Ionis Files Form 144 Reporting Insider Sales

Ionis Pharmaceuticals reported Form 144 sales of Common Stock by brokers/dealers on behalf of insiders.

Rhea-AI Filing Summary

Ionis Pharmaceuticals reported Form 144 sales of Common Stock by brokers/dealers on behalf of insiders. The excerpt lists trades with share counts of 4,902, 1,823, and 37,277 executed on 01/16/2026, 03/10/2026, and related RSUs dated 04/15/2026.

Key Figures

Reported trade - shares: 4,902 shares Reported trade - shares: 1,823 shares Reported trade - shares: 37,277 shares +3 more

6 metrics

Reported trade - shares 4,902 shares listed under Securities To Be Sold / RSUs (04/15/2026)

Reported trade - shares 1,823 shares Securities Sold During The Past 3 Months (01/16/2026)

Reported trade - shares 37,277 shares Securities Sold During The Past 3 Months (03/10/2026)

Dollar figure shown 138,475.08 amount listed next to 1,823-share trade

Dollar figure shown 2,827,324.68 amount listed next to 37,277-share trade

Identifier or code 165192011 numeric value present in the excerpt

Key Terms

Form 144, RSUs, Broker-dealer

3 terms

Form 144 regulatory

"144: Securities Sold During The Past 3 Months"

Form 144 is a document that investors must file with the government when they plan to sell a large number of shares of a company's stock. It helps ensure transparency so everyone knows how many shares are being sold and when, which can impact the stock's price.

RSUs financial

"RSUs granted under 2011 Equity Incentive Plan"

RSUs, or restricted stock units, are a form of company shares given to employees as part of their compensation. They are typically awarded with certain restrictions, such as a waiting period before they can be fully owned or sold, similar to earning a gift that becomes fully yours over time. For investors, RSUs can impact a company's stock offerings and reflect how much the company relies on stock-based incentives to attract and retain talent.

Broker-dealer market

"Morgan Stanley Smith Barney 1585 Broadway New York NY 10036"

A broker-dealer is a licensed firm or individual that both executes trades on behalf of clients (acting as a broker) and buys or sells securities for its own account (acting as a dealer). Investors care because broker-dealers provide the plumbing of markets — they place orders, hold or move cash and securities, offer research or advice, and their stability and fees directly affect trade execution, costs, and the safety of client funds; think of them as a combined travel agent and taxi for your investments.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What does the Ionis (IONS) Form 144 filing report?

It reports insider-related sales of Common Stock through broker-dealers on specified dates. The filing lists broker names, trade dates, share counts (for example 4,902, 1,823, 37,277) and dollar amounts shown in the excerpt.

Who executed the trades reported in the Form 144 for IONS?

Broker-dealers named include Morgan Stanley Smith Barney and Stifel Nicolaus. The excerpt attributes specific share sales and dates to these firms as the executing brokers for the reported transactions.

Are the reported securities connected to compensation at Ionis?

Yes; the excerpt references RSUs granted under the 2011 Equity Incentive Plan with an award date of 04/15/2026. The filing links at least one security type to compensation-related restricted stock units.

What sizes and dollar values appear in the Form 144 excerpt?

The excerpt shows share counts of 4,902, 1,823, and 37,277 with numeric dollar figures 138,475.08 and 2,827,324.68 associated with specific trades in the provided text.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Accepted by SEC EDGAR 04/16/2026 - 06:49 PM EDT Learn about SEC filing dates

Form 144 Filer Information	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
FORM 144

144: Filer Information

Filer CIK	0001791857
Filer CCC	XXXXXXXX
Is this a LIVE or TEST Filing?	LIVE TEST
Submission Contact Information
Name
Phone
E-Mail Address

144: Issuer Information

Name of Issuer	IONIS PHARMACEUTICALS INC
SEC File Number	000-19125
Address of Issuer	2855 GAZELLE COURT CARLSBAD CALIFORNIA 92010
Phone	7609319200
Name of Person for Whose Account the Securities are To Be Sold	Jenne Kyle
See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.
Relationship to Issuer	Officer

144: Securities Information

Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange
Common Stock	Morgan Stanley Smith Barney 1585 Broadway New York NY 10036	4902	369600.09	165192011	04/16/2026	NASDAQ

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *
Common Stock	04/15/2026	RSUs granted under 2011 Equity Incentive Plan	Ionis Pharmaceuticals			4902	04/15/2026	Compensation

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Name and Address of Seller	Title of Securities Sold	Date of Sale	Amount of Securities Sold	Gross Proceeds
Morgan Stanley Smith Barney 1585 Broadway New York NY 10036	Common Stock	01/16/2026	1823	138475.08
Stifel Nicholaus & Company Inc 501 N Broadway St Louis MO 63102	Common Stock	03/10/2026	37277	2827324.68

144: Remarks and Signature

Remarks
Date of Notice	04/16/2026
ATTENTION:
The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.
Signature	Kyle Jenne
ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)