Nkarta (NKTX) widens Q2 2026 loss but sees cash runway into 2029
Rhea-AI Filing Summary
Nkarta, Inc. reported second quarter 2026 results while advancing its NKX019 autoimmune program. Enrollment is ongoing across all indications in the Ntrust-1 and Ntrust-2 dose-escalation trials at a regimen of 4 billion cells per dose across three doses, and outpatient dosing has begun at community-based sites with potential re-dosing.
As of June 30, 2026, Nkarta held $243.2 million in cash, cash equivalents, restricted cash and investments, and expects this to fund its current operating plan into 2029. For the quarter, research and development expenses were $29.0 million and general and administrative expenses were $14.1 million, both higher than the prior-year period. Net loss was $40.4 million, or $0.54 per share, including $11.8 million of non-cash charges such as $8.0 million of impairments, $2.7 million of depreciation and $1.9 million of share-based compensation.
Positive
- Cash runway into 2029 based on a cash, cash equivalents, restricted cash and investments balance of $243.2 million as of June 30, 2026.
- Clinical progress for NKX019 with ongoing enrollment in Ntrust-1 and Ntrust-2, initiation of outpatient dosing at community-based sites, and planned initial clinical data presentation in 2026.
Negative
- Net loss increased to $40.4 million (or $0.54 per share) in Q2 2026 compared with $22.977 million (or $0.31 per share) in Q2 2025.
- Operating expenses rose significantly, with R&D at $29.046 million and G&A at $14.082 million in Q2 2026 versus $20.778 million and $6.408 million a year earlier.
- Cash and investments declined to $243.178 million at June 30, 2026 from $295.129 million at December 31, 2025, reflecting continued cash usage.
Filing Explained
The filing identifies a planned 2026 medical-conference presentation of initial Ntrust-1 and Ntrust-2 clinical data, making that presentation the next specified disclosure milestone.
8-K Event Classification
Key Figures
Key Terms
lymphodepletion medical
CAR-NK cell therapy medical
chimeric antigen receptor medical
right-of-use assets financial
autoimmune diseases medical
dose escalation medical
Earnings Snapshot
Nkarta expects its current cash, cash equivalents, restricted cash and investments to fund its current operating plan into 2029.
AI-generated analysis. How Rhea-AI works. Not financial advice.
FAQ
What was Nkarta (NKTX)'s net loss for the second quarter of 2026?
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What were Nkarta (NKTX)'s R&D and G&A expenses in Q2 2026?
What clinical progress did Nkarta (NKTX) report for NKX019 and the Ntrust trials?
Which autoimmune diseases are targeted in Nkarta (NKTX)'s Ntrust-1 and Ntrust-2 trials?
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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
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Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
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Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
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Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
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Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).
Emerging growth company
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Item 2.02 Results of Operations and Financial Condition.
On August 10, 2026, Nkarta, Inc. (the “Company”) will issue a press release announcing its financial results for the second quarter ended June 30, 2026. A copy of the Company’s press release is attached hereto as Exhibit 99.1.
The information in Item 2.02 of this Current Report on Form 8-K (including Exhibit 99.1) shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be, or be deemed, incorporated by reference in any filings under the Securities Act of 1933, as amended (the “Securities Act”), unless the Company specifically states that the information is to be considered “filed” under the Exchange Act or incorporates it by reference into a filing under the Securities Act or the Exchange Act.
Item 9.01 Financial Statements and Exhibits.
(d) Exhibits.
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Description |
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99.1 |
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Press Release, dated August 10, 2026, entitled “Nkarta Reports Second Quarter 2026 Financial Results and Corporate Highlights” |
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Cover Page Interactive Data File (embedded within the Inline XBRL document). |
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SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
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Nkarta, Inc. |
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Date: August 10, 2026 |
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By: |
/s/ Nadir Mahmood |
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Nadir Mahmood |
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President |
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Exhibit 99.1
Nkarta Reports Second Quarter 2026 Financial Results and Corporate Highlights
SOUTH SAN FRANCISCO, Calif., August 10, 2026 (GLOBE NEWSWIRE) -- Nkarta, Inc. (Nasdaq: NKTX), a clinical-stage biotechnology company developing engineered natural killer (NK) cell therapies to treat autoimmune diseases, today reported financial results for the second quarter ended June 30, 2026.
“Expanding access to NKX019 in the communities where autoimmune patients already receive care is central to how we're advancing this program," said Paul J. Hastings, Chief Executive Officer of Nkarta. "This quarter, we continued to enroll patients across all indications in Ntrust-1 and Ntrust-2 at the 4 billion cell dose level. Following our recent agreement with the FDA on outpatient dosing, we have begun administrating NKX019 through our expanding network of community-based sites, with re-dosing available, if needed, to patients in both trials. We look forward to presenting our initial clinical dataset from Ntrust-1 and Ntrust-2 at a medical conference in 2026.”
NKX019 Clinical Program Progress and Upcoming Milestones
Second Quarter 2026 Financial Highlights
Financial Guidance
About the Ntrust℠ Clinical Trials in Autoimmune Disease
Ntrust-1 (NCT06557265) and Ntrust-2 (NCT06733935) are multi-center, open label, dose escalation clinical trials in patients with autoimmune disease receiving lymphodepletion followed by CD19-targeted CAR-NK cell therapy. Both trials will assess the safety of NKX019 in people living with autoimmune diseases as well as its potential to achieve durable remission via a “reset” of the immune system through the elimination of pathogenic B cells.
The Ntrust trials are enrolling up to 12 patients per dose level per disease indication across systemic sclerosis, idiopathic inflammatory myopathy, ANCA-associated vasculitis, rheumatoid arthritis, lupus nephritis, and primary membranous nephropathy. Additional participants may be enrolled if needed to refine patient populations for further study.
In both studies, patients now receive a three-dose cycle of NKX019 on Days 0, 3, and 7 following lymphodepletion with fludarabine and cyclophosphamide or cyclophosphamide alone, if they have significant cytopenia at baseline. Leveraging the engineering of NKX019, no patients in either trial will receive supplemental cytokines or antibody-based therapeutics. This approach is designed to evaluate the single-agent activity of NKX019 and facilitate a more rapid path to regulatory approval. Patients in both trials may also receive additional cycles, if needed, to restore response or enable a deeper response.
About NKX019
NKX019 is an allogeneic, cryopreserved, off-the-shelf immunotherapy candidate that uses natural killer (NK) cells derived from the peripheral blood of healthy adult donors. It is engineered with a humanized CD19-directed chimeric antigen receptor (CAR) for enhanced cell targeting and a proprietary, membrane-bound form of interleukin-15 (IL-15) for greater persistence and activity without exogenous cytokine support. CD19 is a biomarker for normal B
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cells as well as those implicated in autoimmune disease. Nkarta is evaluating NKX019 in multiple autoimmune conditions.
About Nkarta
Nkarta is a clinical-stage biotechnology company advancing the development of allogeneic, off-the-shelf natural killer (NK) cell therapies for people living with autoimmune diseases. By harnessing the power of the innate immune system to eliminate pathogenic B cells driving the autoimmune response, Nkarta is advancing novel cell therapies engineered for deep therapeutic impact. The on-demand availability and outpatient dosing of our CAR-NK cells enables a broad population of patients with different autoimmune conditions to conveniently access NK cell therapy in community health settings. For more information, please visit the company’s website at www.nkartatx.com.
Cautionary Note on Forward-Looking Statements
Statements contained in this press release regarding matters that are not historical facts are “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. Words such as “anticipates,” “believes,” “expects,” “intends,” “plans,” “potential,” “projects,” “would” and “future” or similar expressions are intended to identify forward-looking statements. Examples of these forward-looking statements include, but are not limited to, statements concerning Nkarta’s expectations regarding any or all of the following: Nkarta’s position, plans, strategies, and timelines for the continued and future clinical development and commercial potential of NKX019 (including the future availability and disclosure of clinical data and other updates from Nkarta’s clinical trials); the therapeutic potential, accessibility and tolerability of NKX019 for the treatment of autoimmune diseases, including as a result of advancing Nkarta’s dose escalation and expansion of outpatient dosing in community-based settings; and Nkarta’s expected cash runway.
Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These risks and uncertainties include, among others: Nkarta’s limited operating history and historical losses; Nkarta’s lack of any products approved for sale and its ability to achieve profitability; the risk that the results of preclinical studies and early-stage clinical trials may not be predictive of future results; Nkarta’s ability to raise additional funding to complete the development and any commercialization of its product candidates; Nkarta’s dependence on the clinical success of NKX019; that Nkarta may be delayed in initiating, enrolling patients in or completing its clinical trials; competition from third parties that are developing products for similar uses; Nkarta’s ability to obtain, maintain and protect its intellectual property; Nkarta’s dependence on third parties in connection with manufacturing, clinical trials and pre-clinical studies; the complexity of the manufacturing process for CAR NK cell therapies; and the success of Nkarta’s recent (and any future) cost containment measures.
These and other risks and uncertainties are described more fully in Nkarta’s filings with the Securities and Exchange Commission (“SEC”), including the “Risk Factors” section of Nkarta’s
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Quarterly Report on Form 10-Q for the quarter ended March 31, 2026, filed with the SEC on May 12, 2026, and Nkarta’s other documents subsequently filed with or furnished to the SEC. All forward-looking statements contained in this press release speak only as of the date on which they were made. Except to the extent required by law, Nkarta undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.
Nkarta, Inc.
Condensed Statements of Operations
(in thousands, except share and per share data)
(Unaudited)
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Three Months Ended June 30, |
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Six Months Ended June 30, |
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2026 |
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2025 |
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2026 |
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2025 |
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Operating expenses |
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Research and development |
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$ |
29,046 |
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$ |
20,778 |
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$ |
54,034 |
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$ |
44,950 |
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General and administrative |
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14,082 |
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6,408 |
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19,970 |
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18,800 |
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Total operating expenses |
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43,128 |
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27,186 |
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74,004 |
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63,750 |
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Loss from operations |
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(43,128 |
) |
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(27,186 |
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(74,004 |
) |
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(63,750 |
) |
Other income, net: |
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Interest income |
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2,538 |
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3,970 |
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5,376 |
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8,346 |
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Other income, net |
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222 |
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239 |
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428 |
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444 |
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Total other income, net |
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2,760 |
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4,209 |
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5,804 |
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8,790 |
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Net loss |
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$ |
(40,368 |
) |
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$ |
(22,977 |
) |
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$ |
(68,200 |
) |
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$ |
(54,960 |
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Net loss per share, basic and diluted |
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$ |
(0.54 |
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$ |
(0.31 |
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$ |
(0.92 |
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$ |
(0.74 |
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Weighted average shares used to compute |
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74,494,855 |
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73,977,625 |
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74,377,069 |
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73,947,220 |
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4
Nkarta, Inc.
Condensed Balance Sheets
(in thousands)
(Unaudited)
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June 30, |
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December 31, |
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Assets |
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Cash, cash equivalents, restricted cash and investments |
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$ |
243,178 |
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$ |
295,129 |
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Property and equipment, net |
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56,768 |
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66,721 |
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Operating lease right-of-use assets |
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30,942 |
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34,429 |
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Other assets |
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6,757 |
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7,930 |
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Total assets |
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$ |
337,645 |
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$ |
404,209 |
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Liabilities and stockholders' equity |
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Accounts payable, accrued and other liabilities |
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$ |
16,368 |
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$ |
15,464 |
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Operating lease liabilities |
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73,539 |
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76,420 |
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Total liabilities |
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89,907 |
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91,884 |
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Stockholders’ equity |
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247,738 |
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312,325 |
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Total liabilities and stockholders’ equity |
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$ |
337,645 |
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$ |
404,209 |
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Nkarta Media/Investor Contact:
Nadir Mahmood
Nkarta, Inc.
nmahmood@nkartatx.com
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