MindWalk (NASDAQ: HYFT) debuts ReefIQ context layer for AI drug discovery

Rhea-AI Filing Summary

MindWalk Holdings Corp. announced the launch of ReefIQ™, a HYFT-powered biological context layer that connects fragmented drug-discovery data to AI reasoning workflows. ReefIQ links sequences, structures, assays, omics, literature, evidence, provenance, and program history into governed, queryable biological context for AI-enabled discovery.

The platform sits between client discovery data and AI models, feeding MindWalk’s LensAI™ reasoning layer and customer-selected agent models. HYFT® provides the underlying biological representation, while ReefIQ harmonizes customer data and governance, and LensAI applies retrieval, analysis, target discovery, candidate diligence, hypothesis generation, and portfolio decision support.

MindWalk positions ReefIQ as the foundation for future life-sciences engagements, with architecture designed for flexible integration across data governance, model access, and compute deployment. The company notes that LensAI is already used in contracted, recurring arrangements with life-sciences customers.

Key Figures

Knowledge Graph patterns: 660 million biological patterns Knowledge Graph relationships: 25 billion relationships Ticker symbol: NASDAQ: HYFT

3 metrics

Knowledge Graph patterns 660 million biological patterns Scale of HYFT Knowledge Graph powering ReefIQ

Knowledge Graph relationships 25 billion relationships Relationships in HYFT Knowledge Graph

Ticker symbol NASDAQ: HYFT MindWalk Holdings Corp. listing

Key Terms

biological context layer, HYFT, LensAI, Knowledge Graph, +2 more

6 terms

biological context layer technical

"launched ReefIQ™, a HYFT-powered biological context layer for AI drug discovery"

HYFT technical

"HYFT® is MindWalk’s core biological pattern technology"

LensAI technical

"LensAI™ is the reasoning and application layer"

Knowledge Graph technical

"a continuously evolving Knowledge Graph of 660 million biological patterns"

A knowledge graph is a structured map that links facts about people, companies, products, and events so a computer can understand how they relate to one another. For investors, it turns scattered data—news, filings, research—into clear connections (like a labeled map) that reveal risks, hidden relationships, and opportunities faster, improving due diligence and decision-making without relying on a single document.

life-sciences AI financial

"In life-sciences AI, the durable advantage is not the model"

agentic AI technical

"to host the agentic AI workflows pharma is racing to deploy"

Agentic AI refers to computer systems that can make their own decisions and take actions without needing someone to tell them what to do each time. It's like giving a robot a degree of independence to solve problems or achieve goals on its own, which matters because it could change how we work and interact with technology in everyday life.

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Available on EDGAR 06/10/2026 - 09:44 AM Accepted by SEC EDGAR 06/10/2026 - 09:43 AM Learn about SEC filing dates

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

Form 6-K

REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16

OF THE SECURITIES EXCHANGE ACT OF 1934

For the month of June, 2026.

Commission File Number: 001-39530

MindWalk Holdings Corp.

3204 - 4464 Markham Street, Victoria, British Columbia V8Z 7X8

(Address of principal executive office)

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

Form 20-F ☒ Form 40-F ☐

EXHIBIT INDEX

Exhibit	Description
99.1	Press Release dated June 10, 2026

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

	MINDWALK HOLDINGS CORP.
Date: June 10, 2026
	By:	/s/ Jennifer Bath
	Name:	Jennifer Bath
	Title:	President and Chief Executive Officer

99.1

MindWalk Holdings Corp. (NASDAQ: HYFT) Launches ReefIQ™, a Biological Context Layer for AI Drug Discovery

ReefIQ turns fragmented biological data into governed, queryable context for AI-enabled drug discovery and biologics development.

Victoria, Canada, June 10, 2026 — MindWalk Holdings Corp. (“MindWalk”) (NASDAQ: HYFT), a bio-native AI company, today launched ReefIQ™, a HYFT-powered biological context layer for AI drug discovery and biologics development, that sits between client discovery data and AI reasoning workflows.

Biology is connected, but drug-discovery data is often fragmented across files, formats, systems, teams, and workflows. ReefIQ reconnects those representations before AI workflows act on them, linking fragmented data into MindWalk's biological representation foundation. Sequences, structures, assay outputs, omics, literature, evidence, provenance, and program history are transformed into a governed, queryable connected biological context for AI-enabled discovery.

"In life-sciences AI, the durable advantage is not the model a team licenses but the biological context it can reason over. Biology is connected by evolutionary constraint; discovery data arrives fragmented across files and systems, and that gap is where insight is lost. ReefIQ is designed to close it, preserving what every program learns, including the programs that fail, as governed context rather than isolated files. In a regulated setting, that is what makes reasoning trustworthy, and trustworthy is what compounds into the clinic," said Dr. Jennifer Bath, PhD, CEO and President of MindWalk Holdings Corp.

LensAI and customer-selected agent models can then retrieve, analyze, and generate hypotheses from connected biological context rather than isolated files.

HYFT® is MindWalk’s core biological pattern technology. It provides the underlying biological representation foundation with explicit relationships across sequence, structure, function, mechanism, pathway, evidence, and literature.

ReefIQ™ is the client biological context layer built on HYFT. It harmonizes client discovery data, links it to MindWalk’s biological representation foundation, preserves provenance and program history, and exposes governed, queryable context to LensAI and customer-selected agent models.

LensAI™ is the reasoning and application layer. It uses ReefIQ’s connected biological context to support retrieval, analysis, target discovery, candidate diligence, hypothesis generation, and portfolio decision support.

HYFT powers the biological representation. ReefIQ organizes and governs the context. LensAI applies reasoning workflows.

Why this layer matters

Drug-discovery organizations generate valuable context in every program: positive results, negative results, assay conditions, design decisions, mechanism hypotheses, literature links, and reasons candidates did not advance. ReefIQ preserves that context as governed, queryable knowledge. As data are added, the network is enriched and its relationships and annotations are refined. Future programs benefit from the ever-compounding evidence and insights.

Inspired by cumulative biological systems

A reef grows by connecting what came before into a living structure. ReefIQ uses that metaphor for scientific knowledge: each dataset, result, program, and piece of evidence can become part of a governed context layer for future discovery.

“ReefIQ operationalizes the HYFT information network for drug discovery,” said Dirk Van Hyfte, MD, PhD, Chief Technology Officer of MindWalk. “HYFT provides the biological representation foundation, representing the complex relationships in biology; ReefIQ links customer data to that foundation and exposes governed context to LensAI and customer-selected agent models operating within agreed governance. The goal is to support retrieval, analysis, and hypothesis generation over connected biological context while preserving provenance, deployment flexibility, and customer-defined controls.”

What comes next

ReefIQ™ is designed to become the foundation for MindWalk's future life-sciences engagements: a HYFT-powered biological context layer beneath LensAI™ and client-selected model or agent workflows. The architecture supports flexible integration across data governance, model access, and compute deployment. LensAI is already in contracted, recurring arrangements with life-sciences customers today. Interested parties may request a private briefing through Investor Relations.
For more information about the technology, please visit: https://www.mindwalkai.com/reefiq

About MindWalk Holdings Corp.

MindWalk Holdings Corp. (NASDAQ: HYFT) is a bio-native AI company building the BioIntelligence infrastructure that life sciences AI and agentic AI require. Its proprietary HYFT® system powers ReefIQ™, the biological context layer for life sciences, a function-aware representation organized around HYFT pattern-objects that span sequence and structural biology, refined over 20 years of curation by a continuously evolving Knowledge Graph of 660 million biological patterns and 25 billion relationships, that enriches data at ingestion and compounds in analytical value with every program run on the platform. The LensAI™ platform operates on this infrastructure to enable target discovery, candidate diligence, and portfolio decision support, and to host the agentic AI workflows pharma is racing to deploy. MindWalk's architecture is designed so that the HYFT representation layer, not any individual AI model, is the durable, compounding competitive asset.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of applicable United States and Canadian securities laws. Forward-looking statements are often identified by terms such as "expects," "intends," "plans," "anticipates," "believes," "estimates," "targets," or similar expressions. Forward-looking statements in this press release include, without limitation, statements regarding: the launch and branding of ReefIQ, the Company's biological context layer for life sciences, including trademark clearance of the product name; the characterization of ReefIQ as a HYFT-powered biological context layer that sits between client discovery data and AI reasoning workflows, of HYFT as the technology that powers the biological representation, and of LensAI as the reasoning and application layer that operates over that context; the description of an architecture intended to support flexible integration across data governance, model access, and compute deployment in regulated life-sciences workflows; the characterization of the Knowledge Graph's scale (660 million biological patterns and 25 billion relationships) and of ReefIQ enrichment as compounding in analytical value over time; statements regarding contracted, recurring arrangements with life-sciences customers; and the Company's business development objectives.

Forward-looking statements are based on management's current expectations and assumptions and are subject to known and unknown risks, uncertainties, and other factors that may cause actual results to differ materially, including: risks relating to the branding, market acceptance, and commercial outcomes of ReefIQ, including trademark availability and clearance for the ReefIQ name; the build-out and certification of compliance capabilities for regulated workloads; the ability to convert engagement into contracted arrangements; the technical performance of AI-based discovery methods and of the underlying compute infrastructure; the ability to enter into pharmaceutical, infrastructure, or other partnership arrangements; competition; intellectual property risks; regulatory determinations; and capital markets conditions. Additional information is available in MindWalk's Annual Report on Form 20-F and other filings on SEDAR+ (sedarplus.ca) and EDGAR (sec.gov/edgar). Except as required by law, MindWalk undertakes no obligation to update any forward-looking statement. Nothing in this press release constitutes investment advice. This press release does not constitute an offer to sell or the solicitation of an offer to buy any securities.

Trademarks: HYFT® is a registered trademark of MindWalk Holdings Corp. LensAI™, ReefIQ™, HYFT Base™, HYFT Matrix™, HYFT Prime™, and B cell Llama™ are trademarks of MindWalk Holdings Corp. or its subsidiaries.

Source: MindWalk Holdings Corp.

Contacts: Investor Relations, Louie Toma, CPA, CFA, Managing Director, CoreIR, investors@mindwalkai.com

FAQ

What did MindWalk Holdings Corp. (IPA) announce regarding ReefIQ?

MindWalk launched ReefIQ™, a HYFT-powered biological context layer for AI drug discovery and biologics development. It connects fragmented discovery data into governed, queryable biological context that AI systems can use for retrieval, analysis, hypothesis generation, and portfolio decision support in life-sciences workflows.

How does ReefIQ fit with HYFT and LensAI in MindWalk’s AI stack?

HYFT® provides MindWalk’s biological representation foundation, encoding relationships across sequence, structure, function, and evidence. ReefIQ™ harmonizes and links client discovery data to this foundation, while LensAI™ sits on top as the reasoning and application layer for retrieval, target discovery, diligence, and decision support.

Why is ReefIQ important for AI-driven drug discovery according to MindWalk (IPA)?

MindWalk says durable advantage in life-sciences AI comes from biological context, not just models. ReefIQ preserves program results, negative findings, assay conditions, and hypotheses as governed, queryable knowledge so future discovery programs can leverage cumulative evidence rather than isolated, fragmented files and datasets.

What kinds of data can ReefIQ handle for life-sciences customers?

ReefIQ is described as linking sequences, structures, assay outputs, omics data, literature, evidence, provenance, and program history. These are transformed into a connected, governed context layer that AI reasoning workflows like LensAI and customer-selected agent models can query, analyze, and use to generate new hypotheses.

How large is MindWalk’s HYFT Knowledge Graph that underpins ReefIQ?

MindWalk states that its Knowledge Graph spans 660 million biological patterns and 25 billion relationships. This graph refines relationships and annotations as new data and programs are added, aiming to enrich data at ingestion and compound analytical value over time for life-sciences discovery use cases.

Does MindWalk (IPA) already have customers using this AI infrastructure?

The company notes that its LensAI platform is already involved in contracted, recurring arrangements with life-sciences customers. ReefIQ is intended to become the biological context foundation beneath LensAI and client-selected model or agent workflows across regulated, governance-sensitive drug-discovery environments.

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