[Form 4] Structure Therapeutics Inc. Insider Trading Activity

Rhea-AI Filing Summary

Coll Crespo Blas, Chief Medical Officer of Structure Therapeutics Inc. (GPCR), reported a change in beneficial ownership for ordinary shares on 09/18/2025. The filing shows 8,106 ordinary shares were disposed (D) at a reported price of $7.7433 per share. After the transaction the reporting person beneficially owned 216,807 ordinary shares. The filing explains the 8,106 shares represent shares withheld by the issuer to satisfy income tax obligations related to the vesting of a restricted share unit award. The form notes that the issuer’s ordinary shares may be represented by ADSs, with each ADS equal to three ordinary shares.

Positive

• Transaction identified as tax withholding for RSU vesting, indicating an administrative rather than discretionary market sale
• Reporting person retains significant ownership with 216,807 ordinary shares after the transaction

Negative

• Reduction in direct share count by 8,106 ordinary shares due to withholding

Insights

Financial Analyst

TL;DR: Routine insider withholding sale to cover taxes; not a market-disposition signal and ownership remains substantial.

The reported disposal of 8,106 ordinary shares at $7.7433 each is identified as shares withheld to satisfy income tax on vested RSUs, which typically indicates a non-discretionary transaction rather than an active sale. The reporting person continues to beneficially own 216,807 shares after the transaction, preserving vested equity exposure. This type of transaction usually has limited informational content about company prospects because it serves administrative tax purposes.

Corporate Governance Expert

TL;DR: Administrative share withholding reported; disclosure aligns with Section 16 reporting requirements.

The Form 4 discloses a withholding event tied to RSU vesting, fulfilling Section 16 transparency for officers. The signature by an attorney-in-fact and the explanation that shares were withheld for tax obligations are consistent with standard practice. There is no indication of unreported related-party transactions or changes in role; the filing shows continued beneficial ownership, which supports governance continuity.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Coll Crespo Blas

(Last) (First) (Middle)

C/O STRUCTURE THERAPEUTICS INC.

601 GATEWAY BLVD., SUITE 900

(Street)

SOUTH SAN FRANCISCO CA 94080

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Structure Therapeutics Inc. [ GPCR ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	CHIEF MEDICAL OFFICER

3. Date of Earliest Transaction (Month/Day/Year)
09/18/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Ordinary Shares(1)	09/18/2025		F		8,106(2)	D	$7.7433	216,807	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. The Ordinary Shares of the Issuer may be represented by American Depositary Shares ("ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

2. Represents shares withheld by the Issuer to satisfy income tax obligations associated with the vesting of a restricted share unit award.

	/s/ Jun Yoon, Attorney-in-Fact	09/22/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What did GPCR insider Coll Crespo Blas report on 09/18/2025?

The Form 4 reports a disposal of 8,106 ordinary shares at $7.7433 per share, reported as withholding to satisfy income tax on vested RSUs.

How many shares does Coll Crespo Blas own after the transaction?

The reporting person beneficially owned 216,807 ordinary shares following the reported transaction.

Why were the 8,106 shares disposed of according to the filing?

The filing explains the 8,106 shares were withheld by the issuer to satisfy income tax obligations associated with vested restricted share units.

Was this an open-market sale or a withholding event?

The Form 4 characterizes the transaction as a withholding event to cover taxes on RSU vesting, not an open-market sale.

Do the issuer’s ADSs relate to the ordinary shares reported?

Yes. The filing notes ordinary shares may be represented by ADSs, with each ADS representing three ordinary shares.