OPKO Health director Paganelli sells 4,426 shares

John A. Paganelli reported 389,914 shares held directly after his sale, while the other reported sale involved shares owned by his spouse.

Available on EDGAR 11/05/2026 - 04:07 PM EST Accepted by SEC EDGAR 11/05/2026 - 04:07 PM EST Learn about SEC filing dates

Rhea-AI Filing Summary

OPKO HEALTH, INC. (OPK) director John A. Paganelli sold 4,426 common shares directly on November 5, 2026, at $1.78 per share; he reported 389,914 directly held shares afterward. Securities owned by his spouse were also sold: 9,175 shares at $1.82 per share, with zero shares reported afterward for that indirect holding. Paganelli disclaims beneficial ownership of the spouse-owned securities except to the extent of any pecuniary interest. No Rule 10b5-1 plan is reported.

Insider Trade Summary

Net Seller: 13,601 shares

Net Sell 2 txns

Insider PAGANELLI JOHN A

Role Director

Sold 13,601 shs ($25K)

Share of Position Sold 3.4%

Type	Security	Shares	Price	Value
Sale	Common Stock	4,426	$1.78	$8K
Sale	Common Stock F1	9,175	$1.82	$17K

Holdings After Transaction: Common Stock — 389,914 shares (Direct); Common Stock — 0 shares (Indirect, See Footnote)

Holdings Before and After: Common Stock, 394,340 to 389,914 shares (Direct); Common Stock, 9,175 to 0 shares (Indirect, See Footnote)

Footnotes (1)

1. F1. These securities are owned by Mr. Paganelli's spouse. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of the securities for purposes of Section 16 or for any other purposes.

Key Figures

Direct shares sold: 4,426 shares Direct sale price: $1.78 per share Direct shares following transaction: 389,914 shares +3 more

6 metrics

Direct shares sold 4,426 shares November 5, 2026

Direct sale price $1.78 per share November 5, 2026

Direct shares following transaction 389,914 shares After the November 5, 2026 sale

Spouse-owned shares sold 9,175 shares November 5, 2026

Spouse-owned share sale price $1.82 per share November 5, 2026

Indirect shares following transaction 0 shares After the November 5, 2026 sale

Key Terms

Common Stock, beneficial ownership, pecuniary interest

3 terms

Common Stock financial

"security title: Common Stock"

Common stock represents ownership shares in a company, giving investors a stake in its success and a say in important decisions through voting rights. It is the most common type of stock traded on markets and can provide income through dividends, as well as potential for value growth. For investors, holding common stock means sharing in the company’s profits and risks.

beneficial ownership regulatory

"disclaims beneficial ownership of these securities"

Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.

pecuniary interest regulatory

"except to the extent of any pecuniary interest therein"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

How many OPK shares did director John A. Paganelli sell on November 5, 2026?

John A. Paganelli sold 4,426 shares directly at $1.78 per share, and 9,175 shares owned by his spouse were sold at $1.82 per share. He reported 389,914 shares held directly afterward and disclaimed beneficial ownership of the spouse-owned securities except to the extent of any pecuniary interest.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

PAGANELLI JOHN A

(Last) (First) (Middle)

OPKO HEALTH, INC.

4400 BISCAYNE BLVD.

(Street)

MIAMI FLORIDA 33137

(City) (State) (Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
OPKO HEALTH, INC. [ OPK ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
11/05/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	11/05/2026		S		4,426	D	$1.78	389,914	D
Common Stock	11/05/2026		S		9,175	D	$1.82	0	I	See Footnote(1)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. These securities are owned by Mr. Paganelli's spouse. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of the securities for purposes of Section 16 or for any other purposes.

	Steven D. Rubin, Attorney-in-Fact	11/05/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)