[Form 3] GlycoMimetics, Inc. Initial Statement of Beneficial Ownership

Rhea-AI Filing Summary

Form 3 highlights a new insider position created by the completion of a complex reverse-merger and redomiciliation involving GlycoMimetics, Inc. (now Crescent Biopharma, Inc.; ticker remains CBIO in the filing header, GLYC in metadata). Richard William Scalzo, recently appointed Chief Financial Officer, has filed his initial statement of beneficial ownership dated 23 June 2025 for an event that occurred on 13 June 2025.

Corporate restructuring. • On 13 June 2025 a two-step merger converted Crescent Biopharma into a wholly owned subsidiary of GlycoMimetics, after which the parent renamed itself Crescent Biopharma, Inc. • On 16 June 2025 the issuer completed a change of domicile from Delaware to the Cayman Islands. All existing equity awards automatically converted into rights over Cayman ordinary shares on a one-for-one basis and under identical terms.

Insider equity. Scalzo reports no non-derivative common shares but holds a single derivative position:

• Stock options: 234,383 ordinary shares, exercise price $9.56.
• Vesting schedule: 25 % on 1 Apr 2026; balance vests monthly until 1 Apr 2029, contingent on continued service.
• Expiration: 1 Apr 2035.

Ownership is recorded as direct (D).

Investor take-away. The filing formally registers the CFO as an insider and discloses his incentive package following the merger and offshore reorganisation. Although no immediate share purchases are shown, the sizable option grant aligns compensation with long-term share performance and signals management continuity post-transaction.

Positive

• Timely Section 16(a) compliance demonstrates sound corporate governance following the merger.
• Large, long-dated option grant (234,383 shares at $9.56) aligns new CFO’s incentives with long-term shareholder value.
• Vesting schedule through 2029 supports executive retention during integration of the merged entities.

Negative

• No non-derivative common stock ownership disclosed, limiting immediate direct equity exposure for the CFO.
• High exercise price of $9.56 could diminish motivational value if current market price is well below strike (market price not provided in filing).

Insights

Corporate Governance Expert

TL;DR: Filing confirms CFO’s status, option grant, and post-merger redomiciliation; governance implications neutral-to-positive.

The Form 3 satisfies Section 16(a) requirements by timely disclosing Richard Scalzo’s beneficial ownership within ten days of becoming an officer. The option grant is large (≈234 k shares) and multi-year, promoting retention and alignment with shareholder value. Absence of non-derivative holdings limits immediate ‘skin-in-the-game’ yet is typical for newly appointed executives at closing. The disclosure also documents the chain-of-control changes—two-step merger and Delaware-to-Cayman conversion—which may yield tax or structural advantages but, strictly per filing, only establish Scalzo’s rights continuity. Overall governance impact is neutral to slightly positive: compliance is timely, incentives are long-term, and structural clarity is provided.

Securities Analyst

TL;DR: Insider holds 234k options at $9.56; no common shares; incentive horizon through 2029.

From a capital-markets angle, this filing is informational rather than catalytic. Key metric is option strike of $9.56; investors can compare this to current market price to gauge embedded performance hurdles. Four-year vesting spreads risk and suggests the board anticipates long operational cycles post-merger. No direct share ownership can be interpreted as limited immediate downside exposure, though converts may follow. The dual-merger and Cayman move confirm closing mechanics of a larger corporate event; any valuation impact from tax or regulatory changes is outside this document’s scope. Net effect on share price expectation: minimal, but it adds transparency and signals management in place.

SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person^*

Scalzo Richard William

(Last) (First) (Middle)

C/O CRESCENT BIOPHARMA, INC.

300 FIFTH AVENUE

(Street)

WALTHAM MA 02451

(City) (State) (Zip)

2. Date of Event Requiring Statement (Month/Day/Year)
06/13/2025

3. Issuer Name and Ticker or Trading Symbol
GLYCOMIMETICS INC [ CBIO ]

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief Financial Officer

5. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	(1)(2)(3)	04/01/2035	Ordinary Shares	234,383	$9.56	D

Explanation of Responses:

1. Effective as of June 13, 2025 (the "Effective Time"), (i) a wholly-owned subsidiary of GlycoMimetics, Inc. ("GlycoMimetics") merged with and into Crescent Biopharma, Inc. ("Pre-Merger Crescent") with Pre-Merger Crescent continuing as a wholly owned subsidiary of GlycoMimetics and the surviving corporation of the merger (the "First Merger"), (ii) immediately thereafter, Pre-Merger Crescent merged with and into a second wholly-owned subsidiary of GlycoMimetics ("Second Merger Sub"), with Second Merger Sub being the surviving entity of the merger under the name Crescent Biopharma Operating Company, LLC (the "Second Merger" and, together with the First Merger, the "Merger"). At the Effective Time, GlycoMimetics changed its name to "Crescent Biopharma, Inc." (hereinafter, the "Issuer").

2. This Form gives effect to the Issuer's completion of a conversion from a corporation organized under the laws of the State of Delaware (the "Delaware Corporation") to an exempted company incorporated under the laws of the Cayman Islands (the "Cayman Company"), effective as of June 16, 2025. In connection therewith, each outstanding option or right to acquire shares of common stock of the Delaware Corporation continued in existence in the form of and automatically became an option or right to acquire an equal number of ordinary shares of the Cayman Company under the same terms and conditions.

3. Represents options to purchase the Issuer's ordinary shares received by the Reporting Person in the Merger in exchange for options of Pre-Merger Crescent held by the Reporting Person prior to the Merger. This option will vest as to 25% on April 1, 2026 and in equal monthly installments thereafter through April 1, 2029, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

Remarks:

Exhibit 24 - Power of Attorney

	/s/ Barbara Bispham, as attorney-in-fact for Richard William Scalzo	06/23/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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FAQ

Why did GlycoMimetics (GLYC) file this Form 3?

To disclose CFO Richard Scalzo’s initial beneficial ownership after the June 2025 merger and domicile change.

How many shares can the CFO of GLYC acquire under his option grant?

He holds options for 234,383 ordinary shares of Crescent Biopharma, Inc.

What is the exercise price and term of the reported options?

The strike price is $9.56 and the options expire on 1 Apr 2035.

When do the CFO’s options vest?

25 % vest on 1 Apr 2026; the remainder vest monthly until 1 Apr 2029, subject to continued service.

Did the CFO report any direct common share ownership?

No. The Form 3 lists no non-derivative shares; only derivative (option) holdings are disclosed.

What corporate restructuring is referenced in the filing?

A two-step merger completed on 13 Jun 2025 and a Delaware-to-Cayman redomiciliation effective 16 Jun 2025.