[Form 4/A] IONIS PHARMACEUTICALS INC Amended Insider Trading Activity

Rhea-AI Filing Summary

Ionis Pharmaceuticals (IONS) executive Richard S. Geary filed an amended Form 4 to correct share amounts. On 11/03/2025, he exercised stock options for 775 shares at $60.89 and 905 shares at $56.78, then sold 775 and 905 common shares at a $75.054 weighted average price, with trades ranging from $75.00 to $75.25.

Following these transactions, Geary beneficially owned 59,657 common shares directly. The amendment states it corrects the amounts reported in Column 4.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person^*

Geary Richard S

(Last) (First) (Middle)

2855 GAZELLE COURT

(Street)

CARLSBAD CA 92010

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
IONIS PHARMACEUTICALS INC [ IONS ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	EVP, Chief Development Officer

3. Date of Earliest Transaction (Month/Day/Year)
11/03/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)
11/03/2025

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	11/03/2025		M		775(1)	A	$60.89	60,432	D
Common Stock	11/03/2025		S		775(1)	D	$75.054(2)	59,657	D
Common Stock	11/03/2025		M		905(1)	A	$56.78	60,562	D
Common Stock	11/03/2025		S		905(1)	D	$75.054(2)	59,657	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Non-Qualified Stock Option (right to buy)	$56.78	11/03/2025		M			905(1)	01/02/2023	01/03/2028	Common Stock	905	$0.0	15,538	D
Non-Qualified Stock Option (right to buy)	$60.89	11/03/2025		M			775(1)	01/04/2024	01/01/2027	Common Stock	775	$0.0	19,101	D

Explanation of Responses:

1. This amended Form 4 is being filed to correct the amount of shares acquired or disposed of reported in column 4

2. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $75.00 to $75.25 inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4.

	By: Patrick R. O'Neil, attorney-in-fact For: Richard S. Geary	11/07/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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FAQ

What did IONIS EVP Richard S. Geary report on Form 4/A?

An amended Form 4 correcting amounts. On 11/03/2025 he exercised options for 775 and 905 shares and sold the same counts.

At what prices were the IONS option exercises and sales recorded?

Exercises occurred at $60.89 (775 shares) and $56.78 (905 shares). Sales used a $75.054 weighted average, ranging $75.00–$75.25.

How many IONS shares did Richard S. Geary own after the transactions?

He beneficially owned 59,657 common shares directly after the reported transactions.

What was corrected in this IONS Form 4/A filing?

The amendment corrects the amount of shares acquired or disposed of reported in Column 4.

Were the IONS sales executed in multiple trades?

Yes. The price is a weighted average; trades occurred between $75.00 and $75.25 inclusive.

What roles does the reporting person hold at IONS?

Richard S. Geary is EVP, Chief Development Officer at Ionis Pharmaceuticals.