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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
Date of report (Date of earliest event reported):
February 27, 2026
NEONC TECHNOLOGIES HOLDINGS, INC.
(Exact Name of Registrant as Specified in Its Charter)
Delaware
(State or Other Jurisdiction of Incorporation)
| 001-42567 |
|
92-1954864 |
| (Commission File Number) |
|
(IRS Employer Identification No.) |
| 23975 Park Sorrento, Suite 205 Calabasas, CA |
|
91302 |
| (Address of Principal Executive Offices) |
|
(Zip Code) |
(818) 570-6844
(Registrant’s Telephone Number, Including Area
Code)
N/A
(Former Name or Former Address, if Changed Since Last
Report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):
| ☐ |
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |
| ☐ |
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
| ☐ |
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
| ☐ |
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |
Securities registered pursuant to Section 12(b) of the Act:
| Title of each class |
|
Trading Symbols |
|
Name of each exchange on which registered |
| Common Stock, par value $0.0001 |
|
NTHI |
|
The Nasdaq Stock Market LLC |
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2).
Emerging growth company ☒
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.
| Item 7.01. |
Regulation FD Disclosure. |
On February 27, 2026, NeOnc Technologies Holdings,
Inc. (the “Company”) issued a press release announcing that it will host an investor conference call and webcast on Wednesday,
March 4, 2026, at 9:00 a.m. Eastern Time to present initial data from the Phase 1 dose-escalation portion of the NEO212-01 Phase 1/2 clinical
trial. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K.
The information in this Item 7.01 and Exhibit
99.1 furnished hereto shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended
(the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference
in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in
such a filing.
| Item 9.01. |
Financial Statements and Exhibits. |
| Exhibit No. |
|
Description |
| 99.1 |
|
Press Release, dated February 27, 2026 |
| 104 |
|
Cover Page Interactive Data File (embedded within the Inline XBRL document) |
SIGNATURES
Pursuant to the requirements
of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto
duly authorized.
| Dated: February 27, 2026 |
NeOnc Technologies Holdings, Inc. |
| |
|
|
| |
By: |
/s/ Amir Heshmatpour |
| |
|
Name: |
Amir Heshmatpour |
| |
|
Title: |
Chief
Executive Officer, President and Executive Chairman |
Exhibit 99.1
NeOnc Technologies (Nasdaq: NTHI) to Host Investor
Conference Call to Present Dose-Escalation Results
from Full Phase 1 NEO212-01 Readout for Dosing
and Toxicity
CALABASAS, Calif., Feb. 27, 2026 — NeOnc
Technologies Holdings, Inc. (Nasdaq: NTHI) (“NeOnc” or the “Company”), a multi-Phase 2 clinical-stage biopharmaceutical
company developing novel therapies for central nervous system (CNS) cancers, today announced today announced that it will host an investor
conference call and webcast on March 4, 2026, at 6:00 a.m. Pacific Time / 9:00 a.m. Eastern Time.
During the call, members of the NeOnc management
team and independent members of the Company’s Scientific Advisory Board (SAB) will present initial data from the Phase 1 dose-escalation
portion of the NEO212-01 Phase 1/2 clinical trial, evaluating NeOnc’s proprietary bioconjugated temozolomide (TMZ) platform in an
oral formulation for patients with CNS malignancies.
The discussion will include an update on the Phase
1 dose-escalation portion of the NEO212-01 clinical trial, including safety and toxicity data, dose-escalation observations, pharmacokinetic
findings, and planned regulatory next steps.
Featured Participants:
| ● | Dr. Henry S. Friedman, MD – Deputy Director,
Preston Robert Tisch Brain Tumor Center, Duke University; Independent Member, NTHI Scientific Advisory Board |
| ● | Dr. Alexandra Miller, MD – Chief Neuro-oncology,
Brain Tumor Program, NYU Langone Health; Independent Member, NTHI Scientific Advisory Board |
| ● | Amir Heshmatpour – Chief Executive Officer,
Executive Chairman and President |
| ● | Dr. Thomas C. Chen, MD, PhD – Chief Medical
Officer and Chief Scientific Officer |
| ● | Dr. Josh Neman, PhD – Chief Clinical Officer |
| ● | Keithly Garnett – Chief Financial Officer |
Conference Call Details:
| ● | Time: 6:00 a.m. PT / 9:00 a.m. ET |
| ● | Webcast: A live webcast can be accessed
at: https://www.webcaster5.com/Webcast/Page/3151/53708 or by visiting https://investors.neonc.com |
ABOUT NEONC TECHNOLOGIES HOLDINGS, INC.
NeOnc Technologies Holdings, Inc. is a clinical-stage
life sciences company focused on the development and commercialization of central nervous system therapeutics that are designed to address
the persistent challenges in overcoming the blood-brain barrier. The company’s NEO™ drug development platform has produced
a portfolio of novel drug candidates and delivery methods with patent protections extending to 2038. These proprietary chemotherapy agents
have demonstrated positive effects in laboratory tests on various types of cancers and in clinical trials treating malignant gliomas.
NeOnc’s NEO100™ and NEO212™ therapeutics are in Phase II human clinical trials and are advancing under FDA Fast-Track
and Investigational New Drug (IND) status. The company has exclusively licensed an extensive worldwide patent portfolio from the University
of Southern California consisting of issued patents and pending applications related to NEO100, NEO212, and other products from the NeOnc
patent family for multiple uses, including oncological and neurological conditions.
For more about NeOnc and its pioneering technology,
visit https://neonc.com
Important Cautions Regarding Forward Looking
Statements
This press release contains “forward-looking
statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange
Act of 1934, as amended. These forward-looking statements can be identified by terminology such as “may,” “will,”
“should,” “intend,” “expect,” “plan,” “budget,” “forecast,” “anticipate,”
“believe,” “estimate,” “predict,” “potential,” “continue,” “evaluating,”
or similar words. Statements that contain these words should be read carefully, as they discuss our future expectations, projections of
future results of operations or financial condition, or other forward-looking information. These statements reflect our current expectations
based on information available at this time, but future events may differ materially from those anticipated. We assume no obligation to
revise or update any forward-looking statements, whether as a result of new information, future developments, or otherwise, except as
required by applicable securities laws and regulations. “NEO100” and NEO “212” are registered trademarks of NeOnc
Technologies Holdings, Inc.
Company Contact:
info@neonc.com
Investor Contact:
James Carbonara
Hayden IR
(646)-755-7412
james@haydenir.com
