Ionis director sells 16,000 shares at $75.1043 via 10b5-1

Ionis Pharmaceuticals (IONS): Director transaction reported.

Rhea-AI Filing Summary

Ionis Pharmaceuticals (IONS): Director transaction reported. On 10/31/2025, director Joseph Loscalzo exercised a non-qualified stock option for 16,000 shares at an exercise price of $52.22 per share and sold 16,000 shares the same day. The reported sale price was a weighted average of $75.1043, with individual trades executed between $75.00 and $75.47.

The option originated from a grant exercisable since 07/03/2018 and expiring on 07/02/2027, and the director reported 0 derivative securities remaining afterward. Following these transactions, direct beneficial ownership was 36,330 shares. The sale was made pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2024.

Insider Trade Summary

Exercise and Sale: 16,000 shares ($366K approx. pre-tax spread)

Exercise and Sale 3 txns

Insider LOSCALZO JOSEPH

Role Director

Sold 16,000 shs ($1.20M)

Approx. gross sale proceeds $1.20M

Approx. exercise cost $836K

Approx. pre-tax spread $366K

Type	Security	Shares	Price	Value
Exercise	Non-Qualified Stock Option (right to buy)	16,000	$0.00	$0.00
Exercise	Common Stock	16,000	$52.22	$836K
Sale	Common Stock	16,000	$75.1043	$1.20M

Holdings After Transaction: Non-Qualified Stock Option (right to buy) — 0 contracts (Direct); Common Stock — 36,330 shares (Direct)

Footnotes (2)

1. F1. Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 13, 2024.
2. F2. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $75.00 to $75.47 inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

Who filed the Form 4 for IONS and what is their role?

Director Joseph Loscalzo reported the transactions for Ionis Pharmaceuticals.

What shares did IONSs director sell and at what price?

He sold 16,000 shares at a $75.1043 weighted average, with trades from $75.00 to $75.47.

What options did the IONS director exercise?

He exercised a non-qualified stock option for 16,000 shares at an exercise price of $52.22.

How many IONS shares does the director own after the transactions?

Following the transactions, he directly beneficially owned 36,330 shares.

Was the IONS share sale under a Rule 10b5-1 plan?

Yes. The sale was made pursuant to a Rule 10b5-1 plan adopted on August 13, 2024.

When were the option and its expiration for the IONS director?

The option was exercisable since 07/03/2018 and expires on 07/02/2027.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Accepted by SEC EDGAR 11/03/2025 - 08:14 PM Learn about SEC filing dates

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

X

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

LOSCALZO JOSEPH

(Last) (First) (Middle)

2855 GAZELLE COURT

(Street)

CARLSBAD CA 92010

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
IONIS PHARMACEUTICALS INC [ IONS ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

3. Date of Earliest Transaction (Month/Day/Year)
10/31/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	10/31/2025		M		16,000	A	$52.22	52,330	D
Common Stock	10/31/2025		S		16,000(1)	D	$75.1043(2)	36,330	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Non-Qualified Stock Option (right to buy)	$52.22	10/31/2025		M			16,000	07/03/2018	07/02/2027	Common Stock	16,000	$0.0	0	D

Explanation of Responses:

1. Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 13, 2024.

2. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $75.00 to $75.47 inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.

	By: Patrick R. O'Neil, attorney-in-fact For: Joseph Loscalzo	11/03/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.