[Form 4] STANDARD BIOTOOLS INC. Insider Trading Activity

Rhea-AI Filing Summary

STANDARD BIOTOOLS INC. (LAB) received a Form 4 reporting open-market stock purchases by Casdin-affiliated investment entities, which are both directors and 10% owners. On 11/24/2025, they bought 150,000 shares of common stock at a weighted average price of $1.4325 per share. On 11/25/2025, they bought an additional 7,550,000 shares at a weighted average price of $1.3031 per share.

Following these transactions, one indirect holding line shows 71,750,000 shares beneficially owned, with ownership attributed to Casdin Partners Master Fund, L.P. and related entities. The filing also reports 2,901,062 shares held directly by Eli Casdin and additional indirect holdings of 13,939,637 and 2,744,219 shares through other Casdin-managed funds, reflecting a sizable continuing stake in LAB.

Insights

Equity Ownership Analyst

Large affiliated holder, designated as director, reports substantial open-market share purchases at low-dollar prices.

The reporting group related to Casdin entities, identified as both Director and 10% Owner of STANDARD BIOTOOLS INC., reports sizable open-market common stock purchases. On 11/24/2025 they bought 150,000 shares at a weighted average price of about $1.4325, and on 11/25/2025 they bought 7,550,000 shares at a weighted average price of about $1.3031. After these transactions, one indirect holding line shows 71,750,000 shares, highlighting a large consolidated position through affiliated vehicles.

The filing breaks out ownership across several entities: Casdin Partners Master Fund, Casdin Private Growth Equity Fund and Fund II, and Eli Casdin personally. Some positions are held indirectly (marked "I") through funds and general partners, while 2,901,062 shares are shown as directly owned by Eli Casdin and additional blocks are held by related funds. The explanatory notes clarify that ownership is often "deemed" and that each reporting person disclaims beneficial ownership beyond its economic interest.

The remarks explain that Eli Casdin has been deputized to represent the reporting persons on the issuer’s board, so each may be treated as a director for Section 16 purposes. The concrete items to watch are the reported purchase dates of 11/24/2025 and 11/25/2025, the aggregate reported indirect holding of 71,750,000 shares, and any future Form 4 filings that show changes in these large fund-related positions.

Insider Trade Summary

Net Buyer: 7,700,000 shares ($10,053,280)

Net Buy 5 txns

Insider Casdin Partners Master Fund, L.P., Casdin Partners GP, LLC, Casdin Capital, LLC, Casdin Eli, CASDIN PRIVATE GROWTH EQUITY FUND GP, LLC, Casdin Private Growth Equity Fund II GP, LLC, Casdin Private Growth Equity Fund II, L.P., Casdin Private Growth Equity Fund, L.P.

Role Director, 10% Owner | Director, 10% Owner | Director, 10% Owner | Director, 10% Owner | Director | Director | Director | Director

Bought 7,700,000 shs ($10.05M)

Type	Security	Shares	Price	Value
Purchase	Common Stock, $0.001 par value per share	7,550,000	$1.3031	$9.84M
Purchase	Common Stock, $0.001 par value per share	150,000	$1.4325	$215K
holding	Common Stock, $0.001 par value per share	--	--	--
holding	Common Stock, $0.001 par value per share	--	--	--
holding	Common Stock, $0.001 par value per share	--	--	--

Holdings After Transaction: Common Stock, $0.001 par value per share — 71,750,000 shares (Indirect, See footnote); Common Stock, $0.001 par value per share — 2,901,062 shares (Direct)

Footnotes (1)

1. The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $1.4290 to $1.4396. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares bought at each separate price within the range set forth in this footnote. The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $1.30 to $1.3843. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares bought at each separate price within the range set forth in this footnote. The securities are owned directly by Casdin Partners Master Fund, L.P. (the "Master Fund") and may be deemed to be indirectly beneficially owned by (i) Casdin Capital, LLC ("Casdin"), the investment adviser to the Master Fund, (ii) Casdin Partners GP, LLC (the "GP"), the general partner of the Master Fund, and (iii) Eli Casdin, the managing member of Casdin and the GP. The securities are owned directly by Eli Casdin. The securities are owned directly by Casdin Private Growth Equity Fund II, L.P. (the "Equity Fund II") and may be deemed to be indirectly beneficially owned by (i) Casdin, the investment adviser to the Equity Fund II, and (ii) Eli Casdin, the managing member of Casdin. The securities are owned directly by Casdin Private Growth Equity Fund, L.P. (the "Equity Fund") and may be deemed to be indirectly beneficially owned by (i) Casdin, the investment adviser to the Equity Fund, and (ii) Eli Casdin, the managing member of Casdin.

Form 4 Insider Transactions: What Each Field Means →

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Casdin Partners Master Fund, L.P.

(Last) (First) (Middle)

1350 AVENUE OF THE AMERICAS

SUITE 2600

(Street)

NEW YORK NY 10019

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
STANDARD BIOTOOLS INC. [ LAB ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

3. Date of Earliest Transaction (Month/Day/Year)
11/24/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

	Form filed by One Reporting Person
X	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock, $0.001 par value per share	11/24/2025		P		150,000	A	$1.4325(1)	64,200,000	I	See footnote(3)
Common Stock, $0.001 par value per share	11/25/2025		P		7,550,000	A	$1.3031(2)	71,750,000	I	See footnote(3)
Common Stock, $0.001 par value per share								2,901,062	D(4)
Common Stock, $0.001 par value per share								13,939,637	I	See footnote(5)
Common Stock, $0.001 par value per share								2,744,219	I	See footnote(6)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

1. Name and Address of Reporting Person^*

Casdin Partners Master Fund, L.P.

(Last) (First) (Middle)

1350 AVENUE OF THE AMERICAS

SUITE 2600

(Street)

NEW YORK NY 10019

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

X	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

Casdin Partners GP, LLC

(Last) (First) (Middle)

1350 AVENUE OF THE AMERICAS

SUITE 2600

(Street)

NEW YORK NY 10019

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

X	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

Casdin Capital, LLC

(Last) (First) (Middle)

1350 AVENUE OF THE AMERICAS

SUITE 2600

(Street)

NEW YORK NY 10019

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

X	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

Casdin Eli

(Last) (First) (Middle)

1350 AVENUE OF THE AMERICAS

SUITE 2600

(Street)

NEW YORK NY 10019

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

X	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

CASDIN PRIVATE GROWTH EQUITY FUND GP, LLC

(Last) (First) (Middle)

1350 AVENUE OF THE AMERICAS

SUITE 2600

(Street)

NEW YORK NY 10019

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

Casdin Private Growth Equity Fund II GP, LLC

(Last) (First) (Middle)

1350 AVENUE OF THE AMERICAS, SUITE 2600

(Street)

NEW YORK NY 10019

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

Casdin Private Growth Equity Fund II, L.P.

(Last) (First) (Middle)

1350 AVENUE OF THE AMERICAS

SUITE 2600

(Street)

NEW YORK NY 10019

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

Casdin Private Growth Equity Fund, L.P.

(Last) (First) (Middle)

1350 AVENUE OF THE AMERICAS

SUITE 2600

(Street)

NEW YORK NY 10019

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

Explanation of Responses:

1. The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $1.4290 to $1.4396. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares bought at each separate price within the range set forth in this footnote.

2. The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $1.30 to $1.3843. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares bought at each separate price within the range set forth in this footnote.

3. The securities are owned directly by Casdin Partners Master Fund, L.P. (the "Master Fund") and may be deemed to be indirectly beneficially owned by (i) Casdin Capital, LLC ("Casdin"), the investment adviser to the Master Fund, (ii) Casdin Partners GP, LLC (the "GP"), the general partner of the Master Fund, and (iii) Eli Casdin, the managing member of Casdin and the GP.

4. The securities are owned directly by Eli Casdin.

5. The securities are owned directly by Casdin Private Growth Equity Fund II, L.P. (the "Equity Fund II") and may be deemed to be indirectly beneficially owned by (i) Casdin, the investment adviser to the Equity Fund II, and (ii) Eli Casdin, the managing member of Casdin.

6. The securities are owned directly by Casdin Private Growth Equity Fund, L.P. (the "Equity Fund") and may be deemed to be indirectly beneficially owned by (i) Casdin, the investment adviser to the Equity Fund, and (ii) Eli Casdin, the managing member of Casdin.

Remarks:

Eli Casdin has been deputized to represent the Reporting Persons on the board of directors of the Issuer. By virtue of Mr. Casdin's representation, for purposes of Section 16 of the Securities Exchange Act of 1934 (the "Exchange Act"), each of the Reporting Persons may be deemed directors by deputization of the Issuer. Each Reporting Person disclaims beneficial ownership in the securities reported on this Form 4 except to the extent of its pecuniary interest, if any, therein, and this report shall not be deemed to be an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose.

	Casdin Partners Master Fund, LP, By: Casdin Partners GP, LLC, its General Partner, By: /s/ Eli Casdin, Managing Member	11/26/2025
	Casdin Partners GP LLC, By: /s/ Eli Casdin, Managing Member	11/26/2025
	Casdin Capital LLC, By: /s/ Eli Casdin, Managing Member	11/26/2025
	/s/ Eli Casdin, Eli Casdin	11/26/2025
	Casdin Private Growth Equity Fund GP, LLC, By: /s/ Eli Casdin, Managing Member	11/26/2025
	Casdin Private Growth Equity Fund GP II, LLC, By: /s/ Eli Casdin, Managing Member	11/26/2025
	Casdin Private Growth Equity Fund, L.P., By: Casdin Private Growth Equity Fund GP, LLC, its General Partner, By: /s/ Eli Casdin, Managing Member	11/26/2025
	Casdin Private Growth Equity Fund, L.P., By: Casdin Private Growth Equity Fund II GP, LLC, its General Partner, By: /s/ Eli Casdin, Managing Member	11/26/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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