BlackRock (NASDAQ: KPTI) reports 5.6% ownership of Therapeutics Inc shares

Rhea-AI Filing Summary

BlackRock, Inc. reports a significant ownership stake in THERAPEUTICS INC common stock. BlackRock and certain of its subsidiaries and affiliates beneficially own 1,266,084 shares of common stock, representing 5.6% of the outstanding class.

BlackRock has sole voting power over 1,251,563 shares and sole dispositive power over 1,266,084 shares, with no shared voting or dispositive power reported. The shares are held across various investment clients, where different persons may have rights to dividends or sale proceeds, but no individual other than BlackRock is reported to hold more than five percent of the total outstanding common shares.

Key Figures

Shares beneficially owned: 1,266,084 shares Percent of class owned: 5.6% Sole voting power: 1,251,563 shares +3 more

6 metrics

Shares beneficially owned 1,266,084 shares Common stock of THERAPEUTICS INC reported by BlackRock, Inc.

Percent of class owned 5.6% Portion of THERAPEUTICS INC common stock class held by BlackRock, Inc.

Sole voting power 1,251,563 shares Shares of THERAPEUTICS INC over which BlackRock, Inc. has sole voting power

Shared voting power 0 shares Shares of THERAPEUTICS INC with shared voting power reported by BlackRock, Inc.

Sole dispositive power 1,266,084 shares Shares of THERAPEUTICS INC BlackRock, Inc. can solely dispose of

Shared dispositive power 0 shares Shares of THERAPEUTICS INC with shared dispositive power reported

Key Terms

beneficially owned, Sole Voting Power, Sole Dispositive Power, Percent of class, +1 more

5 terms

beneficially owned financial

"this reflects the securities beneficially owned, or deemed to be beneficially owned"

Beneficially owned describes securities or assets where a person has the economic rights and control—such as the right to receive dividends and to direct voting—even if legal title is held in another name. Think of it like having the keys and using a car that’s registered to someone else: you get the benefits and make decisions. Investors care because beneficial ownership reveals who truly controls value and voting power, affecting corporate decisions and takeover dynamics.

Sole Voting Power financial

"5 | Sole Voting Power 1,251,563.00 6 | Shared Voting Power 0.00"

Sole voting power is the exclusive right to cast votes attached to a shareholder’s stock without needing approval from anyone else. Like holding the only remote control for a TV, it lets that holder decide corporate matters such as board members, mergers, and policy changes, making it important to investors because it concentrates control and can strongly influence a company’s strategy and the value of its shares.

Sole Dispositive Power financial

"7 | Sole Dispositive Power 1,266,084.00 8 | Shared Dispositive Power 0.00"

Sole dispositive power is the exclusive legal authority to decide what happens to a security — for example, whether to sell, transfer, or retain shares — without needing anyone else’s permission. Investors care because it signals who truly controls the economic outcome of an investment: like holding the only key to a safe, the holder can realize gains or losses and may trigger regulatory reporting, insider rules, or influence over corporate ownership.

Percent of class financial

"(b) | Percent of class: 5.6 %"

Percent of class is the portion of a specific category of securities—such as a company’s common shares, preferred shares, or a bond series—that takes part in or approves a corporate action (vote, consent, tender, etc.). Investors watch this number because it reveals how much support or opposition exists within that particular shareholder group; like counting how many members of a club back a proposal, it can determine whether a plan passes or how influence is distributed.

Power of Attorney regulatory

"Exhibit 24: Power of Attorney Exhibit 99: Item 7"

A power of attorney is a legal document that allows one person to make decisions and act on behalf of another person, often in financial or legal matters. It’s like giving someone a trusted helper or agent the authority to handle important tasks if you are unable to do so yourself. This matters to investors because it can impact how their assets are managed or transferred if they become unable to oversee their affairs.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 07/28/2026 - 04:47 PM Accepted by SEC EDGAR 07/28/2026 - 04:44 PM Learn about SEC filing dates

FAQ

What percentage of KPTI does BlackRock, Inc. report owning in this Schedule 13G?

BlackRock, Inc. reports beneficial ownership of 5.6% of THERAPEUTICS INC (KPTI) common stock, representing 1,266,084 shares. This makes BlackRock a significant institutional holder exceeding the five percent reporting threshold.

How many KPTI shares does BlackRock, Inc. have voting power over?

BlackRock, Inc. reports sole voting power over 1,251,563 shares of THERAPEUTICS INC common stock and no shared voting power. This figure reflects shares controlled by specified BlackRock business units.

What is the total number of KPTI shares BlackRock, Inc. can dispose of?

BlackRock, Inc. has sole dispositive power over 1,266,084 shares of THERAPEUTICS INC common stock and no shared dispositive power. Dispositive power refers to the authority to sell or otherwise direct the disposition of these shares.

Does any other person hold more than 5% of KPTI shares through BlackRock’s positions?

BlackRock states that various persons may receive dividends or sale proceeds from KPTI shares, but no one person’s interest exceeds five percent of the total outstanding common shares of THERAPEUTICS INC.

Which BlackRock entities are included in this KPTI ownership report?

The filing covers securities beneficially owned by certain business units of BlackRock, Inc. and its subsidiaries and affiliates. It expressly excludes other business units whose ownership is disaggregated under SEC Release No. 34-39538.

Who signed the Schedule 13G for BlackRock, Inc. regarding KPTI?

The Schedule 13G is signed by Spencer Fleming, a Managing Director of BlackRock, Inc., dated 07/28/2026, with a Power of Attorney provided as Exhibit 24 authorizing the execution.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

KARYOPHARM THERAPEUTICS INC

(Name of Issuer)

Common Stock

(Title of Class of Securities)

48576U205

(CUSIP Number)

06/30/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 48576U205

1

Names of Reporting Persons

BlackRock, Inc.

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 1,251,563.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 1,266,084.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

1,266,084.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.6 %

12

Type of Reporting Person (See Instructions)

HC

SCHEDULE 13G

Item 1.
(a)	Name of issuer: KARYOPHARM THERAPEUTICS INC
(b)	Address of issuer's principal executive offices: 85 WELLS AVENUE SECOND FLOOR NEWTON MA 02459
Item 2.
(a)	Name of person filing: BlackRock, Inc. In accordance with SEC Release No. 34-39538 (January 12, 1998), this Schedule 13G reflects the securities beneficially owned, or deemed to be beneficially owned, by certain business units (collectively, the "Reporting Business Units") of BlackRock, Inc. and its subsidiaries and affiliates. It does not include securities, if any, beneficially owned by other business units whose beneficial ownership of securities are disaggregated from that of the Reporting Business Units in accordance with such release.
(b)	Address or principal business office or, if none, residence: BlackRock, Inc., 50 Hudson Yards New York, NY 10001
(c)	Citizenship: See Item 4 of Cover Page
(d)	Title of class of securities: Common Stock
(e)	CUSIP Number(s): 48576U205
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 1266084
(b)	Percent of class: 5.6 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 1251563
	(ii) Shared power to vote or to direct the vote: 0
	(iii) Sole power to dispose or to direct the disposition of: 1266084
	(iv) Shared power to dispose or to direct the disposition of: 0
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. Various persons have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of the common stock of KARYOPHARM THERAPEUTICS INC. No one person's interest in the common stock of KARYOPHARM THERAPEUTICS INC is more than five percent of the total outstanding common shares.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. See Exhibit 99
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

BlackRock, Inc.

Signature:	Spencer Fleming
Name/Title:	Managing Director
Date:	07/28/2026

Exhibit Information

Exhibit 24: Power of Attorney Exhibit 99: Item 7