NuCana plc files as a foreign private issuer, and its SEC materials document Form 6-K current reports, UK annual report materials, annual general meeting notices, and voting procedures for holders of American Depositary Shares. The filings connect the company’s ordinary-share governance with its ADS program and describe how depositary voting instructions are handled for shareholder meetings.
Recent filings also furnish financial results, unaudited condensed consolidated financial statements, management discussion and analysis, and clinical-program updates for NUC-7738 and NUC-3373. Other disclosures cover patent announcements, board and executive-role changes, Nasdaq continued-listing compliance for the ADSs, and incorporation of selected 6-K information into registration statements on Form F-3 and Form S-8.
NuCana plc director and CEO Hugh Griffith has filed an initial Form 3 reporting his equity holdings in the company. He reports direct ownership of 1,000,000 Ordinary Shares and American Depositary Shares, with one entry showing 52 American Depositary Shares. According to the disclosure, each American Depositary Share represents 5,000 Ordinary Shares of NuCana plc.
The filing also lists several option awards over Ordinary Shares, all held directly. These include separate option positions over 62,499,995, 1,221,867,885, 1,544,328,984, 691,582,704 and 831,561,761 underlying Ordinary Shares, each with very low exercise prices in Pounds Sterling. Footnotes state that some options are fully vested and expire between June 20, 2035 and January 14, 2036, while others vest in annual installments through June 20, 2029 and January 14, 2030, subject to continued service.
NuCana plc reports that Hugh S. Griffith has returned to his role as Chief Executive Officer and principal executive officer, effective December 15, 2025.
During his health-related leave, Executive Chairman Andrew Kay had been acting as the company’s principal executive officer; upon Mr. Griffith’s return, Mr. Kay resumed his prior position as Chairman of the Board. The update is also stated to be incorporated by reference into NuCana’s existing shelf and equity compensation registration statements on Form F-3 and Form S-8.
NuCana plc furnished a Form 6-K noting it issued a press release announcing third quarter 2025 financial results and provided accompanying materials. The filing includes unaudited condensed consolidated financial statements as of September 30, 2025 (Exhibit 99.1), Management’s Discussion and Analysis for the three and nine months ended September 30, 2025 and 2024 (Exhibit 99.2), and the November 13, 2025 press release (Exhibit 99.3).
Exhibits 99.1 and 99.2 are incorporated by reference into the Company’s registration statements on Form F-3 (File No. 333-281576) and Form S-8 (File Nos. 333-223476 and 333-248135). Exhibit 99.3 is being furnished and is not deemed filed. The Company also disclosed that, effective October 21, 2025, Bali Muralidhar, M.D., Ph.D. resigned from the Board and all committees; the resignation was not the result of any dispute regarding operations, policies, or practices.
NuCana plc (NCNA) reported that the China National Intellectual Property Administration issued a new patent covering NUC‑7738’s composition of matter. The update was communicated via a press release attached as Exhibit 99.1.
The information is incorporated by reference into the company’s registration statements on Form F‑3 (File No. 333-281576) and Form S‑8 (File Nos. 333-223476, 333-248135). The press release is being furnished, not filed, under the Exchange Act.
NuCana plc furnished a Form 6-K announcing it issued a press release about new research presented at ESMO 2025. The presentation covers a model system investigating the synergistic effects of NUC-7738 and PD-1 inhibition in primary organoids derived from patients with renal cell carcinoma.
The press release is attached as Exhibit 99.1 and is incorporated by reference. The information in Exhibit 99.1 is being furnished and not deemed filed under the Exchange Act.
NuCana plc reported an update via Form 6-K, stating that on October 14, 2025 it announced the publication of new data from the NuTide:303 clinical study evaluating NUC-3373 on medRxiv, alongside complementary preclinical findings published in the peer‑reviewed journal PLOS ONE.
The company furnished a press release as Exhibit 99.1. The information is being furnished, not filed, under the Exchange Act and is not subject to Section 18 liabilities, nor incorporated into other filings except by specific reference.
NuCana plc has confirmed that it is now in compliance with all applicable continued listing criteria of The Nasdaq Capital Market. This follows earlier notices from Nasdaq that the bid price of NuCana’s American Depositary Shares had fallen below the minimum bid price requirement, and had also closed below $0.10 per share for 10 consecutive trading days, which put the shares at risk of delisting.
The company presented a plan to regain compliance at a Nasdaq Hearings Panel meeting on August 21, 2025. On September 4, 2025, Nasdaq’s Office of the General Counsel notified NuCana that it is in compliance with Nasdaq’s listing rules, meaning its ADSs can continue trading on The Nasdaq Capital Market under current criteria.
NuCana plc reported that it will give a presentation at the European Society for Medical Oncology (ESMO) Congress 2025, which takes place October 17-21, 2025 in Berlin, Germany. This update comes via a company press release dated September 3, 2025, which is included as an exhibit to the report. The content of the press release is furnished for informational purposes and is not treated as filed under U.S. securities law unless specifically incorporated into other company disclosures.
NuCana plc submitted a Form 6-K as a foreign private issuer to provide investors with its second quarter 2025 information. The filing states that a press release announcing Q2 2025 financial results, unaudited condensed consolidated financial statements as of June 30, 2025, and Management’s Discussion and Analysis are attached as Exhibits 99.1–99.3.
The financial statements and MD&A are expressly incorporated by reference into NuCana’s existing Form F-3 and Form S-8 registration statements, while the press release is furnished, not filed, and is excluded from incorporation by reference except where specifically noted.