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Evogene (NASDAQ: EVGN) cuts 2025 net loss to $7.8 million amid AI focus

Filing Impact
(Neutral)
Filing Sentiment
(Neutral)
Form Type
6-K

Rhea-AI Filing Summary

Evogene Ltd. reported 2025 results showing a smaller overall loss alongside a major strategic shift toward its ChemPass AI generative small‑molecule platform. Net loss for 2025 narrowed to approximately $7.8 million from about $18.1 million, mainly due to lower operating expenses and a $6.4 million gain on the sale of Lavie Bio and MicroBoost AI for Ag to ICL, recorded in $5.7 million of income from discontinued operations.

Full‑year revenues fell to roughly $3.9 million from $5.6 million as certain AgPlenus and Corteva revenues and Casterra seed sales declined. A $2.2 million Casterra inventory impairment pushed 2025 cost of revenues to about $4.1 million, driving an operating loss of $14.0 million. Cash, cash equivalents and short‑term deposits were about $13.0 million at year‑end, after using $13.5 million in operating cash during 2025, while management exited non‑core assets, resized the organization and highlighted new AI collaborations with Google Cloud in pharma and agriculture.

Positive

  • Net loss reduced materially: 2025 net loss was approximately $7.8 million versus about $18.1 million in 2024, helped by lower operating expenses and $5.7 million income from discontinued operations, including a $6.4 million gain on the Lavie Bio and MicroBoost AI for Ag sale to ICL.

Negative

  • Revenue decline and cash burn: 2025 revenues fell to about $3.9 million from $5.6 million, while Evogene used roughly $13.5 million in operating cash during 2025 and recorded a $14.0 million operating loss, indicating continued pressure on the core business and liquidity.

Insights

Loss narrows on cost cuts and asset sale, but revenue and cash remain pressure points.

Evogene reduced its 2025 net loss to approximately $7.8 million from about $18.1 million, helped by lower R&D, G&A and sales costs and a $6.4 million gain on selling Lavie Bio and MicroBoost AI for Ag to ICL. Operating loss still reached about $14.0 million, reflecting weaker revenues and higher cost of revenues.

Revenue declined to roughly $3.9 million from $5.6 million, with AgPlenus milestones, Corteva collaboration revenues, and Casterra seed sales all lower. A Casterra inventory impairment of about $2.2 million pushed 2025 cost of revenues to around $4.1 million, turning gross profit into a small gross loss.

Year‑end cash, cash equivalents and short‑term deposits were about $13.0 million, after net cash used in operating activities of roughly $13.5 million in 2025 and $2.7 million in Q4 2025. Continuing progress of ChemPass AI™, including Google Cloud collaborations and pharma and ag‑chemical partnerships, will be central to how effectively Evogene can translate its focused strategy into future revenue and reduce ongoing cash burn.



UNITED STATES
 SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

FORM 6-K
 
REPORT OF FOREIGN PRIVATE ISSUER
PURSUANT TO RULE 13a-16 OR 15d-16 OF
THE SECURITIES EXCHANGE ACT OF 1934
 
For the month of March 2026
 
Commission File Number: 001-36187

EVOGENE LTD.
  (Translation of Registrant’s Name into English)
 
13 Gad Feinstein Street, Park Rehovot, Rehovot 7638517, Israel
(Address of principal executive offices)
 
Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.
 
Form 20-F        Form 40-F
 


CONTENTS
 
On March 5, 2026, Evogene Ltd. (“Evogene”) announced its financial results for the fourth quarter and fiscal year ended December 31, 2025.  A Copy of the press release announcing those results is furnished as Exhibit 99.1 to this Report of Foreign Private Issuer on Form 6-K (this “Form 6-K”) and is incorporated herein by reference.
 
Evogene is holding a conference call on March 5, 2026 to discuss its quarterly results for the quarter ended December 31, 2025 and, in connection with that call, will make available to its investors a slide presentation to provide additional information regarding its business and its financial results. That slide presentation is attached as Exhibit 99.2 to this Form 6-K and is incorporated herein by reference.
 
The GAAP financial statements tables contained in the press release attached to this Form 6-K are incorporated by reference in the registration statements on Form F-3 (Securities and Exchange Commission (“SEC”) File No. 333-277565), and Form S-8 (SEC File Nos. 333-193788, 333-201443, 333-203856, 333-259215, and 333-286197) of Evogene, and will be a part thereof from the date on which this Form 6-K is submitted, to the extent not superseded by documents or reports subsequently filed or furnished.
 

SIGNATURE
 
Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
 



Date: March 5, 2026
 
EVOGENE LTD.
(Registrant)

By: /s/ Yaron Eldad
Yaron Eldad
Chief Financial Officer


 
EXHIBIT INDEX
 
EXHIBIT NO.
DESCRIPTION
99.1
Press Release: Evogene Reports Fourth Quarter and Full Year 2025 Financial Results.
99.2
Slide presentation for conference call of Evogene held on March 5, 2026, discussing Evogene’s quarterly financial results for the fourth quarter of 2025.




Exhibit 99.1

Evogene Reports Fourth Quarter and Full Year 2025 Financial Results
 
Conference call and webcast: today, March 05, 2026, 9:00 AM ET
 
Rehovot, Israel – March 5, 2026 – Evogene Ltd. (Nasdaq, TASE: EVGN), a pioneering company in computational chemistry specializing in the generative AI design of small molecules for the pharmaceutical and agricultural industries, today announced its financial results for the fourth quarter and full year ended December 31, 2025. 
 
Mr. Ofer Haviv, President & CEO of Evogene, stated: “During 2025, we executed a clear and decisive strategic shift. After a comprehensive review of our technology assets, target markets, and capital allocation priorities, we sharpened our focus to drive sustainable long-term value by concentrating on a single proprietary tech-engine - ChemPass AI™- for small-molecule discovery and optimization. We streamlined our operations to focus on two high-impact markets: pharma and agriculture, while discontinuing non-core activities, divesting misaligned assets, resizing the organization, and aligning our business development efforts with this focused strategy. ChemPass AI™’s competitive advantage combines two core strengths: generating truly novel molecules and simultaneously optimizing multiple critical parameters from the outset.
 
Throughout 2025, ChemPass AI™ was advanced through proprietary internal developments and strategic collaborations with Google Cloud. Our first collaboration delivered a foundation model trained on 38 billion structures, achieving 90% design precision, based on our calculation - approximately tripling our benchmarks for accuracy. A second collaboration, launched in February 2026, integrates AI agents via Google Cloud Vertex AI to automate workflows, reduce manual errors, and further strengthen candidate quality and commercial potential.
 
Evogene’s offering - our proprietary small-molecule product candidates - combines three unique powerful characteristics: novel molecules representing new and diverse chemical structures; optimized for simultaneous multi-parameters from the earliest design stages; and highly potent compounds refined through targeted experimental validation.
 
Our business model is built on an integrated, partnership-driven approach that supports both collaborations and the in-house advancement of proprietary candidates. Projects begin with joint strategic alignment and continue through rigorous experimental validation, with partners actively engaged at every stage and programs tailored to specific scientific and commercial objectives.
 
In pharma, since the second half of 2025, we have advanced multiple partnered drug discovery programs, with ChemPass AI™ candidates progressing into experimental testing by our partners; four collaborations have been publicly disclosed to date.
 
In agriculture, AgPlenus applies ChemPass AI™ to novel herbicide and fungicide development, supported by strategic collaborations with Bayer and Corteva and a differentiated internal pipeline, positioning us for continued growth.”
 
Mr. Haviv continued: “As part of our focused strategy, we discontinued non-core activities, divested misaligned assets, and resized the organization. During 2025, Lavie Bio was acquired by ICL. In early 2026, Biomica licensed its lead oncology candidate, BMC128, to Lishan Pharmaceuticals. No additional activity is expected from these companies.  At the same time, Evogene has retained select activities with meaningful value potential that are not at the core of our new strategy, including Casterra, and intends to continue supporting these activities until their full potential is realized.
 
Looking ahead, the advancement of proprietary small-molecule product candidates is at the heart of Evogene’s mission. Supported by ChemPass AI™, our differentiated generative AI tech-engine, disciplined capital allocation across two high-potential markets, and strong strategic partnerships, we believe Evogene is well-positioned on a clearly defined and focused path toward sustainable long-term value creation.”



Financial Highlights:
 
As part of the Company’s updated strategic plan, management implemented an organizational realignment and cost-reduction initiative. The effects of these measures are reflected in the significant decrease in operating expenses, net, which declined to approximately $13.8 million for the year ended 2025, compared to approximately $22.0 million in 2024. The impact is also evident in the fourth-quarter results, with total operating expenses, net, of approximately $3.2 million, compared to approximately $4.3 million in the corresponding period of 2024. The Company expects this reduced expense level to be sustained in future periods.
 
In 2025, Lavie Bio, our subsidiary focused on agricultural biologicals, completed the sale of the majority of its operations to ICL Group Ltd. As a result of this transaction, Lavie Bio no longer maintains employees, and its operating expense level has decreased significantly. Lavie Bio anticipates distributing the majority of its remaining cash to its shareholders, including Evogene, during 2026.
 
During 2025, as part of the Company’s updated strategic plan, we scaled down Biomica’s operations and research and development activities and reduced its personnel to a minimal level. In early 2026, Biomica entered into a license agreement with Lishan Pharmaceuticals for its lead oncology candidate, BMC128. Following this transaction, Biomica does not expect to conduct further material operational activities and anticipates distributing the majority of its remaining cash to its shareholders, including Evogene.
 
With respect to AgPlenus, we integrated AgPlenus, our ag-chemical subsidiary, into our core operations, with the objective of maximizing the value of our ChemPass AI platform for the development of novel ag-chemical products. In alignment with the Company’s updated organizational structure, AgPlenus was resized and streamlined to reflect the revised operating model.
 
During 2025, due to a significant decline in demand for castor seeds, Casterra Ag ceased its operations in Kenya, reduced its headcount and overall expense level, and is currently focusing its activities on the Brazilian market. As a result of these developments, Casterra recorded an impairment of approximately $2.2 million related to its seed inventory. This impairment is presented within Cost of Sales in the consolidated financial statements in a separate line item.
 
In February 2026, we entered into a warrant inducement agreement with an existing investor providing for the immediate exercise in full of its August 2024 Series A and Series B warrants, resulting in gross proceeds to the Company of approximately $3.4 million, before deduction of placement agent fees and other offering expenses. In consideration for such exercise, the investor will receive, in a private placement, new unregistered Series A-1 and Series B-1 warrants to purchase up to an aggregate of 5,076,924 ordinary shares. The new warrants are exercisable immediately at an exercise price of $1.25 per ordinary share.
 


Financial reports:
 
Cash Position - As of December 31, 2025, Evogene held consolidated cash, cash equivalents, and short-term bank deposits of approximately $13.0 million. The consolidated cash usage during the fourth quarter of 2025 was approximately $3.0 million. Excluding Lavie Bio and Biomica, Evogene and its other subsidiaries used approximately $2.4 million in cash during the fourth quarter of 2025.
 
Revenues for 2025 totaled approximately $3.9 million, compared to approximately $5.6 million in the same period the previous year, reflecting a decrease of approximately $1.7 million. The decrease was primarily driven by lower revenue recognized from AgPlenus’ activity, which included one-time payment during the first quarter of 2024 and revenues recognized from the collaboration agreement with Corteva, that was completed during 2024. Revenues for the fourth quarter of 2025 were approximately $0.3 million; a decrease compared to approximately $1.5 million in the same period last year. The decrease was mainly due to reduced seed sales generated by Casterra during the fourth quarter of 2025.
 
Cost of Revenues for the year ending 2025 was approximately $4.1 million, compared to approximately $2.4 million in the previous year. The increase was primarily attributable to an inventory impairment of approximately $2.2 million recorded by Casterra during the fourth quarter of 2025 mainly due to its decision to cease its operations in Kenya as noted above. Cost of revenues for the fourth quarter of 2025 was $2.3 million, compared to $0.7 million in the fourth quarter of the previous year. The increase in quarterly cost of revenues was mainly driven by the same inventory impairment of Casterra as noted above.
 
R&D Expenses, net of non-refundable grants, for the year 2025 were approximately $8.0 million, a decrease of approximately $4.5 million compared to $12.5 million in the year 2024. The decrease was primarily due to reduced R&D expenses in Biomica, Casterra and AgPlenus. In the fourth quarter of 2025, R&D expenses were approximately $1.8 million, down from approximately $2.7 million in the same period of 2024. This decrease is mainly attributed to decreased expenses in Biomica.
 
Sales and Marketing Expenses for the year 2025 were approximately $1.5 million, a decrease of approximately $0.5 million compared to approximately $2.0 million in the same period last year. The decrease was mainly due to reductions in Evogene and Biomica personnel costs. Sales and marketing expenses for the fourth quarters of 2025 and 2024 were approximately $0.3 million and $0.4 million, respectively.
 
General and Administrative Expenses for the year 2025 decreased to approximately $4.3 million from approximately $7.0 million in the same period last year. This decrease is mainly attributable to expenses recorded during the year 2024 related to a provision for doubtful debt for one of Casterra’s seed suppliers as well as transaction costs associated with Evogene’s fundraising in August 2024. Additional decrease is attributable to a reduction in Biomica’s activities and personnel costs during 2025. General and administrative expenses for the fourth quarter of 2025 decreased to approximately $0.9 million compared to approximately $1.3 million in the same period of the previous year, primarily due to decreased expenses in Evogene and Biomica, as mentioned above.
 
Other Expenses, net of approximately $37 thousand were recorded in 2025 mainly due to the impairment of fixed assets associated with the reduction in Biomica’s activities, partially offset by income recognized in the first quarter of 2025 related to the accounting treatment of Evogene’s sub-lease agreement. The decision to cease Canonic’s operations in the first half of 2024 resulted in other expenses of approximately $0.5 million, primarily due to the impairment of fixed assets.


 
Operating Loss for 2025 was approximately $14.0 million, a significant decrease from approximately $18.8 million in the same period of the previous year, mainly due to decreased operating expenses, partially offset by the decreased revenues as mentioned above and the higher cost of revenues, mainly due to an inventory impairment of approximately $2.2 million recorded by Casterra, in the fourth quarter of 2025. The operating loss for the fourth quarter of 2025 was approximately $5.2 million, an increase from approximately $3.5 million in the same period of the previous year, primarily due to the decreased revenues and increased cost of revenues, mentioned above, partially offset by decreased operating expenses.
 
Financing Income, net for the year 2025 was approximately $0.6 million, compared to approximately $4.0 million in the previous year. The decrease in financing income, net was mainly associated with accounting treatment of pre-funded warrants and warrants issued in August 2024 fund raising. As a result, during the twelve months of 2025 the Company recorded financial income, net, related to pre-funded warrants and warrants of approximately $458 thousand as compared to a financial income of approximately $3.4 million in same period of 2024. Financing expenses, net, for the fourth quarter of 2025 were approximately $0.2 million, compared to financing income, net of approximately $4.5 million in the same period of the previous year. The decrease in financing income is mainly associated with accounting treatment of pre-funded warrants and warrants issued in the August 2024 fund raising as mentioned above.
 
Income from Discontinued Operations, net for the twelve months of 2025 was approximately $5.7 million, compared to a loss of approximately $3.2 million in the same period of 2024. For the fourth quarter of 2025, loss from discontinued operations, net was approximately $16 thousand, compared to a loss of approximately $1.0 million in the fourth quarter of the previous year. These amounts primarily reflect the financial results of Lavie Bio’s operations as well as expenses related to the development and maintenance of MicroBoost AI for Ag, which are presented as a single-line item in the consolidated statements of profit and loss. Following the sale of the majority of Lavie Bio’s assets as well as Evogene’s MicroBoost AI for Ag to ICL, the Company recognized a gain on sale of approximately $6.4 million which is also included in the income (loss) from discontinued operations, net, for the year of 2025.  All prior period amounts have been reclassified to conform to this presentation.
 
Net loss for the twelve months of 2025 was approximately $7.8 million, compared to approximately $18.1 million in the same period last year. The $10.3 million decrease in net loss was primarily due to decreased operating expenses and an income derived from discontinued operations due to the asset sale to ICL, net, partially offset by reduced revenues, higher cost of revenues and a decreased financing income, net.  The net loss for the fourth quarter of 2025 was approximately $5.4 million, compared to net loss of approximately $5 thousand in the same period last year. This increase in net loss was primarily due to decreased financial income, net, decreased revenues, and increased cost of revenues, partially offset by decreased operating expenses, as mentioned above.


About Evogene Ltd.
 
Evogene Ltd. (Nasdaq/TASE: EVGN) is a pioneering company in computational chemistry, specializing in the generative design of small molecules for the pharmaceutical and agricultural industries.
 
At the core of its technology is ChemPass AI™, a proprietary generative AI engine that enables the design of novel, highly potent small molecules optimized across multiple critical parameters. This powerful platform significantly improves success rates while reducing development time and costs.
 
Built on this powerful technological foundation, and through strategic partnerships alongside internal product development, Evogene is focused on creating breakthrough products driven by the integration of scientific innovation with real-world industry needs. We call this approach "Real-World Innovation."
 
Learn more at: www.evogene.com.
 
Forward-Looking Statements
 
This press release contains "forward-looking statements" relating to future events. These statements may be identified by words such as “may,” “could,” “expects,” “hopes,” “intends,” “anticipates,” “plans,” “believes,” “scheduled,” “estimates,” “demonstrates” or words of similar meaning. For example, Evogene is using forward-looking statements in this press release when it discusses ChemPass AI™’s competitive advantage, the potential success of Evogene’s proprietary small-molecule product candidates, the potential success of Evogene’s collaboration with third parties, Casterra’s potential, Evogene’s potential to create value. Such statements are based on current expectations, estimates, projections and assumptions, describe opinions about future events, involve certain risks and uncertainties which are difficult to predict and are not guarantees of future performance. Therefore, actual future results, performance or achievements of Evogene and its subsidiaries may differ materially from what is expressed or implied by such forward-looking statements due to a variety of factors, many of which are beyond the control of Evogene, including, the aftermath of the recent war between Israel and each of (i) the terrorist groups, Hamas and Hezbollah, (ii) Iran, and (iii) other regional terrorist groups supported by Iran, and any destabilizations in Israel, neighboring territories or the Middle East region, as well as those additional risk factors identified those risk factors contained in Evogene’s reports filed with the applicable securities authority. In addition, Evogene rely, and expect to continue to rely, on third parties to conduct certain activities, such as their field-trials and pre-clinical studies, and if these third parties do not successfully carry out their contractual duties, comply with regulatory requirements or meet expected deadlines, Evogene and its subsidiaries may experience significant delays in the conduct of their activities. Evogene and its subsidiaries disclaim any obligation or commitment to update these forward-looking statements to reflect future events or developments or changes in expectations, estimates, projections and assumptions.
 
Evogene Investor Relations Contact:
 
Email: ir@evogene.com
Tel: +972-8-9311901
 


CONSOLIDATED STATEMENTS OF FINANCIAL POSITION

U.S. dollars in thousands


   
December 31,
   
December 31,
 
   
2025
   
2024
 
CURRENT ASSETS:
           
Cash and cash equivalents
 
$
12,956
   
$
15,301
 
Restricted cash
   
32
     
10
 
Trade receivables
   
317
     
1,091
 
Other receivables and prepaid expenses
   
1,565
     
2,064
 
Deferred expenses related to issuance of warrants
   
551
     
1,304
 
Inventories
   
210
     
1,819
 
     
15,631
     
21,589
 
LONG-TERM ASSETS:
               
Long-term deposits and other receivables
   
571
     
12
 
Investment accounted for using the equity method
   
43
     
82
 
Deferred expenses related to issuance of warrants
   
1,165
     
1,735
 
Right-of-use-assets
   
1,824
     
2,447
 
    Property, plant and equipment, net
   
812
     
1,804
 
Intangible assets, net
   
-
     
12,195
 
     
4,415
     
18,275
 
                 
   
$
20,046
   
$
39,864
 
CURRENT LIABILITIES:
               
Trade payables
 
$
639
   
$
1,228
 
Employees and payroll accruals
   
861
     
1,869
 
Lease liability
   
716
     
589
 
Liabilities in respect of government grants
   
56
     
323
 
Deferred revenues and other advances
   
17
     
360
 
Warrants and pre-funded warrants liability
   
706
     
2,876
 
Convertible SAFE
   
-
     
10,371
 
Other payables
   
449
     
1,079
 
     
3,444
     
18,695
 
LONG-TERM LIABILITIES:
               
Lease liability
   
1,482
     
1,914
 
Liabilities in respect of government grants
   
3,073
     
4,327
 
Deferred revenues and other advances
   
72
     
90
 
     
4,627
     
6,331
 
SHAREHOLDERS' EQUITY:
               
Ordinary shares of NIS 0.2 par value:
Authorized – 30,000,000 ordinary shares; Issued and outstanding – 8,718,193  shares on December 31, 2025 and  6,514,589 shares on December 31, 2024
   
488
     
363
 
Share premium and other capital reserve
   
281,986
     
272,257
 
Accumulated deficit
   
(282,556
)
   
(274,071
)
                 
 Equity attributable to equity holders of the Company
   
(82
)
   
(1,451
)
                 
Non-controlling interests
   
12,057
     
16,289
 
                 
   Total equity
   
11,975
     
14,838
 
                 
   
$
20,046
   
$
39,864
 
   



CONSOLIDATED STATEMENTS OF PROFIT OR LOSS

U.S. dollars in thousands (except share and per share amounts)

   
Year ended
December 31,
   
Three months ended
December 31,
 
   
2025
   
2024 (*)

 
2025
   
2024 (*)

                               
Revenues
 
$
3,853
   
$
5,577
   
$
314
   
$
1,543
 
Cost of Revenues:
                               
    Inventory impairment
   
2,180
     
-
     
2,180
     
-
 
    Other cost of revenues
   
1,914
     
2,380
     
104
     
692
 
Total Cost of Revenues
   
4,094
     
2,380
     
2,284
     
692
 
                                 
Gross profit (loss)
   
(241
)
   
3,197
     
(1,970
)
   
851
 
                                 
Operating expenses (income):
                               
Research and development, net
   
7,994
     
12,511
     
1,827
     
2,707
 
Sales and marketing
   
1,476
     
1,983
     
298
     
351
 
General and administrative
   
4,286
     
6,993
     
898
     
1,283
 
Other expenses (income)
   
37
     
514
     
219
     
(10
)
                                 
Total operating expenses, net
   
13,793
     
22,001
     
3,242
     
4,331
 
                                 
Operating loss
   
(14,034
)
   
(18,804
)
   
(5,212
)
   
(3,480
)
                                 
Financing income
   
2,466
     
7,393
     
181
     
4,734
 
Financing expenses
   
(1,891
)
   
(3,358
)
   
(350
)
   
(251
)
                                 
Financing income (expenses), net
   
575
     
4,035
     
(169
)
   
4,483
 
                                 
Share of loss (gain) of an associate
   
39
     
39
     
(43
)
   
13
 
                                 
Gain (loss) before taxes on income
   
(13,498
)
   
(14,808
)
   
(5,338
)
   
990
 
Taxes on income
   
1
     
9
     
-
     
7
 
Income (loss) from continuing operations
   
(13,499
)
   
(14,817
)
   
(5,338
)
   
983
 
Income (loss) from discontinued operations, net
   
5,672
     
(3,237
)
   
(16
)
   
(988
)
                                 
Loss
 
$
(7,827
)
 
$
(18,054
)
 
$
(5,354
)
 
$
(5
)
                                 
Attributable to:
                               
Equity holders of the Company
   
(8,485
)
   
(16,485
)
   
(5,309
)
   
427
 
Non-controlling interests
   
658
     
(1,569
)
   
(45
)
   
(432
)
                                 
   
$
(7,827
)
 
$
(18,054
)
 
$
(5,354
)
 
$
(5
)
                                 
Basic and diluted gain (loss) per share from continuing operations, attributable to equity holders of the Company
 
$
(1.70
)
 
$
(2.47
)
 
$
(0.61
)
 
$
0.17
 
                                 
Basic and diluted gain (loss) per share from discontinued operations, attributable to equity holders of the Company
 
$
0.62
   
$
(0.43
)
 
$
(0.002
)
 
$
(0.11
)
                                 
Weighted average number of shares used in computing basic and diluted loss per share
   
7,874,039
     
5,697,245
     
8,718,207
     
6,795,589
 

(*) Reclassified to conform to the current period presentation, following the classification of certain operations as discontinued operations.



CONSOLIDATED STATEMENTS OF CASH FLOS

U.S. dollars in thousands

   
Year ended
December 31,
   
Three months ended
December 31,
 
   
2025
   
2024 (*)
   
2025
   
2024 (*)
 
Cash flows from operating activities:
                       
                         
Loss from continuing operations
 
$
(13,499
)
 
$
(14,817
)
 
$
(5,338
)
 
$
983
 
                                 
Adjustments to reconcile loss to net cash used in operating activities:
                               
                                 
Adjustments to the profit or loss items:
                               
                                 
Depreciation of property, plant and equipment and right-of-use-assets
   
1,144
     
1,381
     
263
     
441
 
Share-based compensation
   
654
     
1,243
     
155
     
263
 
Remeasurement of Convertible SAFE
   
(371
)
   
3
     
-
     
51
 
Net financing expenses (income)
   
(28
)
   
(771
)
   
(49
)
   
(1,013
)
Loss (gain) from sale of property, plant and equipment
   
(209
)
   
525
     
(27
)
   
2
 
Impairment of property, plant and equipment
   
246
     
-
     
246
     
-
 
Inventory impairment
   
2,180
     
-
     
2,180
     
-
 
Revaluation of government grants
   
40
     
-
     
16
     
-
 
Excess of initial fair value of pre-funded warrants over transaction proceeds
   
-
     
2,684
     
-
     
-
 
Amortization of deferred expenses related to issuance of warrants
   
1,323
     
471
     
334
     
334
 
Remeasurement of pre-funded warrants and warrants
   
(1,781
)
   
(6,529
)
   
(117
)
   
(4,589
)
Share of loss of an associate
   
39
     
39
     
(43
)
   
13
 
Taxes on income (tax benefit)
   
(6
)
   
9
     
(7
)
   
7
 
                                 
     
3,231
     
(945
)
   
2,951
     
(4,491
)
Changes in asset and liability items:
                               
Decrease (increase) in trade receivables
   
665
     
(627
)
   
(2
)
   
601
 
Decrease (increase) in other receivables and prepaid expenses
   
1,047
     
806
     
87
     
248
 
Decrease (increase) in inventories
   
(1,019
)
   
(1,277
)
   
(279
)
   
(380
)
Increase (decrease) in trade payables
   
(259
)
   
(630
)
   
188
     
(166
)
Increase (decrease) in employees and payroll accruals
   
(756
)
   
(548
)
   
(192
)
   
(397
)
Increase (decrease) in other payables
   
(570
)
   
222
     
(30
)
   
162
 
Increase (decrease) in deferred revenues and other advances
   
(361
)
   
(559
)
   
(5
)
   
(463
)
                                 
     
(1,253
)
   
(2,613
)
   
(233
)
   
(395
)
Cash received (paid) during the period for:
                               
                                 
Interest received
   
338
     
934
     
117
     
398
 
Interest paid
   
(193
)
   
(67
)
   
(43
)
   
(10
)
Taxes paid
   
(11
)
   
(11
)
   
-
     
(11
)
Net cash used in continuing operating activities
                               
     
(11,387
)
   
(17,519
)
   
(2,546
)
   
(3,526
)
Net cash used in operating activities of discontinued operations
   
(2,115
)
   
(2,181
)
   
(140
)
   
(1,035
)
                                 
Net cash used in operating activities
   
(13,502
)
   
(19,700
)
   
(2,686
)
   
(4,561
)

(*) Reclassified to conform to the current period presentation, following the classification of certain operations as discontinued operations.



CONSOLIDATED STATEMENTS OF CASH FLOWS

U.S. dollars in thousands

   
Year ended
December 31,
   
Three months ended
December 31,
 
   
2025
     
2024 (*)

   
2025
     
2024 (*)

Cash flows from investing activities:
                             
                               
Purchase of property, plant and equipment
   
(135
)
   
(626
)
   
(6
)
   
(322
)
Proceeds from sale of property, plant and equipment
   
78
     
10
     
47
     
-
 
Proceeds from finance sub-lease asset
   
52
     
-
     
23
     
-
 
Withdrawal from (investment in) bank deposits, net
   
(1
)
   
10,190
     
7,399
     
7,773
 
                                 
Net cash provided by (used in) continuing investing activities
   
(6
)
   
9,574
     
7,463
     
7,451
 
                                 
Net cash provided by investing activities of discontinued operations
   
17,744
     
48
     
2,800
     
1,307
 
Net cash provided by investing activities
   
17,738
     
9,622
     
10,263
     
8,758
 
                                 
Cash flows from financing activities:
                               
                                 
Proceeds from issuance of ordinary shares, pre-funded warrants and warrants
   
-
     
5,500
     
-
     
-
 
Proceeds from issuance of ordinary shares, net of issuance expenses
   
4,283
     
123
     
-
     
-
 
Repayment of lease liability
   
(526
)
   
(886
)
   
(133
)
   
(310
)
Proceeds from government grants
   
-
     
134
             
-
 
Repayment of convertible SAFE
   
(10,000
)
   
-
     
-
     
-
 
Repayment of government grants
   
(244
)
   
(298
)
   
(122
)
   
-
 
                                 
Net cash provided by (used in) continuing financing activities
   
(6,487
)
   
4,573
     
(255
)
   
(310
)
                                 
Net cash provided by (used in) financing activities of discontinued operations
   
(115
)
   
83
     
(1
)
   
104
 
                                 
Net cash provided by (used in) financing activities
   
(6,602
)
   
4,656
     
(256
)
   
(206
)
                                 
Exchange rate differences - cash and cash equivalent balances
   
21
     
(49
)
   
9
     
(7
)
                                 
Increase (decrease) in cash and cash equivalents
   
(2,345
)
   
(5,471
)
   
7,330
     
3,984
 
                                 
Cash and cash equivalents, beginning of the period
   
15,301
     
20,772
     
5,626
     
11,317
 
                                 
Cash and cash equivalents, end of the period
 
$
12,956
   
$
15,301
   
$
12,956
   
$
15,301
 

(*) Reclassified to conform to the current period presentation, following the classification of certain operations as discontinued operations.

   
Year ended
December 31,
   
Three months ended
December 31,
 
   
2025
   
2024
   
2025
   
2024
 
Acquisition of property, plant and equipment
   
2
     
120
     
-
     
120
 
Increase of right-of-use-asset recognized with corresponding lease liability
   
207
     
2,307
     
-
     
-
 
Exercise of pre-funded warrants
   
389
     
2,289
     
-
     
2,289
 
Derecognition of property, plant and equipment under a finance lease
   
13
     
-
     
-
     
-
 
Investment in affiliated Company with corresponding deferred revenues
           
120
     
-
     
-
 
 


Exhibit 99.2

 March 05, 2026  EARNINGS CALL   Q4 & ANNUAL 2025  OFER HAVIV | PRESIDENT & CEO 
 

 FORWARD LOOKING STATEMENT  This presentation contains "forward-looking statements" relating to future events, and Evogene Ltd. (the “Company”), may from time to time make other statements, regarding our outlook or expectations for future financial or operating results and/or other matters regarding or affecting us that are considered “forward-looking statements” as defined in the U.S. Private Securities Litigation Reform Act of 1995 (the “PSLRA”) and other securities laws, as amended. Statements that are not statements of historical fact may be deemed to be forward-looking statements. Such forward-looking statements may be identified by the use of such words as “believe”, “expect”, “anticipate”, “should”, “planned”, “estimated”, “intend” and “potential” or words of similar meaning. We are using forward-looking statements in this presentation when we discuss our value drivers, commercialization efforts and timing, product development and launches, estimated market sizes and milestones, pipeline, as well as our capabilities and technology.   Such statements are based on current expectations, estimates, projections and assumptions, describe opinions about future events, involve certain risks and uncertainties which are difficult to predict and are not guarantees of future performance. Readers are cautioned that certain important factors may affect the Company's actual results and could cause such results to differ materially from any forward-looking statements that may be made in this presentation. Therefore, actual future results, performance or achievements, and trends in the future may differ materially from what is expressed or implied by such forward-looking statements due to a variety of factors, many of which are beyond our control, including, without limitation, the aftermath of the recent war between Israel and each of (i) the terrorist groups, Hamas and Hezbollah, (ii) Iran, and (iii) other regional terrorist groups supported by Iran, and any destabilizations in Israel, neighboring territories or the Middle East region,  and those described in greater detail in Evogene's Annual Report on Form 20-F and in other information Evogene files and furnishes with the Israel Securities Authority and the U.S. Securities and Exchange Commission, including those factors under the heading “Risk Factors”.   Except as required by applicable securities laws, we disclaim any obligation or commitment to update any information contained in this presentation or to publicly release the results of any revisions to any statements that may be made to reflect future events or developments or changes in expectations, estimates, projections and assumptions.  The information contained herein does not constitute a prospectus or other offering document, nor does it constitute or form part of any invitation or offer to sell, or any solicitation of any invitation or offer to purchase or subscribe for, any securities of Evogene or the Company, nor shall the information or any part of it or the fact of its distribution form the basis of, or be relied on in connection with, any action, contract, commitment or relating thereto or to the securities of Evogene or the Company.  The trademarks included herein are the property of the owners thereof and are used for reference purposes only. Such use should not be construed as an endorsement of our products or services.  2 
 

 Earnings Call Q4 2025   AGENDA  By Ofer Haviv  CEO Update  By Yaron Eldad  CFO Update   Q&A 
 

 EVOGENE PIONEERSREAL-WORLD INNOVATION   Using a proprietary generative AI engine, we design highly potent and novel small molecules, optimized across multiple-parameters, for the pharmaceutical and ag-chemical industries  4 
 

 GEN AI ENGINE  Growing number of collaborations for diverse drug targets  Strategic collaborations for ag-chemical development   with proven results  PIONEERING IN PHARMA  REVOLUTIONIZING AG  OUR STORY  ChemPass AI™ - computational engine for the design & optimization of small molecules 
 

          NOVELTY - VAST CHEMICAL TERRITORIES  based on a 38B-molecule chemical library, the engine designs novel compounds that are synthesizable and active, while accessing unexplored chemical space and creating new IP opportunities  INTRODUCING CHEMPASS AI™:   BREAKING CHEMICAL SPACE LIMITATION &  MULTI-PARAMETER DESIGN   HIGH-POTENCY - CHEMISTRY THAT PERFORMS  AI-first designed molecules optimized through targeted experimental validation  MULTI-PARAMETER OPTIMIZATIONmultiple-parameters optimized simultaneously, tailored to project-specific chemical, biological, and physical constraints, increasing probability of success  6 
 

 7  Technological Collaborations with GOOGLE CLOUDfrom generative models to autonomous discovery   First Collaboration – FIRST-IN-CLASS FOUNDATION MODEL  Successful completion of a proprietary generative AI model for novel molecular product candidates addressing multiple parameters, based on 38 billion molecular structures, delivered 90% precision compared to approx. 30% in traditional GPT models.  Second Collaboration – ADVANCED AI AGENTS INTEGRATION   Integration of AI agents into ChemPass AI™ using Google Cloud Vertex AI to decrease manual errors, accelerate design-make-test-analyze cycles, and enable scalable discovery of patentable small molecules with improved probability of development success for pharmaceutical and agricultural pipelines.   Initiated Feb. 2026  “This expanded collaboration with Evogene demonstrates the power of integrating cutting-edge artificial intelligence into scientific research. By leveraging our technology to deploy advanced AI agents, we are enabling Evogene to automate and scale their complex discovery workflows. This foundation accelerates the speed and precision of identifying small molecules, further cementing Evogene's role as a leader in next-generation molecular design for the pharmaceutical and agricultural industries”  BOAZ MAOZ, MANAGING DIRECTOR, GOOGLE CLOUD ISRAEL (10.02.2026) 
 

 Potency (Binding Affinity)  Selectivity  ML Models (QSAR)  Scaffold  Solubility  Lipophilicity (LogP)  Molecular Weight  Hydrogen Bond Donors/Acceptors  Chemical Stability  Metabolic Stability  Synthetic Accessibility  IP/Novelty  EVOGENE’S UNIQUE OFFERING –   PROPRIETARY   MOLECULAR DESIGN  8  A POWERFUL COMBINATION OF CAPABILITIES :  Novel molecules are generated based on vast and diverse chemical territories  Simultaneously optimized for multi-parameter requirements from day one  Highly potent molecules optimized through targeted experimental validation 
 

 Literature search, data preprocessing and target modeling  Target elucidation and biological interpretation  HITSCREENING  TARGETPREPROCESSING  HIT-TO-LEAD  Purchase hits and test activity and selectivity  Synthesis of novel leads and validation  Identify potential hits using PointHit  Identify elaborated analogs using ActiveSearch  Generate novel leads using LeadOptGPT  CHEMPASS AI™  PARTNER / INTERNAL pipeline  LEADOPTIMIZATION  Purchase analogs and test activity and selectivity  9  Capturing the value of Chempass ai™ - our business model   Through collaborations & in-house development  PROPRIETARY PRODUCT CANDIDATE  DEVELOPMENT STAGES 
 

 10  PHARMA DIVISION – Drugs  EXTERNAL COLLABORATIONS  Neutrophil-Derived Inflammatory Diseases  Demyelination Disorders  Lung Cancer  Metabolic Disease  EXTERNAL COLLABORATIONS  Herbicides   Herbicides   INTERNAL PIPELINE  Wheat Blotch  EVOGENE - REAL-WORLD INNOVATION  AG DIVISION* – Ag-Chemicals  AG DIVISION* – Operations in this field are conducted through our subsidiary, AgPlenus. 
 

                               11  High-potency molecules  AI-first designed molecules optimized through targeted experimental validation  Novel Chemical Space & IP  Based on a 38B-molecule chemical library, the platform designs active novel compounds   We design highly potent and novel small molecules, optimized across multiple-parameters, for the pharmaceutical and ag-chemical industries.  MULTI-PARAMETER OPTIMIZATION   Simultaneously optimizes chemical & biological parameters  PIONEERING IN PHARMA  Growing number of collaborations addressing diverse drug targets for the benefit of human health  REVOLUTIONIZING AG  Proven impact in Agriculture. Computational chemistry drives real-world agricultural impact  Generating real-world innovation          
 

 Earnings Call Q3 2025   AGENDA  By Ofer Haviv  CEO Update  By Yaron Eldad  CFO Update   Q&A  unique  
 


 13  EVOGENE SUBSIDIARIES’ ACTIVITY  
 

 CFO UPDATE  Financial Highlights 
 

 CFO UPDATE  Financial Highlights 
 


 CFO UPDATE  Financial Highlights 



 Earnings Call Q3 2025   AGENDA  By Ofer Haviv  CEO Update  By Yaron Eldad  CFO Update   Q&A 
 

 THANK YOU 
 

FAQ

How did Evogene Ltd. (EVGN) perform financially in 2025?

Evogene reduced its 2025 net loss to approximately $7.8 million from about $18.1 million in 2024. The improvement came mainly from lower operating expenses and $5.7 million income from discontinued operations, partly offset by weaker revenues and higher cost of revenues, including a Casterra inventory impairment.

What were Evogene’s revenues and operating loss for 2025?

Evogene generated approximately $3.9 million in revenues in 2025, down from about $5.6 million a year earlier, mainly due to lower AgPlenus, Corteva, and Casterra contributions. Operating loss was roughly $14.0 million versus $18.8 million in 2024, reflecting cost reductions but also higher cost of revenues.

What is Evogene’s cash position and cash usage as of December 31, 2025?

As of December 31, 2025, Evogene held about $13.0 million in consolidated cash, cash equivalents and short‑term bank deposits. Net cash used in operating activities was roughly $13.5 million for 2025 and about $2.7 million in the fourth quarter, highlighting ongoing cash burn despite strategic streamlining.

How did discontinued operations impact Evogene’s 2025 results?

Income from discontinued operations, net, was approximately $5.7 million in 2025 versus a $3.2 million loss in 2024. This mainly reflects Lavie Bio’s results and the sale of Lavie Bio’s assets and MicroBoost AI for Ag to ICL, which generated a $6.4 million gain for Evogene.

What strategic changes did Evogene implement around ChemPass AI in 2025?

Evogene refocused on a single proprietary generative AI engine, ChemPass AI™, for small‑molecule discovery in pharma and agriculture. It discontinued non‑core activities, divested misaligned assets like Lavie Bio, resized the organization, and advanced collaborations, including foundation and AI‑agent projects with Google Cloud.

How did Evogene’s research and development spending change in 2025?

Research and development expenses, net of non‑refundable grants, decreased to about $8.0 million in 2025 from roughly $12.5 million in 2024. The reduction mainly reflects lower R&D spending at Biomica, Casterra, and AgPlenus as Evogene streamlined activities around its ChemPass AI strategy.

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