[Form 4] GRAIL, Inc. Insider Trading Activity

Rhea-AI Filing Summary

GRAIL, Inc. (GRAL) reported an insider tax-related stock sale by its Chief Financial Officer. On 11/17/2025, the CFO disposed of 1,697 shares of common stock in an automatic sell-to-cover transaction at a weighted average price of $79.2 per share. These sales were executed by a broker to cover withholding taxes due upon the vesting and delivery of an equity award, rather than as a discretionary open-market sale.

After this transaction and a small correction of 10 shares to fix a prior reporting error, the reporting person beneficially owns 284,077 shares of GRAIL common stock, including 641 shares acquired through the company’s employee stock purchase plan on November 14, 2025.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Freidin Aaron

(Last) (First) (Middle)

C/O GRAIL, INC.

1525 O'BRIEN DRIVE

(Street)

MENLO PARK CA 94025

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
GRAIL, Inc. [ GRAL ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief Financial Officer

3. Date of Earliest Transaction (Month/Day/Year)
11/17/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	11/17/2025		S		1,697	D	$79.2(1)	284,077(2)(3)	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. Represents automatic sell-to-cover transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

2. Includes 641 shares acquired under the Company's ESPP purchased on November 14, 2025.

3. Adjusted to reduce the reported holdings by 10 shares of Common Stock to correct an inadvertent error in Column 4 of the Form 4 filed on August 19, 2025.

Remarks:

	/s/Abram Barth, as Attorney-in-Fact for Aaron Freidin	11/19/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What insider transaction did GRAIL (GRAL) disclose in this Form 4?

The filing discloses that GRAIL's Chief Financial Officer sold 1,697 shares of common stock on 11/17/2025 in an automatic sell-to-cover transaction to cover withholding taxes upon award vesting and share delivery.

At what price were the GRAIL (GRAL) shares sold in the CFO’s transaction?

The 1,697 GRAIL common shares were sold at a weighted average price of $79.2 per share, calculated by the broker executing the block trade.

How many GRAIL (GRAL) shares does the CFO beneficially own after this Form 4 transaction?

Following the reported transaction and a minor correction, the reporting person beneficially owns 284,077 shares of GRAIL common stock.

Was the GRAIL (GRAL) CFO’s sale part of a tax-withholding transaction?

Yes. The filing states the sale represents automatic sell-to-cover transactions executed by a broker to cover withholding taxes due upon the vesting and delivery of an equity award.

Does the GRAIL (GRAL) Form 4 include shares from an employee stock purchase plan?

Yes. The beneficial ownership total includes 641 shares acquired under the company’s employee stock purchase plan, purchased on November 14, 2025.

Did the GRAIL (GRAL) Form 4 correct any prior reporting error?

The filing notes that the reported holdings were adjusted to reduce the total by 10 shares of common stock to correct an inadvertent error in a Form 4 filed on August 19, 2025.