STOCK TITAN

[Form 4] Ionis Pharmaceuticals, Inc. Insider Trading Activity

Filing Impact
(High)
Filing Sentiment
(Negative)
Form Type
4
Rhea-AI Filing Summary

Joseph T. Baroldi, Executive Vice President and Chief Business Officer of Ionis Pharmaceuticals (IONS), reported multiple transactions dated 09/03/2025. The filing shows purchases/issuances of non-qualified stock options with a $31.80 exercise price totaling 32,800 options (three grants/exercises of 2,800, 15,000 and 15,000) that underlie common stock. On the same date the reporting person sold 32,800 common shares in multiple transactions at weighted average prices of $62.0101 and $59.0864 as noted. The Form 4 states the sales were made pursuant to a Rule 10b5-1 trading plan adopted May 2, 2025. Following the reported transactions, the filing lists various beneficial ownership totals and discloses 3,071 shares indirectly owned by spouse.

Joseph T. Baroldi, Vicepresidente Esecutivo e Chief Business Officer di Ionis Pharmaceuticals (IONS), ha comunicato più operazioni datate 03/09/2025. La segnalazione indica l'acquisto/concessione di opzioni su azioni non qualificate con prezzo di esercizio pari a $31,80 per un totale di 32.800 opzioni (tre assegnazioni/esercizi di 2.800, 15.000 e 15.000) sottostanti azioni ordinarie. Nello stesso giorno la persona segnalante ha venduto 32.800 azioni ordinarie in più operazioni a prezzi medi ponderati di $62,0101 e $59,0864, come indicato. Il modulo Form 4 specifica che le vendite sono state effettuate ai sensi di un piano di trading Rule 10b5-1 adottato il 2 maggio 2025. A seguito delle operazioni riportate, la documentazione elenca vari totali di titolarità beneficiaria e dichiara la presenza di 3.071 azioni possedute indirettamente dal coniuge.

Joseph T. Baroldi, Vicepresidente Ejecutivo y Chief Business Officer de Ionis Pharmaceuticals (IONS), informó múltiples transacciones con fecha 03/09/2025. La presentación muestra compras/concesiones de opciones sobre acciones no calificadas con precio de ejercicio de $31.80 por un total de 32.800 opciones (tres concesiones/ejercicios de 2.800, 15.000 y 15.000) subyacentes a acciones ordinarias. Ese mismo día, la persona informante vendió 32.800 acciones ordinarias en varias operaciones a precios promedio ponderados de $62.0101 y $59.0864, según consta. El Formulario 4 indica que las ventas se realizaron en virtud de un plan de negociación Rule 10b5-1 adoptado el 2 de mayo de 2025. Tras las operaciones reportadas, la presentación enumera distintos totales de propiedad beneficiaria y declara 3.071 acciones poseídas indirectamente por el cónyuge.

Joseph T. Baroldi, Ionis Pharmaceuticals(IONS)의 수석부사장 겸 최고사업책임자는 2025-09-03자 다수의 거래를 신고했습니다. 제출서류에는 행사가 $31.80인 비자격 스톡옵션 총 32,800주(2,800주, 15,000주, 15,000주의 세 건 부여/행사)가 보통주에 대한 기초자산으로 기재되어 있습니다. 같은 날 해당 보고인은 여러 거래에서 가중평균가 $62.0101$59.086432,800주 보통주를 매도했습니다. Form 4에는 이 매도가 2025년 5월 2일 채택된 Rule 10b5-1 거래계획에 따라 이루어졌다고 명시되어 있습니다. 보고된 거래 이후 제출서류는 다양한 실질적 보유 총액을 기재하고 배우자에 의해 간접 소유된 3,071주를 공개하고 있습니다.

Joseph T. Baroldi, Vice-président exécutif et Chief Business Officer d'Ionis Pharmaceuticals (IONS), a déclaré plusieurs opérations datées du 03/09/2025. Le dépôt indique des achats/attributions d'options d'achat d'actions non qualifiées avec un prix d'exercice de 31,80 $ pour un total de 32 800 options (trois attributions/exercices de 2 800, 15 000 et 15 000) portant sur des actions ordinaires. Le même jour, la personne déclarante a vendu 32 800 actions ordinaires lors de plusieurs transactions à des prix moyens pondérés de 62,0101 $ et 59,0864 $, comme indiqué. Le formulaire 4 précise que les ventes ont été effectuées en vertu d'un plan de négociation Rule 10b5-1 adopté le 2 mai 2025. À la suite des opérations déclarées, le dépôt énumère différents totaux de détention bénéficiaire et révèle 3 071 actions détenues indirectement par le conjoint.

Joseph T. Baroldi, Executive Vice President und Chief Business Officer von Ionis Pharmaceuticals (IONS), meldete mehrere Transaktionen datiert 03.09.2025. Die Einreichung zeigt Käufe/Gewährungen nicht qualifizierter Aktienoptionen mit einem Ausübungspreis von $31,80 in Höhe von insgesamt 32.800 Optionen (drei Zuteilungen/Ausübungen zu 2.800, 15.000 und 15.000), die zugrunde liegenden Stammaktien entsprechen. Am selben Tag verkaufte die meldende Person 32.800 Stammaktien in mehreren Transaktionen zu gewichteten Durchschnittspreisen von $62,0101 und $59,0864, wie angegeben. Das Formblatt 4 gibt an, dass die Verkäufe gemäß einem Rule-10b5-1-Handelsplan, der am 2. Mai 2025 angenommen wurde, erfolgt sind. Nach den gemeldeten Transaktionen listet die Einreichung verschiedene Summen der wirtschaftlichen Eigentümerschaft auf und offenbart 3.071 Aktien, die indirekt vom Ehepartner gehalten werden.

Positive
  • Disclosure compliance: The Form 4 provides detailed transaction codes, quantities, weighted-average prices, and 10b5-1 plan disclosure
  • 10b5-1 plan stated: Sales were executed under a written trading plan adopted May 2, 2025, which supports an affirmative defense under Rule 10b5-1
  • Options reported with exercise price: Non-qualified stock options are listed with a clear $31.80 exercise price and exercisability/expiration dates
Negative
  • Substantial insider sales: The reporting person sold a total of 32,800 common shares on 09/03/2025, which is potentially material to investors monitoring insider selling
  • Concentrated same-day activity: Multiple large transactions occurred on a single date, which may draw investor attention despite plan disclosure

Insights

TL;DR: Insider executed sizable option-related acquisitions and matched sales on one day via a 10b5-1 plan, producing no clear one-way signal.

The Form 4 documents concurrent option acquisitions/issuances at a $31.80 exercise price and sales of an equal aggregate number of common shares on 09/03/2025. Sales were executed under a Rule 10b5-1 plan adopted May 2, 2025, with weighted average sale prices reported at $62.0101 and $59.0864. From an analytical viewpoint, contemporaneous option activity and plan-based sales are often routine compensation and liquidity management actions rather than firm-specific revelations. The filing provides explicit prices, quantities, and the plan disclosure, allowing verification without inference.

TL;DR: Disclosure follows Section 16 requirements and includes a 10b5-1 plan statement, supporting compliance and transparency.

The report identifies Joseph T. Baroldi as an officer and provides transaction codes, quantities, exercise prices, and the 10b5-1 plan adoption date. The presence of the trading-plan checkbox and detailed weighted-average price footnotes indicates adherence to disclosure norms and readiness to supply tranche-level pricing on request. The filing documents indirect spousal ownership of 3,071 shares, which is properly disclosed. There are no statements in the filing that imply regulatory or governance issues beyond routine insider reporting.

Joseph T. Baroldi, Vicepresidente Esecutivo e Chief Business Officer di Ionis Pharmaceuticals (IONS), ha comunicato più operazioni datate 03/09/2025. La segnalazione indica l'acquisto/concessione di opzioni su azioni non qualificate con prezzo di esercizio pari a $31,80 per un totale di 32.800 opzioni (tre assegnazioni/esercizi di 2.800, 15.000 e 15.000) sottostanti azioni ordinarie. Nello stesso giorno la persona segnalante ha venduto 32.800 azioni ordinarie in più operazioni a prezzi medi ponderati di $62,0101 e $59,0864, come indicato. Il modulo Form 4 specifica che le vendite sono state effettuate ai sensi di un piano di trading Rule 10b5-1 adottato il 2 maggio 2025. A seguito delle operazioni riportate, la documentazione elenca vari totali di titolarità beneficiaria e dichiara la presenza di 3.071 azioni possedute indirettamente dal coniuge.

Joseph T. Baroldi, Vicepresidente Ejecutivo y Chief Business Officer de Ionis Pharmaceuticals (IONS), informó múltiples transacciones con fecha 03/09/2025. La presentación muestra compras/concesiones de opciones sobre acciones no calificadas con precio de ejercicio de $31.80 por un total de 32.800 opciones (tres concesiones/ejercicios de 2.800, 15.000 y 15.000) subyacentes a acciones ordinarias. Ese mismo día, la persona informante vendió 32.800 acciones ordinarias en varias operaciones a precios promedio ponderados de $62.0101 y $59.0864, según consta. El Formulario 4 indica que las ventas se realizaron en virtud de un plan de negociación Rule 10b5-1 adoptado el 2 de mayo de 2025. Tras las operaciones reportadas, la presentación enumera distintos totales de propiedad beneficiaria y declara 3.071 acciones poseídas indirectamente por el cónyuge.

Joseph T. Baroldi, Ionis Pharmaceuticals(IONS)의 수석부사장 겸 최고사업책임자는 2025-09-03자 다수의 거래를 신고했습니다. 제출서류에는 행사가 $31.80인 비자격 스톡옵션 총 32,800주(2,800주, 15,000주, 15,000주의 세 건 부여/행사)가 보통주에 대한 기초자산으로 기재되어 있습니다. 같은 날 해당 보고인은 여러 거래에서 가중평균가 $62.0101$59.086432,800주 보통주를 매도했습니다. Form 4에는 이 매도가 2025년 5월 2일 채택된 Rule 10b5-1 거래계획에 따라 이루어졌다고 명시되어 있습니다. 보고된 거래 이후 제출서류는 다양한 실질적 보유 총액을 기재하고 배우자에 의해 간접 소유된 3,071주를 공개하고 있습니다.

Joseph T. Baroldi, Vice-président exécutif et Chief Business Officer d'Ionis Pharmaceuticals (IONS), a déclaré plusieurs opérations datées du 03/09/2025. Le dépôt indique des achats/attributions d'options d'achat d'actions non qualifiées avec un prix d'exercice de 31,80 $ pour un total de 32 800 options (trois attributions/exercices de 2 800, 15 000 et 15 000) portant sur des actions ordinaires. Le même jour, la personne déclarante a vendu 32 800 actions ordinaires lors de plusieurs transactions à des prix moyens pondérés de 62,0101 $ et 59,0864 $, comme indiqué. Le formulaire 4 précise que les ventes ont été effectuées en vertu d'un plan de négociation Rule 10b5-1 adopté le 2 mai 2025. À la suite des opérations déclarées, le dépôt énumère différents totaux de détention bénéficiaire et révèle 3 071 actions détenues indirectement par le conjoint.

Joseph T. Baroldi, Executive Vice President und Chief Business Officer von Ionis Pharmaceuticals (IONS), meldete mehrere Transaktionen datiert 03.09.2025. Die Einreichung zeigt Käufe/Gewährungen nicht qualifizierter Aktienoptionen mit einem Ausübungspreis von $31,80 in Höhe von insgesamt 32.800 Optionen (drei Zuteilungen/Ausübungen zu 2.800, 15.000 und 15.000), die zugrunde liegenden Stammaktien entsprechen. Am selben Tag verkaufte die meldende Person 32.800 Stammaktien in mehreren Transaktionen zu gewichteten Durchschnittspreisen von $62,0101 und $59,0864, wie angegeben. Das Formblatt 4 gibt an, dass die Verkäufe gemäß einem Rule-10b5-1-Handelsplan, der am 2. Mai 2025 angenommen wurde, erfolgt sind. Nach den gemeldeten Transaktionen listet die Einreichung verschiedene Summen der wirtschaftlichen Eigentümerschaft auf und offenbart 3.071 Aktien, die indirekt vom Ehepartner gehalten werden.

SEC Form 4
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Estimated average burden
hours per response: 0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Baroldi Joseph

(Last) (First) (Middle)
2855 GAZELLE COURT

(Street)
CARLSBAD CA 92010

(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
IONIS PHARMACEUTICALS INC [ IONS ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director 10% Owner
X Officer (give title below) Other (specify below)
EVP, Chief Business Officer
3. Date of Earliest Transaction (Month/Day/Year)
09/03/2025
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 09/03/2025 M 2,800 A $31.8 34,726 D
Common Stock 09/03/2025 S 2,800(1) D $62.0101(2) 31,926 D
Common Stock 09/03/2025 M 15,000 A $31.8 46,926 D
Common Stock 09/03/2025 S 30,000(1) D $59.0864(3) 16,926 D
Common Stock 09/03/2025 M 15,000 A $31.8 31,926 D
Common Stock 3,071 I by Spouse
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Non-Qualified Stock Option (right to buy) $31.8 09/03/2025 M 2,800 01/31/2023 01/30/2032 Common Stock 2,800 $0.0 83,900 D
Non-Qualified Stock Option (right to buy) $31.8 09/03/2025 M 15,000 01/31/2023 01/30/2032 Common Stock 15,000 $0.0 68,900 D
Non-Qualified Stock Option (right to buy) $31.8 09/03/2025 M 15,000 01/31/2023 01/30/2032 Common Stock 15,000 $0.0 53,900 D
Explanation of Responses:
1. Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on May 2, 2025.
2. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $58.59 to $59.26 inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.
3. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $62.00 to $62.03 inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4.
By: Patrick R. O'Neil, attorney-in-fact For: Joseph T. Baroldi 09/04/2025
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
Ionis Pharmaceuticals

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9.46B
158.09M
0.72%
108.62%
7.27%
Biotechnology
Pharmaceutical Preparations
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United States
CARLSBAD