[Form 4] Guardant Health, Inc. Insider Trading Activity

Rhea-AI Filing Summary

Craig Eagle, Chief Medical Officer of Guardant Health, reported transactions on 09/15/2025 related to the vesting of restricted stock units (RSUs) granted June 9, 2023. A tranche of 1,402 shares vested and were delivered at no cash price to the reporting person. To satisfy tax withholding obligations, the company retained 711 shares at an effective withholding price of $54.79 per share.

After these transactions the reporting person beneficially owned 37,482 shares of Guardant Health common stock. The RSU award vests over three years (33% vested June 15, 2024; remaining 67% vests in equal quarterly installments over the following two years). The Form 4 was signed by an attorney-in-fact on 09/17/2025.

Positive

• RSU vesting aligns management and shareholder interests by converting long-term incentives into owned shares
• Filing discloses vesting schedule and withholding details, showing procedural transparency

Negative

• None.

Insights

Securities Analyst

TL;DR: Routine executive RSU vesting with shares withheld for taxes, producing a modest change in reported beneficial ownership.

The transactions reflect a scheduled vesting of long-term incentive compensation rather than a market purchase or sale. Delivery of 1,402 vested shares and the withholding of 711 shares to satisfy tax obligations at $54.79 per share are administrative outcomes common for equity awards. The net effect reduced the reporting person's outstanding shares compared to immediately prior holdings but leaves the insider with material continuing ownership of 37,482 shares. This filing is procedural and typically has limited direct valuation impact on the company.

Corporate Governance Expert

TL;DR: Standard equity compensation mechanics; disclosure is timely and explains vesting schedule and tax withholding.

The Form 4 documents the mechanics of a restricted stock unit grant originally awarded on June 9, 2023 with a three-year vesting schedule. The company retained shares to meet tax withholding, explicitly noting the retained amount did not exceed the tax liability. The filing includes required explanatory notes and an attorney-in-fact signature, indicating procedural compliance with Section 16 reporting obligations. This is a routine governance disclosure rather than an operational or strategic event.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person^*

EAGLE CRAIG

(Last) (First) (Middle)

3100 HANOVER STREET

(Street)

PALO ALTO CA 94304

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Guardant Health, Inc. [ GH ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief Medical Officer

3. Date of Earliest Transaction (Month/Day/Year)
09/15/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	09/15/2025		M		1,402	A	$0	38,193	D
Common Stock	09/15/2025		F		711(1)	D	$54.79	37,482	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Restricted Stock Units	$0	09/15/2025		M			1,402	(2)	(3)	Common Stock	1,402	$0	4,206	D

Explanation of Responses:

1. These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability.

2. This represents a restricted stock unit award granted on June 9, 2023 that vests over a three-year period. 33% of the shares subject to such award vested on June 15, 2024. The remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter.

3. Not applicable for Restricted Stock Units.

Remarks:

	/s/ John G. Saia, as attorney-in-fact for Craig Eagle	09/17/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What did Guardant Health (GH) Chief Medical Officer Craig Eagle report on 09/15/2025?

The Form 4 reports the vesting of 1,402 restricted stock units and the withholding of 711 shares for taxes at $54.79 per share.

How many Guardant Health shares does Craig Eagle beneficially own after the reported transactions?

The filing states the reporting person beneficially owned 37,482 shares after the transactions.

When was the RSU grant originally made and what is its vesting schedule?

The RSU award was granted on June 9, 2023; 33% vested on June 15, 2024 and the remaining 67% vests in equal quarterly installments over the next two years.

Why were 711 shares retained by the company?

The company retained 711 shares to satisfy the tax withholding obligations of the award-holder; the filing states the amount retained did not exceed the tax liability.

Who signed the Form 4 and when?

The Form 4 was signed by John G. Saia, as attorney-in-fact for Craig Eagle on 09/17/2025.