Filed
Pursuant to Rule 424(b)(5)
Registration
No. 333-279425
PROSPECTUS
SUPPLEMENT NO. 2
(to
Prospectus dated May 22, 2024 and
Prospectus
Supplement dated September 3, 2024)

IMUNON,
INC.
Up
to $10,000,000 of Common Stock
This
prospectus supplement amends and supplements the information in the prospectus supplement, dated September 3, 2024 (the “ATM Prospectus
Supplement”), to the accompanying base prospectus, dated May 22, 2024 (the “Base Prospectus” and, collectively with
the ATM Prospectus Supplement, the “Prospectus”) filed as part of our registration statement on Form S-3 (File No. 333-279425)
(the “Registration Statement”), relating to the offer, issuance and sale of shares of our common stock, par value $0.01 per
share (“Common Stock”), from time to time pursuant to the terms of
an At the Market Offering Agreement, dated as of May 25, 2022, as amended by Amendment No. 1 to At the Market Offering Agreement, dated
as of May 15, 2024 (as amended, the “Sales Agreement”), by and between us and H.C. Wainwright & Co., LLC, as sales agent
or principal (“Wainwright” or the “sales agent”). Through the date hereof, we have sold an aggregate of $1,815,267
of shares of our Common Stock through the sales agent under the Sales Agreement. This prospectus supplement should be read in conjunction
with the Prospectus, and is qualified by reference thereto, except to the extent that the information herein amends or supersedes the
information contained in the Prospectus. This prospectus supplement is not complete without, and may only be delivered or utilized in
connection with, the Prospectus, and any future amendments or supplements thereto.
We are filing this prospectus supplement to amend
and supplement the Prospectus to increase the aggregate amount we intend to sell pursuant to the Sales Agreement. As of the date of this
prospectus supplement, we are offering up to an aggregate of $10,000,000 of our Common Stock for sale under the Sales Agreement, which
includes $5,500,000 that was originally authorized pursuant to the ATM Prospectus Supplement and an additional $4,500,000 pursuant to
this prospectus supplement and does not include the shares of Common Stock previously sold pursuant to the Sales Agreement.
As of the date of this prospectus supplement, the
aggregate market value of our outstanding Common Stock held by non-affiliates was approximately $79,075,969, based on 31,828,425
shares of Common Stock outstanding as of the date of this prospectus supplement, of which 31,504,370 shares are held by non-affiliates,
and a price of $2.51 per share, which was the last reported sale price of our Common Stock on The Nasdaq Stock Market LLC (“Nasdaq”)
on June 2, 2025. As a result, our public float has increased above $75.0 million, and we are no longer subject to the limitations
contained in General Instruction I.B.6 of Form S-3 as of the date of this prospectus supplement. If we become subject to the offering
limits in General Instruction I.B.6 of Form S-3 in the future, we will file another prospectus supplement.
Our Common Stock is listed on Nasdaq under the symbol
“IMNN.” On July 18, 2025, the last reported sale price for our Common Stock on Nasdaq was $0.552 per share.
The
validity of the shares being offered hereby will be passed upon by Thompson Hine LLP.
Investing
in our securities involves a high degree of risk. Before making an investment decision, please read “Risk Factors” beginning
on page S-3 of the ATM Prospectus Supplement and the other documents and information contained or incorporated by reference in this prospectus
supplement and the ATM Prospectus Supplement.
Neither
the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined
if this prospectus supplement is truthful or complete. Any representation to the contrary is a criminal offense.
H.C.
Wainwright & Co.
The
date of this prospectus supplement is July 22, 2025