Lyra Therapeutics (NASDAQ: LYRA) CEO sells 1,702 shares for RSU tax under 10b5-1 plan

Rhea-AI Filing Summary

Lyra Therapeutics, Inc. reported an insider tax-related share sale by its President & CEO, Maria Palasis. On 01/06/2026, she sold 1,702 shares of Lyra common stock at a price of $3.364 per share. The filing states that these shares were sold to cover taxes due upon the vesting of restricted stock units, under a mandatory Rule 10b5-1 trading instruction adopted on January 1, 2025. After this transaction, she beneficially owned 1,096,733 shares of Lyra common stock directly.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

X

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Palasis Maria

(Last) (First) (Middle)

C/O LYRA THERAPEUTICS, INC.

480 ARSENAL WAY

(Street)

WATERTOWN MA 02472

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Lyra Therapeutics, Inc. [ LYRA ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	President & CEO

3. Date of Earliest Transaction (Month/Day/Year)
01/06/2026

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	01/06/2026		S(1)		1,702	D	$3.364	1,096,733	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. Shares were sold to cover taxes upon the vesting of restricted stock units ("RSUs") pursuant to a mandatory Rule 10b5-1 trading instruction in the award agreement adopted by the Reporting Person on January 1, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

	/s/ Jason Cavalier, Attorney-in-Fact for Maria Palasis, Ph.D.	01/08/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
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FAQ

What insider transaction did Lyra Therapeutics (LYRA) report for Maria Palasis?

Lyra Therapeutics reported that President & CEO Maria Palasis sold 1,702 shares of common stock on 01/06/2026 at $3.364 per share.

Why did Maria Palasis sell 1,702 Lyra (LYRA) shares?

The filing explains that the 1,702 shares were sold to cover taxes upon the vesting of restricted stock units, under a mandatory Rule 10b5-1 trading instruction in her award agreement.

How many Lyra Therapeutics (LYRA) shares does Maria Palasis own after this Form 4?

After the reported transaction, Maria Palasis beneficially owned 1,096,733 shares of Lyra Therapeutics common stock, held directly.

What is the role of Maria Palasis at Lyra Therapeutics (LYRA)?

Maria Palasis is identified in the filing as both a Director and the company’s President & CEO.

Was the Lyra (LYRA) share sale by Maria Palasis under a Rule 10b5-1 plan?

Yes. The filing states the RSU tax-cover sale was executed pursuant to a mandatory Rule 10b5-1 trading instruction adopted on January 1, 2025.

Does this Lyra (LYRA) Form 4 involve any derivative securities?

No derivative securities are reported in the transaction table; the filing lists only common stock in the non-derivative section.