[Form 4] GRAIL, Inc. Insider Trading Activity

Rhea-AI Filing Summary

Insider sale reported for GRAIL, Inc. (GRAL). The reporting person, Joshua J. Ofman (an officer listed as President), sold 81,385 shares of GRAIL common stock on 10/06/2025 in transactions executed as a block trade at a weighted average price of $62.5 per share. After the reported sale, Mr. Ofman beneficially owned 396,797 shares. The Form 4 was signed by an attorney-in-fact on 10/08/2025. The filer states the reported price is a broker-calculated weighted average for multiple sell-to-cover transactions and offers to provide detailed per-trade pricing on request.

Positive

• Timely SEC disclosure of the officer's sale, including offer to provide detailed per-trade pricing
• Post-transaction holdings disclosed: 396,797 shares remain beneficially owned, giving clear ownership context

Negative

• Material insider sale of 81,385 shares on 10/06/2025, which reduces executive ownership
• No 10b5-1 plan indication is checked on the form, so the filing does not state the sale was under a prearranged plan

Insights

Corporate Governance Analyst

TL;DR: Officer reported a block sale of 81,385 shares, reducing holdings to 396,797 shares.

The sale is a clear, reportable change in beneficial ownership by a named officer on 10/06/2025, executed as a block trade at a weighted average price of $62.5. The filing discloses the broker-calculated average and offers to provide per-trade prices on request, which supports transparency about the execution details.

The main dependencies are the reason for the sale and whether it was part of a planned trading program; the form does not check the Rule 10b5-1 box and provides no plan detail. Investors may note potential short-term signaling from an officer sale, but the filing contains no allegation or explanatory claim beyond price calculation and post-sale holdings. Watch for any subsequent Form 4 or company disclosures that state the sale was pre-planned or part of routine tax/covering activity within weeks.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Ofman Joshua J.

(Last) (First) (Middle)

C/O GRAIL, INC.

1525 O'BRIEN DRIVE

(Street)

MENLO PARK CA 94025

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
GRAIL, Inc. [ GRAL ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	President

3. Date of Earliest Transaction (Month/Day/Year)
10/06/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	10/06/2025		S		81,385	D	$62.5(1)	396,797	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. The price reported in Column 4 is a weighted average price calculated by the broker executing the sell-to-cover transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Remarks:

	/s/Donald Lang, as Attorney-in-Fact for Joshua Ofman	10/08/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What did the GRAL insider sell on 10/06/2025?

The reporting person sold 81,385 shares of GRAIL common stock on 10/06/2025 at a weighted average price of $62.5 per share.

Who filed this Form 4 for GRAL?

The Form 4 reports transactions by Joshua J. Ofman, listed as an officer (President). The signature is by an attorney-in-fact dated 10/08/2025.

How many GRAL shares does the reporting person own after the sale?

After the reported transaction, the reporting person beneficially owned 396,797 shares.

Was the sale executed under a 10b5-1 trading plan?

No 10b5-1 box is checked on the form; the filing does not indicate the sale was made under a prearranged trading plan.

Is the reported $62.5 price per share the exact trade price?

The form states $62.5 is a broker-calculated weighted average for multiple sell-to-cover transactions and offers to provide per-trade prices on request.