STOCK TITAN

[Form 4] Ionis Pharmaceuticals, Inc. Insider Trading Activity

Filing Impact
(High)
Filing Sentiment
(Very Negative)
Form Type
4
Rhea-AI Filing Summary

Brett P. Monia, Chief Executive Officer and Director of Ionis Pharmaceuticals (IONS), reported multiple transactions on 09/03/2025 that offset each other, resulting in no net change to total common shares held. On that date the reporting person acquired 203,814 shares through exercises and market purchases and sold 203,814 shares under a Rule 10b5-1 trading plan adopted August 13, 2024. The filings show weighted-average sale prices in three ranges: $58.57–$59.55, $59.60–$60.57, and $60.61–$61.48. Following the transactions the reporting person beneficially owned 180,009 common shares. The Form 4 also lists exercises of non-qualified stock options at strike prices of $32.60, $37.58, and $53.77, with resulting increases in underlying common shares reported in Table II.

Brett P. Monia, Amministratore Delegato e Direttore di Ionis Pharmaceuticals (IONS), ha dichiarato il 03/09/2025 una serie di operazioni che si sono compensate tra loro, senza modificare il numero complessivo di azioni ordinarie possedute. In quella data la persona segnalante ha acquisito 203.814 azioni mediante esercizi e acquisti sul mercato e ha venduto 203.814 azioni nell'ambito di un piano di trading ai sensi della Rule 10b5-1 adottato il 13 agosto 2024. I documenti indicano prezzi medi ponderati di vendita in tre fasce: 58,57–59,55 $, 59,60–60,57 $ e 60,61–61,48 $. Dopo le operazioni la persona segnalante deteneva in modo beneficiario 180.009 azioni ordinarie. Il Modulo 4 riporta inoltre l'esercizio di opzioni non qualificate con prezzi di esercizio di 32,60 $, 37,58 $ e 53,77 $, con conseguenti aumenti delle azioni sottostanti riportati nella Tabella II.

Brett P. Monia, Director Ejecutivo y miembro del consejo de Ionis Pharmaceuticals (IONS), informó el 03/09/2025 sobre múltiples transacciones que se compensaron entre sí, sin producir un cambio neto en el número total de acciones ordinarias en su posesión. Ese día la persona informante adquirió 203.814 acciones mediante ejercicios y compras en el mercado y vendió 203.814 acciones conforme a un plan de negociación Rule 10b5-1 adoptado el 13 de agosto de 2024. Los registros muestran precios de venta promedio ponderados en tres rangos: 58,57–59,55 $, 59,60–60,57 $ y 60,61–61,48 $. Tras las operaciones, la persona informante poseía de forma beneficiaria 180.009 acciones ordinarias. El Formulario 4 también detalla ejercicios de opciones sobre acciones no calificadas con precios de ejercicio de 32,60 $, 37,58 $ y 53,77 $, con los aumentos correspondientes en las acciones subyacentes consignados en la Tabla II.

Ionis Pharmaceuticals(IONS)의 최고경영자 겸 이사인 Brett P. Monia는 2025년 9월 3일 여러 건의 거래를 보고했으며, 이 거래들은 서로 상쇄되어 보유한 보통주 총수에는 순변동이 없었습니다. 해당 일자에 보고자는 옵션 행사 및 시장 매수를 통해 203,814주를 취득했고, 2024년 8월 13일 채택된 Rule 10b5-1 거래계획에 따라 203,814주를 매도했습니다. 제출 서류에는 가중평균 매도 가격이 세 구간으로 표시되어 있습니다: $58.57–$59.55, $59.60–$60.57, 및 $60.61–$61.48. 거래 이후 보고자는 180,009주의 보통주를 실질적으로 보유하고 있었습니다. Form 4에는 또한 행사가격이 $32.60, $37.58, 및 $53.77인 비자격 스톡옵션 행사 내용이 기재되어 있으며, 그에 따른 기초 보통주 수의 증가가 표 II에 보고되어 있습니다.

Brett P. Monia, directeur général et administrateur d'Ionis Pharmaceuticals (IONS), a déclaré le 03/09/2025 plusieurs opérations qui se sont compensées, sans entraîner de variation nette du nombre total d'actions ordinaires détenues. À cette date, la personne débitrice a acquis 203 814 actions par des exercices et des achats sur le marché et a vendu 203 814 actions dans le cadre d'un plan de transaction Rule 10b5-1 adopté le 13 août 2024. Les documents indiquent des prix de vente moyens pondérés dans trois fourchettes : 58,57–59,55 $, 59,60–60,57 $ et 60,61–61,48 $. À l'issue des opérations, la personne déclarante détenait à titre bénéficiaire 180 009 actions ordinaires. Le formulaire 4 mentionne également des exercices d'options non qualifiées avec des prix d'exercice de 32,60 $, 37,58 $ et 53,77 $, entraînant des augmentations des actions sous-jacentes consignées dans le tableau II.

Brett P. Monia, Chief Executive Officer und Direktor von Ionis Pharmaceuticals (IONS), meldete am 03.09.2025 mehrere Transaktionen, die sich gegenseitig aufhoben und zu keiner Nettoveränderung der insgesamt gehaltenen Stammaktien führten. An diesem Tag erwarb die meldepflichtige Person 203.814 Aktien durch Ausübungen und Käufe am Markt und verkaufte 203.814 Aktien im Rahmen eines Rule‑10b5‑1‑Tradingplans, der am 13. August 2024 eingeführt wurde. Die Unterlagen führen gewichtete Durchschnittsverkaufspreise in drei Bereichen auf: $58,57–$59,55, $59,60–$60,57 und $60,61–$61,48. Nach den Transaktionen hielt die meldepflichtige Person wirtschaftlich 180.009 Stammaktien. In Formular 4 sind zudem die Ausübungen nicht qualifizierter Aktienoptionen zu Ausübungspreisen von $32,60, $37,58 und $53,77 aufgeführt, mit den daraus resultierenden Erhöhungen der zugrundeliegenden Stammaktien in Tabelle II.

Positive
  • Acquisitions and option exercises totaling 203,814 shares increased immediate liquidity from exercised options
  • Sales executed under a Rule 10b5-1 trading plan, indicating pre-planned compliance with insider trading rules
  • Detailed footnotes disclose weighted-average price ranges and offer to provide per-price breakdowns on request
Negative
  • Substantial gross sales of 203,814 shares on a single date, which may be viewed as significant insider liquidity
  • Beneficial ownership decreased to 180,009 shares after the transactions, reflecting a lower reported holding

Insights

Insider executed option exercises and matched sales under a 10b5-1 plan; net share position unchanged.

The Form 4 shows coordinated option exercises and open-market sales totaling 203,814 shares on 09/03/2025. Sales were executed under a pre-established Rule 10b5-1 plan, with weighted-average prices spanning about $58.57 to $61.48. Exercises occurred at strike prices between $32.60 and $53.77, converting options into common shares. The activity appears liquidity-driven rather than a directional change in ownership: the total acquired equals total sold and the post-transaction beneficial ownership is reported as 180,009 shares.

Transactions comply with a 10b5-1 plan and reflect routine insider liquidity and option exercises.

The disclosure specifically notes a Rule 10b5-1 trading plan adopted August 13, 2024, and provides weighted-average sale price ranges with an undertaking to disclose per-price details on request. Multiple option exercises are disclosed with grant/exercise dates and expiration dates, and Table II reconciles options converted into common shares. Documentation and footnotes are consistent with transparent insider reporting practices, with no unexplained transfers or indirect holdings reported.

Brett P. Monia, Amministratore Delegato e Direttore di Ionis Pharmaceuticals (IONS), ha dichiarato il 03/09/2025 una serie di operazioni che si sono compensate tra loro, senza modificare il numero complessivo di azioni ordinarie possedute. In quella data la persona segnalante ha acquisito 203.814 azioni mediante esercizi e acquisti sul mercato e ha venduto 203.814 azioni nell'ambito di un piano di trading ai sensi della Rule 10b5-1 adottato il 13 agosto 2024. I documenti indicano prezzi medi ponderati di vendita in tre fasce: 58,57–59,55 $, 59,60–60,57 $ e 60,61–61,48 $. Dopo le operazioni la persona segnalante deteneva in modo beneficiario 180.009 azioni ordinarie. Il Modulo 4 riporta inoltre l'esercizio di opzioni non qualificate con prezzi di esercizio di 32,60 $, 37,58 $ e 53,77 $, con conseguenti aumenti delle azioni sottostanti riportati nella Tabella II.

Brett P. Monia, Director Ejecutivo y miembro del consejo de Ionis Pharmaceuticals (IONS), informó el 03/09/2025 sobre múltiples transacciones que se compensaron entre sí, sin producir un cambio neto en el número total de acciones ordinarias en su posesión. Ese día la persona informante adquirió 203.814 acciones mediante ejercicios y compras en el mercado y vendió 203.814 acciones conforme a un plan de negociación Rule 10b5-1 adoptado el 13 de agosto de 2024. Los registros muestran precios de venta promedio ponderados en tres rangos: 58,57–59,55 $, 59,60–60,57 $ y 60,61–61,48 $. Tras las operaciones, la persona informante poseía de forma beneficiaria 180.009 acciones ordinarias. El Formulario 4 también detalla ejercicios de opciones sobre acciones no calificadas con precios de ejercicio de 32,60 $, 37,58 $ y 53,77 $, con los aumentos correspondientes en las acciones subyacentes consignados en la Tabla II.

Ionis Pharmaceuticals(IONS)의 최고경영자 겸 이사인 Brett P. Monia는 2025년 9월 3일 여러 건의 거래를 보고했으며, 이 거래들은 서로 상쇄되어 보유한 보통주 총수에는 순변동이 없었습니다. 해당 일자에 보고자는 옵션 행사 및 시장 매수를 통해 203,814주를 취득했고, 2024년 8월 13일 채택된 Rule 10b5-1 거래계획에 따라 203,814주를 매도했습니다. 제출 서류에는 가중평균 매도 가격이 세 구간으로 표시되어 있습니다: $58.57–$59.55, $59.60–$60.57, 및 $60.61–$61.48. 거래 이후 보고자는 180,009주의 보통주를 실질적으로 보유하고 있었습니다. Form 4에는 또한 행사가격이 $32.60, $37.58, 및 $53.77인 비자격 스톡옵션 행사 내용이 기재되어 있으며, 그에 따른 기초 보통주 수의 증가가 표 II에 보고되어 있습니다.

Brett P. Monia, directeur général et administrateur d'Ionis Pharmaceuticals (IONS), a déclaré le 03/09/2025 plusieurs opérations qui se sont compensées, sans entraîner de variation nette du nombre total d'actions ordinaires détenues. À cette date, la personne débitrice a acquis 203 814 actions par des exercices et des achats sur le marché et a vendu 203 814 actions dans le cadre d'un plan de transaction Rule 10b5-1 adopté le 13 août 2024. Les documents indiquent des prix de vente moyens pondérés dans trois fourchettes : 58,57–59,55 $, 59,60–60,57 $ et 60,61–61,48 $. À l'issue des opérations, la personne déclarante détenait à titre bénéficiaire 180 009 actions ordinaires. Le formulaire 4 mentionne également des exercices d'options non qualifiées avec des prix d'exercice de 32,60 $, 37,58 $ et 53,77 $, entraînant des augmentations des actions sous-jacentes consignées dans le tableau II.

Brett P. Monia, Chief Executive Officer und Direktor von Ionis Pharmaceuticals (IONS), meldete am 03.09.2025 mehrere Transaktionen, die sich gegenseitig aufhoben und zu keiner Nettoveränderung der insgesamt gehaltenen Stammaktien führten. An diesem Tag erwarb die meldepflichtige Person 203.814 Aktien durch Ausübungen und Käufe am Markt und verkaufte 203.814 Aktien im Rahmen eines Rule‑10b5‑1‑Tradingplans, der am 13. August 2024 eingeführt wurde. Die Unterlagen führen gewichtete Durchschnittsverkaufspreise in drei Bereichen auf: $58,57–$59,55, $59,60–$60,57 und $60,61–$61,48. Nach den Transaktionen hielt die meldepflichtige Person wirtschaftlich 180.009 Stammaktien. In Formular 4 sind zudem die Ausübungen nicht qualifizierter Aktienoptionen zu Ausübungspreisen von $32,60, $37,58 und $53,77 aufgeführt, mit den daraus resultierenden Erhöhungen der zugrundeliegenden Stammaktien in Tabelle II.

SEC Form 4
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Estimated average burden
hours per response: 0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Monia Brett P

(Last) (First) (Middle)
2855 GAZELLE COURT

(Street)
CARLSBAD CA 92010

(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
IONIS PHARMACEUTICALS INC [ IONS ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
X Director 10% Owner
X Officer (give title below) Other (specify below)
Chief Executive Officer
3. Date of Earliest Transaction (Month/Day/Year)
09/03/2025
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 09/03/2025 M 102,900 A $53.77 282,909 D
Common Stock 09/03/2025 S 16,615(1) D $59.119(2) 266,294 D
Common Stock 09/03/2025 M 42,030 A $37.58 308,324 D
Common Stock 09/03/2025 S 127,500(1) D $60.1337(3) 180,824 D
Common Stock 09/03/2025 M 31,316 A $32.6 212,140 D
Common Stock 09/03/2025 M 27,568 A $32.6 239,708 D
Common Stock 09/03/2025 S 59,699(1) D $61.0629(4) 180,009 D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Non-Qualified Stock Option (right to buy) $32.6 09/03/2025 M 31,316 01/03/2023 01/02/2032 Common Stock 31,316 $0.0 67,741 D
Non-Qualified Stock Option (right to buy) $32.6 09/03/2025 M 27,568 01/03/2023 01/02/2032 Common Stock 27,568 $0.0 40,173 D
Non-Qualified Stock Option (right to buy) $37.58 09/03/2025 M 42,030 01/03/2024 01/02/2033 Common Stock 42,030 $0.0 76,643 D
Non-Qualified Stock Option (right to buy) $53.77 09/03/2025 M 102,900 01/02/2020 01/01/2026 Common Stock 102,900 $0.0 0 D
Explanation of Responses:
1. Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 13, 2024.
2. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $58.57 to $59.55 inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.
3. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $59.60 to $60.57 inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4.
4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $60.61 to $61.48 inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (4) on this Form 4.
By: Patrick R. O'Neil, attorney-in-fact For: Brett P. Monia 09/04/2025
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What insider transactions did Ionis (IONS) CEO Brett Monia report on 09/03/2025?

The Form 4 reports that Brett Monia acquired 203,814 shares (including option exercises) and sold 203,814 shares on 09/03/2025, resulting in a reported beneficial ownership of 180,009 shares.

Were the sales by Brett Monia executed under a 10b5-1 plan?

Yes. Footnote 1 states the shares were sold pursuant to a Rule 10b5-1 Trading Plan adopted August 13, 2024.

What price ranges were reported for the sales on the Form 4?

The sales were disclosed as weighted-average prices in three ranges: $58.57–$59.55, $59.60–$60.57, and $60.61–$61.48.

What option exercises are disclosed in the filing?

Table II shows non-qualified stock option exercises converting options into 31,316; 27,568; 42,030; and 102,900 common shares at strike prices of $32.60, $32.60, $37.58, and $53.77, respectively.

Does the Form 4 indicate any indirect beneficial ownership?

All ownership shown in the filing is reported as Direct (D); no indirect beneficial ownership forms are indicated.
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