS-1 trial of ERAS-0015 in RAS-mutant solid tumors, incorporating more patients and longer follow-up, with a focus on safety, monotherapy activity, and combination potential with panitumumab.

What is ERAS-0015 in Erasca (ERAS)'s pipeline?

ERAS-0015 is described as a pan-RAS molecular glue being tested in patients with RAS-mutant solid tumors. Erasca views it as having broad potential, including use as monotherapy and in combinations, and is exploring potentially registration-enabling development paths.

What were the key treatment-related adverse events in Erasca (ERAS)'s AURORAS-1 data?

In 72 patients, common treatment-related adverse events included rash in 52 patients (72%), diarrhea in 23 (32%), stomatitis in 14 (19%), and nausea in 10 (14%). Dose interruptions occurred in 9 patients (13%), reductions in 6 (8%), with no discontinuations.

How did Erasca (ERAS) characterize ERAS-0015's tolerability and safety?

Erasca stated that with additional patients and follow-up, monotherapy safety data remained consistent with prior disclosure and ERAS-0015 continued to be generally well tolerated, while also providing a detailed table of treatment-related adverse events occurring in at least 10% of patients.

What future development plans did Erasca (ERAS) discuss for ERAS-0015?

Erasca discussed accelerating potentially registration-enabling development for ERAS-0015 in high-value indications, including monotherapy in KRAS G12X pancreatic ductal adenocarcinoma and combinations with panitumumab in metastatic colorectal cancer, subject to clinical results and regulatory feedback.

What risks and uncertainties did Erasca (ERAS) highlight around ERAS-0015?

Erasca emphasized that interim results may change, trials may face delays, ERAS-0015 may not show expected benefits, FDA may require more data, and there are risks related to safety, efficacy, collaborations, cash resources, and intellectual property disputes including litigation with Revolution Medicines.

AI-generated analysis. How Rhea-AI works. Not financial advice.

Understanding 8-K Material Events →

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Accepted by SEC EDGAR 07/13/2026 - 04:19 PM Learn about SEC filing dates

false 0001761918 0001761918 2026-07-13 2026-07-13

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): July 13, 2026

Erasca, Inc.

(Exact name of Registrant as Specified in Its Charter)

Delaware		001-40602		83-1217027
(State or Other Jurisdiction of Incorporation)		(Commission File Number)		(IRS Employer Identification No.)
3115 Merryfield Row
Suite 300
San Diego, California				92121
(Address of Principal Executive Offices)				(Zip Code)

Registrant’s Telephone Number, Including Area Code: (858) 465-6511

(Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

Title of each class		Trading Symbol(s)		Name of each exchange on which registered
Common Stock, $0.0001 par value per share		ERAS		Nasdaq Global Select Market

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company ☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 8.01 Other Events.

On July 13, 2026, Erasca, Inc. (the “Company”) announced updated preliminary Phase 1 data for its potentially best-in-class, pan-RAS molecular glue ERAS-0015 in patients with RAS-mutant solid tumors. Updated preliminary data from the Company’s ongoing AURORAS-1 Phase 1 trial in the U.S. builds on the Company’s April 2026 announcement, with additional patients and longer follow-up.

Additional Results from AURORAS-1 Trial

Encouraging Monotherapy Responses Observed in Second Line or Greater (“2L+”) KRAS G12X Pancreatic Ductal Adenocarcinoma (“PDAC”)¹

• 57% uORR_8wk (N=7) at recommended dose for expansion (“RDE”) of 32 mg once daily (“QD”)²

• Across doses, all patients with either confirmed or unconfirmed responses remained on treatment

• At RDE of 32 mg QD, 6 of 7 enrolled patients remained on treatment; at RDE of 24 mg QD, 6 of 8 enrolled patients remained on treatment

With Additional Patients and Longer Follow-up, Monotherapy Safety Data Remained Consistent with Prior Disclosure and ERAS-0015 Continued to be Generally Well-Tolerated¹

• Frequency and severity of treatment-related adverse events (“TRAEs”) remained consistent with the Company’s April 2026 announcement

• Mostly low-grade TRAEs, no dose-limiting toxicities (“DLTs”), low rate of dose interruptions or reductions due to TRAEs, and no discontinuations due to TRAEs

• Median relative dose intensity was 100% at both 24 mg QD and 32 mg QD

Promising Combination Potential with Panitumumab in Metastatic Colorectal Cancer, including Clearance of First Dose Escalation Cohort³

• No DLTs were observed for the combination in the 16 mg cohort during dose escalation in four DLT-evaluable patients

• Backfill enrollment is ongoing in the 16 mg combination cohort

• Dose escalation is ongoing with continued enrollment in the 24 mg combination cohort

Accelerating Potentially Registration-Enabling Development Plans in Highest Value Indications

• Initiate potentially registration-enabling trial in non-small-cell lung cancer (“NSCLC”) patients as 2L+ therapy in the first half of 2027

• Initiate Phase 3 pivotal trial in PDAC patients as first line therapy in 2027

• Initiate Phase 3 pivotal trial in RAS-mutant NSCLC patients in the second half of 2027 or first half of 2028

¹  Data cutoff (“DCO”) May 25, 2026

²  The uORR_8wk is the overall response rate (ORR) (confirmed and unconfirmed responses) for patients who received first dose of ERAS-0015 at least 8 weeks prior to the May 25, 2026 cutoff date

³  DCO July 6, 2026

Additional AURORAS-1 Safety Data

The following table summarizes all treatment-related adverse events occurring in 10% or more of patients in the AURORAS-1 trial as of the May 25, 2026 DCO date:

Summary of TRAEs occurring in ≥10% of patients

Patients with RASm NSCLC and PDAC Treated at PAD (16-32mg) ERAS-0015 (N=72)

TRAEs, n (%)		Grade 1		Grade 2		Grade 31		Grade 4		All Grades
Rash2, n (%)		37 (51)		13 (18)		2 (3)		0		52 (72)
Diarrhea, n (%)		17 (24)		5 (7)		1 (1)		0		23 (32)
Stomatitis, n (%)		9 (13)		3 (4)		2 (3)		0		14 (19)
Nausea, n (%)		9 (13)		1 (1)		0		0		10 (14)
TRAEs leading to dose interruptions, n (%)										9 (13)
TRAEs leading to dose reductions, n (%)										6 (8)
TRAEs leading to dose discontinuations, n (%)										0

¹  One Grade 3 TRAE of pneumonitis progressed to Grade 5 after withdrawal of supportive care per patient decision. The patient was a 66 year-old male with heavily pretreated metastatic pancreatic adenocarcinoma who received 24 mg of ERAS-0015. The patient had pulmonary metastases, a history of right lung cryoablation and no history of lung radiation. The patient presented to the ER approximately a month after starting ERAS-0015 with Grade 3 pneumonitis that was treated aggressively with immediate discontinuation of ERAS-0015, high dose steroids and infliximab. The patient requested withdrawal of supportive care and ultimately died of the event.

²  Rash events are identified using following preferred term rash pustular, rash papular, rash maculo-papular, rash macular, rash, erythema and dermatitis acneiform (uncoded terms rash acneiform and rash, are also included).

Cautionary Note Regarding Forward-Looking Statements

The Company cautions you that statements contained in this report regarding matters that are not historical facts are forward-looking statements. The forward-looking statements are based on the Company’s current beliefs and expectations and include, but are not limited to: the Company’s expectations regarding the potential therapeutic benefits of its product candidates, including ERAS-0015, and the planned advancement of its development pipeline, including the anticipated timing of data readouts for the AURORAS-1 trial, and the initiation of the clinical trials of ERAS-0015 described in this report, the Company’s expectations that its planned clinical trials will serve as registrational-enabling studies, characterizations of the clinical profile of ERAS-0015, the broad potential of ERAS-0015 to become a foundational therapy for multiple RAS-mutant solid tumors, the potential for ERAS-0015 to be used in combination therapies, the potential for ERAS-0015 to be best-in-class. Actual results may differ from those set forth in this report due to the risks and uncertainties inherent in the Company’s business, including, without limitation: the timing of its clinical data readouts, including for the AURORAS-1 trial may be delayed; the Company’s product candidates, including ERAS-0015, may not demonstrate therapeutic benefits that the Company expects; interim, topline and preliminary results of a clinical trial are not necessarily indicative of final results and one or more of the clinical outcomes may materially change as patient enrollment continues, following more comprehensive reviews of the data and as more patient data becomes available, including the risk that an unconfirmed partial response to treatment may not ultimately result in a confirmed partial response to treatment after follow-up evaluations; the Company’s approach to the discovery and development of product candidates based on its singular focus on shutting down the RAS/MAPK pathway, a novel and unproven approach; results from preclinical studies not necessarily being predictive of future results; the

Company’s assumptions around which programs may have a higher probability of success may not be accurate, and the Company may expend its limited resources to pursue a particular product candidate and/or indication and fail to capitalize on product candidates or indications with greater development or commercial potential; potential delays in the commencement, enrollment, data readout, and completion of clinical trials and preclinical studies; the Company’s dependence on third parties in connection with manufacturing, research, and preclinical and clinical testing; unexpected adverse side effects or inadequate efficacy of the Company’s product candidates that may limit their development, regulatory approval, and/or commercialization, or may result in recalls or product liability claims; the Company’s planned potentially registration-enabling trials may be delayed based on Food and Drug Administration (“FDA”) feedback or requirements, as the FDA retains broad discretion to require additional clinical data prior to the conduct of a registrational trial or submission for regulatory approval; even if the Company’s planned trials are successful, they may not support regulatory approval; unfavorable results from preclinical studies or clinical trials; the inability to realize any benefits from the Company’s current licenses, acquisitions, and collaborations, and any future licenses, acquisitions, or collaborations, and the Company’s ability to fulfill its obligations under such arrangements; regulatory developments in the United States and foreign countries; the Company’s ability to obtain and maintain intellectual property protection for its product candidates and maintain its rights under intellectual property licenses, including its ability to successfully defend against allegations raised by, or any litigation initiated by, Revolution Medicines (“RevMed”) that ERAS-0015 infringes patents held by RevMed or was derived from RevMed trade secrets; the sufficiency of the Company’s cash, cash equivalents, and marketable securities to fund operations; the Company may use its capital resources sooner than it expects; and other risks described in the Company’s prior filings with the Securities and Exchange Commission (“SEC”), including under the heading “Risk Factors” in our annual report on Form 10-K for the year ended December 31, 2025, and any subsequent filings with the SEC. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and the Company undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement, which is made under the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

						Erasca, Inc.
Date: July 13, 2026				By:		/s/ Ebun Garner
						Ebun Garner, Chief Legal Officer

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