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Exozymes (Nasdaq: EXOZ) filed an 8-K disclosing entry into the NSF-funded Meta-PURE initiative under the CFIRE program. The three-year cooperative agreement—total award $9.2 million—will deliver about $3 million to Exozymes beginning 1 July 2025.

As the project’s key industrial partner, Exozymes will build a cell-free ATP-generating “power plant” and a production module for high-value fragrance compound santalene. These plug-and-play modules aim to speed reaction times and boost yields across multiple synthetic-biology applications. No additional financial statements, guidance, or dilution were reported.

Exozymes (Nasdaq: EXOZ) ha presentato un modulo 8-K annunciando l'ingresso nell'iniziativa Meta-PURE finanziata dalla NSF nell'ambito del programma CFIRE. L'accordo cooperativo triennale—con un premio totale di 9,2 milioni di dollari—prevede di assegnare circa 3 milioni di dollari a Exozymes a partire dal 1° luglio 2025.

Come partner industriale chiave del progetto, Exozymes realizzerà una “centrale elettrica” ATP-generante senza cellule e un modulo di produzione per il composto aromatico di alto valore santalene. Questi moduli plug-and-play sono progettati per accelerare i tempi di reazione e aumentare le rese in diverse applicazioni di biologia sintetica. Non sono state riportate ulteriori dichiarazioni finanziarie, indicazioni o diluizioni.

Exozymes (Nasdaq: EXOZ) presentó un formulario 8-K revelando su participación en la iniciativa Meta-PURE financiada por NSF bajo el programa CFIRE. El acuerdo cooperativo de tres años—con un premio total de 9.2 millones de dólares—entregará aproximadamente 3 millones de dólares a Exozymes a partir del 1 de julio de 2025.

Como socio industrial clave del proyecto, Exozymes construirá una “central eléctrica” generadora de ATP sin células y un módulo de producción para el compuesto fragante de alto valor santaleno. Estos módulos plug-and-play buscan acelerar los tiempos de reacción y aumentar los rendimientos en múltiples aplicaciones de biología sintética. No se reportaron estados financieros adicionales, orientaciones ni diluciones.

Exozymes (나스닥: EXOZ)는 CFIRE 프로그램 하에 NSF 지원 Meta-PURE 이니셔티브 참여를 공개하는 8-K 보고서를 제출했습니다. 3년간의 협력 계약으로 총 상금은 920만 달러이며, 2025년 7월 1일부터 약 300만 달러가 Exozymes에 지급됩니다.

프로젝트의 핵심 산업 파트너로서 Exozymes는 세포 없는 ATP 생성 '발전소'와 고부가가치 향료 화합물인 산탈렌 생산 모듈을 구축할 예정입니다. 이 플러그 앤 플레이 모듈들은 반응 시간을 단축하고 여러 합성생물학 응용 분야에서 수율을 향상시키는 것을 목표로 합니다. 추가 재무제표, 지침 또는 희석은 보고되지 않았습니다.

Exozymes (Nasdaq : EXOZ) a déposé un rapport 8-K annonçant son entrée dans l'initiative Meta-PURE financée par la NSF dans le cadre du programme CFIRE. L'accord de coopération de trois ans—d'un montant total de 9,2 millions de dollars—attribuera environ 3 millions de dollars à Exozymes à partir du 1er juillet 2025.

En tant que partenaire industriel clé du projet, Exozymes construira une « centrale électrique » génératrice d’ATP sans cellules ainsi qu’un module de production pour le composé parfumé de grande valeur santalène. Ces modules plug-and-play visent à accélérer les temps de réaction et à augmenter les rendements dans diverses applications de biologie synthétique. Aucune autre information financière, prévision ou dilution n’a été communiquée.

Exozymes (Nasdaq: EXOZ) hat einen 8-K-Bericht eingereicht, in dem der Eintritt in die NSF-finanzierte Meta-PURE-Initiative im Rahmen des CFIRE-Programms bekannt gegeben wird. Die dreijährige Kooperationsvereinbarung—mit einem Gesamtvolumen von 9,2 Millionen US-Dollar—wird ab dem 1. Juli 2025 etwa 3 Millionen US-Dollar an Exozymes auszahlen.

Als wichtiger Industriepartner des Projekts wird Exozymes ein zellfreies ATP-erzeugendes „Kraftwerk“ und ein Produktionsmodul für die hochwertige Duftstoffverbindung Santalene entwickeln. Diese Plug-and-Play-Module sollen Reaktionszeiten verkürzen und Ausbeuten in verschiedenen Anwendungen der synthetischen Biologie erhöhen. Weitere Finanzberichte, Prognosen oder Verwässerungen wurden nicht gemeldet.

Positive
  • $3 million non-dilutive NSF funding secured via Meta-PURE cooperative agreement commencing July 1 2025 and running three years
  • Designation as key industrial partner in a $9.2 million synthetic-biology initiative enhances credibility and potential partnership pipeline
Negative
  • None.

Insights

TL;DR – $3M NSF grant adds non-dilutive capital and tech validation; modest but clearly positive.

The cooperative agreement provides Exozymes with roughly $1 million per year in non-dilutive funding, strengthening cash resources while avoiding equity dilution. Recognition by the NSF and Georgia Tech elevates the firm’s credibility in cell-free biomanufacturing, potentially easing future partnering and grant pursuits. Although the filing lacks revenue metrics, the size of the award appears meaningful for an early-stage platform company and creates a timeline of staged milestone payments that could act as near-term catalysts. Immediate commercial revenue impact is limited, but the technical deliverables—an ATP “power plant” and santalene module—could lead to higher-margin licensing or product opportunities if successfully validated.

TL;DR – Grant de-risks R&D, but scale-up economics remain unaddressed.

The Meta-PURE project aligns with market demand for flexible, cell-free production of nutraceuticals and specialty chemicals. Exozymes’ decoupled energy-production module is technically compelling and may shorten development cycles for coalition partners. However, the filing offers no insight into downstream manufacturing economics, IP rights allocation, or revenue-sharing terms—all critical to eventual monetization. Investors should monitor whether the company retains exclusive rights to the ATP module or adopts an open-platform model that could dilute pricing power. Absent cost and margin data, the commercial outlook is still speculative, keeping overall impact neutral to modestly positive.

Exozymes (Nasdaq: EXOZ) ha presentato un modulo 8-K annunciando l'ingresso nell'iniziativa Meta-PURE finanziata dalla NSF nell'ambito del programma CFIRE. L'accordo cooperativo triennale—con un premio totale di 9,2 milioni di dollari—prevede di assegnare circa 3 milioni di dollari a Exozymes a partire dal 1° luglio 2025.

Come partner industriale chiave del progetto, Exozymes realizzerà una “centrale elettrica” ATP-generante senza cellule e un modulo di produzione per il composto aromatico di alto valore santalene. Questi moduli plug-and-play sono progettati per accelerare i tempi di reazione e aumentare le rese in diverse applicazioni di biologia sintetica. Non sono state riportate ulteriori dichiarazioni finanziarie, indicazioni o diluizioni.

Exozymes (Nasdaq: EXOZ) presentó un formulario 8-K revelando su participación en la iniciativa Meta-PURE financiada por NSF bajo el programa CFIRE. El acuerdo cooperativo de tres años—con un premio total de 9.2 millones de dólares—entregará aproximadamente 3 millones de dólares a Exozymes a partir del 1 de julio de 2025.

Como socio industrial clave del proyecto, Exozymes construirá una “central eléctrica” generadora de ATP sin células y un módulo de producción para el compuesto fragante de alto valor santaleno. Estos módulos plug-and-play buscan acelerar los tiempos de reacción y aumentar los rendimientos en múltiples aplicaciones de biología sintética. No se reportaron estados financieros adicionales, orientaciones ni diluciones.

Exozymes (나스닥: EXOZ)는 CFIRE 프로그램 하에 NSF 지원 Meta-PURE 이니셔티브 참여를 공개하는 8-K 보고서를 제출했습니다. 3년간의 협력 계약으로 총 상금은 920만 달러이며, 2025년 7월 1일부터 약 300만 달러가 Exozymes에 지급됩니다.

프로젝트의 핵심 산업 파트너로서 Exozymes는 세포 없는 ATP 생성 '발전소'와 고부가가치 향료 화합물인 산탈렌 생산 모듈을 구축할 예정입니다. 이 플러그 앤 플레이 모듈들은 반응 시간을 단축하고 여러 합성생물학 응용 분야에서 수율을 향상시키는 것을 목표로 합니다. 추가 재무제표, 지침 또는 희석은 보고되지 않았습니다.

Exozymes (Nasdaq : EXOZ) a déposé un rapport 8-K annonçant son entrée dans l'initiative Meta-PURE financée par la NSF dans le cadre du programme CFIRE. L'accord de coopération de trois ans—d'un montant total de 9,2 millions de dollars—attribuera environ 3 millions de dollars à Exozymes à partir du 1er juillet 2025.

En tant que partenaire industriel clé du projet, Exozymes construira une « centrale électrique » génératrice d’ATP sans cellules ainsi qu’un module de production pour le composé parfumé de grande valeur santalène. Ces modules plug-and-play visent à accélérer les temps de réaction et à augmenter les rendements dans diverses applications de biologie synthétique. Aucune autre information financière, prévision ou dilution n’a été communiquée.

Exozymes (Nasdaq: EXOZ) hat einen 8-K-Bericht eingereicht, in dem der Eintritt in die NSF-finanzierte Meta-PURE-Initiative im Rahmen des CFIRE-Programms bekannt gegeben wird. Die dreijährige Kooperationsvereinbarung—mit einem Gesamtvolumen von 9,2 Millionen US-Dollar—wird ab dem 1. Juli 2025 etwa 3 Millionen US-Dollar an Exozymes auszahlen.

Als wichtiger Industriepartner des Projekts wird Exozymes ein zellfreies ATP-erzeugendes „Kraftwerk“ und ein Produktionsmodul für die hochwertige Duftstoffverbindung Santalene entwickeln. Diese Plug-and-Play-Module sollen Reaktionszeiten verkürzen und Ausbeuten in verschiedenen Anwendungen der synthetischen Biologie erhöhen. Weitere Finanzberichte, Prognosen oder Verwässerungen wurden nicht gemeldet.

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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

 

 

 

FORM 8-K

 

Current Report Pursuant to Section 13 or 15(d) of

the Securities Exchange Act of 1934

 

Date of Report (Date of earliest event reported):

June 26, 2025

 

EXOZYMES INC.

(Exact name of registrant as specified in its charter)

 

Nevada   001-42204   83-4550057

(State or other jurisdiction

of incorporation)

 

(Commission

File Number)

 

(I.R.S. Employer

Identification No.)

 

750 Royal Oaks Drive, Suite 106

Monrovia, CA 91016

(Address of principal executive offices and zip code)

 

Registrant’s telephone number, including area code: (626) 415-1488

 

Check the appropriate box below if the Form 8-K is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

 

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
   
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
   
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
   
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

 

Securities registered pursuant to Section 12(b) of the Exchange Act:

 

Title of each class   Trading Symbol(s)   Name of each exchange on which registered
Common Stock   EXOZ   Nasdaq Capital Market

 

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

 

Emerging growth company

 

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.

 

 

 

 

 

 

Item 1.01 — Entry into Material Agreement.

 

eXoZymes Inc. (the “Company”) has been selected to participate in the Meta-PURE initiative, a National Science Foundation (“NSF”) funded project under the CFIRE (Cell-Free Systems Toward Increased Range of Use-Inspired Applications) program aimed at transforming the scalability and accessibility of cell-free systems to expand real-world applications. The project coalition of partner enterprises is being led by The Georgia Institute of Technology. Meta-PURE will build a suite of standardized, interoperable ‘modules’ for cell-free biomanufacturing, enabling plug-and-play modules that can rapidly shift between use cases - from high-value nutraceuticals, to essential chemicals or pharmaceuticals. Meta-PURE is part of the CFIRE program and supported under Cooperative Agreement No. 2452482.

 

eXoZymes will serve as the key industrial partner with Meta-PURE, with an approximate $3 million share of the total project award of $9.2 million. The project will commence July 1, 2025, and will run for three years.

 

eXoZymes will develop a cell free ATP-generating module - essentially a cell-free power plant - that fuels different chemical production modules to be developed now and in the future, supporting cell-free manufacturing of several market-relevant targets. eXoZymes’s technology permits decoupling the power module from the production module, enabling faster reaction times, greater product yields, and making the development of production modules more accessible for our coalition partners across a broad spectrum of synthetic biology applications. The other coalition partners will develop targets spanning a wide range of complexity and markets, relying on eXoZymes’ plug-and-play cell-free power plant, which will be tested and optimized to both purified and lysate-based exozymes biosolutions to ensure compatibility and performance.

 

eXoZymes’ role also includes developing a production module for santalene, an extremely high-value fragrance compound, traditionally extracted from sandalwood for use in aromatherapy and traditional medicine formulations. Derivates of santalene have been investigated in pharmaceutical use cases.

 

Item 9.01. Financial Statements and Exhibits.

 

(d) Exhibits

 

Exhibits   Description of Exhibit
     
99.1   Press release dated June 26, 2025 regarding participation in CFIRE program
     
104   Cover Page Interactive Data File (embedded within the Inline XBRL Document)

 

 

 

 

SIGNATURES

 

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

 

Date: June 26, 2025 EXOZYMES INC.
       
    By /s/ Fouad Nawaz
      Fouad Nawaz,
      Vice President, Finance

 

 

 

FAQ

How much funding will EXOZ receive under the Meta-PURE initiative?

The filing states Exozymes will receive approximately $3 million of the total $9.2 million award over three years.

When does the Meta-PURE project start and how long will it last?

The project commences on July 1, 2025 and is scheduled to run for three years.

What is Exozymes’ role in the Meta-PURE coalition?

Exozymes will develop a cell-free ATP-generating module and a production module for the high-value fragrance compound santalene.

Which program funds Meta-PURE and what is its objective?

Meta-PURE is backed by the National Science Foundation’s CFIRE program, aiming to create standardized, plug-and-play cell-free biomanufacturing modules.

Did the 8-K include any financial statements or earnings guidance?

No. The filing focused solely on the material agreement; it did not provide financial statements or forward-looking guidance.
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