GRAIL CEO sells 61,452 shares, exercises options

Ofman's sales were made under a Rule 10b5-1 trading plan adopted on December 2, 2025.

Rhea-AI Filing Summary

GRAIL, Inc. Chief Executive Officer Joshua J. Ofman exercised options covering 26,452 common shares at $14 per share on September 21, 2026, and acquired 26,452 common shares. His reported option position following the exercise was 37,032 shares. The option was originally granted on March 6, 2020, and its performance condition was determined to be met on November 1, 2024.

On September 21, 2026, Ofman also sold 61,452 common shares in eight transactions, at reported per-share prices from $92.3152 to $110.0000; seven of the reported prices were weighted averages for multiple sales. The sales were made under a Rule 10b5-1 trading plan adopted on December 2, 2025.

Insider Trade Summary 10b5-1

Exercise and sale activity reported; no spread calculated

Exercise and Sale 10 txns

Insider Ofman Joshua J.

Role Chief Executive Officer

Sold 61,452 shs ($6.01M)

Approx. gross sale proceeds $6.01M

Approx. exercise cost $370K

Type	Security	Shares	Price	Value
Exercise	Stock Option F9	26,452	$0.00	$0.00
Exercise	Common Stock	26,452	$14.00	$370K
Sale	Common Stock F2, F1	2,125	$92.3152	$196K
Sale	Common Stock F3, F1	1,454	$93.606	$136K
Sale	Common Stock F4, F1	37,752	$94.9828	$3.59M
Sale	Common Stock F5, F1	6,200	$96.4308	$598K
Sale	Common Stock F6, F1	1,400	$97.8414	$137K
Sale	Common Stock F7, F1	421	$99.8499	$42K
Sale	Common Stock F8, F1	2,100	$100.6805	$211K
Sale	Common Stock F1	10,000	$110.00	$1.10M

Holdings After Transaction: Stock Option — 37,032 contracts (Direct); Common Stock — 362,271 shares (Direct)

Footnotes (9)

1. F1. The sale transactions reported in this Form 4 are made pursuant to a Rule 10b5-1 trading plan adopted on December 2, 2025
2. F2. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $92.04 to $92.93 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote
3. F3. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $93.04 to $93.90 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote
4. F4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $94.5 to $95.00 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote
5. F5. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $96.00 to $96.71 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote
6. F6. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $97.74 to $98.00 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote
7. F7. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $99.42 to $100.28 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote
8. F8. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $100.68 to $100.69 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote
9. F9. Represents an option originally granted on March 6, 2020 for which the performance condition was determined to be met on November 1, 2024. The option vests and becomes exercisable in thirty-six substantially equal monthly installments beginning December 1, 2024. As of September 21, 2026, approximately 61% of the shares subject to the option had vested, and the remaining approximately 39% of the shares vests over the remaining period afterwards.

Key Figures

Options exercised: 26,452 shares Exercise price: $14 per share Common shares acquired: 26,452 shares +3 more

6 metrics

Options exercised 26,452 shares September 21, 2026

Exercise price $14 per share Options exercised on September 21, 2026

Common shares acquired 26,452 shares September 21, 2026

Common shares sold 61,452 shares Eight transactions on September 21, 2026

Option position following exercise 37,032 shares Reported following the September 21, 2026 exercise

Reported sale prices $92.3152–$110.0000 per share Reported prices across eight sales; seven were weighted averages for multiple sales

Key Terms

Rule 10b5-1 trading plan, weighted average price, performance condition, substantially equal monthly installments

4 terms

Rule 10b5-1 trading plan regulatory

"made pursuant to a Rule 10b5-1 trading plan adopted on December 2, 2025"

A Rule 10b5-1 trading plan is a pre-arranged schedule that allows company insiders to buy or sell stock at specific times, even if they have inside information. It helps prevent accusations of unfair trading by making these transactions look planned and transparent, rather than sneaky or illegal.

weighted average price financial

"The price reported in Column 4 is a weighted average price"

Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.

performance condition technical

"the performance condition was determined to be met on November 1, 2024"

substantially equal monthly installments technical

"vests and becomes exercisable in thirty-six substantially equal monthly installments"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

How many GRAL shares did CEO Joshua J. Ofman sell?

Joshua J. Ofman sold 61,452 common shares on September 21, 2026, in eight reported transactions. The reported per-share prices ranged from $92.3152 to $110.0000; seven of the reported prices were weighted averages for multiple sales.

How many GRAL shares did CEO Joshua J. Ofman acquire through option exercise?

He exercised options covering 26,452 common shares at $14 per share and acquired 26,452 common shares on September 21, 2026. His reported option position following the exercise was 37,032 shares.

How did Joshua J. Ofman's GRAL option vest?

The option vested and became exercisable in thirty-six substantially equal monthly installments beginning December 1, 2024. As of September 21, 2026, approximately 61% of the shares subject to the option had vested, and the remaining approximately 39% was to vest over the remaining period.

AI-generated analysis. How Rhea-AI works. Not financial advice.

Form 4 Insider Transactions: What Each Field Means →

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Available on EDGAR 09/23/2026 - 04:37 PM Accepted by SEC EDGAR 09/23/2026 - 04:37 PM Learn about SEC filing dates

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

X

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Ofman Joshua J.

(Last) (First) (Middle)

C/O GRAIL, INC.

250 S. MATHILDA AVE. SUITE 100

(Street)

SUNNYVALE CALIFORNIA 94086

(City) (State) (Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
GRAIL, Inc. [ GRAL ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief Executive Officer

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
09/21/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	09/21/2026		M		26,452	A	$14	423,723	D
Common Stock	09/21/2026		S		2,125	D(1)	$92.3152(2)	421,598	D
Common Stock	09/21/2026		S		1,454	D(1)	$93.606(3)	420,144	D
Common Stock	09/21/2026		S		37,752	D(1)	$94.9828(4)	382,392	D
Common Stock	09/21/2026		S		6,200	D(1)	$96.4308(5)	376,192	D
Common Stock	09/21/2026		S		1,400	D(1)	$97.8414(6)	374,792	D
Common Stock	09/21/2026		S		421	D(1)	$99.8499(7)	374,371	D
Common Stock	09/21/2026		S		2,100	D(1)	$100.6805(8)	372,271	D
Common Stock	09/21/2026		S		10,000	D(1)	$110	362,271	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option	$14	09/21/2026		M			26,452	(9)	03/05/2030	Common Stock	26,452	$0	37,032	D

Explanation of Responses:

1. The sale transactions reported in this Form 4 are made pursuant to a Rule 10b5-1 trading plan adopted on December 2, 2025

2. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $92.04 to $92.93 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote

3. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $93.04 to $93.90 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote

4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $94.5 to $95.00 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote

5. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $96.00 to $96.71 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote

6. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $97.74 to $98.00 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote

7. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $99.42 to $100.28 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote

8. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $100.68 to $100.69 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote

9. Represents an option originally granted on March 6, 2020 for which the performance condition was determined to be met on November 1, 2024. The option vests and becomes exercisable in thirty-six substantially equal monthly installments beginning December 1, 2024. As of September 21, 2026, approximately 61% of the shares subject to the option had vested, and the remaining approximately 39% of the shares vests over the remaining period afterwards.

Remarks:

	/s/Abram Barth, as Attorney-in-Fact for Joshua Ofman	09/23/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)