STOCK TITAN

Mineralys Therapeutics (MLYS) director trades 3,000 shares under plan

Filing Impact
(Neutral)
Filing Sentiment
(Neutral)
Form Type
4

Rhea-AI Filing Summary

Mineralys Therapeutics director Daphne Karydas reported an option exercise and share sale. She exercised stock options to acquire 3,000 shares of common stock at $12.02 per share, then sold 3,000 common shares in an open-market transaction at $25.00 per share.

After these transactions, she directly holds 6,200 shares of common stock and 41,000 stock options. The filing notes that these trades were carried out under a pre-arranged Rule 10b5-1 trading plan adopted on December 30, 2025.

Positive

  • None.

Negative

  • None.
Insider Karydas Daphne
Role Director
Sold 3,000 shs ($75K)
Type Security Shares Price Value
Exercise Stock Option 3,000 $0.00 --
Exercise Common Stock 3,000 $12.02 $36K
Sale Common Stock 3,000 $25.00 $75K
Holdings After Transaction: Stock Option — 41,000 shares (Direct); Common Stock — 9,200 shares (Direct)
Footnotes (1)
  1. These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on December 30, 2025. The stock option vests in 36 monthly installments beginning on October 13, 2023.
Options exercised 3,000 shares Stock options exercised into common stock at $12.02 per share
Exercise price $12.02/share Strike price for 3,000 exercised stock options
Shares sold 3,000 shares Common stock sold in open-market transaction at $25.00
Sale price $25.00/share Price for 3,000 Mineralys Therapeutics common shares sold
Common shares held 6,200 shares Direct Mineralys Therapeutics common stock ownership after transactions
Options held 41,000 options Stock options outstanding after the reported exercise
10b5-1 plan adoption date December 30, 2025 Pre-arranged trading plan governing the reported transactions
Option vesting term 36 monthly installments Vesting schedule beginning October 13, 2023
Rule 10b5-1 trading plan financial
"These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on December 30, 2025."
A Rule 10b5-1 trading plan is a pre-arranged schedule that allows company insiders to buy or sell stock at specific times, even if they have inside information. It helps prevent accusations of unfair trading by making these transactions look planned and transparent, rather than sneaky or illegal.
Stock Option financial
"security_title": "Stock Option""
A stock option is a contract that gives you the right to buy or sell a company's stock at a specific price within a certain time frame. People use them to potentially make money if the stock's price moves favorably or to protect against losses. It's like holding a coupon that can be used to buy or sell stock at a set price later on.
Exercise or conversion of derivative security financial
"transaction_code_description": "Exercise or conversion of derivative security""
open-market sale financial
"transaction_action": "open-market sale""
An open-market sale is when a shareholder sells existing shares directly on a public exchange to any willing buyer, rather than through a private deal. Think of it like putting goods on a busy market stall where price is set by supply and demand; for investors it matters because such sales increase available supply, can put short-term downward pressure on the stock price, and signal changes in liquidity or investor confidence.
derivative security financial
"transaction_code_description": "Exercise or conversion of derivative security""
A derivative security is a financial contract whose value comes from the price or performance of something else, such as a stock, bond, commodity, or market index. For investors it acts like an insurance policy or a wager: it can be used to protect against losses, lock in prices, or amplify gains and losses, so it can change a portfolio’s risk and potential return without owning the underlying asset directly.
SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Karydas Daphne

(Last)(First)(Middle)
150 N. RADNOR CHESTER RD.
SUITE F200

(Street)
RADNOR PENNSYLVANIA 19087

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Mineralys Therapeutics, Inc. [ MLYS ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
XDirector10% Owner
Officer (give title below)Other (specify below)
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
03/31/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock03/31/2026M(1)3,000A$12.029,200D
Common Stock03/31/2026S(1)3,000D$256,200D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option$12.0203/31/2026M(1)3,000 (2)09/13/2033Common Stock3,000$041,000D
Explanation of Responses:
1. These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on December 30, 2025.
2. The stock option vests in 36 monthly installments beginning on October 13, 2023.
Remarks:
/s/ Adam Levy, Attorney-in-fact04/02/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

FAQ

What insider transactions did Mineralys Therapeutics (MLYS) director Daphne Karydas report?

Daphne Karydas reported exercising stock options for 3,000 Mineralys Therapeutics shares, then selling 3,000 common shares in an open-market transaction. These moves converted option-based compensation into stock and then into cash while leaving her with a continuing equity position.

How many Mineralys Therapeutics (MLYS) shares did the director sell and at what price?

She sold 3,000 shares of Mineralys Therapeutics common stock at a price of $25.00 per share in an open-market transaction. This sale followed the exercise of stock options that delivered the same number of shares into her direct ownership.

At what price did the Mineralys Therapeutics (MLYS) director exercise her stock options?

She exercised stock options covering 3,000 underlying Mineralys Therapeutics shares at an exercise price of $12.02 per share. This transaction converted derivative securities into common stock as part of her equity compensation arrangement with the company.

What are Daphne Karydas’s holdings in Mineralys Therapeutics (MLYS) after these transactions?

After the reported transactions, she directly holds 6,200 shares of Mineralys Therapeutics common stock and 41,000 stock options. These positions show she retains both current share ownership and a significant remaining option-based interest in the company.

Were the Mineralys Therapeutics (MLYS) insider trades made under a Rule 10b5-1 plan?

Yes. The filing states the transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on December 30, 2025. Such plans pre-schedule trades, which can make the timing less indicative of the insider’s short-term market view.

How do the Mineralys Therapeutics (MLYS) option terms affect the director’s compensation?

The filing notes that the stock option vests in 36 monthly installments beginning October 13, 2023. This structure gradually delivers exercisable options over three years, aligning a portion of the director’s compensation with Mineralys Therapeutics’ long-term share performance.