IONIS Form 144 Details: 22,400-Share Sale Via Goldman Sachs on 10/01/2025

Rhea-AI Filing Summary

IONIS PHARMACEUTICALS, INC. (IONS) Rule 144 notice reports a proposed sale of 22,400 shares of common stock through Goldman Sachs & Co. LLC on 10/01/2025, with an aggregate market value of $1,473,920. The filing lists total shares outstanding of 159,391,229. The securities were acquired on multiple dates by the reporting party (option exercise and restricted stock units), including notable lots: 3,560 shares (09/16/2020), 6,394 shares (07/17/2018), 5,300 shares (02/14/2014) and 4,677 shares (07/15/2024). The filing also discloses related sales by the Joseph H. Wender Trust totaling 33,600 shares in Sep–Oct 2025 for gross proceeds of approximately $1.98 million. Other issuer identification fields are blank in the form content provided.

Positive

• Use of an established broker: The proposed sale is routed through Goldman Sachs & Co. LLC, indicating standard market execution.
• Complete acquisition history provided: The filing lists specific acquisition dates and nature (option exercise, RSUs) for the shares to be sold.

Negative

• Related trust sales disclosed: The Joseph H. Wender Trust sold 33,600 shares in Sep–Oct 2025 for approximately $1.98 million in gross proceeds.
• Issuer identification incomplete: Several issuer fields are blank in the provided content, limiting verification within this document.

Insights

Securities Compliance Analyst

TL;DR: Routine Rule 144 filing showing a non-event insider sale through a major broker; related trust sales disclosed.

The notice documents a planned sale of 22,400 common shares via Goldman Sachs on 10/01/2025 under Rule 144, with acquisition history showing option exercises and multiple restricted stock unit grants. The form also discloses related trust disposals of 33,600 shares in Sep–Oct 2025 producing roughly $1.98 million in gross proceeds. From a compliance perspective, the filing provides required acquisition dates, nature of acquisition, and recent sales by an affiliated trust. Several issuer identification fields in the provided content are blank, which limits cross-verification within this document.

Corporate Finance Analyst

TL;DR: Transaction size is small relative to outstanding shares; disclosed proceeds from recent trust sales are modest.

The 22,400-share proposed sale represents a small fraction of the reported 159.4 million shares outstanding. Acquisition records show mixes of option exercises and RSU vesting across 2014–2024, indicating compensation-derived holdings being liquidated. The Joseph H. Wender Trust sales (33,600 shares) generated approximately $1.98 million in gross proceeds over Sep–Oct 2025. These are straightforward disclosure items with limited direct implication for company fundamentals based solely on this filing.

Form 144 Filer Information	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
FORM 144

144: Filer Information

Filer CIK
Filer CCC
Is this a LIVE or TEST Filing?	LIVE TEST
Submission Contact Information
Name
Phone
E-Mail Address

144: Issuer Information

Name of Issuer

SEC File Number

Address of Issuer

Phone

Name of Person for Whose Account the Securities are To Be Sold

See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.

Relationship to Issuer

144: Securities Information

Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange
Common Stock	Goldman Sachs & Co. LLC 200 West Street New York NY 10282	22400	1473920	159391229	10/01/2025	NASD

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *
Common Stock	09/16/2020	Acquired upon option exercise	The Issuer			3560	09/16/2020	Option exercise
Common Stock	07/03/2017	Acquired as compensation -- Restricted Stock Units	The Issuer			468	07/03/2017	Compensation
Common Stock	07/03/2017	Acquired as compensation -- Restricted Stock Units	The Issuer			667	07/03/2017	Compensation
Common Stock	07/03/2017	Acquired as compensation -- Restricted Stock Units	The Issuer			667	07/03/2017	Compensation
Common Stock	07/03/2017	Acquired as compensation -- Restricted Stock Units	The Issuer			667	07/03/2017	Compensation
Common Stock	07/15/2024	Acquired as compensation -- Restricted Stock Units	The Issuer			4677	07/15/2024	Compensation
Common Stock	02/14/2014	Acquired as compensation -- Restricted Stock Units	The Issuer			5300	02/14/2014	Compensation
Common Stock	07/17/2018	Acquired upon option exercise	The Issuer			6394	07/17/2018	Option exercise

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Name and Address of Seller	Title of Securities Sold	Date of Sale	Amount of Securities Sold	Gross Proceeds
Joseph H. Wender Trust Dtd 10/3/2000 2855 Gazelle Court Carlsbad CA 92010	Common Stock	09/02/2025	5600	322174.16
Joseph H. Wender Trust Dtd 10/3/2000 2855 Gazelle Court Carlsbad CA 92010	Common Stock	09/02/2025	11200	616432.32
Joseph H. Wender Trust Dtd 10/3/2000 2855 Gazelle Court Carlsbad CA 92010	Common Stock	09/03/2025	11200	673548.96
Joseph H. Wender Trust Dtd 10/3/2000 2855 Gazelle Court Carlsbad CA 92010	Common Stock	10/01/2025	5600	366794.96

144: Remarks and Signature

Remarks

Date of Notice

Date of Plan Adoption or Giving of Instruction, If Relying on Rule 10b5-1

ATTENTION:

The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.

Signature

ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)

FAQ

How many IONS shares are proposed for sale under this Form 144?

The notice reports a proposed sale of 22,400 shares of IONIS common stock.

When is the approximate date of the proposed IONS sale?

The filing lists the approximate date of sale as 10/01/2025.

Which broker is handling the proposed sale of IONS shares?

The sale is to be handled by Goldman Sachs & Co. LLC (200 West Street, New York, NY 10282).

What acquisition methods produced the shares being sold in the IONS filing?

Shares were acquired via option exercises and as restricted stock units (RSUs) on multiple dates between 2014 and 2024.

Were there any related sales of IONS shares recently filed?

Yes. The Joseph H. Wender Trust sold a total of 33,600 shares on Sep–Oct 2025, generating about $1.98 million in gross proceeds.