Fulcrum Therapeutics Q3 net loss narrows to $10.9M
Sentiment and the balance of points
Rhea-AI Sentiment reads the wording of the document, how positive or negative its language is on a 1 to 5 scale. The balance of points shown with the takes weighs what the document actually discloses, so the two can disagree, for example when a trial that missed its main goal is described in upbeat language.
Fulcrum Therapeutics, Inc. (FULC) reported a third-quarter net loss of $10.939 million, compared with $19.595 million a year earlier; nine-month net loss was $56.009 million versus $54.546 million. Operating cash use for the nine months was $48.171 million, compared with $43.267 million. Cash, cash equivalents and marketable securities totaled $306.5 million as of September 30, 2026.
FULC ceased active research and development after discontinuing pociredir and reduced its workforce approximately 85%, from 57 to nine. It entered a merger agreement with Slate Medicines on August 16, 2026; closing is expected in the fourth quarter of 2026, subject to stockholder approval and other conditions. If completed, FULC would change its name to Slate Medicines, and Slate management is expected to become management of the combined company. In connection with closing, FULC expects to declare a $275 million aggregate cash dividend, subject to adjustment under the agreement. On November 7, 2026, FULC and Slate agreed to sell early-stage fetal hemoglobin assets to an unaffiliated pharmaceutical company for approximately $7 million in cash; closing is contingent on the merger or, if the agreement is terminated, receipt of any necessary approvals.
How this balance works
Rhea-AI gives every point it takes from this document a weight. Minor counts 1, Moderate 3 and Major 9, so one Major point outweighs several Minor ones. The bar adds up the weights on each side, and when neither side holds more than 65% of the total the balance reads Mixed.
It reads the document as published, with the same rules for every company, and it does not look at what the market expected or at how the stock traded, so a point can be objectively good on a day the stock falls.
Rhea-AI Sentiment measures something else, the tone of the wording.
Positive
- Moderate pointThird-quarter net loss was $10.939 million, compared with $19.595 million a year earlier.
Negative
- Major pointActive research and development ceased; the workforce fell approximately 85%, from 57 to nine.
- Moderate pointNine-month operating cash use rose to $48.171 million from $43.267 million.
Filing Explained
For accounting purposes, Fulcrum expects Slate to be treated as acquiring its assets and liabilities if the merger closes.
The proposed merger remains subject to stockholder approval and other closing conditions; it includes issuance of Fulcrum common shares, and Slate equity holders are expected to hold a substantial majority of combined-company voting rights. That issuance would reduce existing Fulcrum holders’ percentage ownership if the transaction closes. Slate will designate all initial directors of the combined company.
The separate at-the-market program permits gradual share sales into the market, but Fulcrum reports no shares issued or sold under its up-to-
Key Figures
Key Terms
in-substance reverse recapitalization technical
pre-funded warrants financial
right-of-use asset financial
assets held for sale financial
fair value hierarchy financial
anti-dilutive effect financial
FAQ
AI-generated questions and answers. How Rhea-AI works. Not financial advice.
When is the FULC-Slate merger expected to close?
What termination fees could apply to the FULC-Slate merger agreement?
How would proceeds from FULC’s fetal hemoglobin asset sale affect the merger dividend?
AI-generated analysis. How Rhea-AI works. Not financial advice.
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM
(Mark One)
For the quarterly period ended
or
For the transition period from to
Commission File Number:
(Exact name of registrant as specified in its charter)
(State or other jurisdiction of incorporation or organization) |
(I.R.S. Employer Identification No.) |
(Address of principal executive offices) |
(Zip Code) |
(
(Registrant’s telephone number, including area code)
Securities registered pursuant to Section 12(b) of the Act:
Title of each class |
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Trading Symbol(s) |
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Name of each exchange on which registered |
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The |
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.
Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
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Emerging growth company |
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If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No
As of November 8, 2026, the registrant had
CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS
This Quarterly Report on Form 10-Q contains forward-looking statements, which reflect our current views with respect to, among other things, our operations and financial performance. All statements other than statements of historical facts contained in this Quarterly Report on Form 10-Q, including statements regarding our strategy, future operations, future financial position, future revenue, projected costs, prospects, plans, objectives of management and expected market growth are forward-looking statements. The words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “outlook,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “would,” and the negative version of these words and other similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words and include, among other statements, express or implied statements regarding:
We may not actually achieve the plans, intentions or expectations disclosed in our forward-looking statements, and you should not place undue reliance on our forward-looking statements. Such forward looking statements are subject to various risks and uncertainties. Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements we make. We have included important factors in the cautionary statements included in this Quarterly Report on Form 10-Q, particularly in the “Summary Risk Factors” below and in the “Management’s Discussion and Analysis of Results of Operations” section, that we believe could cause actual results or events to differ materially from the forward-looking statements that we make. Our forward-looking statements do not reflect the potential impact of any future acquisitions, mergers, dispositions, collaborations, joint ventures or investments we may make or enter into.
You should read this Quarterly Report on Form 10-Q and the documents that we have filed as exhibits to this Quarterly Report on Form 10-Q completely and with the understanding that our actual future results may be materially different from what we expect. The forward-looking statements contained in this Quarterly Report on Form 10-Q are made as of the date of this Quarterly Report on Form 10-Q, and we do not assume any obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by applicable law.
SUMMARY RISK FACTORS
i
Our business is subject to a number of risks that if realized could materially affect our business, financial condition, results of operations, cash flows and access to liquidity. Our principal risks include the following:
ii
iii
Table of Contents
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Page |
PART I. |
FINANCIAL INFORMATION |
1 |
Item 1. |
Financial Statements |
1 |
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Consolidated Balance Sheets as of September 30, 2026 and December 31, 2025 |
1 |
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Consolidated Statements of Operations and Comprehensive Loss for the three and nine months ended September 30, 2026 and 2025 |
2 |
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Consolidated Statements of Stockholders’ Equity for the three and nine months ended September 30, 2026 and 2025 |
3 |
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Consolidated Statements of Cash Flows for the nine months ended September 30, 2026 and 2025 |
4 |
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Notes to Consolidated Financial Statements |
5 |
Item 2. |
Management’s Discussion and Analysis of Financial Condition and Results of Operations |
18 |
Item 3. |
Quantitative and Qualitative Disclosures About Market Risk |
26 |
Item 4. |
Controls and Procedures |
26 |
PART II. |
OTHER INFORMATION |
27 |
Item 1. |
Legal Proceedings |
27 |
Item 1A. |
Risk Factors |
27 |
Item 2. |
Unregistered Sales of Equity Securities and Use of Proceeds |
27 |
Item 3. |
Defaults Upon Senior Securities |
27 |
Item 4. |
Mine Safety Disclosures |
27 |
Item 5. |
Other Information |
27 |
Item 6. |
Exhibits |
28 |
Signatures |
29 |
|
In this Quarterly Report on Form 10-Q, unless otherwise stated or as the context otherwise requires, references to “Fulcrum,” “Fulcrum Therapeutics,” “the Company,” “we,” “us,” “our” and similar references refer to Fulcrum Therapeutics, Inc. together with its consolidated subsidiary. The Fulcrum Therapeutics logo and other trademarks or service marks of Fulcrum Therapeutics, Inc. appearing in this Quarterly Report on Form 10-Q are the property of Fulcrum Therapeutics, Inc. This Quarterly Report on Form 10-Q also contains registered marks, trademarks and trade names of other companies. All other trademarks, registered marks and trade names appearing herein are the property of their respective holders.
PART I—FINANCIAL INFORMATION
Item 1. Financial Statements.
Fulcrum Therapeutics, Inc.
Consolidated Balance Sheets
(In thousands, except share and per share amounts)
(Unaudited)
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September 30, |
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December 31, |
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Assets |
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Current assets: |
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Cash and cash equivalents |
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Marketable securities |
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Restricted cash |
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Prepaid expenses and other current assets |
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Total current assets |
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Property and equipment, net |
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Operating lease right-of-use assets |
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Non-current restricted cash |
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Other assets |
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Total assets |
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Liabilities and stockholders’ equity |
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Current liabilities: |
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Accounts payable |
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$ |
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Accrued expenses and other current liabilities |
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Operating lease liability, current |
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Total current liabilities |
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Operating lease liability, excluding current portion |
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Other liabilities, excluding current portion |
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Total liabilities |
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Commitments and contingencies (Note 12) |
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Stockholders’ equity: |
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Preferred stock, $ |
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Common stock, $ |
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Additional paid-in capital |
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Accumulated other comprehensive (loss) gain |
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Accumulated deficit |
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( |
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Total stockholders’ equity |
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Total liabilities and stockholders’ equity |
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$ |
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$ |
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The accompanying notes are an integral part of these financial statements.
1
Fulcrum Therapeutics, Inc.
Consolidated Statements of Operations and Comprehensive Loss
(In thousands, except per share data)
(Unaudited)
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Three Months Ended |
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Nine Months Ended |
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2026 |
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2025 |
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2026 |
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2025 |
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Operating expenses: |
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Research and development |
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General and administrative |
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Impairment of long-lived assets |
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Restructuring expenses |
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Total operating expenses |
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Loss from operations |
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( |
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Other income, net |
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Net loss |
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$ |
( |
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$ |
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$ |
( |
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$ |
( |
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Net loss per share, basic and diluted |
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$ |
( |
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$ |
( |
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$ |
( |
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$ |
( |
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Weighted-average common shares outstanding, basic and diluted |
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Comprehensive loss: |
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Net loss |
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$ |
( |
) |
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$ |
( |
) |
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$ |
( |
) |
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$ |
( |
) |
Other comprehensive (loss) gain: |
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Unrealized (loss) gain on marketable securities |
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( |
) |
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( |
) |
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Total other comprehensive (loss) gain |
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( |
) |
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( |
) |
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Comprehensive loss |
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$ |
( |
) |
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$ |
( |
) |
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$ |
( |
) |
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$ |
( |
) |
The accompanying notes are an integral part of these financial statements.
2
Fulcrum Therapeutics, Inc.
Consolidated Statements of Stockholders’ Equity
(In thousands, except share amounts)
(Unaudited)
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Common Stock |
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Additional |
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Accumulated |
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Accumulated |
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Total |
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Shares |
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Amount |
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Capital |
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Gain (Loss) |
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Deficit |
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Equity |
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Balance at December 31, 2024 |
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( |
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Vesting of restricted stock awards |
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— |
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— |
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— |
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— |
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— |
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Stock-based compensation expense |
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— |
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— |
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— |
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— |
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Unrealized loss on marketable securities |
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— |
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— |
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— |
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( |
) |
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— |
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( |
) |
Net loss |
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— |
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— |
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— |
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— |
|
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( |
) |
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( |
) |
Balance at March 31, 2025 |
|
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$ |
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$ |
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$ |
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$ |
( |
) |
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$ |
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|||||
Issuance of common stock under employee benefit plans |
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— |
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— |
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— |
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|||
Vesting of restricted stock awards |
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— |
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— |
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— |
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— |
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— |
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Stock-based compensation expense |
|
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— |
|
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— |
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— |
|
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— |
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||
Unrealized gain on marketable securities |
|
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— |
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— |
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— |
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— |
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Net loss |
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— |
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— |
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— |
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— |
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( |
) |
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( |
) |
Balance at June 30, 2025 |
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( |
) |
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|||||
Issuance of common stock under employee benefit plans |
|
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— |
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— |
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— |
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|||
Stock-based compensation expense |
|
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— |
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— |
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— |
|
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— |
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||
Unrealized gain on marketable securities |
|
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— |
|
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— |
|
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— |
|
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— |
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||
Net loss |
|
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— |
|
|
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— |
|
|
|
— |
|
|
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— |
|
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|
( |
) |
|
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( |
) |
Balance at September 30, 2025 |
|
|
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( |
) |
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|||||
Balance at December 31, 2025 |
|
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( |
) |
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|||||
Issuance of common stock under employee benefit plans |
|
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— |
|
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— |
|
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— |
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|||
Vesting of restricted stock awards |
|
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— |
|
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— |
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— |
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— |
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— |
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|
Stock-based compensation expense |
|
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— |
|
|
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— |
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— |
|
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— |
|
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||
Unrealized loss on marketable securities |
|
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— |
|
|
|
— |
|
|
|
— |
|
|
|
( |
) |
|
|
— |
|
|
|
( |
) |
Net loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
( |
) |
|
|
( |
) |
Balance at March 31, 2026 |
|
|
|
|
$ |
|
|
$ |
|
|
$ |
( |
) |
|
$ |
( |
) |
|
$ |
|
||||
Issuance of common stock under employee benefit plans |
|
|
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— |
|
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— |
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— |
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|||
Issuance of common stock pursuant to pre-funded warrant exercise |
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( |
) |
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— |
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— |
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|||
Stock-based compensation expense |
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— |
|
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— |
|
|
|
|
|
|
— |
|
|
|
— |
|
|
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|
||
Unrealized loss on marketable securities |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
( |
) |
|
|
— |
|
|
|
( |
) |
Net loss |
|
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— |
|
|
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— |
|
|
|
— |
|
|
|
— |
|
|
|
( |
) |
|
|
( |
) |
Balance at June 30, 2026 |
|
|
|
|
$ |
|
|
$ |
|
|
$ |
( |
) |
|
$ |
( |
) |
|
$ |
|
||||
Issuance of common stock under employee benefit plans |
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|
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— |
|
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|
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|
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|||||
Stock-based compensation expense |
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— |
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— |
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|
|
|
|
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|
||||
Unrealized loss on marketable securities |
|
|
— |
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— |
|
|
|
|
|
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( |
) |
|
|
|
|
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( |
) |
||
Net loss |
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|
— |
|
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— |
|
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|
|
|
|
|
|
|
( |
) |
|
|
( |
) |
||
Balance at September 30, 2026 |
|
|
|
|
$ |
|
|
$ |
|
|
$ |
( |
) |
|
$ |
( |
) |
|
$ |
|
||||
The accompanying notes are an integral part of these financial statements.
3
Fulcrum Therapeutics, Inc.
Consolidated Statements of Cash Flows
(In thousands)
(Unaudited)
|
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Nine Months Ended |
|
|||||
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2026 |
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2025 |
|
||
Operating activities |
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||
Net loss |
|
$ |
( |
) |
|
$ |
( |
) |
Adjustments to reconcile net loss to net cash used in operating activities: |
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Depreciation expense |
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Stock-based compensation expense |
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Net accretion of discounts on marketable securities |
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( |
) |
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( |
) |
Impairment of long-lived assets |
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|
||
Changes in operating assets and liabilities: |
|
|
|
|
|
|
||
Unbilled accounts receivable |
|
|
|
|
|
|
||
Prepaid expenses and other current assets |
|
|
|
|
|
|
||
Operating lease assets and liabilities |
|
|
( |
) |
|
|
( |
) |
Other assets |
|
|
|
|
|
|
||
Accounts payable |
|
|
( |
) |
|
|
|
|
Accrued expenses and other liabilities |
|
|
( |
) |
|
|
( |
) |
Net cash used in operating activities |
|
$ |
( |
) |
|
$ |
( |
) |
Investing activities |
|
|
|
|
|
|
||
Purchases of marketable securities |
|
|
( |
) |
|
|
( |
) |
Maturities of marketable securities |
|
|
|
|
|
|
||
Proceeds received on sale of equipment |
|
|
|
|
|
|
||
Purchases of property and equipment |
|
|
( |
) |
|
|
( |
) |
Net cash (used in) provided by investing activities |
|
|
( |
) |
|
|
|
|
Financing activities |
|
|
|
|
|
|
||
Payment of offering costs |
|
|
( |
) |
|
|
|
|
Proceeds from issuance of common stock under benefit plans, net |
|
|
|
|
|
|
||
Net cash provided by financing activities |
|
|
|
|
|
|
||
Net decrease in cash, cash equivalents and restricted cash |
|
|
( |
) |
|
|
( |
) |
Cash, cash equivalents, and restricted cash, beginning of period |
|
|
|
|
|
|
||
Cash, cash equivalents, and restricted cash, end of period |
|
$ |
|
|
$ |
|
||
Supplemental cash flow information |
|
|
|
|
|
|
||
Non-cash investing and financing activities: |
|
|
|
|
|
|
||
Cash paid for operating lease liabilities |
|
$ |
|
|
$ |
|
||
Issuance of common stock receivable |
|
$ |
|
|
|
|
||
Property and equipment purchases unpaid at end of period |
|
|
|
|
|
|
||
The following table provides a reconciliation of the cash, cash equivalents, and restricted cash balances as of each of the periods shown above:
|
|
September 30, |
|
|
September 30, |
|
||
Cash and cash equivalents |
|
$ |
|
|
$ |
|
||
Restricted cash |
|
|
|
|
|
|
||
Total cash, cash equivalents, and restricted cash |
|
$ |
|
|
$ |
|
||
The accompanying notes are an integral part of these financial statements.
4
Fulcrum Therapeutics, Inc.
Notes to Consolidated Financial Statements
1. Nature of the Business and Basis of Presentation
Fulcrum Therapeutics, Inc. (the “Company”) was incorporated in Delaware on August 18, 2015 and historically focused on developing small molecules to improve the lives of patients with genetically-defined rare diseases in areas of high unmet medical need. On June 1, 2026, the Company announced the discontinuation of its pociredir program for the treatment of sickle cell disease (“SCD”) and in connection therewith, implemented a restructuring plan to significantly reduce the Company’s operating expenses and preserve capital, reducing the Company’s workforce by approximately
Recent Developments
On August 16, 2026, the Company entered into an Agreement and Plan of Merger (the “Merger Agreement”), by and among the Company, Fusion Merger Sub I, Inc., a Delaware corporation and a wholly owned subsidiary of Fulcrum (“Merger Sub I”), Fusion Merger Sub II, LLC, a Delaware limited liability company and a wholly owned subsidiary of Fulcrum (“Merger Sub II”), and Slate Medicines, Inc., a Delaware corporation (“Slate”). Subject to the satisfaction or waiver of the conditions set forth in the Merger Agreement, among other things, Merger Sub I will merge with and into Slate, with Slate surviving the merger as the surviving corporation (the “First Merger”), and as part of the same overall transaction, Slate will merge with and into Merger Sub II, with Merger Sub II continuing as a wholly owned subsidiary of the Company and the surviving entity of the merger (the “Second Merger”) and together with the First Merger, the “Merger”). The Merger is intended to qualify as a tax-free reorganization for U.S. federal income tax purposes and is expected to close in the fourth quarter of 2026, assuming satisfaction or waiver of all of the conditions of the Merger Agreement. In addition, in connection with the closing the Merger, the Company expects to declare a cash dividend to its pre-Merger stockholders of $
If the Merger is completed, the Company will continue as the surviving corporation after the Merger, but will change its name to Slate Medicines, Inc., and the management of Slate is expected to become the management of the combined surviving corporation. The surviving company is expected to pursue the business activities of Slate following the closing of the Merger. Upon termination of the Merger Agreement under specified circumstances, the Company may be required to pay Slate a termination fee of $
On September 2, 2026, the Company filed with the Securities and Exchange Commission (the “SEC”) a registration statement on Form S-4 (as it may be amended, the “Registration Statement”), that includes a proxy statement/prospectus relating to the Merger and the related transactions, including the issuance of shares of Company common stock in the Merger and the matters to be submitted to the Company’s stockholders for their approval. The Registration Statement was declared effective on November 4, 2026 but the Merger remains subject to approval by the Company’s stockholders and the satisfaction or waiver of the other conditions to the closing of the Merger.
Risks
The Company is subject to a number of risks and uncertainties, including, but not limited to, its ability to consummate the Merger, its ability to preserve capital, dependence on key personnel following the workforce reduction, its ability to satisfy its remaining obligations, and the need to comply with government regulations and public-company reporting requirements.
Basis of Presentation
The accompanying consolidated financial statements have been prepared in conformity with generally accepted accounting principles in the United States of America (“GAAP”). Any reference in these notes to applicable guidance is meant to refer to the authoritative GAAP as found in the Accounting Standards Codification (“ASC”) and Accounting Standards Updates (“ASU”) of the Financial Accounting Standards Board (“FASB”).
The accompanying consolidated financial statements and footnotes to the financial statements have been prepared on the same basis as the most recently audited annual consolidated financial statements and, in the opinion of management, reflect all normal recurring adjustments necessary for the fair presentation of the Company’s financial position as of September 30, 2026 and the results
5
of its operations and its cash flows for the three and nine months ended September 30, 2026 and 2025. The results for the three and nine months ended September 30, 2026 are not necessarily indicative of results to be expected for the year ending December 31, 2026, any other interim periods, or any future year or period. These consolidated financial statements should be read in conjunction with the Company’s audited consolidated financial statements and the notes thereto for the year ended December 31, 2025 included in the Company’s Annual Report on Form 10-K filed with the SEC on February 24, 2026 (the “Annual Report on Form 10-K”).
Liquidity
The Company has incurred recurring losses and negative cash flows from operations since inception and has primarily funded its operations with proceeds from the sale of shares of its capital stock and from upfront payments received from collaboration and license agreements. As of September 30, 2026, the Company had an accumulated deficit of $
2. Summary of Significant Accounting Policies
Principles of Consolidation
The accompanying consolidated financial statements include the accounts of the Company and its wholly owned subsidiary, Fulcrum Therapeutics Securities Corp., which is a Massachusetts subsidiary created to buy, sell, and hold securities. All intercompany transactions and balances have been eliminated.
Summary of Significant Accounting Policies
The significant accounting policies and estimates used in the preparation of the accompanying consolidated financial statements are described in the Company’s audited consolidated financial statements for the year ended December 31, 2025 included in the Company’s Annual Report on Form 10-K. There have been no material changes in the Company’s significant accounting policies during the nine months ended September 30, 2026, other than as described below.
Use of Estimates
Long-Lived Assets and Impairment
Long-lived assets consist of property and equipment and operating lease right-of-use assets. The Company reviews long-lived assets for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset (or asset group) may not be recoverable. The Company groups long-lived assets with other assets and liabilities at the lowest level for which identifiable cash flows are largely independent of the cash flows of other assets and liabilities. Recoverability is measured by comparing the carrying amount of an asset group to the estimated undiscounted future cash flows expected to result from its use and eventual disposition. If the carrying amount is not recoverable, an impairment loss is recognized equal to the amount by which the carrying amount exceeds fair value, with fair value estimated using the income, market or cost approach as appropriate. During the nine months
6
ended September 30, 2026, the cessation of active research and development activities and the decision to dispose of assets used in those activities were identified as indicators of impairment. See Note 3, “Fair Value Measurements,” and Note 5, “Property and Equipment, Net.”
Assets Held for Sale
The Company classifies long-lived assets as held for sale when the applicable criteria in ASC 360-10-45 are met, including that the sale is probable and expected to be completed within one year. Assets held for sale are measured at the lower of carrying amount or fair value less costs to sell and are no longer depreciated. Amounts received from a buyer prior to the transfer of control are recorded as a deposit (contract liability) until the criteria for recognizing the sale are met.
Off-Balance Sheet Risk and Concentrations of Credit Risk
The Company has no significant off-balance sheet risk such as foreign exchange contracts, option contracts, or other foreign hedging arrangements. Financial instruments that potentially expose the Company to concentrations of credit risk consist primarily of cash, cash equivalents, marketable securities, and restricted cash. The Company’s cash, cash equivalents, and restricted cash are deposited in accounts at large financial institutions. The Company believes it is not exposed to significant credit risk due to the financial strength of the depository institutions in which the cash, cash equivalents and restricted cash are held. The Company maintains its cash equivalents in U.S. Treasury securities and money market funds that invest in U.S. Treasury securities. The Company’s marketable securities consist of U.S. Treasury securities and corporate bonds, and potentially subject the Company to concentrations of credit risk. The Company has adopted an investment policy that limits the amounts the Company may invest in any one type of investment. The Company has not experienced any credit losses and does not believe it is exposed to any significant credit risk on these funds.
Recent Accounting Pronouncements
In November 2024, the FASB issued ASU No. 2024-03, Income Statement—Reporting Comprehensive Income—Expense Disaggregation Disclosures, which requires disclosure of additional information about specific expense categories in the notes to the financial statements on an interim and annual basis. The standard is effective for fiscal years beginning after December 15, 2026, and for interim periods beginning after December 15, 2027, with early adoption permitted. The Company is currently evaluating the disclosure requirements related to this new standard.
3. Fair Value Measurements
The following tables present information about the Company’s financial assets measured at fair value on a recurring basis and indicate the fair value hierarchy classification of such fair values as of September 30, 2026 and December 31, 2025 (in thousands):
|
|
Fair Value Measurements at |
|
|||||||||||||
|
|
Total |
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
||||
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Money market funds |
|
$ |
|
|
$ |
|
|
$ |
|
|
$ |
|
||||
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
|
||||
U.S. Treasury securities |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Corporate bonds |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Total |
|
$ |
|
|
$ |
|
|
$ |
|
|
$ |
|
||||
|
|
Fair Value Measurements at |
|
|||||||||||||
|
|
Total |
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
||||
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Money market funds |
|
$ |
|
|
$ |
|
|
$ |
|
|
$ |
|
||||
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Government agency securities |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Corporate bonds |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Total |
|
$ |
|
|
$ |
|
|
$ |
|
|
$ |
|
||||
7
There were
Assets Measured at Fair Value on a Nonrecurring Basis
During the nine months ended September 30, 2026, the Company measured certain long-lived assets at fair value on a nonrecurring basis in connection with impairment charges recorded as a result of the discontinuation of the pociredir program and the related restructuring. The Company’s operating lease right-of-use asset was written down to its estimated fair value of zero, determined using an income approach based on the present value of estimated net sublease cash flows over the remaining lease term (a Level 3 measurement using significant unobservable inputs, including estimated sublease rates, expected downtime, free rent and other concessions, and a discount rate). The related leasehold improvements were written down to an estimated fair value of zero. Laboratory equipment classified as held for sale was measured at fair value less costs to sell, based on the $
4. Cash Equivalents and Marketable Securities
Cash equivalents and marketable securities consisted of the following as of September 30, 2026 and December 31, 2025 (in thousands):
|
|
Fair Value Measurements at |
|
|||||||||||||
|
|
Amortized |
|
|
Gross |
|
|
Gross |
|
|
Fair Value |
|
||||
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Money market funds |
|
$ |
|
|
$ |
|
|
$ |
|
|
$ |
|
||||
Total cash equivalents |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
|
||||
U.S. Treasury securities |
|
|
|
|
|
|
|
|
( |
) |
|
|
|
|||
Corporate bonds |
|
|
|
|
|
|
|
|
( |
) |
|
|
|
|||
Total marketable securities |
|
|
|
|
|
|
|
|
( |
) |
|
|
|
|||
Total cash equivalents and marketable securities |
|
$ |
|
|
$ |
|
|
$ |
( |
) |
|
$ |
|
|||
|
|
Fair Value Measurements at |
|
|||||||||||||
|
|
Amortized |
|
|
Gross |
|
|
Gross |
|
|
Fair Value |
|
||||
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Money market funds |
|
$ |
|
|
$ |
|
|
$ |
|
|
$ |
|
||||
Total cash equivalents |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Marketable securities: |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Government agency securities |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Corporate bonds |
|
|
|
|
|
|
|
|
( |
) |
|
|
|
|||
Total marketable securities |
|
|
|
|
|
|
|
|
( |
) |
|
|
|
|||
Total cash equivalents and marketable securities |
|
$ |
|
|
$ |
|
|
$ |
( |
) |
|
$ |
|
|||
There were
The Company has the intent and ability to hold its debt securities until recovery. The Company did
8
5. Property and Equipment, Net
Property and equipment, net consisted of the following (in thousands):
|
|
September 30, |
|
|
December 31, |
|
||
Lab equipment |
|
$ |
|
|
$ |
|
||
Furniture and fixtures |
|
|
|
|
|
|
||
Computer equipment |
|
|
|
|
|
|
||
Software |
|
|
|
|
|
|
||
Leasehold improvements |
|
|
|
|
|
|
||
Total property and equipment |
|
|
|
|
|
|
||
Less: accumulated depreciation |
|
|
( |
) |
|
|
( |
) |
Property and equipment, net |
|
$ |
|
|
$ |
|
||
Depreciation expense for the three months ended September 30, 2026 and 2025 was zero and $
In connection with the discontinuation of the pociredir program and the related restructuring, during the three months ended June 30, 2026 the Company ceased use of its laboratory and recognized impairment and disposal charges related to its long-lived assets. The Company recorded an impairment charge of $
6. Additional Balance Sheet Detail
Prepaid expenses and other current assets consisted of the following (in thousands):
|
|
September 30, |
|
|
December 31, |
|
||
Prepaid expenses |
|
$ |
|
|
$ |
|
||
Interest income receivable |
|
|
|
|
|
|
||
Prepaid sign-on bonuses subject to vesting provisions |
|
|
|
|
|
|
||
Total prepaid expenses and other current assets |
|
$ |
|
|
$ |
|
||
Accrued expenses and other current liabilities consisted of the following (in thousands):
|
|
September 30, |
|
|
December 31, |
|
||
Payroll and benefits |
|
$ |
|
|
$ |
|
||
External research and development |
|
|
|
|
|
|
||
Professional services |
|
|
|
|
|
|
||
Other |
|
|
|
|
|
|
||
Total accrued expenses and other current liabilities |
|
$ |
|
|
$ |
|
||
7. Preferred Stock
As of September 30, 2026 and December 31, 2025,
9
8. Common Stock
As of September 30, 2026 and December 31, 2025,
As of September 30, 2026 and December 31, 2025, the Company has reserved for future issuance the following number of shares of common stock:
|
|
September 30, |
|
|
December 31, |
|
||
Shares reserved for exercises of outstanding stock options |
|
|
|
|
|
|
||
Shares reserved for vesting of restricted stock units |
|
|
|
|
|
|
||
Shares reserved for future issuance under the 2019 Stock Incentive Plan |
|
|
|
|
|
|
||
Shares reserved for future issuance under the 2019 Employee Stock Purchase Plan |
|
|
|
|
|
|
||
Shares reserved for future issuance under the 2022 Inducement Stock Incentive Plan |
|
|
|
|
|
|
||
Shares reserved for future issuance for pre-funded warrants |
|
|
|
|
|
|
||
|
|
|
|
|
|
|
||
10
Pre-Funded Warrants
In August 2024, the Company entered into separate exchange agreements with RA Capital Healthcare Fund, L.P. (“RA Capital”) and another existing institutional stockholder, pursuant to which (i) RA Capital exchanged
9. Stock-based Compensation Expense
2016 Stock Incentive Plan
In July 2016, the Company adopted the 2016 Stock Incentive Plan (the “2016 Plan”), which provided for the grant of restricted stock awards, restricted stock units, incentive stock options, non-statutory stock options, and other stock-based awards to the Company’s eligible employees, officers, directors, consultants, and advisors. As of the effective date of the 2019 Stock Incentive Plan (the “2019 Plan”), and as of September 30, 2026,
2019 Stock Incentive Plan
On July 2, 2019, the Company’s stockholders approved the 2019 Plan, which became effective on July 17, 2019. The 2019 Plan provides for the grant of incentive stock options, non-statutory stock options, stock appreciation rights, restricted stock awards, restricted stock units and other stock-based awards to the Company’s officers, employees, directors, consultants and advisors. The number of shares initially reserved for issuance under the 2019 Plan was
The shares of common stock underlying any awards that expire, terminate, or are otherwise surrendered, cancelled, forfeited or repurchased by the Company under the 2016 Plan or the 2019 Plan will be added back to the shares of common stock available for issuance under the 2019 Plan. As of July 17, 2019, no further awards will be made under the 2016 Plan.
2022 Inducement Stock Incentive Plan
In February 2022, the Company’s board of directors adopted the 2022 Inducement Stock Incentive Plan (the “Inducement Plan”), pursuant to which the Company may grant, subject to the terms of the Inducement Plan and Nasdaq rules, nonstatutory stock options, stock appreciation rights, restricted stock awards, restricted stock units, and other stock-based awards. The Company initially reserved a total of
11
Stock Options
Stock options granted by the Company typically vest over a
|
|
Number of |
|
|
Weighted |
|
|
Weighted |
|
|
Aggregate |
|
||||
Outstanding at December 31, 2025 |
|
|
|
|
$ |
|
|
|
|
|
$ |
|
||||
Granted |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Exercised |
|
|
( |
) |
|
|
|
|
|
|
|
|
|
|||
Cancelled |
|
|
( |
) |
|
|
|
|
|
|
|
|
|
|||
Outstanding at September 30, 2026 |
|
|
|
|
$ |
|
|
|
|
|
$ |
|
||||
Exercisable at September 30, 2026 |
|
|
|
|
$ |
|
|
|
|
|
$ |
|
||||
The aggregate intrinsic value of stock options is calculated as the difference between the exercise price of the stock options and the fair value of the Company’s common stock as of the balance sheet date for those options that had exercise prices lower than the fair value of the Company’s common stock.
The weighted average grant date fair value of stock options granted in the three and nine months ended September 30, 2026 was zero and $
The fair value of stock options granted during the three and nine months ended September 30, 2026 and 2025 has been calculated on the date of grant using the following weighted average assumptions:
|
|
Three Months |
|
|
Three Months |
|
|
Nine Months |
|
|
Nine Months |
|
||||
Risk-free interest rate |
|
|
% |
|
|
% |
|
|
% |
|
|
% |
||||
Expected dividend yield |
|
|
% |
|
|
% |
|
|
% |
|
|
% |
||||
Expected term (years) |
|
|
— |
|
|
|
|
|
|
|
|
|
|
|||
Expected stock price volatility |
|
|
% |
|
|
% |
|
|
% |
|
|
% |
||||
Restricted Stock Units
The Company has also granted restricted stock units. The shares of common stock underlying restricted stock units typically vest over a four-year period. The shares of common stock are recorded in stockholders’ equity as they vest.
12
The following table summarizes the Company’s restricted stock unit activity during the nine months ended September 30, 2026:
|
|
Number of |
|
|
Weighted |
|
||
Unvested at December 31, 2025 |
|
|
|
|
$ |
|
||
Granted |
|
|
|
|
|
|
||
Vested |
|
|
( |
) |
|
|
|
|
Cancelled |
|
|
( |
) |
|
|
|
|
Unvested at September 30, 2026 |
|
|
|
|
$ |
|
||
Stock-based Compensation Expense
The total compensation cost recognized in the statements of operations and comprehensive loss associated with all stock-based compensation awards granted by the Company is as follows (in thousands):
|
|
Three Months Ended |
|
|
Nine Months Ended |
|
||||||||||
|
|
2026 |
|
|
2025 |
|
|
2026 |
|
|
2025 |
|
||||
General and administrative |
|
$ |
|
|
$ |
|
|
$ |
|
|
$ |
|
||||
Research and development |
|
|
|
|
$ |
|
|
|
|
|
|
|
||||
Total stock-based compensation expense |
|
$ |
|
|
$ |
|
|
$ |
|
|
$ |
|
||||
As of September 30, 2026, the Company had an aggregate of $
2019 Employee Stock Purchase Plan
On July 2, 2019, the Company’s stockholders approved the 2019 Employee Stock Purchase Plan (the “ESPP”), which became effective on July 17, 2019. A total of
10. License and Collaboration Agreements
Sanofi Agreement
In May 2024, the Company entered into a collaboration and license agreement (the “Sanofi Agreement”) with Genzyme Corporation (“Sanofi”), pursuant to which the Company granted Sanofi an exclusive license to commercialize losmapimod, an oral small molecule for the treatment of facioscapulohumeral muscular dystrophy, outside of the United States.
In September 2024, the Company discontinued development of losmapimod following topline results from the Phase 3 REACH trial. On December 18, 2024, Sanofi provided written notice of termination for convenience, and the agreement terminated in its entirety on
During the three and nine months ended September 30, 2026, the Company recorded
13
CAMP4 Agreement
In July 2023, the Company entered into a license agreement (the “CAMP4 Agreement”) with CAMP4 Therapeutics Corporation (“CAMP4”), pursuant to which the Company obtained a worldwide exclusive license to certain intellectual property related to CAMP4’s Diamond-Blackfan anemia (“DBA”) program. Under the terms of the agreement, the Company was responsible for development and commercialization of any licensed products, and CAMP4 would have been eligible to receive development, regulatory, and sales milestone payments, as well as royalties on net sales of licensed products.
In April 2025, the Company incurred a $
In February 2026, the Company announced the discontinuation of its bone marrow failure syndromes program, including DBA. On April 23, 2026, the Company delivered written notice to terminate the CAMP4 Agreement for convenience. The agreement has been terminated with no further obligations.
11. Leases
Operating Leases
26 Landsdowne Street
In November 2017, the Company entered into a lease agreement for its current corporate headquarters comprising approximately
In September 2026, the Company entered into a lease termination agreement with the landlord that revised the lease end date to December 31, 2026 and provides that a lease termination fee of $
The future minimum lease payments associated with the 26 Landsdowne Street lease as of September 30, 2026, are as follows (in thousands):
2026(1) |
|
|
|
|
2027 |
|
|
|
|
2028 |
|
|
|
|
Total minimum lease payments |
|
|
|
|
Less: imputed interest |
|
|
( |
) |
Total lease liability |
|
$ |
|
(1)
14
12. Commitments and Contingencies
Indemnification Agreements
In the ordinary course of business, the Company may provide indemnification of varying scope and terms to vendors, lessors, business partners and other parties with respect to certain matters arising out of the relationship between such parties and the Company. In addition, the Company has entered into indemnification agreements with members of its board of directors and senior management that will require the Company, among other things, to indemnify them against certain liabilities that may arise by reason of their status or service as directors or officers. The maximum potential amount of future payments the Company could be required to make under these indemnification agreements is, in many cases, unlimited. To date, the Company has not incurred any material costs as a result of such indemnifications. The Company is not aware of any claims under indemnification arrangements, and it has
Legal Proceedings
The Company is not currently a party to any material legal proceedings. At each reporting date, the Company evaluates whether or not a potential loss amount or a potential range of loss is probable and reasonably estimable under the provisions of the authoritative guidance that addresses accounting for contingencies. The Company expenses the costs related to its legal proceedings as they are incurred. No such costs have been incurred during the three and nine months ended September 30, 2026.
13. Defined Contribution Plan
The Company has a defined contribution savings plan under Section 401(k) of the Internal Revenue Code (the “
14. Net (Loss) Income per Share
Basic net (loss) income per share is calculated by dividing net (loss) income by the weighted average number of common shares outstanding during the period. During the nine months ended September 30, 2026, all outstanding pre-funded warrants were exercised for shares of common stock, as described in Note 8. The shares of common stock issued upon exercise are included in the weighted average number of common shares outstanding from their respective dates of issuance. For the three and nine months ended September 30, 2026, the weighted average number of common shares outstanding included shares of common stock issuable upon the exercise of pre-funded warrants that were exercisable for little or no consideration.
The following common stock equivalents were excluded from the calculation of diluted net loss per share for the periods indicated because including them would have had an anti-dilutive effect:
|
|
Three Months Ended |
|
|
Nine Months Ended |
|
||||||||||
|
|
2026 |
|
|
2025 |
|
|
2026 |
|
|
2025 |
|
||||
Stock options |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Restricted stock units |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Total |
|
|
|
|
|
|
|
|
|
|
|
|
||||
15
15. Segment Information
Segment reporting is prepared on the same basis that the Company's chief executive officer, who is the Company's chief operating decision maker (the “CODM”), utilizes to manage the business and makes decisions on how to allocate resources and assess performance of the business. The Company and the CODM view the Company's operations as a single operating segment. The Company's singular focus is on developing small molecules to improve the lives of patients with genetically defined rare diseases in areas of high unmet medical need.
The Company's reportable segment operating expenses and net loss for the three and nine months ended September 30, 2026 and 2025 are as follows (in thousands):
|
|
Three months ended |
|
|
Nine Months Ended |
|
||||||||||
|
|
2026 |
|
|
2025 |
|
|
2026 |
|
|
2025 |
|
||||
Operating expenses: |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Research and development |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Pociredir external expenses |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Losmapimod external expenses |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Employee compensation expenses (excluding stock-based compensation expenses) |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Stock-based compensation expenses |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Pre-development candidate expenses and unallocated expenses |
|
|
|
|
|
|
|
|
|
|
|
|
||||
General and administrative |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Impairment of long-lived assets |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Restructuring expenses |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Total operating expenses |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Loss from operations |
|
|
( |
) |
|
|
( |
) |
|
|
( |
) |
|
|
( |
) |
Other income, net |
|
|
|
|
|
|
|
|
|
|
|
|
||||
Net loss |
|
$ |
( |
) |
|
$ |
( |
) |
|
$ |
( |
) |
|
$ |
( |
) |
16. Restructuring Expenses
On May 31, 2026, the Company’s board of directors approved a restructuring plan to significantly reduce the Company’s operating expenses and preserve capital following the discontinuation of pociredir.
During three and nine months ended September 30, 2026, the Company recorded aggregate restructuring charges of $
The following table summarizes the Company’s restructuring activity (in thousands):
Accrued restructuring charges as of December 31, 2025 |
|
$ |
|
|
Restructuring charges incurred during the period |
|
|
|
|
Amounts paid during the period |
|
|
( |
) |
Accrued restructuring charges as of September 30, 2026 |
|
$ |
|
16
In June 2026, the Compensation Committee approved cash retention arrangements for the Company’s nine remaining full-time employees, with aggregate potential payments of approximately $
17. Subsequent Events
On November 7 2026, the Company and Slate entered into an asset purchase agreement providing for the sale of the Company’ early stage fetal hemoglobin assets to an unaffiliated third party pharmaceutical company for approximately $
17
Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations.
The following discussion and analysis of our financial condition and results of operations should be read together with our consolidated financial statements and related notes appearing elsewhere in this Quarterly Report on Form 10-Q and our Annual Report on Form 10-K filed with the Securities and Exchange Commission, or SEC, on February 24, 2026. Some of the information contained in this discussion and analysis or set forth elsewhere in this Quarterly Report on Form 10-Q, including information with respect to our plans and strategy for our business, includes forward-looking statements that involve risks and uncertainties. As a result of many factors, including those factors set forth in the “Summary Risk Factors” and under the caption "Risk Factors" in our other filings with the SEC, our actual results could differ materially from the results described in, or implied by, the forward-looking statements contained in the following discussion and analysis. See “Cautionary Note Regarding Forward-Looking Statements.”
Overview
We are a clinical-stage biopharmaceutical company that historically focused on developing small molecules to improve the lives of patients with genetically defined rare diseases in areas of high unmet medical need. In June 2026, we announced the discontinuation of our pociredir program for the treatment of sickle cell disease, or SCD, and the initiation of a comprehensive review of strategic alternatives intended to maximize stockholder value and engaged Leerink Partners LLC as our financial advisor to assist our board of directors in the review. This process resulted in the entry intdo the Merger Agreement discussed below. In early November 2026, we also entered into an agreement to dispose of our early stage HbF assets for $7.0 million in cash, which we expect to close after consummation of the Merger (or if the Merger does not occur, as promptly as practicable following termination of the Merger Agreement).
Merger Agreement
On August 16, 2026, we entered into the Merger Agreement, by and among us, Merger Sub I, Merger Sub II and Slate, pursuant to which, and subject to the satisfaction or waiver of the conditions set forth in the Merger Agreement, among other things, Merger Sub I will merge with and into Slate, with Slate surviving the merger as the surviving corporation, or the First Merger, and as part of the same overall transaction, Slate will merge with and into Merger Sub II, with Merger Sub II continuing as our wholly owned subsidiary and the surviving entity of the merger, or the Second Merger and together with the First Merger, the Merger. The Merger is intended to qualify as a tax-free reorganization for U.S. federal income tax purposes and is expected to close in the fourth quarter of 2026, assuming satisfaction or waiver of all of the conditions of the Merger Agreement. In addition, in connection with the closing the Merger, we expect to declare a cash dividend to its pre-Merger stockholders of $275 million in the aggregate, or the Cash Dividend, provided such amount is subject to adjustment as set forth in the Merger Agreement.
If the Merger is completed, we will continue as the surviving corporation after the Merger, but will change our name to Slate Medicines, Inc., and the management of Slate is expected to become the management of the combined surviving corporation. The surviving company is expected to pursue the business activities of Slate following the closing of the Merger. The Merger Agreement contains certain termination rights of each of us and Slate. Upon termination of the Merger Agreement under specified circumstances, we may be required to pay Slate a termination fee of $10 million, and in certain other circumstances, Slate may be required to pay us a termination fee of $15 million.
We expect to treat the Merger as a reverse merger and account for it as an in-substance reverse recapitalization of our company by Slate in accordance with U.S. generally accepted accounting principles, or U.S. GAAP as, at close, the transaction is, in essence, the issuance of equity for our net assets, which primarily consist of nominal non-operating assets and liabilities at the time of the Merger. For accounting purposes, our financial statements will become those of Slate, and Slate will be considered to be acquiring our assets and liabilities in this transaction based on the terms of the Merger Agreement and other factors, including: (i) Slate’s equity holders will own a substantial majority of the voting rights in the combined company; (ii) Slate’s largest stockholder will retain the largest interest in the combined company; (iii) Slate will designate all of the initial members of the board of directors of the combined company; and (iv) Slate’s executive management team will become the management of the combined company. In addition, Slate concluded that any acquired in-process research and development assets of our company at the closing of the Merger would be de-minimis and would not be further pursued by Slate.
On September 2, 2026, we filed with the SEC a registration statement on Form S-4, as it may be amended, or the Registration Statement, that includes a proxy statement/prospectus relating to the Merger and the related transactions, including the issuance of shares of our common stock in the Merger and the matters to be submitted to our stockholders for their approval. The Registration Statement was declared effective on November 4, 2026 but the Merger remains subject to approval by our stockholders and the satisfaction or waiver of the other conditions to the closing of the Merger.
18
Early Stage Assets Disposition
On November 7 2026, we and Slate entered into an asset purchase agreement providing for the sale of our early stage HbF assets to an unaffiliated third party pharmaceutical company for approximately $7.0 million in cash. The closing of the sale is contingent upon consummation of the Merger (or in the event the Merger Agreement is terminated, upon receipt of any necessary approvals). We expect that the proceeds from the asset sale will be funded into escrow prior to the Closing of the Merger and will be credited to our net cash for purposes of the Merger Agreement and increase the amount of the Cash Dividend.
General
We have incurred significant operating losses since our inception. Our net losses were $56.0 million and $54.5 million for the nine months ended September 30, 2026 and 2025, respectively. As of September 30, 2026, we had an accumulated deficit of $650.3 million.
Following the discontinuation of pociredir and the subsequent restructuring that we substantially completed in the second quarter of 2026, we ceased active research and development activities and significantly reduced our operating expenses as we pursue consummation of the Merger. In the near term, however, we expect to incur restructuring charges, long-lived asset impairment charges, and professional and advisory fees and other costs in connection with the consummation of the transactions contemplated by the Merger Agreement, a considerable portion of which will be incurred regardless of whether we complete the Merger.
As of September 30, 2026, we had $306.5 million in cash, cash equivalents, and marketable securities. We believe that our existing cash, cash equivalents, and marketable securities as of September 30, 2026 will enable us to fund our operating expenses and capital expenditure requirements for at least the next 12 months from the date of this Quarterly Report on Form 10-Q. See “—Liquidity and Capital Resources.”
Components of Results of Operations
Revenue
We have not generated any revenue from product sales. Following the discontinuation of our pociredir program, we do not expect to generate revenue from the sale of any products unless we resume our prior research and development activities.
We may generate revenue in the future from license or collaboration agreements, or from other transactions involving our product candidates, intellectual property or other assets, including in connection with our review of strategic alternatives. We cannot predict if, when or to what extent we will generate any such revenue.
Operating Expenses
Research and Development Expenses
Research and development expenses represent costs incurred by us for the discovery, development, and manufacture of our product candidates and include:
19
We expense research and development costs as incurred. We recognize expenses for certain development activities, such as clinical trials and manufacturing, based on an evaluation of the progress to completion of specific tasks using data such as patient enrollment or other information provided to us by our vendors. Payments for these activities are based on the terms of the individual agreements, which may differ from the pattern of expenses incurred. Non-refundable advance payments for goods or services to be received in the future for use in research and development activities are recorded as prepaid expenses. These amounts are recognized as an expense as the goods are delivered or the related services are performed, or until it is no longer expected that the goods will be delivered or the services rendered.
External costs represent a significant portion of our research and development expenses, which we track on a program-by-program basis following the nomination of a development candidate. Our internal research and development expenses consist primarily of personnel-related expenses, including stock-based compensation expense. We do not track our internal research and development expenses on a program-by-program basis as the resources are deployed across multiple projects.
The following table summarizes our external research and development expenses by program for the three and nine months ended September 30, 2026 and 2025. Pre-development candidate expenses, unallocated expenses and internal research and development expenses are classified separately.
|
|
Three Months Ended |
|
|
Nine Months Ended |
|
||||||||||
(in thousands) |
|
2026 |
|
|
2025 |
|
|
2026 |
|
|
2025 |
|
||||
Pociredir external expenses |
|
$ |
1,851 |
|
|
$ |
5,412 |
|
|
$ |
12,431 |
|
|
$ |
13,769 |
|
Losmapimod external expenses |
|
|
— |
|
|
|
169 |
|
|
|
— |
|
|
|
1,104 |
|
Pre-development candidate expenses and unallocated expenses |
|
|
289 |
|
|
|
4,698 |
|
|
|
8,076 |
|
|
|
14,371 |
|
Internal research and development expenses |
|
|
891 |
|
|
|
4,017 |
|
|
|
9,052 |
|
|
|
11,443 |
|
Total research and development expenses |
|
$ |
3,031 |
|
|
$ |
14,296 |
|
|
$ |
29,559 |
|
|
$ |
40,687 |
|
On June 1, 2026, we announced the discontinuation of our pociredir program. In connection with the related restructuring, we have ceased our active research and development activities as we pursue the consummation of the transactions contemplated in the Merger Agreement. As a result, we expect our research and development expenses to decline significantly in future periods.
General and Administrative Expenses
General and administrative expenses consist of personnel-related costs, including salaries, benefits and stock-based compensation expense, for our personnel in executive, finance and accounting, human resources, business operations and other administrative functions, legal fees related to patent, intellectual property and corporate matters, fees paid for accounting and tax services, consulting fees and facility-related costs not otherwise included in research and development expenses.
We expect general and administrative expenses to decrease in future periods as a result of the most recent reduction in our workforce, offset in part by professional, legal, accounting and advisory fees that we are incurring, and expect to continue to incur, in connection with consummation of the transactions contemplated by the Merger Agreement and our continuing obligations as a public company.
Impairment of Long-Lived Assets
Impairment of long-lived assets consists of charges to write down the carrying value of our operating lease right-of-use asset, related leasehold improvements, and laboratory equipment to their estimated fair values. These charges were recognized in connection with the restructuring and the wind-down of our research and development operations, which reduced the recoverable value of these assets. In September 2026, we entered into a lease termination agreement with the landlord providing that in exchange for a one-time payment of $6.1 million, our building lease will terminate as of December 31, 2026.
Restructuring Expenses
Restructuring expenses consist of one-time employee termination benefits, including severance, employee benefits and related costs, recognized in connection with the restructuring plan approved by our board of directors on May 31, 2026.
20
Other Income, Net
Other income, net consists primarily of interest income related to our investments in cash equivalents and marketable securities.
Results of Operations
Comparison of the Three Months ended September 30, 2026 and 2025
The following summarizes our results of operations for the three months ended September 30, 2026 and 2025 along with the changes in those items in dollars:
|
|
Three Months Ended |
|
|
Change |
|
||||||
(in thousands) |
|
2026 |
|
|
2025 |
|
|
$ |
|
|||
Operating expenses: |
|
|
|
|
|
|
|
|
|
|||
Research and development |
|
|
3,031 |
|
|
|
14,296 |
|
|
|
(11,265 |
) |
General and administrative |
|
|
8,436 |
|
|
|
7,562 |
|
|
|
874 |
|
Impairment of long-lived assets |
|
|
2,163 |
|
|
|
— |
|
|
|
2,163 |
|
Restructuring expenses |
|
|
230 |
|
|
|
— |
|
|
|
230 |
|
Total operating expenses |
|
|
13,860 |
|
|
|
21,858 |
|
|
|
(7,998 |
) |
Loss from operations |
|
|
(13,860 |
) |
|
|
(21,858 |
) |
|
|
7,998 |
|
Other income, net |
|
|
2,921 |
|
|
|
2,263 |
|
|
|
658 |
|
Net loss |
|
$ |
(10,939 |
) |
|
$ |
(19,595 |
) |
|
$ |
8,656 |
|
Research and Development Expenses
The following table summarizes our research and development expenses for the three months ended September 30, 2026 and 2025:
|
|
Three Months Ended |
|
|
Change |
|
||||||
(in thousands) |
|
2026 |
|
|
2025 |
|
|
$ |
|
|||
External research and development |
|
$ |
2,057 |
|
|
$ |
8,378 |
|
|
$ |
(6,321 |
) |
Employee compensation |
|
|
889 |
|
|
|
4,017 |
|
|
|
(3,128 |
) |
Laboratory supplies |
|
|
8 |
|
|
|
481 |
|
|
|
(473 |
) |
Facility costs |
|
|
49 |
|
|
|
1,131 |
|
|
|
(1,082 |
) |
Other |
|
|
28 |
|
|
|
289 |
|
|
|
(261 |
) |
Total research and development expenses |
|
$ |
3,031 |
|
|
$ |
14,296 |
|
|
$ |
(11,265 |
) |
Research and development expense decreased by $11.3 million from $14.3 million for the three months ended September 30, 2025 to $3.0 million for the three months ended September 30, 2026. The decrease in research and development expense was primarily attributable to the following:
21
General and Administrative Expenses
The following table summarizes our general and administrative expenses for the three months ended September 30, 2026 and 2025:
|
|
Three Months Ended |
|
|
Change |
|
||||||
(in thousands) |
|
2026 |
|
|
2025 |
|
|
$ |
|
|||
Employee compensation |
|
$ |
2,625 |
|
|
$ |
4,482 |
|
|
$ |
(1,857 |
) |
Professional services |
|
|
4,405 |
|
|
|
2,203 |
|
|
|
2,202 |
|
Facility costs |
|
|
423 |
|
|
|
260 |
|
|
|
163 |
|
Other |
|
|
983 |
|
|
|
617 |
|
|
|
366 |
|
Total general and administrative expenses |
|
$ |
8,436 |
|
|
$ |
7,562 |
|
|
$ |
874 |
|
General and administrative expenses increased by $0.8 million from $7.6 million for the three months ended September 30, 2025 to $8.4 million for the three months ended September 30, 2026. The increase in general and administrative expenses was primarily attributable to the following:
Impairment of Long-Lived Assets
Impairment charges were $2.2 million for the three months ended September 30, 2026 related to the write down of the operating lease right-of-use asset associated with our 26 Landsdowne Street facility due to us entering into a lease termination agreement with the landlord in September 2026 which revised the lease end date to December 31, 2026. During the three months ended September 30, 2025, there were no charges related to the impairment of long-lived assets.
Restructuring expenses
Restructuring charges were $0.2 million for the three months ended September 30, 2026, compared to zero for the three months ended September 30, 2025.
22
Other Income, Net
Other income, net increased by $0.6 million from $2.3 million for the three months ended September 30, 2025 to $2.9 million for the three months ended September 30, 2026. The increase was primarily due to an increase in our average cash, cash equivalents, and marketable securities balance.
Comparison of the Nine Months ended September 30, 2026 and 2025
The following summarizes our results of operations for the nine months ended September 30, 2026 and 2025 along with the changes in those items in dollars:
|
|
Nine Months Ended |
|
|
Change |
|
||||||
(in thousands) |
|
2026 |
|
|
2025 |
|
|
$ |
|
|||
Operating expenses: |
|
|
|
|
|
|
|
|
|
|||
Research and development |
|
|
29,559 |
|
|
|
40,687 |
|
|
|
(11,128 |
) |
General and administrative |
|
|
24,000 |
|
|
|
21,389 |
|
|
|
2,611 |
|
Impairment of long-lived assets |
|
|
7,249 |
|
|
|
— |
|
|
|
7,249 |
|
Restructuring expenses |
|
|
4,548 |
|
|
|
— |
|
|
|
4,548 |
|
Total operating expenses |
|
|
65,356 |
|
|
|
62,076 |
|
|
|
3,280 |
|
Loss from operations |
|
|
(65,356 |
) |
|
|
(62,076 |
) |
|
|
(3,280 |
) |
Other income, net |
|
|
9,347 |
|
|
|
7,530 |
|
|
|
1,817 |
|
Net loss |
|
$ |
(56,009 |
) |
|
$ |
(54,546 |
) |
|
$ |
(1,463 |
) |
Research and Development Expenses
The following table summarizes our research and development expenses for the nine months ended September 30, 2026 and 2025:
|
|
Nine Months Ended |
|
|
Change |
|
||||||
(in thousands) |
|
2026 |
|
|
2025 |
|
|
$ |
|
|||
External research and development |
|
$ |
16,715 |
|
|
$ |
23,147 |
|
|
$ |
(6,432 |
) |
Employee compensation |
|
|
9,052 |
|
|
|
11,444 |
|
|
|
(2,392 |
) |
Laboratory supplies |
|
|
521 |
|
|
|
1,812 |
|
|
|
(1,291 |
) |
Facility costs |
|
|
2,002 |
|
|
|
3,357 |
|
|
|
(1,355 |
) |
Other |
|
|
1,269 |
|
|
|
927 |
|
|
|
342 |
|
Total research and development expenses |
|
$ |
29,559 |
|
|
$ |
40,687 |
|
|
$ |
(11,128 |
) |
Research and development expense decreased by $11.1 million from $40.7 million for the nine months ended September 30, 2025 to $29.6 million for the nine months ended September 30, 2026. The decrease in research and development expense was primarily attributable to the following:
23
The following table summarizes our general and administrative expenses for the nine months ended September 30, 2026 and 2025:
|
|
Nine Months Ended |
|
|
Change |
|
||||||
(in thousands) |
|
2026 |
|
|
2025 |
|
|
$ |
|
|||
Employee compensation |
|
$ |
11,240 |
|
|
$ |
12,967 |
|
|
$ |
(1,727 |
) |
Professional services |
|
|
8,945 |
|
|
|
5,767 |
|
|
|
3,178 |
|
Facility costs |
|
|
1,089 |
|
|
|
897 |
|
|
|
192 |
|
Other |
|
|
2,726 |
|
|
|
1,758 |
|
|
|
968 |
|
Total general and administrative expenses |
|
$ |
24,000 |
|
|
$ |
21,389 |
|
|
$ |
2,611 |
|
General and administrative expenses increased by $2.6 million from $21.4 million for the nine months ended September 30, 2025 to $24.0 million for the nine months ended September 30, 2026. The increase in general and administrative expenses was primarily attributable to the following:
Impairment of Long-Lived Assets
Impairment charges were $7.2 million for the nine months ended September 30, 2026, and included $5.8 million related to the write down of the operating lease right-of-use asset associated with our 26 Landsdowne Street facility, $1.3 million related to the impairment of leasehold improvements, and $0.1 million related to the write-down of laboratory equipment to fair value less costs to sell upon its classification as held for sale. In September 2026, we entered into a lease termination agreement for our 26 Landsdowne Street facility with the landlord which revised the lease end date to December 31, 2026. During the nine months ended September 30, 2025, there were no charges related to the impairment of long-lived assets.
Restructuring expenses
Restructuring charges were $4.5 million for the nine months ended September 30, 2026, compared to $0.4 million for the nine months ended September 30, 2025.
Other Income, Net
Other income, net increased by $1.8 million from $7.5 million for the nine months ended September 30, 2025 to $9.3 million for the nine months ended September 30, 2026. The increase was primarily due to an increase in our average cash, cash equivalents, and marketable securities balance.
Liquidity and Capital Resources
Sources of Liquidity
We have incurred significant operating losses since our inception. We have not generated any revenue from product sales, and, following the discontinuation of our pociredir program, we do not expect to generate revenue from sales of any products if we do not resume our research and development activities. As of September 30, 2026, we have funded our operations primarily with aggregate gross proceeds of $967.5 million from the sale of shares of our capital stock and from upfront payments received under our collaboration and license agreements. As of September 30, 2026, we had cash, cash equivalents, and marketable securities of $306.5 million.
24
In February 2024, we entered into a controlled equity offeringsm agreement with Cantor Fitzgerald & Co. and Stifel, Nicolaus & Company, Incorporated, as agents, with respect to an at-the-market, or ATM, offering program pursuant to which we may offer and sell, from time to time in our sole discretion, shares of our common stock, par value $0.001 per share, having an aggregate offering price of up to $100.0 million through the agents. As of September 30, 2026, we have not issued or sold any shares of common stock under the ATM offering program nor do we anticipate using our ATM offering program pending consummation of the transactions contemplated by the Merger Agreement.
Cash Flows
The following table provides information regarding our cash flows for the nine months ended September 30, 2026:
|
|
Nine Months Ended |
|
|||||
(in thousands) |
|
2026 |
|
|
2025 |
|
||
Net cash used in operating activities |
|
$ |
(48,171 |
) |
|
$ |
(43,267 |
) |
Net cash (used in) provided by investing activities |
|
|
(33,303 |
) |
|
|
31,768 |
|
Net cash provided by financing activities |
|
|
242 |
|
|
|
365 |
|
Net decrease in cash, cash equivalents and restricted cash |
|
$ |
(81,232 |
) |
|
$ |
(11,134 |
) |
Net Cash Used in Operating Activities
Net cash used in operating activities was $48.2 million during the nine months ended September 30, 2026 compared to $43.3 million during the nine months ended September 30, 2025. The increase in net cash used in operating activities of $4.9 million was primarily due to an increase in net loss.
Net Cash (Used in) Provided By Investing Activities
Net cash used in investing activities was $33.3 million during the nine months ended September 30, 2026 compared to net cash provided by investing activities of $31.8 million during the nine months ended September 30, 2025. The increase in net cash used in investing activities of $65.1 million was primarily due an increase in net purchases of marketable securities during the nine months ended September 30, 2026, as compared to net maturities of marketable securities during the nine months ended September 30, 2025.
Net Cash Provided By Financing Activities
Net cash provided by financing activities was $0.2 million during the nine months ended September 30, 2026 compared to $0.4 million during the nine months ended September 30, 2025. Net cash provided by financing activities during the nine months ended September 30, 2026 consisted of net proceeds of $0.6 million from the issuance of common stock under our benefit plan, partially offset by $0.3 million of offering costs paid in connection with the December 2025 public offering of our common stock and pre-funded warrants. Net cash provided by financing activities during the nine months ended September 30, 2025 primarily consisted of net proceeds of $0.4 million from the issuance of common stock under our benefit plans.
Funding Requirements
Following the discontinuation of pociredir and the restructuring, we expect our operating expenses and cash used in operations to decrease substantially in future periods, offset in the near term by cash outflows for restructuring, costs to exit our facility, including any lease termination costs, and professional and advisory fees incurred in connection with our consummation of the transactions contemplated by the Merger Agreement.
Our future funding requirements will depend on many factors, including: the outcome, timing and costs of our ability to consummate the transactions contemplated by the Merger Agreement (including payment of the cash dividend contemplated thereby); the cash outflows required to complete the restructuring; our ongoing costs of operating as a public company; and, if we do not consummate the transactions contemplated by the Merger Agreement, the costs and timing of a potential dissolution and liquidation or resumption of active research and development activities and operations as an independent company.
25
Critical Accounting Policies and Estimates
Our management’s discussion and analysis of our financial condition and results of operations are based on our consolidated financial statements, which have been prepared in accordance with generally accepted accounting principles in the United States. The preparation of these consolidated financial statements requires us to make judgments and estimates that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the consolidated financial statements, and the reported amounts of expenses during the reporting periods. Our estimates are based on our historical experience, known trends and events, and on various other factors that we believe are reasonable under the circumstances, the results of which form the basis for making judgments about the carrying value of assets and liabilities and amount of expense recognized that are not readily apparent from other sources. Actual results may differ from these estimates under different assumptions or conditions. We evaluate our estimates and assumptions on an ongoing basis. The effects of material revisions in estimates, if any, will be reflected in the consolidated financial statements prospectively from the date of change in estimates. During the three months ended September 30, 2026, there were no material changes to our critical accounting policies from those described in our Annual Report on Form 10-K filed with the SEC on February 24, 2026, other than as described in Note 2 to our consolidated financial statements appearing elsewhere in this Quarterly Report on Form 10-Q.
Recently Issued Accounting Pronouncements
A description of recently issued accounting pronouncements that may potentially impact our financial position and results of operations is disclosed in Note 2 to our consolidated financial statements appearing elsewhere in this Quarterly Report on Form 10-Q.
Item 3. Quantitative and Qualitative Disclosures About Market Risk.
We are a smaller reporting company, as defined in Rule 12b-2 under the Securities Exchange Act of 1934, as amended, for this reporting period and are not required to provide the information required under this item.
Item 4. Controls and Procedures.
Evaluation of Disclosure Controls and Procedures
Our management, with the participation of our Chief Executive Officer (our principal executive officer) and our Chief Financial Officer (our principal financial officer), evaluated the effectiveness of our disclosure controls and procedures as of September 30, 2026. The term “disclosure controls and procedures,” as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended, or the Exchange Act, means controls and other procedures of a company that are designed to ensure that information required to be disclosed by a company in the reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the SEC’s rules and forms. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed by a company in the reports that it files or submits under the Exchange Act is accumulated and communicated to the company’s management, including its principal executive and principal financial officers, or persons performing similar functions, as appropriate to allow timely decisions regarding required disclosure. Our management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving their objectives and our management necessarily applies its judgment in evaluating the cost-benefit relationship of possible controls and procedures. Based on the evaluation of our disclosure controls and procedures as of September 30, 2026, our Chief Executive Officer and our Chief Financial Officer concluded that, as of such date, our disclosure controls and procedures were effective at the reasonable assurance level.
Changes in Internal Control over Financial Reporting
There was no change in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15(d)-15(f) under the Exchange Act) that occurred during the period covered by this Quarterly Report on Form 10-Q that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.
26
PART II—OTHER INFORMATION
Item 1. Legal Proceedings.
Not applicable.
Item 1A. Risk Factors.
We are a smaller reporting company, as defined in Rule 12b-2 under the Securities Exchange Act of 1934, as amended, for this reporting period and are not required to provide the information required under this item.
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.
Not applicable.
Item 3. Defaults Upon Senior Securities.
Not applicable.
Item 4. Mine Safety Disclosures.
Not applicable.
Item 5. Other Information.
(a) None.
(b) None.
(c) Director and Officer Trading Plans and Arrangements
27
Item 6. Exhibits.
Exhibit Number |
|
Description |
2.1#
|
|
Agreement and Plan of Merger, dated as of August 16, 2026, by and among the Registrant, Fusion Merger Sub I, Inc., Fusion Merger Sub II, LLC and Slate Medicines, Inc (incorporated by reference to Exhibit 2.1 to the Registrant’s Current Report on Form 8-K filed with the Securities and Exchange Commission on August 17, 2026). |
3.1 |
|
Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant’s Current Report on Form 8-K filed with the Securities and Exchange Commission on July 22, 2019). |
3.2 |
|
Certificate of Amendment of the Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant’s Current Report on Form 8-K filed with the Securities and Exchange Commission on June 9, 2023). |
3.3 |
|
Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.2 to the Registrant’s Current Report on Form 8-K filed with the Securities and Exchange Commission on July 22, 2019). |
10.1 |
|
Form of Fulcrum Support Agreement (incorporated by reference to Exhibit 10.1 to the Registrant’s Current Report on Form 8-K filed with the Securities and Exchange Commission on August 17, 2026). |
10.2
|
|
Form of Slate Support Agreement (incorporated by reference to Exhibit 10.2 to the Registrant’s Current Report on Form 8-K filed with the Securities and Exchange Commission on August 17, 2026). |
10.3 |
|
Form of Lock-Up Agreement (incorporated by reference to Exhibit 10.3 to the Registrant’s Current Report on Form 8-K filed with the Securities and Exchange Commission on August 17, 2026). |
10.4# |
|
Form of Securities Purchase Agreement (incorporated by reference to Exhibit 10.4 to the Registrant’s Current Report on Form 8-K filed with the Securities and Exchange Commission on August 17, 2026). |
10.5 |
|
Form of Registration Rights Agreement (incorporated by reference to Exhibit 10.5 to the Registrant’s Current Report on Form 8-K filed with the Securities and Exchange Commission on August 17, 2026). |
31.1* |
|
Certification of Principal Executive Officer Pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002. |
31.2* |
|
Certification of Principal Financial Officer Pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002. |
32.1+ |
|
Certification of Principal Executive Officer Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002. |
32.2+ |
|
Certification of Principal Financial Officer Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002. |
101.INS |
|
Inline XBRL Instance Document |
101.SCH |
|
Inline XBRL Taxonomy Extension Schema With Embedded Linkbase Documents |
104 |
|
Cover Page Interactive Data File (formatted as Inline XBRL with applicable taxonomy extension information contained in Exhibits 101). |
# Exhibits and/or schedules have been omitted pursuant to Item 601(a)(5) of Regulation S-K. The Registrant hereby undertakes to furnish supplementally copies of any of the omitted exhibits and schedules upon request by the Securities and Exchange Commission provided, however, that the Registrant may request confidential treatment pursuant to Rule 24b-2 under the Exchange Act for any exhibits or schedules so furnished.
* Filed herewith.
+ Furnished herewith.
28
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
|
|
FULCRUM THERAPEUTICS, INC. |
|
|
|
|
|
Date: November 12, 2026 |
|
By: |
/s/ Alex C. Sapir |
|
|
|
Alex C. Sapir |
|
|
|
President and Chief Executive Officer (Principal Executive Officer) |
|
|
|
|
Date: November 12, 2026 |
|
By: |
/s/ Alan Musso |
|
|
|
Alan Musso |
|
|
|
Chief Financial Officer (Principal Financial Officer) |
|
|
|
|
29