[144] IONIS PHARMACEUTICALS INC SEC Filing

Rhea-AI Filing Summary

Form 144 notice shows a proposed sale of 1,625 common shares by an insider who acquired them as restricted stock units on 04/15/2025. The shares are to be sold through Stifel Nicolaus & Company on 10/06/2025 with an aggregate market value of $112,725.00 based on the filing. The issuer reports 159,391,229 shares outstanding.

The filer disclosed prior insider sales totaling 60,000 shares during the past three months (sales on 09/03/2025, 09/05/2025, 09/09/2025, and 10/02/2025) generating $3,724,770.00 in gross proceeds. The current notice states the securities were paid for in cash at acquisition and were granted by the issuer as RSUs.

Positive

• Securities were granted as restricted stock units, indicating standard equity compensation.
• Sale uses a registered broker (Stifel Nicolaus), implying routine market execution.
• Proposed sale value is $112,725.00, a modest amount relative to total shares outstanding.

Negative

• Insider previously sold 60,000 shares in the past three months, generating $3,724,770.00, which may indicate continued insider selling activity.
• Planned sale adds to recent disposals, potentially increasing near-term supply from this holder.

Insights

Insider Transactions Specialist

Small scheduled RSU sale with recent larger disposals.

The notice records a planned sale of 1,625 shares granted as restricted stock units on 04/15/2025

Recent activity shows 60,000 shares sold in the prior three months for $3,724,770.00, which may indicate ongoing vesting-driven or liquidity-motivated dispositions rather than a single large block sale.

Monitor reported sale dates around 10/06/2025 for execution and any additional filings that update the number of shares sold.

Equity Markets Analyst

Transaction size is small relative to outstanding shares.

The current proposed sale has an aggregate value of $112,725.00 against reported outstanding shares of 159,391,229, representing a de minimis absolute position size on a company-wide basis.

Because the sale will be handled by a registered broker (Stifel Nicolaus), execution will follow market mechanisms; watch for a Form 4 or amended 144 showing actual execution and any variation from the planned 10/06/2025 timing.

Form 144 Filer Information	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
FORM 144

144: Filer Information

Filer CIK
Filer CCC
Is this a LIVE or TEST Filing?	LIVE TEST
Submission Contact Information
Name
Phone
E-Mail Address

144: Issuer Information

Name of Issuer

SEC File Number

Address of Issuer

Phone

Name of Person for Whose Account the Securities are To Be Sold

See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.

Relationship to Issuer

144: Securities Information

Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange
Common Stock	Stifel Nicolaus & Company Inc 501 N Broadway St. Louis MO 63102	1625	112725.00	159391229	10/06/2025	Nasdaq

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *
Common Stock	04/15/2025	Restricted Stock Units	Issuer			1625	04/15/2025	Cash

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Name and Address of Seller	Title of Securities Sold	Date of Sale	Amount of Securities Sold	Gross Proceeds
Joseph Baroldi 2855 Gazette Ct Carlsbad CA 92010	Common Stock	10/02/2025	15000	1020210.00
Joseph Baroldi 2855 Gazette Ct Carlsbad CA 92010	Common Stock	09/03/2025	32800	1946222.00
Joseph Baroldi 2855 Gazette Ct Carlsbad CA 92010	Common Stock	09/05/2025	250	15500.00
Joseph Baroldi 2855 Gazette Ct Carlsbad CA 92010	Common Stock	09/09/2025	11950	742838.00

144: Remarks and Signature

Remarks

Date of Notice

Date of Plan Adoption or Giving of Instruction, If Relying on Rule 10b5-1

ATTENTION:

The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.

Signature

ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)

FAQ

What does IONS Form 144 disclose about the planned sale?

It discloses a proposed sale of 1,625 common shares to be executed on 10/06/2025 through Stifel Nicolaus with an aggregate market value of $112,725.00.

How were the shares acquired by the seller in the IONS filing?

The shares were acquired on 04/15/2025 as restricted stock units (RSUs) and payment was recorded as cash at acquisition.

How many IONS shares have been sold by this person in the past three months?

The filing lists four prior sales totaling 60,000 shares on 09/03/2025, 09/05/2025, 09/09/2025, and 10/02/2025, with gross proceeds of $3,724,770.00.

What is the issuer's share count in the Form 144?

The filing reports 159,391,229 shares outstanding for the issuer.

Who is the broker handling the planned sale in the IONS Form 144?

The broker named is Stifel Nicolaus & Company Inc based in St. Louis, Missouri.