[Form 4] Monopar Therapeutics Insider Trading Activity

Rhea-AI Filing Summary

Monopar Therapeutics (MNPR) insider filing: Andrew Cittadine, the company's Chief Operating Officer and a director, reported equity activity dated 09/30/2025. He received 4,327 shares upon vesting and settlement of restricted stock units. To satisfy tax withholding on the vesting, 1,896 shares were surrendered at an indicated price of $81.67 per share.

After these transactions the filing shows beneficial ownership figures reported on the form: 50,185 shares following the acquisition line and 48,289 shares following the withholding line; the form also lists 38,674 restricted stock units/RSU-related shares held following the reported transactions. The form is executed by attorney-in-fact Quan Vu on 10/02/2025.

Positive

• 4,327 shares acquired on vesting and settlement of RSUs, reflecting compensation alignment
• No open-market sale reported beyond tax withholding, indicating no active divestiture

Negative

• 1,896 shares withheld to pay taxes at $81.67, reducing the reporting person’s net shares

Insights

Corporate Governance Expert

Routine executive RSU vesting with tax withholding; no open-market sale reported.

The filing documents scheduled vesting of RSUs rather than an open-market purchase or sale. That indicates the change in the reporting person’s common stock position resulted from compensation plan mechanics, not a discretionary market trade. Because shares were withheld to cover taxes, there is no net sale disclosed beyond the withholding transaction documented at $81.67 per share.

Compensation & Equity Expert

Vesting schedule consistent with prior grants; partial settlement reduced outstanding RSUs.

The report references grant schedules from 2022, 2023, and 2025 and shows 4,327 RSUs vested and settled on 09/30/2025, with 1,896 shares withheld for tax. The filing also lists remaining RSU-related shares (38,674), which reflects ongoing vesting schedules extending through 2028 as disclosed in the explanations.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person^*

Cittadine Andrew

(Last) (First) (Middle)

1000 SKOKIE BLVD SUITE 350

(Street)

WILMETTE IL 60091

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Monopar Therapeutics [ MNPR ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief Operating Officer

3. Date of Earliest Transaction (Month/Day/Year)
09/30/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	09/30/2025		M		4,327	A	(1)	50,185	D
Common Stock	09/30/2025		F		1,896(2)	D	$81.67	48,289	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Restricted Stock Units	(1)	09/30/2025		M			4,327	(3)(4)(5)	(3)(4)(5)	Common Stock	4,327	$0	38,674	D

Explanation of Responses:

1. Represents shares acquired on vesting and settlement of restricted stock units.

2. Represents shares withheld by the issuer to pay for the applicable withholding tax due upon vesting of restricted stock units.

3. On February 2, 2022, the reporting person was granted 13,000 restricted stock units, vesting 6/48ths (1,625 shares) on June 30, 2022, and 3/48ths (813 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2025. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement.

4. On February 1, 2023, the reporting person was granted 15,647 restricted stock units, vesting 6/48ths (1,956 shares) on June 30, 2023, and 3/48ths (978 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2026. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement.

5. On March 4, 2025, the reporting person was granted 40,581 restricted stock units, vesting 6/48ths (5,073 shares) on June 30, 2025, and 3/48ths (2,536 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2028. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement.

	/s/ Quan Vu, Attorney-in-fact	10/02/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What did MNPR COO Andrew Cittadine report on Form 4?

He reported that 4,327 shares were issued upon vesting of restricted stock units on 09/30/2025, and 1,896 shares were withheld for taxes at $81.67 per share.

How many shares did the filing show as beneficially owned after the transactions?

The form shows beneficial ownership figures of 50,185 following the acquisition line and 48,289 following the withholding line; it also lists 38,674 RSU-related shares following the reported transactions.

Were any open-market sales reported by the insider in this filing?

No. The filing records acquisition via RSU vesting and shares withheld for taxes; it does not report any open-market sales.

Do the disclosures reference prior RSU grants?

Yes. The explanations cite RSU grants dated 02/02/2022, 02/01/2023, and 03/04/2025 with scheduled vesting periods through 2026 and 2028.

Who signed the Form 4 and when?

The form was executed by attorney-in-fact Quan Vu on 10/02/2025.