[144] IONIS PHARMACEUTICALS INC SEC Filing

Rhea-AI Filing Summary

Ionis Pharmaceuticals, Inc. filed a Form 144 notice reporting a proposed sale of 6,849 shares of common stock, with an aggregate market value of $472,718, to be executed approximately on 10/06/2025 through Stifel Nicolaus & Company on Nasdaq. The shares were acquired as Restricted Stock Units from the issuer on 01/15/2025 and paid for in cash on the same date. The filer reports total shares outstanding of 159,391,229. The notice also lists three prior sales by the same person, Eric Swayze, totaling 38,244 shares sold on 09/02/2025, 10/01/2025, and 10/02/2025, generating combined gross proceeds of $2,346,609. The signer affirms no undisclosed material adverse information and references Rule 10b5-1 conditions.

Positive

• Planned sale is modest: only 6,849 shares versus 159,391,229 outstanding
• Securities were acquired as RSUs on 01/15/2025, indicating compensation-related origin
• Recent prior sales disclosed (total 38,244 shares), showing transparency in insider transactions

Negative

• Concentrated recent selling: 38,244 shares sold in three transactions generating $2,346,609, which may be viewed as insider liquidity
• No Rule 10b5-1 plan date provided in the notice, leaving uncertainty about pre-planned sale protection

Insights

Insider Compliance Analyst

TL;DR: Reported sales are routine insider liquidity from RSUs and consistent with Rule 144 disclosures.

The filing shows a planned sale of 6,849 shares (acquired as RSUs on 01/15/2025) with an aggregate market value of $472,718, through Stifel on 10/06/2025. The seller also disclosed three recent sales totaling 38,244 shares and $2,346,609 in gross proceeds across 09/02/2025, 10/01/2025, and 10/02/2025.

These items indicate insider liquidity rather than a single large block sale; compliance hinges on whether the trades follow a documented plan like Rule 10b5-1 and on the filer’s representation of no undisclosed material information. Monitor filing dates and any stated plan adoption date for clarity on pre-planned trading protection within the next weeks.

Form 144 Filer Information	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
FORM 144

144: Filer Information

Filer CIK
Filer CCC
Is this a LIVE or TEST Filing?	LIVE TEST
Submission Contact Information
Name
Phone
E-Mail Address

144: Issuer Information

Name of Issuer

SEC File Number

Address of Issuer

Phone

Name of Person for Whose Account the Securities are To Be Sold

See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.

Relationship to Issuer

144: Securities Information

Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange
Common Stock	Stifel Nicolaus & Company Inc 501 N Broadway St. Louis MO 63102	6849	472718.00	159391229	10/06/2025	Nasdaq

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *
Common Stock	01/15/2025	Restricted Stock Units	Issuer			6849	01/15/2025	Cash

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Name and Address of Seller	Title of Securities Sold	Date of Sale	Amount of Securities Sold	Gross Proceeds
Eric Swayze 2855 Gazelle Ct Carlsbad CA 92010	Common Stock	10/02/2025	12972	859082.00
Eric Swayze 2855 Gazelle Ct Carlsbad CA 92010	Common Stock	10/01/2025	14142	934662.00
Eric Swayze 2855 Gazelle Ct Carlsbad CA 92010	Common Stock	09/02/2025	11130	552865.00

144: Remarks and Signature

Remarks

Date of Notice

Date of Plan Adoption or Giving of Instruction, If Relying on Rule 10b5-1

ATTENTION:

The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.

Signature

ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)

FAQ

What does Ionis (IONS) report in this Form 144?

The filing reports a proposed sale of 6,849 shares of common stock (aggregate market value $472,718) to be sold around 10/06/2025 via Stifel Nicolaus on Nasdaq.

How were the shares acquired that are being sold?

The shares were acquired as Restricted Stock Units on 01/15/2025 and the purchase was paid in cash on that date.

Who recently sold shares for the account referenced in the filing?

Eric Swayze sold 11,130, 14,142, and 12,972 shares on 09/02/2025, 10/01/2025, and 10/02/2025, respectively, totaling 38,244 shares and $2,346,609 in gross proceeds.

What fraction of Ionis shares does the proposed sale represent?

The proposed sale of 6,849 shares is a small fraction of the reported 159,391,229 shares outstanding.

Does the filing indicate a Rule 10b5-1 trading plan date?

No specific plan adoption date is provided in the notice; the filer references Rule 10b5-1 conditions but did not state a plan date.