Welcome to our dedicated page for GH Research PLC SEC filings (Ticker: GHRS), a comprehensive resource for investors and traders seeking official regulatory documents including 10-K annual reports, 10-Q quarterly earnings, 8-K material events, and insider trading forms.
GH Research PLC filings document foreign private issuer current reports for a clinical-stage biopharmaceutical company developing mebufotenin product candidates for depression. The company’s Form 6-K reports furnish press releases, corporate presentations, manuscripts, and conference materials related to GH001 in treatment-resistant depression, including Phase 2b results, open-label extension data, and FDA/IND regulatory updates.
The filing record also covers operating and financial results, material-event disclosures, shareholder voting matters, capital-structure information, material agreements, and clinical or regulatory disclosures. These documents describe the company’s research and development focus, product-candidate pipeline, governance reporting, and formal exhibits used to communicate trial publications and business updates.
RA Capital and related persons report a 12.4% stake in GH Research PLC as of June 30, 2025. The filing shows aggregate ownership of 7,676,697 Ordinary Shares out of 62,028,145 outstanding, based on the issuer's February 15, 2025 filing. The RA Capital Healthcare Fund directly holds 7,485,080 shares (12.1%) and RA Capital Nexus Fund II holds 191,617 shares. Reported holdings reflect shared voting and shared dispositive power only; sole voting and dispositive power are zero. The filing states RA Capital serves as investment adviser and has sole power to vote and dispose of the funds’ reported shares, while the funds disclaim beneficial ownership for purposes of Section 13(d) because they delegated those powers and may not revoke that delegation on less than 61 days’ notice.
Terwey Theis reports beneficial ownership of 4,692,903 ordinary shares of GH Research PLC, representing 7.6% of the outstanding class based on 62,029,395 shares outstanding as of June 30, 2025. The disclosure shows the reporting person is a German citizen and holds sole voting and sole dispositive power over all reported shares, with no shared voting or dispositive arrangements.
This Schedule 13G amendment documents a substantial ownership position above the 5% threshold that requires public disclosure; it does not specify transactions, motives, or any arrangements with other holders.
GH Research PLC (NASDAQ: GHRS) filed a Form 6-K reporting that it has submitted a complete response to the U.S. FDA concerning the clinical hold on its Investigational New Drug (IND) application for GH001. The submission was made in June 2025 and disclosed to investors via a press release dated 20 June 2025 (attached as Exhibit 99.1).
The filing does not disclose FDA feedback, timelines, or whether the hold will be lifted. Management expressly states it will not update the press release or forward-looking statements, underscoring regulatory uncertainty. No financial statements, earnings metrics, or other operational updates accompany the filing.
Investor takeaway: The response filing is an incremental regulatory step that could enable clinical trials of GH001 to resume if the FDA is satisfied. However, material impact remains contingent on the FDA’s decision; therefore, the risk profile for GHRS is largely unchanged until further notice.