[Form 4] Opko Health Inc. Insider Trading Activity

Rhea-AI Filing Summary

Phillip Frost M.D. and related entities reported multiple dispositions of OPKO HEALTH, INC. (OPK) common stock on 08/18/2025. The Form 4 shows a reported sale (transaction code G) of 440,000 shares for $0 and additional dispositions of 3,568,951 shares. Following the reported transactions, the filing lists 214,236,448 shares and 30,127,177 shares held indirectly by affiliated trusts and entities, with ownership described in footnotes clarifying trustee/beneficiary relationships. The filing is signed by Phillip Frost, M.D., individually and as trustee, indicating the report covers both his individual and related trust holdings.

Positive

• Timely disclosure of insider transactions via a filed Form 4, satisfying Section 16 reporting requirements
• Detailed ownership footnotes clarify trustee, beneficiary and partnership relationships for indirect holdings

Negative

• Large dispositions reported: 440,000 shares and 3,568,951 shares disposed on 08/18/2025
• Substantial indirect holdings remain with affiliated entities: 214,236,448 shares and 30,127,177 shares, indicating material insider exposure

Insights

Securities Analyst

TL;DR Insider reported large dispositions and substantial indirect holdings through affiliated trusts; filing documents governance relationships.

The Form 4 discloses significant share movements by Phillip Frost and affiliated entities on 08/18/2025. The largest reported numeric items are disposals of 440,000 and 3,568,951 shares and indirect holdings of 214,236,448 and 30,127,177 shares across Frost-controlled trusts and partnerships. Footnotes detail trustee/beneficiary and limited partner structures, and the reporting person disclaims beneficial ownership except for pecuniary interest. The disclosure is procedural and clarifies ownership chains relevant for Section 16 compliance.

Corporate Governance Expert

TL;DR Filing documents material insider dispositions and explains complex indirect ownership via trusts and partnerships.

The report emphasizes legal ownership structure: Frost Gamma Investments Trust and Frost-Nevada entities are identified as holders, with Dr. Frost as trustee or controlling shareholder in related entities. The filing includes explicit disclaimers of beneficial ownership except for pecuniary interest, and it is signed by Dr. Frost as required. These details are important for accurately attributing voting and economic interests under disclosure rules.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

FROST PHILLIP MD ET AL

(Last) (First) (Middle)

OPKO HEALTH, INC.

4400 BISCAYNE BLVD.

(Street)

MIAMI FL 33137

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
OPKO HEALTH, INC. [ OPK ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director	X	10% Owner
X	Officer (give title below)		Other (specify below)
	CEO & Chairman

3. Date of Earliest Transaction (Month/Day/Year)
08/18/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

	Form filed by One Reporting Person
X	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	08/18/2025		G		440,000	D	$0	214,236,448	I	See Footnote(1)
Common Stock								3,568,951	D
Common Stock								30,127,177	I	See Footnote(2)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

1. Name and Address of Reporting Person^*

FROST PHILLIP MD ET AL

(Last) (First) (Middle)

OPKO HEALTH, INC.

4400 BISCAYNE BLVD.

(Street)

MIAMI FL 33137

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

X	Director	X	10% Owner
X	Officer (give title below)		Other (specify below)
	CEO & Chairman

1. Name and Address of Reporting Person^*

Frost Gamma Investments Trust

(Last) (First) (Middle)

OPKO HEALTH, INC.

4400 BISCAYNE BLVD.

(Street)

MIAMI FL 33137

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

Explanation of Responses:

1. The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

2. These securities are held by Frost Nevada Investments Trust, of which the Reporting Person is the trustee and Frost-Nevada, L.P. is the sole and exclusive beneficiary. The Reporting Person is one of seven limited partners of Frost-Nevada, L.P. and the sole shareholder of Frost-Nevada Corporation, the sole general partner of Frost-Nevada, L.P. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

	Phillip Frost, M.D., Individually and as Trustee	08/19/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What insider transactions did Phillip Frost report for OPK on 08/18/2025?

The Form 4 reports dispositions on 08/18/2025 including 440,000 shares (transaction code G) and 3,568,951 shares disposed.

How many OPK shares are held indirectly by Frost-controlled entities according to the filing?

The filing lists indirect holdings of 214,236,448 shares and 30,127,177 shares held by affiliated trusts/entities.

Does the Form 4 explain the ownership structure for the reported shares?

Yes. Footnotes describe that Frost Gamma Investments Trust and Frost-Nevada entities hold securities, with explanations of trustee, beneficiary and partnership roles.

Who signed the Form 4 for these transactions?

The Form 4 is signed by Phillip Frost, M.D., individually and as trustee, dated 08/19/2025.

Does the filing assert beneficial ownership for the trusts mentioned?

The reporting person includes disclaimers stating they disclaim beneficial ownership of the trust-held securities except to the extent of any pecuniary interest.