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[8-K] IONIS PHARMACEUTICALS INC Reports Material Event

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8-K
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Ionis Pharmaceuticals (IONS) furnished an 8-K announcing financial results for the quarter ended September 30, 2025. The press release (Exhibit 99.1) presents both GAAP and non-GAAP figures. Non-GAAP results exclude non-cash compensation expense related to equity awards and the related tax effects, which the company says helps users assess and compare performance and project future results and cash flows. The information and exhibit are furnished under Item 2.02 and are not deemed filed under Section 18 of the Exchange Act.

Ionis Pharmaceuticals (IONS) ha inviato un 8-K annunciando i risultati finanziari del trimestre chiuso al 30 settembre 2025. Il comunicato stampa (Allegato 99.1) presenta sia numeri GAAP che non-GAAP. I risultati non-GAAP escludono la retribuzione non monetaria legata agli stock award e gli effetti fiscali correlati, che l'azienda afferma aiutino gli utenti a valutare e confrontare la performance e a proiettare risultati futuri e flussi di cassa. Le informazioni e l'allegato sono forniti ai sensi della voce 2.02 e non sono considerati depositati ai sensi della Sezione 18 dello Exchange Act.

Ionis Pharmaceuticals (IONS) presentó un 8-K anunciando los resultados financieros del trimestre terminado al 30 de septiembre de 2025. El comunicado de prensa (Exhibit 99.1) presenta cifras GAAP y no-GAAP. Los resultados no-GAAP excluyen los gastos de compensación no monetarios relacionados con las recompensas de acciones y los efectos fiscales relacionados, que la compañía afirma ayudar a los usuarios a evaluar y comparar el rendimiento y a proyectar resultados futuros y flujos de efectivo. La información y el anexo se proporcionan conforme al ítem 2.02 y no se consideran presentados conforme a la Sección 18 de la Exchange Act.

Ionis Pharmaceuticals (IONS)가 2025년 9월 30일 종료된 분기의 재무 실적을 발표하는 8-K를 제출했습니다. 보도자료( Exhibit 99.1 )는 GAAP 및 비-GAAP 수치를 모두 제시합니다. 비-GAAP 결과는 주식 보상과 관련된 현금이 아닌 보상 비용 및 관련 세금을 제외하며, 이는 회사가 사용자가 성과를 평가하고 비교하며 향후 결과와 현금 흐름을 예측하는 데 도움이 된다고 설명합니다. 정보와 부록은 항목 2.02에 따라 제출되며 Exchange Act의 섹션 18에 따라 제출된 것으로 간주되지 않습니다.

Ionis Pharmaceuticals (IONS) a déposé un 8-K annonçant les résultats financiers du trimestre clos au 30 septembre 2025. Le communiqué de presse (exhibit 99.1) présente des chiffres GAAP et non-GAAP. Les résultats non-GAAP excluent les frais de compensation non monétaires liés aux attributions d’actions et les effets fiscaux connexes, ce que l’entreprise dit aider les utilisateurs à évaluer et comparer la performance et à prévoir les résultats futurs et les flux de trésorerie. L’information et l’exhibit sont fournies en vertu de l’article 2.02 et ne sont pas considérés comme déposés au titre de la Section 18 du Securities Exchange Act.

Ionis Pharmaceuticals (IONS) hat eine 8-K eingereicht, in der die finanziellen Ergebnisse für das Quartal zum 30. September 2025 bekannt gegeben wurden. Die Pressemitteilung (Anlage 99.1) enthält sowohl GAAP- als auch Non-GAAP-Zahlen. Non-GAAP-Ergebnisse schließen nicht zahlungswirksame Vergütungsaufwendungen im Zusammenhang mit Aktienzuteilungen und die zugehörigen Steuerwirkungen aus, was das Unternehmen so beschreibt, dass es Nutzern hilft, die Leistung zu bewerten und zu vergleichen sowie zukünftige Ergebnisse und Cashflows zu projizieren. Die Informationen und der Anhang werden gemäß Item 2.02 bereitgestellt und gelten nicht als eingereicht gemäß Abschnitt 18 des Exchange Act.

قدمت Ionis Pharmaceuticals (IONS) نموذج 8-K للإعلان عن النتائج المالية للربع المنتهي في 30 سبتمبر 2025. يعرض بيان الصحافة (المرفق 99.1) كلا من أرقام GAAP وغير-GAAP. وتستثني نتائج غير-GAAP مصروفات التعويض غير النقدية المتعلقة بمكافآت الأسهم وآثارها الضريبية المرتبطة بها، والتي تقول الشركة إنها تساعد المستخدمين في تقييم الأداء ومقارنته وتوقع النتائج المستقبلية والتدفقات النقدية. وتُقدَّم المعلومات والمعرض بموجب البند 2.02 وليست مطلقة كـ"مقدّمة" وفقاً للقسم 18 من قانون التبادل.

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Ionis Pharmaceuticals (IONS) ha inviato un 8-K annunciando i risultati finanziari del trimestre chiuso al 30 settembre 2025. Il comunicato stampa (Allegato 99.1) presenta sia numeri GAAP che non-GAAP. I risultati non-GAAP escludono la retribuzione non monetaria legata agli stock award e gli effetti fiscali correlati, che l'azienda afferma aiutino gli utenti a valutare e confrontare la performance e a proiettare risultati futuri e flussi di cassa. Le informazioni e l'allegato sono forniti ai sensi della voce 2.02 e non sono considerati depositati ai sensi della Sezione 18 dello Exchange Act.

Ionis Pharmaceuticals (IONS) presentó un 8-K anunciando los resultados financieros del trimestre terminado al 30 de septiembre de 2025. El comunicado de prensa (Exhibit 99.1) presenta cifras GAAP y no-GAAP. Los resultados no-GAAP excluyen los gastos de compensación no monetarios relacionados con las recompensas de acciones y los efectos fiscales relacionados, que la compañía afirma ayudar a los usuarios a evaluar y comparar el rendimiento y a proyectar resultados futuros y flujos de efectivo. La información y el anexo se proporcionan conforme al ítem 2.02 y no se consideran presentados conforme a la Sección 18 de la Exchange Act.

Ionis Pharmaceuticals (IONS)가 2025년 9월 30일 종료된 분기의 재무 실적을 발표하는 8-K를 제출했습니다. 보도자료( Exhibit 99.1 )는 GAAP 및 비-GAAP 수치를 모두 제시합니다. 비-GAAP 결과는 주식 보상과 관련된 현금이 아닌 보상 비용 및 관련 세금을 제외하며, 이는 회사가 사용자가 성과를 평가하고 비교하며 향후 결과와 현금 흐름을 예측하는 데 도움이 된다고 설명합니다. 정보와 부록은 항목 2.02에 따라 제출되며 Exchange Act의 섹션 18에 따라 제출된 것으로 간주되지 않습니다.

Ionis Pharmaceuticals (IONS) a déposé un 8-K annonçant les résultats financiers du trimestre clos au 30 septembre 2025. Le communiqué de presse (exhibit 99.1) présente des chiffres GAAP et non-GAAP. Les résultats non-GAAP excluent les frais de compensation non monétaires liés aux attributions d’actions et les effets fiscaux connexes, ce que l’entreprise dit aider les utilisateurs à évaluer et comparer la performance et à prévoir les résultats futurs et les flux de trésorerie. L’information et l’exhibit sont fournies en vertu de l’article 2.02 et ne sont pas considérés comme déposés au titre de la Section 18 du Securities Exchange Act.

Ionis Pharmaceuticals (IONS) hat eine 8-K eingereicht, in der die finanziellen Ergebnisse für das Quartal zum 30. September 2025 bekannt gegeben wurden. Die Pressemitteilung (Anlage 99.1) enthält sowohl GAAP- als auch Non-GAAP-Zahlen. Non-GAAP-Ergebnisse schließen nicht zahlungswirksame Vergütungsaufwendungen im Zusammenhang mit Aktienzuteilungen und die zugehörigen Steuerwirkungen aus, was das Unternehmen so beschreibt, dass es Nutzern hilft, die Leistung zu bewerten und zu vergleichen sowie zukünftige Ergebnisse und Cashflows zu projizieren. Die Informationen und der Anhang werden gemäß Item 2.02 bereitgestellt und gelten nicht als eingereicht gemäß Abschnitt 18 des Exchange Act.

قدمت Ionis Pharmaceuticals (IONS) نموذج 8-K للإعلان عن النتائج المالية للربع المنتهي في 30 سبتمبر 2025. يعرض بيان الصحافة (المرفق 99.1) كلا من أرقام GAAP وغير-GAAP. وتستثني نتائج غير-GAAP مصروفات التعويض غير النقدية المتعلقة بمكافآت الأسهم وآثارها الضريبية المرتبطة بها، والتي تقول الشركة إنها تساعد المستخدمين في تقييم الأداء ومقارنته وتوقع النتائج المستقبلية والتدفقات النقدية. وتُقدَّم المعلومات والمعرض بموجب البند 2.02 وليست مطلقة كـ"مقدّمة" وفقاً للقسم 18 من قانون التبادل.

Ionis Pharmaceuticals (IONS) 发布了截至2025年9月30日季度的财务业绩的8-K。 新闻稿(附录 99.1)同时显示 GAAP 与非 GAAP 数字。非 GAAP 结果不包括与股票奖励相关的非现金补偿支出及相关税项,这家公司表示有助于用户评估和比较业绩,并预测未来的业绩和现金流。该信息及附件按第2.02条提供,不被视为根据证券交易法第18条的备案文件。


SECURITIES AND EXCHANGE COMMISSION
Washington, D.C.  20549
 
FORM 8-K
 
CURRENT REPORT
PURSUANT TO SECTION 13 OR 15(d) OF THE
SECURITIES EXCHANGE ACT OF 1934
 
Date of report (Date of earliest event reported):  October 29, 2025
 
IONIS PHARMACEUTICALS, INC.
(Exact Name of Registrant as Specified in Charter)
 
Delaware
(State or Other Jurisdiction of Incorporation)
 
000-19125
 
33-0336973
(Commission File No.)
 
(IRS Employer Identification No.)

2855 Gazelle Court
Carlsbad, CA 92010
(Address of Principal Executive Offices and Zip Code)
 
Registrant’s telephone number, including area code: (760) 931-9200


Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:


Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
 
Securities registered pursuant to Section 12(b) of the Act:

Title of each class
 
Trading symbol
 
Name of each exchange on which registered
Common Stock, $.001 Par Value
 
IONS
 
The Nasdaq Stock Market, LLC

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (Section 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (Section 240.12b-2 of this chapter).
  Emerging growth company               
 
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.   ☐
 


Item 2.02
Results of Operations and Financial Condition.
 
On October 29, 2025, Ionis Pharmaceuticals, Inc. (the “Company”) issued a press release announcing the Company’s financial results for the quarter ended September 30, 2025.  In addition to disclosing results that are determined in accordance with Generally Accepted Accounting Principles (“GAAP”), the Company also discloses pro forma or non-GAAP results of operations, which are adjusted from GAAP to exclude non-cash compensation expense related to equity awards and the related tax effects. The Company is presenting pro forma information excluding non-cash compensation expense and the related tax effects because the Company believes it better enables financial statement users to assess and compare its historical performance and project its future operating results and cash flows.  A copy of the release is furnished with this report as an exhibit pursuant to “Item 2.02. Results of Operations and Financial Condition” of Form 8-K in accordance with SEC Release Nos. 33-8216 and 34-47583.
 
The information in this Current Report on Form 8-K and the Exhibit attached hereto shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934 (the “Exchange Act”) or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933 or the Exchange Act, regardless of any general incorporation language in such filing.
 
Item 9.01.
Financial Statements and Exhibits.
 
(d) Exhibits.
 
Exhibit No.
Description
99.1
Press Release dated October 29, 2025.
   
104
Cover Page Interactive Data File (embedded within the Inline XBRL document).


SIGNATURE
 
Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
 
 
Ionis Pharmaceuticals, Inc.

   
Dated:  October 29, 2025
By:
/s/ Patrick R. O’Neil
 

Patrick R. O’Neil
 

Executive Vice President, Chief Legal Officer and General Counsel



Ionis Pharmaceuticals

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Biotechnology
Pharmaceutical Preparations
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United States
CARLSBAD