Welcome to our dedicated page for Leap Therapeutic SEC filings (Ticker: LPTX), a comprehensive resource for investors and traders seeking official regulatory documents including 10-K annual reports, 10-Q quarterly earnings, 8-K material events, and insider trading forms.
Sorting through Leap Therapeutics’ dense antibody trial data, equity offerings, and risk factors can feel like decoding a lab notebook. Clinical-stage oncology companies publish highly technical disclosures, and the latest 10-Q already runs 200+ pages. If you have ever typed “Leap Therapeutics insider trading Form 4 transactions” or “Leap Therapeutics quarterly earnings report 10-Q filing” into Google, you know the challenge: the information is there, but buried.
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Schedule 13G/A disclosure for Leap Therapeutics, Inc. (LPTX) This filing is a joint Schedule 13G/A by Samsara BioCapital, L.P., Samsara BioCapital GP, LLC and Srinivas Akkaraju reporting that, as of June 30, 2025, each Reporting Person beneficially owns 0 shares (0.0%) of Leap Therapeutics common stock (CUSIP 52187K200). The Reporting Persons state they are not a "group" and provide a Palo Alto business address for the filer. The filing incorporates a prior Joint Filing Statement by reference and is signed by Srinivas Akkaraju on behalf of the entities on August 14, 2025. The statement certifies the securities were not acquired to influence control of the issuer.
Leap Therapeutics reported a difficult quarter marked by clinical progress on its lead asset but acute financial stress. Updated DeFianCe Part B data showed sirexatamab (DKN-01) produced a statistically significant benefit on overall response rate and progression-free survival in colorectal cancer patients with high DKK1, no prior anti‑VEGF therapy, or liver metastasis, with final study results being prepared for conference presentation.
Financially, the company had $18.13 million in cash and cash equivalents and $20.04 million total assets as of June 30, 2025, and reported a $32.08 million net loss for the six months ended June 30, 2025, leaving an accumulated deficit of $499.45 million. Management disclosed substantial doubt about the company’s ability to continue as a going concern, implemented a workforce reduction of approximately 75% and recorded $4.53 million of restructuring charges, and engaged Raymond James to explore strategic alternatives.
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