STOCK TITAN

Kymera Therapeutics (KYMR) CEO sells 80K shares, exercises options

Filing Impact
(Neutral)
Filing Sentiment
(Neutral)
Form Type
4

Rhea-AI Filing Summary

Kymera Therapeutics CEO Nello Mainolfi reported a mix of option exercises and share sales in the company’s stock. On July 1, 2026, he exercised stock options for 80,000 shares of common stock at an exercise price of $2.08 per share, converting a derivative position into regular shares.

That same day, he sold 80,000 shares of common stock in five open-market transactions at weighted average prices ranging from about $112.28 to $116.63 per share. The filing states these trades were executed under a pre-arranged Rule 10b5-1 trading plan dated March 24, 2026, and notes that he continues to hold a substantial direct equity stake in Kymera.

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Insider Mainolfi Nello
Role Chief Executive Officer
Sold 80,000 shs ($9.22M)
Type Security Shares Price Value
Exercise Stock Option (Right to Buy) 80,000 $0.00 --
Exercise Common Stock 80,000 $2.08 $166K
Sale Common Stock 1,883 $112.8046 $212K
Sale Common Stock 6,626 $113.9758 $755K
Sale Common Stock 24,105 $114.9555 $2.77M
Sale Common Stock 44,050 $115.6883 $5.10M
Sale Common Stock 3,336 $116.559 $389K
Holdings After Transaction: Stock Option (Right to Buy) — 135,559 shares (Direct, null); Common Stock — 746,568 shares (Direct, null)
Footnotes (1)
  1. These transactions were effected pursuant to a Rule 10b5-1 trading plan dated March 24, 2026 adopted by the reporting person. This number includes 373 shares acquired under the Registrant's employee stock purchase plan. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $112.28 to $113.27, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $113.36 to $114.23, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $114.29 to $115.27, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $115.31 to $116.23, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $116.29 to $116.63, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The shares underlying this stock option are fully vested and exercisable.
Shares sold 80,000 shares Total common shares sold across five open-market trades on July 1, 2026
Sale price range $112.28–$116.63 per share Weighted average price ranges for the reported open-market sales
Option exercise shares 80,000 shares Common shares acquired via stock option exercise on July 1, 2026
Option exercise price $2.08 per share Exercise price of stock options converted into common stock
Net share change from trades 80,000 shares Net-sell shares reported in transaction summary
Rule 10b5-1 plan date March 24, 2026 Date of pre-arranged trading plan governing these transactions
ESPP shares 373 shares Shares acquired under Kymera’s employee stock purchase plan
Rule 10b5-1 trading plan regulatory
"These transactions were effected pursuant to a Rule 10b5-1 trading plan dated March 24, 2026"
A Rule 10b5-1 trading plan is a pre-arranged schedule that allows company insiders to buy or sell stock at specific times, even if they have inside information. It helps prevent accusations of unfair trading by making these transactions look planned and transparent, rather than sneaky or illegal.
weighted average price financial
"The price reported in Column 4 is a weighted average price"
Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.
employee stock purchase plan financial
"This number includes 373 shares acquired under the Registrant's employee stock purchase plan"
An employee stock purchase plan is a company program that lets workers buy shares through small payroll deductions, often at a discount to the market price and after a set offering period. Think of it like a workplace savings plan that turns into ownership: it encourages employees to share in the company’s success and can create predictable buying or selling of stock that investors watch because it affects supply, demand and employee incentives.
stock option financial
"The shares underlying this stock option are fully vested and exercisable"
A stock option is a contract that gives you the right to buy or sell a company's stock at a specific price within a certain time frame. People use them to potentially make money if the stock's price moves favorably or to protect against losses. It's like holding a coupon that can be used to buy or sell stock at a set price later on.
derivative security financial
"Exercise or conversion of derivative security"
A derivative security is a financial contract whose value comes from the price or performance of something else, such as a stock, bond, commodity, or market index. For investors it acts like an insurance policy or a wager: it can be used to protect against losses, lock in prices, or amplify gains and losses, so it can change a portfolio’s risk and potential return without owning the underlying asset directly.
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Learn about SEC filing dates
SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Mainolfi Nello

(Last)(First)(Middle)
C/O KYMERA THERAPEUTICS, INC.
500 NORTH BEACON STREET, 4TH FLOOR

(Street)
WATERTOWN MASSACHUSETTS 02472

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Kymera Therapeutics, Inc. [ KYMR ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
XDirector10% Owner
XOfficer (give title below)Other (specify below)
Chief Executive Officer
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
07/01/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock07/01/2026M(1)80,000A$2.08746,568(2)D
Common Stock07/01/2026S(1)1,883D$112.8046(3)744,685D
Common Stock07/01/2026S(1)6,626D$113.9758(4)738,059D
Common Stock07/01/2026S(1)24,105D$114.9555(5)713,954D
Common Stock07/01/2026S(1)44,050D$115.6883(6)669,904D
Common Stock07/01/2026S(1)3,336D$116.559(7)666,568D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option (Right to Buy)$2.0807/01/2026M(1)80,000 (8)11/13/2029Common Stock80,000$0135,559D
Explanation of Responses:
1. These transactions were effected pursuant to a Rule 10b5-1 trading plan dated March 24, 2026 adopted by the reporting person.
2. This number includes 373 shares acquired under the Registrant's employee stock purchase plan.
3. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $112.28 to $113.27, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $113.36 to $114.23, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
5. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $114.29 to $115.27, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
6. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $115.31 to $116.23, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
7. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $116.29 to $116.63, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
8. The shares underlying this stock option are fully vested and exercisable.
/s/ Bruce Jacobs, as Attorney-in-Fact07/02/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

FAQ

What did Kymera Therapeutics (KYMR) CEO Nello Mainolfi report in this Form 4?

He reported exercising stock options for 80,000 Kymera shares and selling 80,000 common shares in open-market transactions. The activity reflects both acquiring shares via option exercise and disposing of shares through sales on the same date.

How many Kymera Therapeutics (KYMR) shares did the CEO sell and at what prices?

He sold 80,000 Kymera common shares across five open-market transactions. The weighted average sale prices ranged from about $112.28 to $116.63 per share, with each trade reported at a specific weighted average price in the Form 4.

What stock options did the Kymera (KYMR) CEO exercise in this filing?

He exercised stock options covering 80,000 shares of Kymera common stock at an exercise price of $2.08 per share. A related footnote states the underlying option shares are fully vested and exercisable, and the derivative position is now converted into common stock.

Were the Kymera Therapeutics (KYMR) CEO’s share sales made under a Rule 10b5-1 plan?

Yes. A footnote states the transactions were effected pursuant to a Rule 10b5-1 trading plan dated March 24, 2026. Such plans are pre-arranged trading programs, which can indicate the timing of sales was set in advance rather than decided opportunistically.

What does the Form 4 say about the CEO’s remaining Kymera (KYMR) holdings?

The Form 4 shows updated share balances after each transaction and indicates the CEO continues to hold a significant number of Kymera common shares directly. It also notes that 373 shares were acquired through the company’s employee stock purchase plan.