STOCK TITAN

[Form 4] Ionis Pharmaceuticals, Inc. Insider Trading Activity

Filing Impact
(Neutral)
Filing Sentiment
(Negative)
Form Type
4
Rhea-AI Filing Summary

Ionis Pharmaceuticals (IONS) filed a Form 4 stating that EVP & Chief Clinical Development Officer Eugene Schneider sold 9,549 common shares on 08/04/2025 pursuant to a pre-arranged Rule 10b5-1 trading plan adopted 05/02/2025. The weighted-average sale price was $42.8004, with individual trades executed between $42.315 and $43.45. Gross proceeds are roughly $0.41 million.

Following the disposition, Schneider directly owns 51,507 shares; the sale reduced his direct stake by approximately 15.6 % (from 61,056 shares). No derivative securities were involved. The filing is a routine Section 16 disclosure and does not affect the company’s operations or guidance.

Ionis Pharmaceuticals (IONS) ha presentato un Modulo 4 dichiarando che il EVP e Chief Clinical Development Officer Eugene Schneider ha venduto 9.549 azioni ordinarie il 08/04/2025 in base a un piano di trading Rule 10b5-1 predefinito adottato il 02/05/2025. Il prezzo medio ponderato di vendita è stato di 42,8004 $, con singole operazioni eseguite tra 42,315 $ e 43,45 $. I proventi lordi ammontano a circa 0,41 milioni di dollari.

Dopo la vendita, Schneider detiene direttamente 51.507 azioni; la cessione ha ridotto la sua partecipazione diretta di circa il 15,6 % (da 61.056 azioni). Non sono stati coinvolti strumenti derivati. La comunicazione è una normale dichiarazione ai sensi della Sezione 16 e non influisce sulle operazioni o sulle previsioni della società.

Ionis Pharmaceuticals (IONS) presentó un Formulario 4 indicando que el EVP y Director de Desarrollo Clínico Eugene Schneider vendió 9,549 acciones ordinarias el 08/04/2025 conforme a un plan de negociación Rule 10b5-1 preestablecido adoptado el 02/05/2025. El precio promedio ponderado de venta fue de $42.8004, con operaciones individuales ejecutadas entre $42.315 y $43.45. Los ingresos brutos ascienden a aproximadamente $0.41 millones.

Tras la venta, Schneider posee directamente 51,507 acciones; la venta redujo su participación directa en aproximadamente 15.6 % (de 61,056 acciones). No se involucraron valores derivados. La presentación es una divulgación rutinaria bajo la Sección 16 y no afecta las operaciones ni las previsiones de la empresa.

Ionis Pharmaceuticals(IONS)는 EVP 겸 최고 임상 개발 책임자 Eugene Schneider2025년 8월 4일에 사전에 설정된 Rule 10b5-1 거래 계획에 따라 9,549주 보통주를 매도했다고 Form 4를 제출했습니다. 해당 거래 계획은 2025년 5월 2일에 채택되었습니다. 가중 평균 매도 가격은 $42.8004였으며, 개별 거래 가격은 $42.315에서 $43.45 사이였습니다. 총 매출은 약 41만 달러입니다.

매도 후 Schneider는 직접 51,507주를 보유하게 되었으며, 이번 매도로 그의 직접 지분은 약 15.6% (61,056주에서 감소) 줄었습니다. 파생 증권은 포함되지 않았습니다. 이번 제출은 섹션 16에 따른 정기 공시로 회사의 운영이나 가이던스에는 영향을 미치지 않습니다.

Ionis Pharmaceuticals (IONS) a déposé un formulaire 4 indiquant que le EVP et directeur principal du développement clinique Eugene Schneider a vendu 9 549 actions ordinaires le 08/04/2025 conformément à un plan de trading Rule 10b5-1 préétabli adopté le 02/05/2025. Le prix moyen pondéré de vente était de 42,8004 $, avec des transactions individuelles entre 42,315 $ et 43,45 $. Le produit brut s'élève à environ 0,41 million de dollars.

Après cette cession, Schneider détient directement 51 507 actions ; la vente a réduit sa participation directe d'environ 15,6 % (contre 61 056 actions). Aucun titre dérivé n'a été impliqué. Le dépôt constitue une divulgation routinière en vertu de la Section 16 et n'affecte ni les opérations ni les prévisions de la société.

Ionis Pharmaceuticals (IONS) reichte ein Formular 4 ein, in dem angegeben wurde, dass EVP und Chief Clinical Development Officer Eugene Schneider am 08.04.2025 9.549 Stammaktien im Rahmen eines vorab vereinbarten Rule 10b5-1 Handelsplans verkauft hat, der am 02.05.2025 angenommen wurde. Der gewichtete Durchschnittspreis lag bei 42,8004 $, mit Einzeltransaktionen zwischen 42,315 $ und 43,45 $. Der Bruttoerlös beträgt etwa 0,41 Millionen Dollar.

Nach dem Verkauf besitzt Schneider direkt 51.507 Aktien; der Verkauf verringerte seinen direkten Anteil um etwa 15,6 % (von 61.056 Aktien). Es wurden keine derivativen Wertpapiere einbezogen. Die Meldung ist eine routinemäßige Offenlegung gemäß Abschnitt 16 und hat keine Auswirkungen auf die Geschäftstätigkeit oder Prognosen des Unternehmens.

Positive
  • Sale executed under a pre-scheduled Rule 10b5-1 plan, demonstrating adherence to SEC insider-trading safeguards and governance best practices.
Negative
  • Executive reduced direct holdings by ~15.6 %, which some investors may interpret as a mildly bearish sentiment signal.

Insights

TL;DR: Routine 10b5-1 insider sale; modest size, limited valuation impact.

The transaction equals roughly 0.04 % of Ionis’ 2024 year-end basic share count (~125 m) and 15 % of the insider’s personal holdings, so market impact should be minimal. Because it was executed under a 10b5-1 plan, motive is likely portfolio diversification rather than a signal on fundamentals. Investors may watch subsequent filings to see if sales become a pattern, but one isolated sale does not alter intrinsic value or forward cash-flow assumptions.

TL;DR: Sale complies with governance best practices; no red flags.

Use of an advance-adopted 10b5-1 plan, full price ranges, and attorney-in-fact signature indicate adherence to SEC guidance. The executive maintains a sizeable residual stake (>50 k shares), aligning interests with shareholders. There is no evidence of opportunistic trading ahead of material events. I view the filing as transparent and governance-neutral.

Ionis Pharmaceuticals (IONS) ha presentato un Modulo 4 dichiarando che il EVP e Chief Clinical Development Officer Eugene Schneider ha venduto 9.549 azioni ordinarie il 08/04/2025 in base a un piano di trading Rule 10b5-1 predefinito adottato il 02/05/2025. Il prezzo medio ponderato di vendita è stato di 42,8004 $, con singole operazioni eseguite tra 42,315 $ e 43,45 $. I proventi lordi ammontano a circa 0,41 milioni di dollari.

Dopo la vendita, Schneider detiene direttamente 51.507 azioni; la cessione ha ridotto la sua partecipazione diretta di circa il 15,6 % (da 61.056 azioni). Non sono stati coinvolti strumenti derivati. La comunicazione è una normale dichiarazione ai sensi della Sezione 16 e non influisce sulle operazioni o sulle previsioni della società.

Ionis Pharmaceuticals (IONS) presentó un Formulario 4 indicando que el EVP y Director de Desarrollo Clínico Eugene Schneider vendió 9,549 acciones ordinarias el 08/04/2025 conforme a un plan de negociación Rule 10b5-1 preestablecido adoptado el 02/05/2025. El precio promedio ponderado de venta fue de $42.8004, con operaciones individuales ejecutadas entre $42.315 y $43.45. Los ingresos brutos ascienden a aproximadamente $0.41 millones.

Tras la venta, Schneider posee directamente 51,507 acciones; la venta redujo su participación directa en aproximadamente 15.6 % (de 61,056 acciones). No se involucraron valores derivados. La presentación es una divulgación rutinaria bajo la Sección 16 y no afecta las operaciones ni las previsiones de la empresa.

Ionis Pharmaceuticals(IONS)는 EVP 겸 최고 임상 개발 책임자 Eugene Schneider2025년 8월 4일에 사전에 설정된 Rule 10b5-1 거래 계획에 따라 9,549주 보통주를 매도했다고 Form 4를 제출했습니다. 해당 거래 계획은 2025년 5월 2일에 채택되었습니다. 가중 평균 매도 가격은 $42.8004였으며, 개별 거래 가격은 $42.315에서 $43.45 사이였습니다. 총 매출은 약 41만 달러입니다.

매도 후 Schneider는 직접 51,507주를 보유하게 되었으며, 이번 매도로 그의 직접 지분은 약 15.6% (61,056주에서 감소) 줄었습니다. 파생 증권은 포함되지 않았습니다. 이번 제출은 섹션 16에 따른 정기 공시로 회사의 운영이나 가이던스에는 영향을 미치지 않습니다.

Ionis Pharmaceuticals (IONS) a déposé un formulaire 4 indiquant que le EVP et directeur principal du développement clinique Eugene Schneider a vendu 9 549 actions ordinaires le 08/04/2025 conformément à un plan de trading Rule 10b5-1 préétabli adopté le 02/05/2025. Le prix moyen pondéré de vente était de 42,8004 $, avec des transactions individuelles entre 42,315 $ et 43,45 $. Le produit brut s'élève à environ 0,41 million de dollars.

Après cette cession, Schneider détient directement 51 507 actions ; la vente a réduit sa participation directe d'environ 15,6 % (contre 61 056 actions). Aucun titre dérivé n'a été impliqué. Le dépôt constitue une divulgation routinière en vertu de la Section 16 et n'affecte ni les opérations ni les prévisions de la société.

Ionis Pharmaceuticals (IONS) reichte ein Formular 4 ein, in dem angegeben wurde, dass EVP und Chief Clinical Development Officer Eugene Schneider am 08.04.2025 9.549 Stammaktien im Rahmen eines vorab vereinbarten Rule 10b5-1 Handelsplans verkauft hat, der am 02.05.2025 angenommen wurde. Der gewichtete Durchschnittspreis lag bei 42,8004 $, mit Einzeltransaktionen zwischen 42,315 $ und 43,45 $. Der Bruttoerlös beträgt etwa 0,41 Millionen Dollar.

Nach dem Verkauf besitzt Schneider direkt 51.507 Aktien; der Verkauf verringerte seinen direkten Anteil um etwa 15,6 % (von 61.056 Aktien). Es wurden keine derivativen Wertpapiere einbezogen. Die Meldung ist eine routinemäßige Offenlegung gemäß Abschnitt 16 und hat keine Auswirkungen auf die Geschäftstätigkeit oder Prognosen des Unternehmens.

SEC Form 4
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Estimated average burden
hours per response: 0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Schneider Eugene

(Last) (First) (Middle)
2855 GAZELLE COURT

(Street)
CARLSBAD CA 92010

(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
IONIS PHARMACEUTICALS INC [ IONS ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director 10% Owner
X Officer (give title below) Other (specify below)
EVP, Chf Clinical Develop Ofcr
3. Date of Earliest Transaction (Month/Day/Year)
08/04/2025
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 08/04/2025 S 9,549(1) D $42.8004(2) 51,507 D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Explanation of Responses:
1. Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on May 2, 2025.
2. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $42.315 to $43.45 inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.
By: Patrick R. O'Neil, attorney-in-fact For: Eugene Schneider 08/05/2025
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

How many Ionis (IONS) shares did EVP Eugene Schneider sell?

9,549 common shares were sold on 08/04/2025.

What was the average price of the shares sold by Schneider?

The weighted-average price was $42.8004 per share, with trades between $42.315 and $43.45.

How many Ionis shares does Schneider still own after the sale?

He directly owns 51,507 shares following the transaction.

Was the sale part of a Rule 10b5-1 plan?

Yes. The plan was adopted on May 2, 2025 and covers the disclosed trades.

Does this Form 4 filing involve any derivative securities?

No. The table for derivative securities shows no activity reported in this filing.
Ionis Pharmaceuticals

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6.86B
155.53M
0.82%
107.99%
8.1%
Biotechnology
Pharmaceutical Preparations
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United States
CARLSBAD