[Form 4] EXACT SCIENCES CORP Insider Trading Activity

Exact Sciences Corp. executive James Herriott, SVP, General Counsel & Secretary, reported selling 1,000 shares of the company’s common stock on 11/19/2025 at a price of $70 per share under a pre-arranged Rule 10b5-1 trading plan entered into on March 3, 2025.

Rhea-AI Filing Summary

Exact Sciences Corp. executive James Herriott, SVP, General Counsel & Secretary, reported selling 1,000 shares of the company’s common stock on 11/19/2025 at a price of $70 per share under a pre-arranged Rule 10b5-1 trading plan entered into on March 3, 2025. After this sale, he beneficially owns 11,585 shares directly and 1,556 shares held in a 401(k) plan, for a total of 13,141 shares. In addition, he holds an aggregate of 37,434 vested and unvested stock options and restricted stock units, each unit representing the right to receive one share of common stock.

Insider Trade Summary

Net Seller: 1,000 shares

Net Sell 2 txns

Insider Herriott James

Role SVP, General Counsel & Sec

Sold 1,000 shs ($70K)

Type	Security	Shares	Price	Value
Sale	Common Stock	1,000	$70.00	$70K
holding	Common Stock	--	--	--

Holdings After Transaction: Common Stock — 11,585 shares (Direct); Common Stock — 1,556 shares (Indirect, Held in 401(k) Plan)

Footnotes (2)

1. F1. The transaction reported in this field was effected pursuant to a Rule 10b5-1 trading plan entered into on March 3, 2025.
2. F2. In addition to the shares of Common Stock reported on this Form 4, which total 13,141 shares, Mr. Herriott also holds, in the aggregate, an additional 37,434 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock.

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Accepted by SEC EDGAR 11/21/2025 - 05:30 PM Learn about SEC filing dates

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

X

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Herriott James

(Last) (First) (Middle)

C/O EXACT SCIENCES CORP.

5505 ENDEAVOR LANE

(Street)

MADISON WI 53719

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
EXACT SCIENCES CORP [ EXAS ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	SVP, General Counsel & Sec

3. Date of Earliest Transaction (Month/Day/Year)
11/19/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	11/19/2025		S		1,000(1)	D	$70	11,585(2)	D
Common Stock								1,556	I	Held in 401(k) Plan

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. The transaction reported in this field was effected pursuant to a Rule 10b5-1 trading plan entered into on March 3, 2025.

2. In addition to the shares of Common Stock reported on this Form 4, which total 13,141 shares, Mr. Herriott also holds, in the aggregate, an additional 37,434 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock.

	/s/ James Herriott by Mark Busch, attorney-in- fact	11/21/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.