[SCHEDULE 13G/A] Immunome Inc. SEC Filing

Rhea-AI Filing Summary

FMR LLC and Abigail P. Johnson report beneficial ownership of 13,056,709.11 shares of Immunome Inc. common stock, representing 15.0% of the class. The filing shows sole dispositive power over 13,056,709.11 shares and sole voting power of 13,054,983 shares for FMR LLC, with no shared voting or dispositive power reported. The statement notes that the holdings are held in the ordinary course of business and not for the purpose of changing control. A related position — Fidelity Growth Company Commingled Pool — holds 5,133,293 shares or 5.9%. The filing references an agreement in Exhibit 99 and incorporated powers of attorney for signature authority.

Positive

• Clear, quantified ownership: 13,056,709.11 shares disclosed (15.0%)
• Sole dispositive control reported for the full position, aiding transparency
• Holding stated as ordinary course, with certification denying intent to change control

Negative

• Concentrated stake of 15.0% increases investor attention and potential market impact
• Single large holder reduces free float available to other investors
• Exhibit 99 referenced may contain agreements or arrangements not summarized here

Insights

Institutional Ownership Analyst

FMR and Abigail P. Johnson report a sizable 15.0% stake in Immunome.

The filing documents that 13,056,709.11 shares are beneficially owned with sole dispositive control, and FMR reports nearly identical sole voting authority for most shares. This establishes a material, concentrated position that is clearly disclosed and quantified.

The certification states the shares are held in the ordinary course of business and not to influence control, which reduces immediate governance concerns; monitor any future amendments, 13D filings, or disclosed agreements in Exhibit 99 for changes in intent or coordination.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 1)

IMMUNOME INC

(Name of Issuer)

COMMON STOCK

(Title of Class of Securities)

45257U108

(CUSIP Number)

09/30/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No. 45257U108

1

Names of Reporting Persons

FMR LLC

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 13,054,983.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 13,056,709.11
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

13,056,709.11

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

15.0 %

12

Type of Reporting Person (See Instructions)

HC

SCHEDULE 13G

CUSIP No. 45257U108

1

Names of Reporting Persons

Abigail P. Johnson

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 13,056,709.11
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

13,056,709.11

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

15.0 %

12

Type of Reporting Person (See Instructions)

IN

SCHEDULE 13G

Item 1.
(a)	Name of issuer: IMMUNOME INC
(b)	Address of issuer's principal executive offices: 18702 N. CREEK PARKWAY,SUITE 100,BOTHELL,WA,US, 98011
Item 2.
(a)	Name of person filing: FMR LLC
(b)	Address or principal business office or, if none, residence: 245 Summer Street, Boston, Massachusetts 02210
(c)	Citizenship: Not applicable
(d)	Title of class of securities: COMMON STOCK
(e)	CUSIP No.: 45257U108
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 13056709.11
(b)	Percent of class: 15.0 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: Please see the responses to Items 5 and 6 on the cover page.
	(ii) Shared power to vote or to direct the vote: 0.00
	(iii) Sole power to dispose or to direct the disposition of: 13056709.11
	(iv) Shared power to dispose or to direct the disposition of: 0.00
Item 5.	Ownership of 5 Percent or Less of a Class.
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. One or more other persons are known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the COMMON STOCK of IMMUNOME INC. The interest of Fidelity Growth Company Commingled Pool, in the COMMON STOCK of IMMUNOME INC, amounted to 5133293.00 shares or 5.9% of the total outstanding COMMON STOCK at 09/30/2025.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. See attached Exhibit 99.
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

FMR LLC

Signature:	Stephanie J. Brown
Name/Title:	Duly authorized under Power of Attorney effective as of January 3, 2023, by and on behalf of FMR LLC and its direct and indirect subsidiaries*
Date:	10/06/2025

Abigail P. Johnson

Signature:	Stephanie J. Brown
Name/Title:	Duly authorized under Power of Attorney effective as of January 26, 2023, by and on behalf of Abigail P. Johnson**
Date:	10/06/2025

Comments accompanying signature: * This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on January 10, 2023, accession number: 0000315066-23-000003. ** This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on January 31, 2023, accession number: 0000315066-23-000038.

Exhibit Information

Please see Exhibit 99 for 13d-1(k) (1) agreement.

FAQ

How many Immunome (IMNM) shares does FMR LLC report owning?

FMR LLC reports beneficial ownership of 13,056,709.11 shares.

What percentage of IMNM does the reported position represent?

The disclosed position represents 15.0% of outstanding common stock.

Does the filing indicate voting or dispositive power over the shares?

Yes. FMR reports sole dispositive power over 13,056,709.11 shares and FMR lists sole voting power for 13,054,983 shares.

Is any portion of the stake held on behalf of other Fidelity vehicles?

Yes. Fidelity Growth Company Commingled Pool is reported to hold 5,133,293 shares, or 5.9%.

Does the filing claim the shares were acquired to influence control of Immunome?

No. The certification states the shares were acquired and are held in the ordinary course of business and not to change or influence control.