[Form 4] LAVA Therapeutics NV Insider Trading Activity

Rhea-AI Filing Summary

LAVA Therapeutics (LVTX): insider sales reported by Gilde Healthcare affiliates. The reporting persons disclosed open‑market sales of common shares on multiple dates. On 10/16/2025, they sold 690,239 shares at a weighted average price of $1.49, with 4,128,912 shares beneficially owned afterward. On 10/17/2025, they sold 1,181,131 shares at a weighted average price of $1.47, with 2,947,781 shares beneficially owned afterward. On 10/20/2015, they sold 1,000,000 shares at a weighted average price of $1.46, leaving 1,947,781 shares beneficially owned.

The prices reflect weighted averages across trade ranges disclosed for each date, and the shares are held directly by Cooperatieve Gilde Healthcare IV U.A., with related entities noted; each related entity disclaims beneficial ownership except to the extent of its pecuniary interest.

Insights

Equity Ownership Analyst

Significant open-market insider sales reduced a key holder’s stake; no derivatives reported.

The filing discloses three open‑market sales of **LAVA Therapeutics NV (LVTX)** common shares by a reporting group. Reported sales were 690,239 shares at a weighted average of $1.49 on 10/16/2025, 1,181,131 shares at a weighted average of $1.47 on 10/17/2025, and 1,000,000 shares at a weighted average of $1.46 on 10/20/2015. After these transactions, reported beneficial ownership stands at **1,947,781** shares, held directly by **Cooperatieve Gilde Healthcare IV U.A.**

The filing indicates it was submitted by more than one reporting person, and states that **Gilde Healthcare IV Management B.V.** and **Gilde Healthcare Holding B.V.** disclaim beneficial ownership beyond their pecuniary interests. The sales are coded "S" (open‑market or private sale) and include detailed weighted‑average price ranges, with an undertaking to provide trade‑level detail upon request. No derivative securities are reported in Table II.

Items to watch: subsequent Forms 4 for additional dispositions, any changes in reported beneficial ownership, and whether further transactions occur after 10/17/2025. The weighted‑average price ranges disclosed ($1.44–$1.53) frame recent execution levels for these transactions.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

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X

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Cooperatieve Gilde Healthcare IV U.A.

(Last) (First) (Middle)

STADSPLATEAU 36

(Street)

UTRECHT P7 3521 AZ

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
LAVA Therapeutics NV [ LVTX ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

3. Date of Earliest Transaction (Month/Day/Year)
10/16/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

	Form filed by One Reporting Person
X	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Shares	10/16/2025		S		690,239	D	$1.49(1)	4,128,912	D(2)
Common Shares	10/17/2025		S		1,181,131	D	$1.47(3)	2,947,781	D(2)
Common Shares	10/20/2015		S		1,000,000	D	$1.46(4)	1,947,781	D(2)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

1. Name and Address of Reporting Person^*

Cooperatieve Gilde Healthcare IV U.A.

(Last) (First) (Middle)

STADSPLATEAU 36

(Street)

UTRECHT P7 3521 AZ

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

Gilde Healthcare Holding B.V.

(Last) (First) (Middle)

STADSPLATEAU 36

(Street)

UTRECHT P7 3521 AZ

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

Explanation of Responses:

1. This figure is the weighted average sales price of multiple trades ranging from $1.47 to $1.53 per share. The Reporting Person undertakes to provide the Staff of the Securities and Exchange Commission, LAVA Therapeutics NV or any security holder of LAVA Therapeutics NV full information about the number of shares sold at each separate price upon request.

2. The shares are held directly by Cooperatieve Gilde Healthcare IV U.A. ("Gilde Healthcare"). Gilde Healthcare IV Management BV ("GHCIVM") manages and advises Gilde Healthcare and is owned by Gilde Healthcare Holding BV ("GHH"). Each of GHCIVM and GHH disclaims beneficial ownership of the shares held by Gilde Healthcare, except to the extent of its respective pecuniary interests therein.

3. This figure is the weighted average sales price of multiple trades ranging from $1.44 to $1.52 per share. The Reporting Person undertakes to provide the Staff of the Securities and Exchange Commission, LAVA Therapeutics NV or any security holder of LAVA Therapeutics NV full information about the number of shares sold at each separate price upon request.

4. This figure is the weighted average sales price of multiple trades ranging from $1.44 to $1.51 per share. The Reporting Person undertakes to provide the Staff of the Securities and Exchange Commission, LAVA Therapeutics NV or any security holder of LAVA Therapeutics NV full information about the number of shares sold at each separate price upon request.

	Cooperatieve Gilde Healthcare IV U.A., By: /s/ Edwin de Graaf, Managing Director	10/20/2025
	Gilde Healthcare IV Management B.V., By: /s/ Edwin de Graaf, Managing Director	10/20/2025
	Gilde Healthcare Holding B.V., By: /s/ Edwin de Graaf, Managing Director	10/20/2025
	** Signature of Reporting Person	Date
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